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Fig. 4 | Thrombosis Journal

Fig. 4

From: Hemostatic potential of recombinant von Willebrand factor and standard or pegylated extended half-life recombinant factor VIII on thrombus formation under high shear flow

Fig. 4

Effects of rVWF and rFVIII or peg-EHL-rFVIII in type 1 VWD whole blood using an alternative flow chamber technique (T-TAS). rVWF (1.6 IU/mL), rFVIII (1.0 IU/mL) and/or Peg-EHL-rFVIII (1.0 U/mL) were added to type 1 VWD whole blood and was perfused at 1,000 s− 1 in type I collagen coated flow chambers optimized for T-TAS. pd-VWF/FVIII (1.6 IU/mL/1.0 IU/mL) and PBS was used as positive or negative controls, respectively. The pressure inside the chamber was monitored at 10 and 60 kPa (T10 and T60) and areas under curve (AUC) were calculated. Measurements of T10 or T60 at times > 10 min are recorded as 10 min. Values and error bars represent the mean(± SD) of T10, T60, and AUC in 3 separate flow experiments. *p < 0.05, **p < 0.01, ***p < 0.001, EHL-rFVIII; peg-EHL-rFVIII

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Thrombosis Journal

ISSN: 1477-9560

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