Implementation of non-vitamin K antagonist oral anticoagulants in daily practice: the need for comprehensive education for professionals and patients
© Heidbuchel et al. 2015
Received: 13 January 2015
Accepted: 10 March 2015
Published: 26 May 2015
Non-vitamin K antagonist oral anticoagulants (NOACs) are increasingly used for the prevention and treatment of venous thromboembolism and for stroke prevention in patients with atrial fibrillation. NOACs do not require routine coagulation monitoring, creating a challenge to established systems for patient follow-up based on regular blood tests. Healthcare professionals (HCPs) are required to cope with a mixture of patients receiving either a vitamin K antagonist or a NOAC for the same indications, and both professionals and patients require education about the newer drugs. A European working group convened to consider the challenges facing HCPs and healthcare systems in different countries and the educational gaps that hinder optimal patient management. Group members emphasised the need for regular follow-up and noted national, regional and local variations in set-up and resources for follow-up. Practical incorporation of NOACs into healthcare systems must adapt to these differences, and practical follow-up that works in some systems may not be able to be implemented in others. The initial prescriber of a NOAC should preferably be a true anticoagulation specialist, who can provide initial patient education and coordinate the follow-up. The long-term follow-up care of patients can be managed through specialist coagulation nurses, in a dedicated anticoagulation clinic or by general practitioners trained in NOAC use. The initial prescriber should be involved in educating those who perform the follow-up. Specialist nurses require access to tools, potentially including specific software, to guide systematic patient assessment and workflow. Problem cases should be referred for specialist advice, whereas in cases for which minimal specialist attention is required, the general practitioner could take responsibility for patient follow-up. Hospital departments and anticoagulation clinics should proactively engage with all downstream HCPs (including pharmacists) to ensure their participation in patient management and reinforcement of patient education at every opportunity. Ideally, (transmural) protocols for emergency situations should be developed. Last but not least, patients should be well-informed about their condition, the treatment, possible risk scenarios, including the consequences of non-adherence to prescribed therapy, and the organisation of follow-up care.
Background: non-vitamin K antagonist oral anticoagulants and the need for education
The well-documented limitations of vitamin K antagonists (VKAs) have led to the development of non-VKA oral anticoagulants (NOACs) that have more predictable pharmacological properties, do not require routine coagulation monitoring, depend less on patient and lifestyle factors, and have fewer restrictions in terms of diet and co-medications . NOACs are changing clinical practice and are increasingly used for the prevention and treatment of venous thromboembolism (VTE) and stroke prevention in patients with non-valvular atrial fibrillation (AF).
Unlike VKAs, NOACs are not subject to regular dose adjustments ; however, their use requires changes to established systems for patient follow-up based on regular blood tests. The lack of a need for regular coagulation monitoring should not preclude regular contact with healthcare professionals (HCPs) to oversee the safe and effective management of NOAC therapy. Important checks include monitoring of renal and hepatic function, exclusion of thrombocytopenia or anaemia (especially in elderly patients), assessment of nuisance bleeding or other adverse events, confirmation of adherence to the prescribed medication and evaluation of other aspects of overall treatment and health, including optimal management of hypertension . Because some patients are well managed on VKAs or have conditions for which NOACs are contraindicated (e.g. prosthetic heart valves), HCPs and healthcare systems are increasingly required to cope with patients receiving either a VKA or a NOAC for the same or different indications.
Anecdotal evidence suggests that many HCPs lack education on NOACs and are concerned about prescribing them. Additionally, specific management and follow-up protocols (e.g. for serious bleeding complications) are still in development. Although some patients receiving NOACs may not require frequent contact with an HCP, others, such as those with co-morbid conditions, renal impairment or a high risk of bleeding complications, should be seen more often. HCPs and patients must understand relevant aspects of the prescribed anticoagulant and the important differences between NOACs and VKAs. In many (but not all) countries, monitoring of patients receiving VKAs is usually performed at a dedicated outpatient clinic , and staff at these clinics serve well as focal disseminators of education on NOACs to HCPs and patients.
