Table 3 Unadjusted and adjusted associations between different treatments and mortality
From: Association between antithrombotic therapy and mortality in patients hospitalized for COVID‑19
Outcomes | Treatment regimen | Events, n (%) | Unadjusted OR | P | Multivariable Regression adjusted OR | P | Propensity Score Matching adjusted OR | P |
|---|---|---|---|---|---|---|---|---|
In-hospital mortality | No anticoagulant and no antiplatelet | 473 (11.3) | 1 [Reference] | 1 [Reference] | 1 [Reference] | |||
Antiplatelet | 44 (10.5) | 0.92 (0.67, 1.28) | 0.627 | 0.83 (0.53, 1.30) | 0.413 | 0.63 (0.42, 0.94) | 0.032 | |
OAC with/without antiplatelet | 17 (6.3) | 0.53 (0.32, 0.87) | 0.012 | 0.46 (0.24, 0.87) | 0.017 | 0.35 (0.19, 0.61) | < 0.001 | |
Mechanical ventilation | No anticoagulant and no antiplatelet | 975 (23.3) | 1 [Reference] | 1 [Reference] | 1 [Reference] | |||
Antiplatelet | 82 (19.6) | 0.80 (0.62, 1.03) | 0.087 | 0.89 (0.64, 1.23) | 0.470 | 0.72 (0.52, 0.99) | 0.047 | |
OAC with/without antiplatelet | 47 (17.3) | 0.69 (0.50, 0.96) | 0.025 | 0.62 (0.41, 0.95) | 0.028 | 0.49 (0.33, 0.74) | 0.001 | |
ICU administration | No anticoagulant and no antiplatelet | 315 (7.5) | 1 [Reference] | 1 [Reference] | 1 [Reference] | |||
Antiplatelet | 13 (3.1) | 0.39 (0.22, 0.69) | 0.001 | 0.35 (0.18, 0.71) | 0.003 | 0.33 (0.17, 0.62) | 0.001 | |
OAC with/without antiplatelet | 13 (4.8) | 0.62 (0.35, 1.10) | 0.100 | 0.51 (0.24, 1.06) | 0.070 | 0.60 (0.29, 1.21) | 0.215 | |
AKI | No anticoagulant and no antiplatelet | 157 (3.7) | 1 [Reference] | 1 [Reference] | 1 [Reference] | |||
Antiplatelet | 6 (1.4) | 0.37 (0.16, 0.85) | 0.019 | 0.38 (0.14, 1.06) | 0.063 | 0.29 (0.11, 0.69) | 0.010 | |
OAC with/without antiplatelet | 9 (3.3) | 0.88 (0.45, 1.75) | 0.720 | 0.68 (0.24, 1.88) | 0.455 | 1.30 (0.48, 3.67) | 0.800 |