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  1. Platelet inhibitors are commonly used to reduce the risk of atherothrombotic events. The aim of this study was to determine the impact of platelet inhibitors, specifically clopidogrel and aspirin, on clot kine...

    Authors: Joseph F Dwyer, Jill A McCoy, Ziping Yang, Michael Husser, Heinz Redl, Mary Ann Murphy, Martin Wolfsegger, James P DiOrio, Andreas Goppelt and Shane Donovan

    Citation: Thrombosis Journal 2014 12:10

    Content type: Original basic research

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  2. Venous thromboembolism (VTE) prophylaxis is underutilized for hospitalized patients. The primary objective of this study was to assess the impact of a continuing medical education (CME) program on thromboproph...

    Authors: Fahad Al-Hameed, Hasan M Al-Dorzi and Essam Aboelnazer

    Citation: Thrombosis Journal 2014 12:9

    Content type: Original clinical investigation

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  4. New oral anticoagulant (NOAC) drugs are known to influence the results of some routine hemostasis tests. Further data are needed to enable routine assessment of the effects of NOAC on clotting parameters in so...

    Authors: Raul Altman and Claudio Daniel Gonzalez

    Citation: Thrombosis Journal 2014 12:7

    Content type: Original clinical investigation

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  7. Thromboelastography® (TEG) utilizes kaolin, an intrinsic pathway activator, to assess clotting function. Recent published studies suggest that TEG results are commonly normal in patients receiving warfarin, de...

    Authors: C Michael Dunham, Charlene Rabel, Barbara M Hileman, Jason Schiraldi, Elisha A Chance, Mark T Shima, Alddo A Molinar and David A Hoffman

    Citation: Thrombosis Journal 2014 12:4

    Content type: Original clinical investigation

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  9. The Editors of Thrombosis Journal would like to thank all our reviewers who have contributed to the journal in Volume 11 (2013).

    Authors: Yukio Ozaki and Hugo ten Cate

    Citation: Thrombosis Journal 2014 12:2

    Content type: Reviewer acknowledgement

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  10. Paxillin is a LIM domain protein localized at integrin-mediated focal adhesions. Although paxillin is thought to modulate the functions of integrins, little is known about the contribution of paxillin to signa...

    Authors: Asuka Sakata, Tsukasa Ohmori, Satoshi Nishimura, Hidenori Suzuki, Seiji Madoiwa, Jun Mimuro, Kazuomi Kario and Yoichi Sakata

    Citation: Thrombosis Journal 2014 12:1

    Content type: Original basic research

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  11. Atrial fibrillation (AF) is a common tachyarrhythmia in Australia, with a prevalence over 10% in older patients. AF is the leading preventable cause of ischaemic stroke, and strokes due to AF have a higher mor...

    Authors: Christopher Ward, Greg Conner, Geoffrey Donnan, Alexander Gallus and Simon McRae

    Citation: Thrombosis Journal 2013 11:27

    Content type: Review

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  12. Left atrial appendage (LAA) thrombosis is an important cause of cardiogenic cerebral thromboembolism. Apixaban is a member of the class of novel oral anticoagulants (NOAC) and is superior to warfarin in preven...

    Authors: Tohru Kawakami, Hiroko Kobayakawa, Hiroyoshi Ohno, Nobukiyo Tanaka and Hiroki Ishihara

    Citation: Thrombosis Journal 2013 11:26

    Content type: Case report

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  13. The worldwide EINSTEIN DVT and EINSTEIN PE studies randomized 8282 patients with acute symptomatic deep-vein thrombosis (DVT) and/or pulmonary embolism (PE) and, for the first time in trials in this setting, i...

    Authors: Yuqi Wang, Chen Wang, Zhong Chen, Jiwei Zhang, Zhihong Liu, Bi Jin, Kejing Ying, Changwei Liu, Yuxia Shao, Zhicheng Jing, Isabelle Ling Meng, Martin H Prins, Ákos F Pap, Katharina Müller and Anthonie WA Lensing

    Citation: Thrombosis Journal 2013 11:25

    Content type: Original clinical investigation

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  14. Lupus anticoagulant (LA) is known to inhibit thrombin generation although patients have an increased risk to develop thrombosis. We tried to determine whether thrombin generation is altered in plasma samples o...

