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Table 7 Neonatal background data

From: Thrombosis-related characteristics of pregnant women with antithrombin deficiency, protein C deficiency and protein S deficiency in Japan

  

AT deficiency n = 77

PC deficiency n = 48

PS deficiency n = 313

Total n = 438

Control n = 1,178,337

Body weight of term newborn babies

(mean ± SD, g)

2784 ± 413.0

2827 ± 546.1

2852 ± 499.0

2837 ± 290.1

2861 ± 566.3

Sex

Male

38

25

168

231 (52.5%)

606,354 (51.3%)

Female

37

23

149

209 (47.5%)

574,518 (48.7%)

Apgar score

1 min

(mean ± SD)

8.1 ± 1.2

7.9 ± 1.3

8.0 ± 1.3

8.0 ± 1.3

8.0 ± 1.4

5 min

(mean ± SD)

9.1 ± 0.6

9.1 ± 0.7

9.0 ± 0.9

9.0 ± 0.8

8.9 ± 1.1

Full term delivery (37 ≤  < 42 GW)

Large for

gestational age (LGA)

0

1

2

3 (0.8%)

8818 (0.9%)

Appropriate for

gestational age (AGA)

57

36

245

338 (86.4%)

909,762 (89.7%)

Small for gestational age (SGA)

12*

6

32

50* (12.8%)

95,434 (9.4%)

Preterm delivery

(22 ≤  < 37 GW)

10

5

43

58 (13.2%)

162,229 (13.8%)

Multiple pregnancy

2

0

9‡

11# (2.5%)

74,310 (6.3%)

Non reassuring fetal status

0‡

4

8#

12§ (2.7%)

90,742 (7.7%)

Neonatal asphyxia (5 min Apgar score < 7)

2*

1*

6§

9§ (2.1%)

125,653 (10.7%)

Deformity

2

1

7

10 (2.3%)

15,990 (1.4%)

Neonatal death

0

0

2

2 (0.5%)

7115 (0.6%)

Other complications

3

5

12

20 (4.6%)

nd

Mean enzyme activity of newborn (mean ± SD, %)

51.5 ± 43.1

13.0 ± 0.00

58.6 ± 32.1

36.2 ± 23.9

nd

  1. AT Antithrombin, GW Gestational weeks, PC Protein C, PS Protein S. The obtained effective number of newborn babies (≥ 22 GW) among controls was 1,178,337. No mark means not significant vs. control, *: P < 0.05 vs. control, ‡: P < 0.01 vs. control, #: P < 0.001 vs. control, §: P < 0.0001 vs. control, nd: not determined. The number of preterm deliveries of women with PS deficiency included 4 cases of twins. The percentages of LGA, AGA and SGA are the respective percentages among the number of full term deliveries. As there were no cases of over term delivery (≥ 42 GW) in thrombophiliac patients, control data are not shown. Abortion cases were excluded from these data