Thrombosis-related characteristics of pregnant women with antithrombin deficiency, protein C deficiency and protein S deficiency in Japan

Table 2 Maternal background data

		AT deficiency	PC deficiency	PS deficiency	Total			AT deficiency	PC deficiency	PS deficiency	Total
Number of cases		80	50	317	447	Number of pregnancies	0	14^‡	9*	40^§	63^§
Combined deficiency (yes)		4	11	13	28		1	37*	20	76^#	133
Family history of thrombosis only (yes)		29	7	31	67		2	21	8	77^‡	116^‡
Past history of thrombosis only (yes)		7	12	37	56		≥ 3	8	13*	122^§	143^§
Both family and past history of thrombosis (yes)		20	5	11	36	Number of deliveries	0	36	27	146	209*
Gene analysis (yes)		24	10	11	45		1	34	19	128*	181^‡
Time of diagnosis	Before current pregnancy	51	38	257	346		2	9	4	37	50
Time of diagnosis	During current pregnancy	29	12	60	101		≥ 3	1	0	4*	5*
Mean activity at diagnosis (mean ± SD, %)		47.6 ± 11.4	48.4 ± 10.5	40.3 ± 13.7	42.8 ± 13.4	Number of spontaneous abortions	0	37	24	108^§	169^§
Mean antigen level at diagnosis (mean ± SD, %)		64.4 ± 30.2	44.8 ± 9.9	55.4 ± 20.0	55.0 ± 20.9		1	7	1^‡	9^§	17^§
Type I deficiency		26	26	36	88		2	3	9^§	38^§	50^§
Type II deficiency		8	0	71	79		≥ 3	2	4^#	64^§	70^§
Type unknown		46	24	210	280	Complications of past pregnancy		27^nd	22^nd	164^nd	213^nd

AT Antithrombin, PC Protein C, PS Protein S, Type I deficiency is classified as a quantitative abnormality in which both the activity and antigen levels are decreased. Type II deficiency is classified as a qualitative abnormality in which the activity level decreases even though the antigen level is normal. The obtained effective number of pregnancies and deliveries among controls were 1,181,079 and 1,179,592, respectively. No mark means not significant vs. control, *: P < 0.05 vs. control, ‡: P < 0.01 vs. control, #: P < 0.001 vs. control, §: P < 0.0001 vs. control, nd: not determined

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