    Authors: Klas Boeer, Leonid Cuznetov and Wolfgang Loesche

    Citation: Thrombosis Journal 2013 11:24

    Content type: Original basic research

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  15. Platelets were activated under the infection with H. pylori in human and mice. We investigated the role of VacA, an exotoxin released by H. pylori in this context. Acid-activated VacA, but not heated VacA, induce...

    Authors: Kaneo Satoh, Toshiya Hirayama, Katsuhiro Takano, Katsue Suzuki-Inoue, Tadashi Sato, Masato Ohta, Junko Nakagomi and Yukio Ozaki

    Citation: Thrombosis Journal 2013 11:23

    Content type: Original basic research

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  18. Plasma protein-C exerts anticoagulatory effects by inactivating factors V and VIII. Hereditary protein C deficiency is transmitted as an autosomal dominant disorder. Homozygous individuals usually develop purp...

    Authors: Syed Maqbool, Vishal Rastogi, Ashok Seth, Satbir Singh, Vijay Kumar and Arif Mustaqueem

    Citation: Thrombosis Journal 2013 11:19

    Content type: Case report

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  19. Standard treatment for venous thromboembolism (VTE) consists of a heparin combined with vitamin K antagonists. Direct oral anticoagulants have been investigated for acute and extended treatment of symptomatic ...

    Authors: Martin H Prins, Anthonie WA Lensing, Rupert Bauersachs, Bonno van Bellen, Henri Bounameaux, Timothy A Brighton, Alexander T Cohen, Bruce L Davidson, Hervé Decousus, Gary E Raskob, Scott D Berkowitz and Philip S Wells

    Citation: Thrombosis Journal 2013 11:21

    Content type: Original clinical investigation

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  20. Anticoagulation with vitamin K antagonists such as warfarin has historically been used for the long term management of patients with thromboembolic disease. However, these agents have a slow onset of action wh...

    Authors: Faryal Tahir, Haris Riaz, Talha Riaz, Maaz B Badshah, Irbaz B Riaz, Ameer Hamza and Hafsa Mohiuddin

    Citation: Thrombosis Journal 2013 11:18

    Content type: Review

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  21. Behcet’s disease is a chronic multi-system disorder of unknown etiology with protean manifestations. Venous thromboembolism is more common than arterial thrombosis, with deep vein thrombosis being the most fre...

    Authors: Hoda Abdel Badaee, Amr Edrees, Sherif Amin, Maher El Amir and Gaafar Ragab

    Citation: Thrombosis Journal 2013 11:17

    Content type: Original clinical investigation

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  22. The incidence of venous thromboembolic disease (VTED) is estimated to be, on average, 1–2 cases per 1,000 individuals per year worldwide. There are few data concerning the incidence rate (IR) of VTED in the Ar...

    Authors: Fernando Javier Vázquez, María Lourdes Posadas-Martínez, Jimena Vicens, Fernán González Bernaldo de Quirós and Diego Hernán Giunta

    Citation: Thrombosis Journal 2013 11:16

    Content type: Original clinical investigation

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  24. Atrial fibrillation (AF) is the most common form of heart arrhythmia and a leading cause of stroke and systemic embolism. Chronic anticoagulation is recommended for preventing those complications. Our study ai...

    Authors: Léon Nshimyumukiza, Julie Duplantie, Mathieu Gagnon, Xavier Douville, Diane Fournier, Carmen Lindsay, Marc Parent, Alain Milot, Yves Giguère, Christian Gagné, François Rousseau and Daniel Reinharz

    Citation: Thrombosis Journal 2013 11:14

    Content type: Original basic research

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  25. Direct oral anticoagulants that target a single coagulation factor have been developed as an alternative to standard therapies with heparin and/or vitamin K antagonists. The purpose of this study was to derive...

    Authors: Martin H Prins and Anthonie WA Lensing

    Citation: Thrombosis Journal 2013 11:13

    Content type: Original clinical investigation

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  26. Microplate-based thrombin generation test (TGT) is widely used as clinical measure of global hemostatic potential and it becomes a useful tool for control of drug potency and quality by drug manufactures. Howe...

    Authors: Yideng Liang, Samuel A Woodle, Alexey M Shibeko, Timothy K Lee and Mikhail V Ovanesov

    Citation: Thrombosis Journal 2013 11:12

    Content type: Original basic research

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  27. Research into new anticoagulants for preventing and treating thromboembolic disorders has focused on targeting single enzymes in the coagulation cascade, particularly Factor Xa and thrombin, inhibition of whic...