This document has been created to consider best practice for dissemination of education and the evolving role of the coagulation clinic in the NOAC era.
Development of this document
A workshop was held in September 2013 involving European HCPs with expertise in anticoagulation from a range of specialties, including cardiologists, haematologists and specialist nurses from Belgium, Finland, Italy, Portugal, Slovenia, Spain and the United Kingdom. This working group was asked to consider the challenges facing HCPs and healthcare systems in their countries with respect to the introduction of NOACs, and the gaps in educational structures and settings that hinder or endanger the optimal management of patients receiving these drugs. The outputs of the discussions were taken forward to create this manuscript. Bayer HealthCare provided logistical support for the meeting.
Current models of anticoagulant prescription and monitoring
To understand the flow of educational information within an anticoagulation management paradigm, it is first necessary to consider commonly used patient management models. These models are built primarily for patients receiving long-term VKA therapy and fall into two main categories: anticoagulation clinic coordination and coordination by general practitioners (GPs). In some systems, a hybrid model exists, in which unstable or complicated patients are seen in a hospital clinic and stable patients are managed by their GP. In all cases, the networking between these functions is critically important.
Anticoagulation clinic model
Patients regularly attend a specialist outpatient clinic for international normalised ratio (INR) monitoring. Following prespecified algorithms, a nurse may take responsibility for INR interpretation and subsequent VKA dose adjustment, or may refer to the supervising consultant cardiologist or haematologist for atypical patients or scenarios. The nurse or consultant (or both) may take responsibility for educating the patient on their condition and treatment. Official anticoagulation clinics exist in several European countries, including Belgium, Italy, the Netherlands, Portugal, Spain, Slovenia, Sweden and the United Kingdom, but in many countries this service is decentralised.
General practitioner model
In the absence of a dedicated outpatient clinic, responsibility for ongoing monitoring of patients receiving chronic anticoagulant therapy generally falls to GPs. GPs tend to be familiar with VKAs and have a detailed knowledge of their patients’ health and lifestyle. Practice nurses may take responsibility for routine INR monitoring in some cases. The GP model is used in Germany and to a variable extent in other countries. The risk of non-uniform management strategies and the lack of quality control may be a drawback of these services. A ptrecent study in the United States reported that the number of patients tested per GP practice was positively associated with INR time in therapeutic range (TTR) .
Possible new models for long-term non-vitamin K antagonist oral anticoagulant care
Advantages, disadvantages and requirements of proposed models for monitoring of patients taking non-vitamin K antagonist oral anticoagulants or vitamin K antagonists
HCP responsible for routine follow-up
Requirements for NOAC integration
Nurse-coordinated anticoagulation clinic
• Nurses well placed to coordinate contact with patients, the initial prescriber and other HCPs
• Requires well-educated expert nurses and resources for an anticoagulation clinic
• Determination of individual patient visit schedules
• Nurses can take a holistic view (co-morbidities), make a full assessment and educate the patient
• Medico-legal liability issues
• Easy-to-manage patients could have primary contact through the GP; clinic could function as a coordinator and remote evaluator of care
• Less intensive for the specialist, allowing them to focus fully on the treatment plan
• Non-medical as well as medical aspects and patient preference to be taken into account when considering whether to switch from VKA to NOAC
Nurse-assisted anticoagulation clinic
Cardiologist/haematologist, assisted by nurse
• Nurse does not require extensive anticoagulation expertise but can still organise patient visits and provide basic checks and education
• Resource- and time-heavy for specialist
• As above
GP coordinated, without anticoagulation clinic
Hospital specialist or specialist GP
• Reduces pressure on hospital resources
• Increased pressure on GP resources
• GPs to maintain contact with patients at a frequency based on patient risks and preferences
• GPs generally know their patients well
• GPs must be well trained in anticoagulation (NOACs as well as VKAs)
• Specialist department to be available to evaluate the patient at the GP’s request
• Can perform home visits
• Good relationship/network needed between hospital departments and local community physicians
• GP may rely on the specialist for his/her own education – only well-educated GPs should be prescribers of NOACs
Anticoagulation clinic models
The cardiologist/haematologist at the anticoagulation clinic may be the primary care coordinator  who manages the workflow and be the point of contact for the patient (Figure 1). This system requires a lower level of nurse expertise, although nurses can still assume much of the daily organisation and patient education. On the other hand, this model is time- and resource-heavy for the responsible physicians. Anticoagulation clinics in Italy, and some in Spain, use this system.
