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Fig. 4 | Thrombosis Journal

Fig. 4

From: SERPINC1 c.1247dupC: a novel SERPINC1 gene mutation associated with familial thrombosis results in a secretion defect and quantitative antithrombin deficiency

Fig. 4

Predicted tertiary structures for WT AT and p.Ser417LysfsTer48 variant (ATfs). Native form of AT is indicated by the exposed reactive center loop (A, indicated by arrows). In silico prediction by C-I-TASSER [9] results in a folding model of ATfs that resembles the latent form of SERPINs. The C-terminal peptide of ATfs with altered amino acid sequence according to the frameshift mutation is differentially positioned in ATfs (B, indicated by arrows)

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Thrombosis Journal

ISSN: 1477-9560

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