    Authors: Meyer Michel Samama, Geneviève Contant, Theodore E Spiro, Elisabeth Perzborn, Lena Le Flem, Céline Guinet, Yves Gourmelin, Gabriele Rohde and Jean-Luc Martinoli

    Citation: Thrombosis Journal 2013 11:11

    Content type: Review

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  28. Unlike traditional anticoagulants, the more recently developed agents rivaroxaban, dabigatran and apixaban target specific factors in the coagulation cascade to attenuate thrombosis. Rivaroxaban and apixaban d...

    Authors: Wolfgang Mueck, Stephan Schwers and Jan Stampfuss

    Citation: Thrombosis Journal 2013 11:10

    Content type: Review

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  32. While the assessment of analytical precision within medical laboratories has received much attention in scientific enquiry, the degree of as well as the sources causing variation between them remains incomplet...

    Authors: Michael Nagler, Lucas M Bachmann, Lorenzo Alberio, Anne Angelillo-Scherrer, Lars M Asmis, Wolfgang Korte, Adriana Mendez, Guido Reber, Hans Stricker, Dimitrios A Tsakiris and Walter A Wuillemin

    Citation: Thrombosis Journal 2013 11:6

    Content type: Original clinical investigation

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  33. Giant left atrium is a condition characterized by huge enlargement of the left atrium with a diameter exceeding 65mm. It is most commonly associated with long standing rheumatic mitral valve disease. We presen...

    Authors: Ahmad K Darwazah and Hamdy El Sayed

    Citation: Thrombosis Journal 2013 11:5

    Content type: Case report

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  34. Deep Vein Thrombosis (DVT) is an important cause of morbidity and is the first cause of maternal death after delivery in Western Nations. The risk of venous thromboembolism is present throughout the pregnancy ...

    Authors: Leslie Fiengo, Federico Bucci, Gregorio Patrizi, Domenico Giannotti and Adriano Redler

    Citation: Thrombosis Journal 2013 11:4

    Content type: Case report

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  35. Early treatment of disseminated intravascular coagulation (DIC) can be associated with improved patient outcomes. The Japanese Ministry of Health and Welfare (JMHW) and the International Society on Thrombosis ...

    Authors: Takahiro Kato, Takamasa Sakai, Miki Kato, Mao Hagihara, Takaaki Hasegawa, Katsuhiko Matsuura and Takashi Nakagawa

    Citation: Thrombosis Journal 2013 11:3

    Content type: Original clinical investigation

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  36. Previous animal studies by us and others have indicated that catheter-administered plasmin or its des-kringle derivatives may be more appropriate alternatives to plasminogen activators for treating thrombolyti...

    Authors: Xiaotao Lin, Yan Wang, Yanwen Zhang, Bing Huang, James J Lin, Scott J Hallock, Hong Yu, Hongwei Shao, Jing Yan, Bo Huang, Xuejun C Zhang, Wei Cao, Xueming Xu and Xinli Lin

    Citation: Thrombosis Journal 2013 11:2

    Content type: Original basic research

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  37. The aim of the present study was to compare circulating levels of selected prothrombotic markers in patients suffering acute myocardial infarction (AMI) with and without left ventricular (LV) thrombus.

    Authors: Svein Solheim, Ingebjørg Seljeflot, Ketil Lunde, Vibeke Bratseth, Svend Aakhus, Kolbjørn Forfang and Harald Arnesen

    Citation: Thrombosis Journal 2013 11:1

    Content type: Original clinical investigation

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  38. Effective treatment of venous thromboembolism (VTE) strikes a balance between prevention of recurrence and bleeding complications. The current standard of care is heparin followed by a vitamin K antagonist suc...

    Authors: Bastian Hass, Jayne Pooley, Adrian E Harrington, Andreas Clemens and Martin Feuring

    Citation: Thrombosis Journal 2012 10:24

    Content type: Review

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  39. Low Frequency Vibro-Percussion (LFVP) assists clearance of thrombi in catheter systems and when applied to the heart and timed to diastole is known to enhance coronary flow. However LFVP on a clotted coronary ...

