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Table 4 Outcomes of current pregnancy

From: Thrombosis-related characteristics of pregnant women with antithrombin deficiency, protein C deficiency and protein S deficiency in Japan

 

AT deficiency n = 80

PC deficiency n = 50

PS deficiency n = 317

Total n = 447

Control n = 1,171,651

Thrombosis

Deep vein thrombosis (DVT)

15

12

32

59 (13.2%)

889 (0.08%)

Pulmonary embolism (PE)

1

0

4

5 (1.1%)

218

(0.02%)

DVT + PE

5

1

4

10 (2.2%)

no data

Cerebral vein thrombosis

1

0

1

2 (0.4%)

no data

Arterial thrombosis

0

1

1

2 (0.4%)

no data

Total (%)

22§ (27.5%)

14§ (28.0%)

42§ (13.2%)

78§ (17.4%)

1107 (0.09%)

Placental abruption

0

0

2

2 (0.4%)

10,036 (0.86%)

Hypertensive disorder of pregnancy (HDP)

1

3

15

19 (4.3%)

68,342 (5.83%)

HELLP (homolysis, elevated liver enzymes,

and low platelet count) syndrome

0

0

2

2 (0.4%)

3447 (0.29%)

Atonic bleeding

3

0

3§

6§ (1.3%)

71,603 (6.11%)

Gestational diabetes mellitus

2

2

13

17* (3.8%)

71,542 (6.11%)

Premature rupture of the membranes

0

0

10§

10§ (2.2%)

5251 (0.45%)

Breech presentation

1

1

2§

4§ (0.9%)

74,781 (6.38%)

Placenta previa/accreta

1

0

5‡

6‡ (1.3%)

5251 (0.45%)

  1. AT Antithrombin, PC Protein C, PS Protein S. In thrombosis among women with thrombophilia, there were significant differences between AT deficiency and PS deficiency, and between PC deficiency and PS deficiency (both p < 0.01). However, there was no significant difference between AT deficiency and PC deficiency. The obtained effective number of deliveries among controls was 1,171,651. No mark means not significant vs. control, *: P < 0.05 vs. control, ‡: P < 0.01 vs. control, §: P < 0.0001 vs. control