General practitioner model
In systems lacking dedicated anticoagulation clinics, the GP is responsible for routine follow-up of patients taking NOACs (Figure 1). The GP can refer to the hospital consultant in the event of problems that require specialist intervention, such as a thromboembolic event or major bleeding episode. GP-based follow-up can ease the demands on hospital resources, and the GP may even perform home visits for elderly patients or others for whom office visits are difficult. Many GPs are currently undereducated about NOAC therapy and may consider that the lack of routine coagulation monitoring means that no follow-up is needed, or may be unwilling to allocate time and resources to educate and evaluate patients receiving NOACs. A good relationship and networking opportunities between cardiology/haematology departments and GPs is, therefore, vital.
GPs should maintain contact with their patients at a frequency advised by the initial prescriber based on the patient’s risk profile and preferences. The GP may rely on the hospital cardiology/haematology department for their own education on NOAC therapy. In some countries (such as Belgium, Finland, Germany, Portugal and Spain), GPs are allowed to initiate anticoagulant treatment. This may not be ideal unless they have specialist knowledge of NOACs, but even so, the mechanisms for quality control remain uncertain.
Important considerations for incorporation of non-vitamin K antagonist oral anticoagulants into all models
For stable patients with AF receiving VKAs, the European Society of Cardiology (ESC) considers a TTR of 70% to constitute good management . However, in real life, an INR range of 2.0–3.0 is often not attained [8,9], and in some randomised clinical studies in which the INR was monitored rigorously, the mean TTR was only 55–65% [10-13]. HCPs should consider whether their patient really is well managed on a VKA; considering the broad indications for NOAC therapy, it is likely that most patients are candidates for switching to NOACs, provided they do not have contraindications. For a patient with poor adherence, the HCP responsible may feel more comfortable with regular monitoring, but constant dose adjustments due to irregular INRs may actually contribute to the problem, and switching to a fixed-dose NOAC may simplify treatment and improve adherence. The possible psychological impact on patients caused by the loss of monitoring visits (e.g. social contact for elderly patients and reassurance that their medication is working) may be overcome by regular visits for other necessary tests or an overall health check. However, the decision to switch or not should be taken by the HCP and the patient in tandem, based on both being informed about the treatment choices available.
To harmonise procedures, a centralised database of all NOAC- and VKA-anticoagulated patients should be created and made available to all relevant HCPs within the local system. This database should provide information on diagnosis, drug and dose regimen and anticipated duration of treatment, alongside agreed standard management protocols. Data on INR measurements and TTR would also be useful to inform decisions about switching. The information within such a system could be controlled by the relevant overseeing specialist department.
Where the healthcare structure allows, long-term management of patients receiving anticoagulation can be efficiently handled by a centralised (anticoagulation) clinic. As an alternative, GPs or specialist nurses with appropriate training and experience can take responsibility, with specialist support and supervision
Initiation of NOAC treatment should be restricted to GPs who receive specialist training and should otherwise be avoided
Practical incorporation of NOACs into healthcare systems must take into account national, regional and local variations in practice as well as available resources; anticoagulation clinics may be best suited to handle routine medical and educational tasks and networking between specialties
Problem cases and scenarios need to be referred to an expert facility run by coagulation specialists
Flow of education to support non-vitamin K antagonist oral anticoagulant implementation: needs, responsibilities and support materials
Patients receiving anticoagulants have contact with different HCPs (including, but not limited to, those specified in this document) at different time points during their treatment. Each of these HCPs has a responsibility to educate and/or reinforce patient education. HCPs must have the appropriate level of knowledge and be able to communicate it effectively in terms that the patient can understand. This requires that information migrates from clinical consultants (usually the initial prescribers) through the layers of the healthcare network to reach the patient. This can occur through regular HCP education meetings in the anticoagulation clinic, adoption of national guidelines, support from patient anticoagulation associations and provision of public information.