    Authors: Andrew Hoffmann and Harjit Gill

    Citation: Thrombosis Journal 2012 10:23

    Content type: Original basic research

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  40. Dual antiplatelet treatment with aspirin and clopidogrel is the antithrombotic treatment recommended after an acute coronary syndrome and/or coronary artery stenting. The evidence for optimal antiplatelet ther...

    Authors: Mila Menozzi, Andrea Rubboli, Antonio Manari, Rossana De Palma and Roberto Grilli

    Citation: Thrombosis Journal 2012 10:22

    Content type: Review

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  41. Hump-nosed pit viper (Genus Hypnale) is a medically important venomous snake in Sri Lanka and Southwestern India which causes significant morbidity and mortality. Envenoming of this snake results in hemostasti...

    Authors: Vijayabala jeevagan, Thashi Chang and Christeine Ariaranee Gnanathasan

    Citation: Thrombosis Journal 2012 10:21

    Content type: Case report

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  42. Venous thromboembolism (VTE) is a leading cause of hospital-related deaths worldwide. However, the proportion of patients at risk of VTE who receive appropriate prophylaxis in Egypt is unknown. The ENDORSE stu...

    Authors: Hadi A Goubran, Sherif Sholkamy, Alaa El-Haddad, Alaa Mahmoud, Mounir A Rizkallah and George Sobhy

    Citation: Thrombosis Journal 2012 10:20

    Content type: Original clinical investigation

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  43. Postprandial hyperlipidemia and hyperglycemia have been related to cardiovascular events. Among different underlying mechanisms platelet activation seems to be responsible too. No comparable data between vario...

    Authors: Helmut Sinzinger and Robert Berent

    Citation: Thrombosis Journal 2012 10:19

    Content type: Review

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  45. Computer-assistance and self-monitoring lower the cost and may improve the quality of anticoagulation therapy. The main purpose of this clinical investigation was to use computer-assisted oral anticoagulant th...

    Authors: Rune Skovgaard Rasmussen, Pernille Corell, Poul Madsen and Karsten Overgaard

    Citation: Thrombosis Journal 2012 10:17

    Content type: Original clinical investigation

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  46. Coronary artery disease (CAD) is a major problem worldwide. Atherosclerosis and thrombosis underlying CAD involve multiple cell types. New and useful diagnostic markers are required. MicroRNAs (miRNAs) are a c...

    Authors: Xiao Sun, Man Zhang, Akimasa Sanagawa, Chieko Mori, Shiori Ito, Soichiro Iwaki, Hiroki Satoh and Satoshi Fujii

    Citation: Thrombosis Journal 2012 10:16

    Content type: Original clinical investigation

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  47. Bleeding remains a potentially lethal complication of cardio-pulmonary bypass (CPB) surgery. The purpose of this study was to obtain a better insight into in vitro thrombin generation in the context of CPB.

    Authors: Rose Said, Véronique Regnault, Marie Hacquard, Jean-Pierre Carteaux and Thomas Lecompte

    Citation: Thrombosis Journal 2012 10:15

    Content type: Original clinical investigation

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  48. Venous Thrombo-embolic disease is currently a hot topic especially in the UK. 25,000 patients per year die of Pulmonary Emboli (PE) in the United Kingdom (UK). Hip and knee arthroplasty surgery is associated w...

    Authors: Padmanabhan Subramanian, Shanjitha Kantharuban, Sophie Shilston and Oliver James Pearce

    Citation: Thrombosis Journal 2012 10:14

    Content type: Original basic research

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  49. Obesity, characterised by increased fat mass and is currently regarded as a pro-inflammatory state and often associated with increased risk of cardiovascular diseases (CVD) including Myocardial infarction. The...

    Authors: Karthick Rajendran, Nalini Devarajan, Manohar Ganesan and Malathi Ragunathan

    Citation: Thrombosis Journal 2012 10:13

    Content type: Original basic research

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  50. Cardiovascular disease with disturbances in the haemostatic system, might lead to thrombotic complications with clinical manifestations like acute myocardial infarction (AMI) and stroke. Activation of the coag...

    Authors: Vibeke Bratseth, Alf-Åge Pettersen, Trine B Opstad, Harald Arnesen and Ingebjørg Seljeflot

    Citation: Thrombosis Journal 2012 10:12

    Content type: Original clinical investigation

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