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  1. The choice of optimal antithrombotic therapy in atrial fibrillation (AF) patients with acute coronary syndrome (ACS) or percutaneous coronary intervention (PCI) remains controversial. The aim of this longitudi...

    Authors: Chiao-Chin Lee, Chiao-Hsiang Chang, Yuan Hung, Chin-Sheng Lin, Shih-Ping Yang, Shu-Meng Cheng, Fan-Han Yu, Wei-Shiang Lin and Wen-Yu Lin
    Citation: Thrombosis Journal 2021 19:100
  2. Long-term oral anticoagulant should be considered or recommended in patients with atrial fibrillation (AF) and CHA2DS2VASc score ≥ 1 for stroke prevention. Warfarin and different direct oral anticoagulants (DO...

    Authors: Wei-Chieh Lee, Pai-Wei Lee, Po-Jui Wu, Yen-Nan Fang, Huang-Chung Chen, Yu-Sheng Lin, Hsiu-Yu Fang, Shang-Hung Chang, Ping-Yen Liu and Mien-Cheng Chen
    Citation: Thrombosis Journal 2021 19:98

    The Correction to this article has been published in Thrombosis Journal 2021 19:106

  3. Knowledge on the pharmacodynamic effects of antiplatelet drugs including clopidogrel and ticagrelor on Asian patients is scarce. We aim to evaluate the effects of the two drugs on platelet reactivity in the tr...

    Authors: Yang Zhang, Rui Peng, Xiaojuan Li, Gaowa Cheng, Ximing Wang, Jinxing Yu, Muxing Hua, Xi Chen and Zhou Zhou
    Citation: Thrombosis Journal 2021 19:97
  4. Acute limb ischemia (ALI) is an important clinical event threatening both life and the affected limbs, but the optimal treatment for ALI remains undefined. The aim of this study was to compare the safety and e...

    Authors: Maofeng Gong, Xu He, Boxiang Zhao, Jie Kong, Jianping Gu and Guoping Chen
    Citation: Thrombosis Journal 2021 19:96
  5. Cancer-associated venous thromboembolism (VTE) is common in patients with primary lung cancer. It has been understudied which authoritative risk assessment score of cancer-associated VTE is optimal for the ass...

    Authors: Wei Xiong, Yunfeng Zhao, He Du, Yanmin Wang, Mei Xu and Xuejun Guo
    Citation: Thrombosis Journal 2021 19:95
  6. Type 3 von Willebrand disease (VWD) exhibits severe hemorrhagic tendency with complicated pathogenesis. The C-terminal cystine knot (CTCK) domain plays an important role in the dimerization and secretion of vo...

    Authors: Yuxin Zhang, Fengwu Chen, Aizhen Yang, Xiaoying Wang, Yue Han, Depei Wu, Yi Wu and Jingyu Zhang
    Citation: Thrombosis Journal 2021 19:94
  7. Immune-mediated necrotizing myopathy (IMNM) is characterized by proximal muscle weakness, elvated serum muscle enzyme levels, myopathic electromyography findings, and necrotic muscle fiber with few inflammator...

    Authors: Jiali Li, Mingming Yan, Jiao Qin, Lingyan He, Cao Dai and Rui Wen
    Citation: Thrombosis Journal 2021 19:92
  8. Anticoagulation in hospitalized COVID-19 patients has been associated with survival benefit; however, the optimal anticoagulant strategy has not yet been defined. The objective of this meta-analysis was to inv...

    Authors: Sirui Zhang, Yupei Li, Guina Liu and Baihai Su
    Citation: Thrombosis Journal 2021 19:91
  9. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is considered to have multiple roles in the development of atherosclerosis, which is recently reported to participate in the thrombotic process. We aimed t...

    Authors: Jia Peng, Ming-Ming Liu, Hui-Hui Liu, Yuan-Lin Guo, Na-Qiong Wu, Qian Dong, Jie Qian, Ke-Fei Dou, Cheng-Gang Zhu and Jian-Jun Li
    Citation: Thrombosis Journal 2021 19:90
  10. Post-operative atrial fibrillation (POAF) is the most common complication after cardiac surgery. Recent studies had shown this phenomenon is no longer considered transitory and is associated with higher risk o...

    Authors: Mariana Fragão-Marques, Francisco Teixeira, Jennifer Mancio, Nair Seixas, João Rocha-Neves, Inês Falcão-Pires and Adelino Leite-Moreira
    Citation: Thrombosis Journal 2021 19:89
  11. Rupture of an atherosclerotic plaque and subsequent exposure of the subendothelial prothrombotic matrix to blood cause arterial thrombosis. Circulating platelets play an indispensable role in the growth of art...