The initial prescriber
Educational needs and responsibilities for healthcare professionals responsible for patients receiving non-vitamin K antagonist oral anticoagulant therapy
The initial prescriber
The anticoagulation clinic nurse
The general practitioner
• Access to the latest data and expert opinion via colleagues, academic literature, and internal and external meetings and congresses
• To receive regular updates on current best practice from the cardiology/haematology department (as detailed above); nurse coordinators also need access to academic literature and the chance to attend national coagulation nursing meetings
• Ongoing updates (6-monthly in the first 1.5 years and annual thereafter) from specialists on evolving treatment options for VTE/AF; these could be provided online or by email, or via an in-hospital training day, and tied to professional development
• Ongoing (annual or ad hoc) updates from anticoagulation clinic nurses and/or GPs regarding the loco-regional organisation of structured anticoagulant care (who is responsible for what, which lines of communication are available, etc.) and questions to ask the patient when filling a prescription (adherence – check blister pack)
• Basic knowledge of their condition, treatment and the importance of adherence
• Simple flowcharts outlining recommended indications, dose adjustment and follow-up
• Clear and concise guides on how to perform follow-up actions (SOPs), including clear instructions on how and when to contact their supervising physician, GPs, other HCPs and patients themselves throughout follow-up
– GPs are likely to be familiar with VKAs but less so with NOACs, and they will need to receive education on the differences between NOACs and other agents, and important aspects of ongoing care of patients receiving NOACs, including patient education
• Awareness of what to do if an adverse event occurs, and ability to differentiate between minor and major events
• Software to assist in these tasks
– What to do in different scenarios; what constitutes an emergency/which issues should be referred via a routine appointment to the coagulation clinic/specialist department
• To patients:
• Regular contact with an HCP responsible for follow-up at a frequency dependent on individual risk assessment
• Provide education to other hospital departments and community GPs on treatment options for VTE/AF (regular updates)
• To the patient (at each visit)
– Support with posters/checklists/desk note reminder cards, references to online sources of information
– Ensure that appropriate questions are asked of the patient when they collect their medication, based on the indication for use and the type of patient (elderly, with renal impairment, etc.) and medication (NOAC, VKA, etc.)
• Materials and tools to assist with ongoing education and therapeutic adherence
– Hospital meetings, including specific training days for GPs if practicable (could link to professional development)
– Provide patient leaflets and checklists to GP offices
– Ensure that patients are not prescribed contraindicated co-medications
– Support with posters, checklists, desk note reminder cards that HCPs can take away and use; provide links to online sources of information
– Continual reinforcement of key educational messages about the anticoagulant they are taking (NOAC or VKA) at each visit (frequency of visits different for each patient based on health and risk factors for thrombosis/bleeding as discussed above)
– Add follow-up information to the patient’s NOAC card
• To take a proactive role in their own treatment
• Provide education and training to anticoagulation clinic nurses (at least 6-monthly updates)
– Informal assessment of patient understanding (e.g. can they name their condition and explain why they have to take an anticoagulant, what the dose is, what signs of bleeding they should be looking out for, etc.?)
• To the patient
• Notify the coagulation clinic and/or GP of any concerns about the patient
– This could take the format of a session co-chaired by a senior nurse from the clinic or a GP experienced in NOAC use plus the specialist to give two different perspectives (practical and scientific)
– Support with printed leaflets and checklists, educational posters in the office, etc.
