Fig. 8

Schematic representation of the regulation of TF activity by interaction with MAGI1. A The interaction of the cytoplasmic domain of TF with the PDZ1 domain of MAGI1 restrains TF. Initiation of cell signalling following the activation of PAR2 on the cell surface may result in (B) the induction of capsase-1 leading to the degradation on MAGI1 into non-functional fragments. C Concurrent phosphorylation of TF by PKC at Ser253 prevents further binding with other MAGI1 proteins on the cells surface. These alterations collectively may promote the processing of TF permitting interaction with fVIIa as an active complex