    Authors: Yuu Oda, Takashi Ito, Yoichiro Yamada, Tadashi Koga, Tomoka Nagasato, Tomoko Ohnishi-Wada, Kazuya Hosokawa, Hiroyuki Fukase, Teruto Hashiguchi and Ikuro Maruyama
    Citation: Thrombosis Journal 2021 19:88
  12. The prevalence of venous thromboembolism (VTE) is high in critically ill patients with COVID-19. Dosing of Low Molecular Weight Heparin (LMWH) for thromboprophylaxis in patients with severe COVID-19 is subject...

    Authors: David Oliver Hamilton, Alexander Main-Ian, Jessie Tebbutt, Maya Thrasher, Alicia Waite and Ingeborg Welters
    Citation: Thrombosis Journal 2021 19:87
  13. Thromboembolic and bleeding events after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are major public concerns leading to vaccine hesitancy. Due to low incidence, an indivi...

    Authors: Noppacharn Uaprasert, Krissana Panrong, Ponlapat Rojnuckarin and Thita Chiasakul
    Citation: Thrombosis Journal 2021 19:86
  14. The present study aimed to explore these characteristics, particularly thin-cap fibroatheroma (TCFA), in relation to residual syntax score (rSS) in patients who presented with acute MI.

    Authors: Xiaoxiao Zhao, Ying Wang, Runzhen Chen, Jiannan Li, Jinying Zhou, Chen Liu, Peng Zhou, Zhaoxue Sheng, Yi Chen, Li Song, Hanjun Zhao and Hongbing Yan
    Citation: Thrombosis Journal 2021 19:85
  15. Superior Vena Cava (SVC) syndrome, is a quite rare but serious complication after pacemaker lead implantation; most patients are asymptomatic due to the development of adequate venous collateral circulation.

    Authors: Nicola Mumoli, Antonino Mazzone, Isabella Evangelista, Marco Cei and Alessandra Colombo
    Citation: Thrombosis Journal 2021 19:84
  16. Few studies detail the evolution of COVID-19 associated coagulopathy. We performed serial thromboelastography (TEG) and laboratory coagulation studies in 40 critically-ill, mechanically ventilated COVID-19 pat...

    Authors: Colette Neethling, Gregory Calligaro, Malcolm Miller and Jessica J. S. Opie
    Citation: Thrombosis Journal 2021 19:83
  17. Timely diagnosis of disseminated intravascular coagulation (DIC) in hemophagocytic lymphohistiocytosis (HLH) patients is crucial but challenging, as HLH interferes with the results of the laboratory tests incl...

    Authors: Liqin Ling, Xunbei Huang, Chaonan Liu, Juan Liao and Jing Zhou
    Citation: Thrombosis Journal 2021 19:82
  18. Cerebral venous sinus thrombosis (CVST) is a relatively rare, but potentially lethal condition. In approximately 15% of the patients, the cause of CVST remains unclear. Conventional clotting tests such as prot...

    Authors: Myrthe M. van der Bruggen, Bram Kremers, Rene van Oerle, Robert J. van Oostenbrugge and Hugo ten Cate
    Citation: Thrombosis Journal 2021 19:81
  19. COVID-19 infection is associated with a hypercoagulable state. Severe COVID-19 patients present with high plasma fibrinogen levels, continuous deposition of fibrin and the presence of microthrombi in their lun...

    Authors: Yael Lichter, Tanya Badelbayov, Irina Shalev, Reut Schvartz, Yishay Szekely, Dan Benisty, Ilana Goldiner, Maxim Kagarlyk, Keren Asraf, Ram Doolman, Efrat Luttwak, Ilya Kirgner, Irit Avivi, Nimrod Adi and Ben-Zion Katz
    Citation: Thrombosis Journal 2021 19:79
  20. The severity of pulmonary arterial hypertension (PAH) is classified based on mean pulmonary artery pressure (mPAP) levels. However, other markers have not been elucidated. Fibrinolytic markers, such as total p...

    Authors: Makoto Shoji, Taiju Matsui, Hideaki Tanaka, Kosuke Nomura, Hiroaki Tsujita, Yusuke Kodama, Shinji Koba, Youichi Kobayashi and Toshiro Shinke
    Citation: Thrombosis Journal 2021 19:78
  21. This study aimed to investigate the background of patients who presented with pulmonary embolism (PE) on contrast-enhanced chest computed tomography (CT) and to explore the risk factors for PE.

    Authors: Kaoru Fujieda, Akiko Nozue, Akie Watanabe, Keiko Shi, Hiroya Itagaki, Yoshihiko Hosokawa, Keiko Nishida, Nobutaka Tasaka, Toyomi Satoh and Ken Nishide
    Citation: Thrombosis Journal 2021 19:77
  22. Venous thromboembolism (VTE) is a common complication among patients with cancer and is one of the most common causes of increased morbidity and mortality. The use of direct oral anticoagulants (DOACs) for thr...

