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Table 7 Clinical outcomes for major or nonmajor surgeries by renal function

From: Management of edoxaban therapy and clinical outcomes in patients undergoing major or nonmajor surgery: a subanalysis of the EMIT-AF/VTE study

 

Major surgeries

Nonmajor surgeries

 

CrCL ≤ 50

(n = 64)

CrCL > 50

(n = 189)

CrCL unknown

(n = 23)

CrCL ≤ 50

(n = 134)

CrCL > 50

(n = 302)

CrCL unknown

(n = 76)

All bleeding

1 (1.6)

10 (5.3)

1 (4.3)

7 (5.2)

6 (2.0)

4 (5.3)

Major bleedinga

0

1 (0.5)

0

1 (0.7)

1 (0.3)

1 (1.3)

CRNMB

0

4 (2.1)

0

1 (0.7)

0

0

Minor bleeding

1 (1.6)

5 (2.6)

1 (4.3)

5 (3.7)

5 (1.7)

3 (3.9)

ACS

0

0

0

0

0

0

Stroke

0

0

0

1 (0.7)

0

0

TIA

0

0

0

0

0

0

SEE

0

1 (0.5)

0

0

0

0

All-cause death

0

2 (1.1)

0

0

0

0

CV death

0

0

0

0

0

0

  1. Data are shown as n (number of events per 100 surgeries)
  2. ACS Acute coronary syndrome, CrCL Creatinine clearance (mL/min), CRNMB Clinically relevant nonmajor bleeding, CV Cardiovascular, n Number of surgeries, SEE Systemic embolism event, TIA Transient ischaemic attack
  3. aInternational Society of Thrombosis and Haemostasis definition