Acute ischemic stroke following Hump-nosed viper envenoming; first authenticated case
© Jeevagan et al.; licensee BioMed Central Ltd. 2012
Received: 20 July 2012
Accepted: 18 September 2012
Published: 20 September 2012
Hump-nosed pit viper (Genus Hypnale) is a medically important venomous snake in Sri Lanka and Southwestern India which causes significant morbidity and mortality. Envenoming of this snake results in hemostastic dysfunction, thrombotic microangiopathy, acute kidney injury and death. This case describes an authenticated first case of ischemic stroke in a 65 year old male following envenoming by H.hypnale in Sri Lanka.
A 65-year-old farmer presented with pain and swelling of his foot following a hump-nosed viper bite. The culprit snake was killed and brought for identification. There was no evidence of systemic envenoming and the 20 minute-whole blood clotting time (20-WBCT) was normal. However, 24 hours later he developed sudden onset left-sided hemiparesis with a muscle power of 3/5, exaggerated tendon reflexes and an extensor plantar response on the left. This was followed by a declining urine output and the development of intractable hiccups. He has been on atorvastatin and aspirin for stable ischaemic heart disease. He did not have hypertension or diabetes mellitus. He has not smoked tobacco for 10 years.
He was treated with supportive care. His urine out put gradually improved without renal replacement therapy and the serum creatinine returned to normal after 5 days. He was discharged home a week later with an out-patient plan for stroke rehabilitation.
Cerebral infarction following snake bite envenoming is uncommon. Arterial thrombotic complications including is chaemic strokes have been reported following Russel viper envenoming in Sri Lanka , but not following hump-nosed viper bites. Our patient developed cerebral infarction 48 hours following hump-nosed viper bite. When considering his age and history of ischemic heart disease it could be a coincidental event. However the presence of potent procoagulants in hump-nosed pit viper venom, made us to consider a possible etiological role of hump-nosed viper envenoming for the cerebral infarction. Furthermore the onset of acute ischemic stroke coincided with the onset of acute kidney injury, which indicated that active venom was present in substantial amounts to damage his kidneys. Elevated D-dimer in our patient is compatible with increased activation of the procoagulant and fibrinolytic mechanisms. In our patient pre existing atherosclerosis might act as a predisposing factor in the mechanism of H.hypnale venom induced thrombotic occlusion.
Clinical and preclinical studies have shown that H.hypnale venom possess strong procoagulant, haemorrhagic and necrotic activities through the presence of phospolipase A2, hyaluronidase, L-amino acid oxidase, thrombin-like enzymes, arginine esterase and various proteases [7–10]. Arginine esterase hydrolase, a thrombin-like enzyme activates clotting factors V and X of the intrinsic and common coagulation pathways leading to thrombin formation and intravascular deposition of fibrin causing vascular occlusion. Furthermore, direct action of the venom on vascular endothelial cells causes vasospasm that may play a role in arterial occlusion [11,, 12]. Phospholipase A2 is a potent vasodilator that can cause acute hypotension and watershed brain infarctions, but this was not the case in our patient.
It is therefore plausible that the hump-nosed viper envenoming was the primary mechanism of vascular occlusion and stroke in our patient, but systematic studies are required to establish a cause-effect relationship. It is curious that although hump-nosed viper venom possesses the potential for vascular occlusion, there were no previous reports of stroke following envenoming. It is possible that stroke following hump-nosed viper bite is a result of a multifactorial process that depends on several factors such as the dose and composition of the venom and an underlying predisposition such as critical cerebral atherosclerosis, or that minor strokes in clinically silent areas of the brain were unrecognized.
To date, there is no effective antivenom for the treatment of hump-nosed viper envenoming. However, if strokes are increasingly recognized following hump-nosed viper bites, an antivenom will be required to prevent thrombotic complications as was shown with a substantial reduction of thrombotic complications in patients treated with antivenom following Bothrops lanceolatus envenoming . This case report is intended to increase the vigilance for arterial thrombosis following hump-nosed viper envenomation.
Written informed consent was obtained from the patient for publication of this Case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
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