    Authors: Norah S. Alsubaie, Shahad M. Al Rammah, Reema A. Alshouimi, Mohammed Y. Alzahrani, Majed S. Al Yami, Abdulaali R. Almutairi, Osamah M. Alfayez, Ghazwa B. Korayem and Omar A. Almohammed
    Citation: Thrombosis Journal 2021 19:76
  23. In the recent COVID19 pandemic, patients with hematological disorders were considered at high risk for severe disease. Limited data is available regarding the course of COVID19 infection in this subgroup.

    Authors: Sufana Shikdar, Azra Borogovac, Elabdallah Mohamad and Mohamad Khawandanah
    Citation: Thrombosis Journal 2021 19:75
  24. Activated protein C resistance (APCR) due to factor V Leiden (FVL) mutation (R506Q) is a major risk factor in patients with venous thromboembolism (VTE). The present study investigated the clinical manifestati...

    Authors: Vahideh Takhviji, Kazem Zibara, Asma Maleki, Ebrahim Azizi, Sanaz Hommayoun, Mohammadreza Tabatabaei, Seyed Esmaeil Ahmadi, Maral Soleymani, Omid Kiani Ghalesardi, Mina Farokhian, Afshin Davari, Pouria Paridar, Anahita Kalantari and Abbas Khosravi
    Citation: Thrombosis Journal 2021 19:74
  25. This study was aimed to determine how platelet reactivity (PR) on dual antiplatelet therapy predicts ischemic and bleeding events in patients underwent percutaneous coronary intervention (PCI).

    Authors: Jing Wang, Jing Wang, Zhou Dong, Jiazheng Ma, Jianzhen Teng, Tong Wang, Xiaofeng Zhang, Qian Gu, Zekang Ye, Inam Ullah, Chuchu Tan, Samee Abdus, Lu Shi, Xiaoxuan Gong and Chunjian Li
    Citation: Thrombosis Journal 2021 19:73
  26. The antithrombotic effect of vitamin K antagonists (VKA) depends on controlled lowering of the activity of factors (F) II and X whereas reductions in FVII and FIX play little role. PT-INR based monitoring, how...

    Authors: Pall T. Onundarson, Ragnar Palsson, Daniel M. Witt and Brynja R. Gudmundsdottir
    Citation: Thrombosis Journal 2021 19:72
  27. Coagulopathy and following massive bleeding are complications of cardiovascular surgery, particularly occurring after procedures requiring prolonged cardiopulmonary bypass (CPB). Reliable and rapid tests for c...

    Authors: Yoshie Kawahara, Kohei Ohtsuka, Kimine Tanaka, Mayumi Yamanaka, Hiroyuki Kamiya, Takayuki Kunisawa and Satoshi Fujii
    Citation: Thrombosis Journal 2021 19:70
  28. Recently, direct oral anticoagulants (DOACs) have been included in guidelines for the treatment of cancer-associated thrombosis (CAT) to be extended to suitable cancer patients. The purpose of this study was t...

    Authors: Kaidireyahan Wumaier, Wenqian Li, Naifei Chen and Jiuwei Cui
    Citation: Thrombosis Journal 2021 19:68
  29. Recently, heparin-induced thrombocytopenia (HIT) after vaccination with the vaccines manufactured by AstraZeneca and Pfizer–BioNTech has been published in the New England Journal of Medicine. These reports state ...

    Authors: Kenji Yamamoto
    Citation: Thrombosis Journal 2021 19:67
  30. This is a review article on heparin-induced thrombocytopenia, an adverse effect of heparin therapy, and vaccine-induced immune thrombotic thrombocytopenia, occurring in some patients administered certain coron...

    Authors: Payel Datta, Fuming Zhang, Jonathan S. Dordick and Robert J. Linhardt
    Citation: Thrombosis Journal 2021 19:66
  31. Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but fatal complication of the Coronavirus Disease 2019 vaccine. The many reports of VITT have mostly been in the Caucasian population. Here, ...

    Authors: Archrob Khuhapinant, Tarinee Rungjirajittranon, Bundarika Suwanawiboon, Yingyong Chinthammitr and Theera Ruchutrakool
    Citation: Thrombosis Journal 2021 19:65
  32. Protein S deficiency (PSD) is an autosomal dominant hereditary disease. In 1984, familial PSD was reported to be prone to recurrent thrombosis. Follow-up studies have shown that heterozygous protein S (PROS1) mut...

    Authors: Yan-ping Zhang, Bin Lin, Yuan-yuan Ji, Ya-nan Hu, Xin-fu Lin, Yi Tang, Jian-hui Zhang, Shao-jie Wu, Sen-lin Cai, Yan-feng Zhou, Ting Chen, Zhu-ting Fang and Jie-wei Luo
    Citation: Thrombosis Journal 2021 19:64
  33. DOAC detection is challenging in emergency situations. Here, we demonstrated recently, that modified thromboelastometric tests can reliably detect and differentiate dabigatran and rivaroxaban. However, whether...