– In the absence of an anticoagulation clinic: follow-up with patients receiving anticoagulants (NOACs or other) at regular intervals (frequency dependent on risk) to remind them of the important aspects of their medication and what to do if they are concerned about an aspect of their health relating to their treatment
• To GPs
– As an adjunct to an anticoagulation clinic: take the opportunity at any patient visit for any reason other than anticoagulation to remind them of the important points regarding their anticoagulant treatment (adherence – check blister pack to make sure all doses taken)
• Which patients are suitable for NOACs (e.g. stable condition, good renal function, knowledgeable about treatment, having a carer in charge of medication) vs which are not (or less) suitable (e.g. confused, elderly, likely to be non-compliant, with contraindications) – support with case studies
– Periodical (3- to 6-monthly?) contact to check on individual patients
• To pharmacists (ad hoc communication):
• Fundamental aspects of each NOAC vs heparin/VKAs (e.g. predictable pharmacology, drug interactions, etc.)
• Those requiring only infrequent visits to the anticoagulation clinic
– Pass on educational information on questions to ask the patient before issuing a repeat prescription (this interaction could be mediated by the patient NOAC card)
• Practical guides (e.g. based on EHRA advice) on topics such as taking a full bleeding history, calculating risk score (CHA2DS2-VASc, HAS-BLED, etc.), switching, appropriate laboratory tests and how to interpret them
• Follow-up on patients who have missed scheduled clinic visits
– Remind about important aspects of pharmacology, drug interactions, etc.
• ‘What to do if…’ guidance, including identification of potential emergency scenarios (serious bleeding event, e.g. head injury, major surgery required) vs minor problems (e.g. nose bleed, minor surgical procedure) and whom to contact in each case
• Receive information on changes of patient status that may lead to an intensification of follow-up (e.g. anaemia, thrombocytopenia, new concomitant medication that may increase the risk of bleeding, exclusion of hypertension)
– Send posters/checklists; encourage pharmacist to get in contact if they have concerns
• Latest information on patient adherence and how it can be improved; which practical tools they can use and offer to patients
– Reminders about key aspects of anticoagulants (NOAC and VKA), e.g. pharmacology, drug interactions, etc., and warning signs to look out for in patients receiving them (e.g. bleeding, vomiting, bruising)
– Smartphone/tablet apps and other online tools could be used in case physical meetings cannot be held
– Support with posters/checklists/desk note reminder cards, references to online sources of information
• Education of the patient about their condition and how it will be managed
• To the pharmacist
– First discussion at point of initial prescription
– Periodical (annual?) contact to remind pharmacists about questions they should ask the patient when filling a repeat prescription for any anticoagulant (e.g. ask the patient to present his/her NOAC card; the pharmacist could also complete a line on the follow-up page of the NOAC card, indicating how many drug doses have been delivered or any other important information), and, specifically for NOAC vs LMWH/VKA, whom to contact in case of concerns
• Emphasise patient understanding of their condition and the drug they are taking (NOAC or VKA), and the importance of correct adherence to the prescribed regimen – use language that the patient can understand
– Key information on pharmacology and drug interactions
• Support with printed leaflets and checklists that the patient can take home – these can include QR codes/online links, but should be physical copies so that patients can keep them in a convenient place and have constant access to them
– Support with posters/checklists/desk note reminder cards, references to online sources of information
– Second discussion to reinforce messages before discharge
• Warning signs to look out for (e.g. anaemia, thrombocytopenia, hypertension, bleeding, vomiting, bruising)
• Importance of keeping follow-up appointments with coagulation clinic/GP
• Why adherence is important
– Support with printed leaflets and checklists as above
– Provision of NOAC card to the patient
After discharge, the initial prescriber often ceases to have primary responsibility for patient follow-up but should remain available to consult in the case of difficulties. The responsible HCP should be aware of the scenarios, such as trauma and acute inflammatory and gastrointestinal diseases (poor absorption or vomiting), that should trigger a specialist consultation. In countries such as Italy, the initial prescriber, in most cases the haematologist working in the anticoagulation clinic, is also responsible for follow-up of patients receiving NOACs.
