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Table 3 Bleeding rates according to the IMPROVE bleeding RAMa

From: External validation and update of the International Medical Prevention Registry on Venous Thromboembolism bleeding risk score for predicting bleeding in acutely ill hospitalized medical patients: a retrospective single-center cohort study in Japan

Risk score grouping

Patients

Incidence of any bleeding

Incidence of major bleeding

 

n (%)

n

% (95% CI)

n

% (95% CI)

Two-risk-group model

     

Low risk (negative)

3,281 (84.6)

43

1.3 (1.0–1.8)

34

1.0 (0.7–1.5)

High risk (positive)

595 (15.4)

15

2.5 (1.5–4.3)

15

2.5 (1.5–4.3)

11-risk group modelb

     

0–1 (0.5)

218 (5.6)

1

0.5 (0.0–6.4)

0

0.0 (0.0–1.7)

1.5–2 (1.75)

444 (11.5)

1

0.2 (0.0–3.3)

1

0.2 (0.0–3.3)

2.5 (2.5)

795 (20.5)

7

0.9 (0.4–2.1)

5

0.7 (0.3–1.8)

3–4 (3.5)

673 (17.4)

12

1.7 (0.9–3.2)

10

1.5 (0.7–2.9)

4.5–5 (4.75)

656 (16.9)

7

1.1 (0.5–2.5)

6

0.9 (0.4–2.3)

5.5–6.5 (6)

494 (12.7)

14

2.9 (1.7–5.0)

11

2.3 (1.2–4.3)

7 (7)

200 (5.2)

3

1.5 (0.4–5.5)

3

1.5 (0.4–5.5)

7.5–8 (7.75)

151 (3.9)

5

3.4 (1.3–8.7)

5

3.4 (1.3–8.7)

8.5–9.5 (9)

157 (4.1)

4

2.8 (0.9–7.9)

4

2.8 (0.9–7.9)

10–12 (11)

58 (1.5)

2

2.7 (0.3–20.6)

2

2.7 (0.3–20.6)

≥ 12.5

28 (0.7)

1

3.5 (0.2–36.5)

1

3.5 (0.2–36.5)

Total

3,876 (100)

58

—

49

—

  1. a. Overall estimates and their 95% CIs based on 20 imputed datasets for missing data synthesized using Rubin’s rules
  2. b. Score intervals (midpoints) defined using the original RAM are presented
  3. CI, confidence interval; IMPROVE, International Medical Prevention Registry on Venous Thromboembolism RAM, risk assessment model