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Fig. 3 | Thrombosis Journal

Fig. 3

From: SERPINC1 c.1247dupC: a novel SERPINC1 gene mutation associated with familial thrombosis results in a secretion defect and quantitative antithrombin deficiency

Fig. 3

Frameshift mutation p.Ser417LysfsTer48 results in a secretion defect. Cell lysates and cell culture supernatants of HEK293T cells transfected with constructs for GFP- or HA-tagged AT or ATfs were compared. While no significant quantitative differences could be detected for AT and ATfs in cell lysate between all mutant and all WT lines (A, C), secretion of ATfs is strongly reduced in all mutant lines compared to all WT lines with a statistical significance of p<0.01 (B, D) (analyzed using one-way ANOVA with Bonferroni and Holm correction, all pairs simultaneously compared). Mean values of n=3 technical replicates of three different cell lines per construct, error bars=standard deviation. One asterisk indicates a significant difference (p<0.05), two asterisks indicate a highly significant difference (p<0.01). If not indicated by brackets, significance refers to all mutant lines compared to all WT lines

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Thrombosis Journal

ISSN: 1477-9560

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