Thrombosis-related characteristics of pregnant women with antithrombin deficiency, protein C deficiency and protein S deficiency in Japan

Table 5 Prophylactic anticoagulation in current pregnancy

		AT deficiency n = 80	PC deficiency n = 50	PS deficiency n = 317	Total n = 447
Antepartum	Prophylactic anticoagulant therapy	42	30	175	247
	Unfractionated heparin (UFH) only	37	18	70	125
	UFH combined with LDA^※	3	12	104	119
	Others^#	2	0	1	3
	No occurrence of thrombosis	38	28	174	240
	Onset of thrombosis	4	2	1	7*
	No prophylactic anticoagulant therapy	38	20	142	200
	No occurrence of thrombosis	21	10	104	135
	Occurrence of thrombosis	17	10	38	65**
Intrapartum	UFH only	19	11	43	73
Postpartum	Prophylactic anticoagulant therapy	72	35	166	273
	UFH/low moleculer weight heparin (LMWH) only	17	12	93	122
	UFH/LMWH combined with warfarin	46	18	62	126
	Others^§	9	5	11	25
	No occurrence of thrombosis	71	34	166	271
	Occurrence of thrombosis	1	1	0	2*
	No prophylactic anticoagulant therapy	8	15	151	174
	No occurrence of thrombosis	8	14	148	170
	Occurrence of thrombosis	0	1	3^$	4**

AT Antithrombin, PC Protein C, PS Protein S. ※: In the antepartum period, there was significantly more frequent use of UFH combined with LDA both in women with PS deficiency (p < 0.0001) and PC deficiency (p < 0.01) than in women with AT deficiency. However, there was no significant difference in women with PS deficiency and PC deficiency. *: All of these 9 cases had a previous history and/or family history of thrombosis. **: Twenty-five of 69 cases had a previous history and/or family history of thrombosis. $: All of these 3 cases developed thrombosis after stopping postpartum prophylactic anticoagulant therapy. #: Others includes one case of warfarin and 2 cases of LMWH. §: Others includes 19 cases of warfarin only, 5 cases of DOAC and one case of UFH combined with LDA. The prophylactic anticoagulation used the most was 10,000 units/day of UFH. The dose of LDA was 80–100 mg/day and that of LMWH was 2000–4000 units/day. Although it is not an anticoagulant therapy, LDA alone without UFH was used in 90 cases (3 cases of AT deficiency, 6 cases of PC deficiency and 81 cases of PS deficiency) in the antepartum period

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