Many cases of VTE or AF are diagnosed in the emergency room. Patients entering the system via this route may never actually be admitted to an inpatient department, but instead may be discharged with a prescription for an oral anticoagulant. It would be preferable for these patients to transition first via an anticoagulation clinic.
The initial prescriber should preferably be an experienced specialist
The initial prescriber is also responsible for initial patient education and for educating other HCPs about thrombotic conditions, anticoagulant treatment and duration, and risk scenarios
The initial prescriber may or may not have primary responsibility for further follow-up, but should be available for consultation and to gather information on complications
Anticoagulation clinic nurse
It is the opinion of this writing group that the follow-up and continuing education of all patients receiving long-term NOAC or VKA anticoagulation in the community is best performed by a specialist anticoagulation clinic, headed either by a specialist nurse(s) (nurse coordinated) or by a cardiologist/haematologist supported by nurses (nurse assisted). In the NOAC era, in patients treated for VTE, an ideal time for a first follow-up visit may be at the point that patients transition from parenteral to dabigatran therapy or from the more intensive doses of apixaban (after 7 days of treatment) or rivaroxaban (after 21 days). During follow-up, the role of the anticoagulation nurse becomes wider than basic INR monitoring and includes other tests, such as calculating creatinine clearance, taking a holistic view of patient care and providing education to patients and other HCPs (Table 2, Figure 1). This education includes knowledge about unstable situations, such as acute illness, starting or stopping co-medications, trauma and management of major and even minor (e.g. tooth extraction) surgery. A single clinic is likely to be responsible for patients receiving NOACs and those receiving VKAs and must address the different requirements of all patients.
A specialist coagulation nurse is well placed to take overall responsibility for patient education and to coordinate follow-up with other HCPs
Coagulation nurses require specialist education, examples of best practice, and access to simple and effective tools to assist with patient education
Specific software tools that help the nurse with systematic assessment of the patient and workflow guidance should be developed and shared
The general practitioner
A GP is often involved in the initial diagnosis of a thromboembolic disorder but should be encouraged to swiftly refer all suspected cases to the specialist hospital department. This is especially important in patients with suspected pulmonary embolism and those with renal or hepatic impairment. It is possible that GPs consider they have a responsibility to prescribe anticoagulation therapy. However, if an established care network with rapid back-up from a specialist centre is available, they may be more willing to refer the prescribing decision to a specialist, which will improve overall patient care.
The GP may be the most frequent point of contact for a patient receiving a NOAC after discharge and can take responsibility for follow-up of patients deemed at low risk. In the absence of an anticoagulation clinic, the role of GPs in patient education assumes greater importance and they will have the main responsibility for long-term patient follow-up (Table 2, Figure 1). Hospital departments and anticoagulation clinics should proactively engage with GPs and provide them with education and training on the management of patients taking NOACs.
A GP education programme for NOACs should have a practical focus and include obligatory training sessions with real-life problems/clinical cases that the GPs can submit for discussion, as well as simple guidance and algorithms. GPs should know whom to contact in the specialist centre in case of questions or concerns about specific patients.
In the absence of an anticoagulation clinic, GPs are likely to take responsibility for the management and ongoing education of patients receiving NOACs
Even when a clinic exists, patients considered at low risk of bleeding may not be required to attend regularly; in this case, the GP may take responsibility for follow-up
GPs should reinforce educational messages regarding anticoagulation with patients at every opportunity, even if the patient is visiting for another reason
Hospital departments or anticoagulation clinics should proactively engage with GPs and provide them with education on NOACs
Pharmacists have an important (and so far underestimated and underused) role in the monitoring of patient adherence to NOAC treatment. In particular, they can check that patients understand the dose and regimen, as well as reinforcing general educational messages (Table 2, Figure 1). Hospital departments or anticoagulation clinics should proactively engage with pharmacists to ensure they can effectively participate in the management of patients receiving anticoagulants. Some countries have national databases that support the pharmacist in evaluating patient adherence. Further research into the development of such systems is warranted.
