Table 1 Dab2 expression and function in megakaryocytes and platelets

Human K562 cells

Increased Dab2 expression during TPA-induced megakaryocytic differentiation

[19, 31–34]

Positive regulation of fibrinogen uptake

Dab2 interacts with integrin β3 and inhibits integrin αIIbβ3 activation

Human CD34⁺ stem cells

Increased Dab2 expression during TPO-induced megakaryocytic differentiation

[10]

Mouse embryonic stem cells/OP9 co-culture

Increased Dab2 expression during mesodermal and megakaryocytic differentiation

[35]

Dab2 is required for mesodermal differentiation

Human platelets

High expression of p82-Dab2 in the cytoplasm and α-granule

[10, 33, 47–49]

Dab2 interacts with the cytoplamic tail of platelet integrin

Secreted Dab2 interacts with integrin αIIb and sulfatide; is a substrate of thrombin

Dab2 regulates fibrinogen binding and homotypic and heterotypic platelet interactions

Mouse platelets

Low expression of p59-Dab2

[9]

Dab2-deficient mice display a prolonged bleeding time and impaired thrombus formation

Dab2 is required for platelet aggregation, fibrinogen uptake, RhoA-ROCK activation, ADP release and integrin αIIbβ3 activation stimulated by low concentration of thrombin