    Authors: Simon T. Schäfer, Anne-Christine Otto, Alice-Christin Acevedo, Klaus Görlinger, Steffen Massberg, Tobias Kammerer and Philipp Groene
    Citation: Thrombosis Journal 2021 19:63
  34. Intermittent pneumatic compression (IPC) is commonly used to prevent deep vein thrombosis (DVT) during hospitalization in patients with acute stroke. However, if DVT exists at admission, IPC of the legs with D...

    Authors: Takahisa Mori, Kazuhiro Yoshioka and Yuhei Tanno
    Citation: Thrombosis Journal 2021 19:62
  35. Immune thrombocytopenia (ITP) is an autoimmune disease characterized as a low platelet count resulting from immune-mediated platelet destruction. Dimethyl fumarate (DMF) is widely applied for the treatment of ...

    Authors: Huan Tong, Yangyang Ding, Xiang Gui, Zengtian Sun, Guozhang Wang, Sixuan Zhang, Zhengqing Xu, Xiamin Wang, Xiaoqi Xu, Wen Ju, Yue Li, Zhenyu Li, Lingyu Zeng, Kailin Xu and Jianlin Qiao
    Citation: Thrombosis Journal 2021 19:61
  36. Thrombin generation (TG) assessed by Calibrated Automated Thrombogram (CAT-I) reflects the overall capacity of plasma to generate thrombin, thus evaluating the balance between the anti- and procoagulant proces...

    Authors: P. L. A. Giesen, A. J. W. Gulpen, R. van Oerle, H. ten Cate, M. Nagy and H. M. H. Spronk
    Citation: Thrombosis Journal 2021 19:60
  37. Thrombosis plays an important role in the Coronavrus Disease 2019 (COVID-19) infection-related complications such as acute respiratory distress syndrome and myocardial infarction. Multiple factors such as oxyg...

    Authors: Mahin Behzadi Fard, Samaneh Behzadi Fard, Shahin Ramazi, Amir Atashi and Zahra Eslamifar
    Citation: Thrombosis Journal 2021 19:59
  38. Previous studies have shown conflicting results regarding the influence of cardiovascular risk-factors on venous thromboembolism. This study aimed to determine if these risk-factors, i.e. physical activity, sm...

    Authors: C. J. MacDonald, A. L. Madika, M. Lajous, M. Canonico, A. Fournier and M. C. Boutron-Ruault
    Citation: Thrombosis Journal 2021 19:58
  39. The coronavirus disease (COVID-19) pandemic has led to an unprecedented worldwide burden of disease. However, little is known of the longer-term implications and consequences of COVID-19. One of these may be a...

    Authors: Rajiv Advani, Torbjørn Austveg Strømsnes, Espen Stjernstrøm and Sebastian T. Lugg
    Citation: Thrombosis Journal 2021 19:57
  40. Coronavirus disease 2019 (COVID-19) pneumonitis associated with severe respiratory failure is associated with high mortality. The pathogenesis of COVID-19 is associated with microembolism or microvascular endo...

    Authors: Fumihiro Ogawa, Yasufumi Oi, Kento Nakajima, Reo Matsumura, Tomoki Nakagawa, Takao Miyagawa, Kazuya Sakai, Ryo Saji, Hayato Taniguchi, Kohei Takahashi, Takeru Abe, Masayuki Iwashita, Mototsugu Nishii and Ichiro Takeuchi
    Citation: Thrombosis Journal 2021 19:55
  41. We review the evidence for tranexamic acid (TXA) for the treatment and prevention of bleeding caused by surgery, trauma and bleeding disorders. We highlight therapeutic areas where evidence is lacking and disc...

    Authors: Anna Ockerman, Thomas Vanassche, Melisa Garip, Christophe Vandenbriele, Matthias M Engelen, Jeroen Martens, Constantinus Politis, Reinhilde Jacobs and Peter Verhamme
    Citation: Thrombosis Journal 2021 19:54
  42. Data are limited on patient background characteristics associated with catheter ablation (CA)-related bleeding events in Japanese patients with non-valvular atrial fibrillation receiving uninterrupted periproc...

    Authors: Ichitaro Abe, Naohiko Takahashi, Yasushi Mukai, Tetsuya Kimura, Keita Yamaguchi, Atsushi Takita, Hideki Origasa and Ken Okumura
    Citation: Thrombosis Journal 2021 19:53

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  • Thrombosis Journal is the official journal of the Asian-Pacific Society on Thrombosis and Hemostasis.

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