Pharmacists are important in checking patient adherence
Hospital departments or anticoagulation clinics should proactively engage with pharmacists and provide them with education on NOACs, including drug interactions
In the NOAC era, with less regimented HCP contact, patients must increasingly take responsibility for their own understanding of their condition and treatment. Primarily, they need to have a basic knowledge of why they are being treated, how their treatment works, the importance of adherence and what to do if an adverse event occurs. Differentiation between a minor event that can be self-managed (e.g. a nose bleed) and one that should prompt them to contact an HCP or go to the emergency department is required. Even if a patient is not regularly attending a GP or anticoagulation clinic, the responsible HCP should keep in regular contact, e.g. with a brief telephone call. Patients should be able to ask questions, and family members should be included if appropriate, such as in the case of patients with diminished self-responsibility. Materials can be provided to remind patients of important information, and these should be tailored to the individual patient. For example, a calendar can help to remind patients to take their treatment, but some patients may find a pill box with days of the week, or a reminder on their mobile telephone, to be more effective. Several organisations also offer online patient support websites, including the EHRA (http://www.afibmatters.org/), the AF Association in the UK (http://www.atrialfibrillation.org.uk/) and Anticoagulation Europe (http://www.anticoagulationeurope.org/). Ideally, some of this content could be translated into local languages. Patients must be aware of the importance of their patient card (Figure 2).
Therapy is likely to be enhanced by proactively involving the patient in the management of their condition; this requires that the appropriate level of information is given using appropriate language, and confirmation that the provided information has been understood by the patient
Educational messages should be reinforced with all patients by all HCPs at every opportunity
Incorporation of NOACs into healthcare systems must take account of national, regional and local variations, and it is recognised that some systems may not be able to incorporate all the suggestions in this document. The initial prescriber of a NOAC should preferably be a specialist, who may handle problem and emergency cases as well as proactively engage with all downstream HCPs to ensure that they participate effectively in patient management and reinforce patient education. The initial prescriber has to consider involvement in the education of other HCPs and coordination of patient follow-up. The long-term care of patients may be managed through an anticoagulation clinic and/or specialist nurses, under guidance and supervision. Coordination by GPs who are trained in NOAC use is an alternative. GPs and pharmacists should be involved in the follow-up pathways that are coordinated by anticoagulation clinics or specialists. Last but not least, the patient should be well informed about their condition, treatment, possible risk situations and the organisation of follow-up care. Only a patient with insight into their condition will be fully adherent to therapy and follow-up and have a successful outcome.
The authors wish to acknowledge Sue Rhodes (VTE Specialist Nurse and Joint Anti-Coagulant Lead, Great Western Hospital, Swindon, UK) for her assistance with the development of this manuscript. Medical writing assistance from Stephen Purver was provided with funding from Bayer HealthCare Pharmaceuticals.
- Cheng JW, Barillari G. Non-vitamin K antagonist oral anticoagulants in cardiovascular disease management: evidence and unanswered questions. J Clin Pharm Ther. 2014;39:118–35.PubMedView ArticleGoogle Scholar
- Heidbuchel H, Verhamme P, Alings M, Antz M, Hacke W, Oldgren J, et al. European Heart Rhythm Association practical guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation. Europace. 2013;15:625–51.PubMedView ArticleGoogle Scholar
- Clark NP. Frequency of monitoring, non-adherence, and other topics dear to an anticoagulation clinic provider. J Thromb Thrombolysis. 2013;35:320–4.PubMedView ArticleGoogle Scholar
- Dlott JS, George RA, Huang X, Odeh M, Kaufman HW, Ansell J, et al. National assessment of warfarin anticoagulation therapy for stroke prevention in atrial fibrillation. Circulation. 2014;129:1407–14.PubMedView ArticleGoogle Scholar
- Berti D, Hendriks JM, Brandes A, Deaton C, Crijns HJ, Camm AJ, et al. A proposal for interdisciplinary, nurse-coordinated atrial fibrillation expert programmes as a way to structure daily practice. Eur Heart J. 2013;34:2725–30.PubMedView ArticleGoogle Scholar
- Salmela B, Joutsi-Korhonen L, Armstrong E, Lassila R. Active online assessment of patients using new oral anticoagulants: bleeding risk, compliance, and coagulation analysis. Semin Thromb Hemost. 2012;38:23–30.PubMedView ArticleGoogle Scholar
- Camm AJ, Lip GYH, De Caterina R, Savelieva I, Atar D, Hohnloser SH, et al. 2012 focused update of the ESC guidelines for the management of atrial fibrillation: an update of the 2010 ESC guidelines for the management of atrial fibrillation. Developed with the special contribution of the European Heart Rhythm Association. Eur Heart J. 2012;33:2719–47.PubMedView ArticleGoogle Scholar
- Hallinen T, Soini EJ, Asseburg C, Kuosmanen P, Laakkonen A. Warfarin treatment among Finnish patients with atrial fibrillation: retrospective registry study based on primary healthcare data. BMJ Open. 2014;4:e004071.PubMed CentralPubMedView ArticleGoogle Scholar
- Molteni M, Cimminiello C. Warfarin and atrial fibrillation: from ideal to real the warfarin affaire. Thromb J. 2014;12:5.PubMed CentralPubMedView ArticleGoogle Scholar
- Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361:1139–51.PubMedView ArticleGoogle Scholar
- Patel MR, Mahaffey KW, Garg J, Pan G, Singer DE, Hacke W, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011;365:883–91.PubMedView ArticleGoogle Scholar
- Granger CB, Alexander JH, McMurray JJ, Lopes RD, Hylek EM, Hanna M, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365:981–92.PubMedView ArticleGoogle Scholar
- Giugliano RP, Ruff CT, Braunwald E, Murphy SA, Wiviott SD, Halperin JL, et al. Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2013;369:2093–104.PubMedView ArticleGoogle Scholar
- Lane DA, Ponsford J, Shelley A, Sirpal A, Lip GYH. Patient knowledge and perceptions of atrial fibrillation and anticoagulant therapy: effects of an educational intervention programme. The West Birmingham Atrial Fibrillation Project. Int J Cardiol. 2006;110:354–8.PubMedView ArticleGoogle Scholar
- Smith DE, Xuereb CB, Pattison HM, Lip GY, Lane DA. TRial of an Educational intervention on patients’ knowledge of Atrial fibrillation and anticoagulant therapy, INR control, and outcome of Treatment with warfarin (TREAT). BMC Cardiovasc Disord. 2010;10:21.PubMed CentralPubMedView ArticleGoogle Scholar
- Clarkesmith DE, Pattison HM, Lip GY, Lane DA. Educational intervention improves anticoagulation control in atrial fibrillation patients: the TREAT randomised trial. PLoS One. 2013;8:e74037.PubMed CentralPubMedView ArticleGoogle Scholar
- Hendriks JM, de Wit R, Crijns HJ, Vrijhoef HJ, Prins MH, Pisters R, et al. Nurse-led care vs. usual care for patients with atrial fibrillation: results of a randomized trial of integrated chronic care vs. routine clinical care in ambulatory patients with atrial fibrillation. Eur Heart J. 2012;33:2692–9.PubMedView ArticleGoogle Scholar
- Hendriks JM, Vrijhoef HJ, Crijns HJ, Brunner-La Rocca HP. The effect of a nurse-led integrated chronic care approach on quality of life in patients with atrial fibrillation. Europace. 2014;16:491–9.PubMedView ArticleGoogle Scholar
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