Articles

The 5, 10 methylenetetrahydrofolate reductase C677T mutation and risk of fetal loss: a case series and review of the literature

The true relationship between methylenetetrahydrofolate reductase C677T homozygosity and risk of recurrent spontaneous abortion is unknown, and it is unclear if women with these mutations should be anticoagula...

Authors: Ivy Altomare, Alan Adler and Louis M Aledort

Influenza infection and risk of acute pulmonary embolism

Influenza infections have been associated with procoagulant changes. Whether influenza infections lead to an increased risk of pulmonary embolism remains to be established.

Authors: Matthijs van Wissen, Tymen T Keller, Brechje Ronkes, Victor EA Gerdes, Hans L Zaaijer, Eric CM van Gorp, Dees PM Brandjes, Marcel Levi and Harry R Büller

Dual antiplatelet therapy and drug eluting stents: a marriage of convenience

Authors: Juan Benezet-Mazuecos, Borja Ibanez and Juan J Badimon

Relationship between ABO blood group and von Willebrand factor levels: from biology to clinical implications

Although a number of studies have demonstrated the influence of ABO blood group on plasma levels of von Willebrand factor (VWF), the nature of this association and its clinical importance is still largely unkn...

Authors: Massimo Franchini, Franco Capra, Giovanni Targher, Martina Montagnana and Giuseppe Lippi

Heat shock inhibits lipopolysaccharide-induced tissue factor activity in human whole blood

During gram-negative sepsis, lipopolysaccharide (LPS) induces tissue factor expression on monocytes. The resulting disseminated intravascular coagulation leads to tissue ischemia and worsens the prognosis of s...

Authors: Christoph Sucker, Kai Zacharowski, Matthias Thielmann and Matthias Hartmann

Combining Taipan snake venom time/Ecarin time screening with the mixing studies of conventional assays increases detection rates of lupus anticoagulants in orally anticoagulated patients

Oral anticoagulation compromises conventional lupus anticoagulant (LA) screening assays. Mixing studies can counteract the oral anticoagulant effect but the dilution reduces sensitivity and can generate false ...

Authors: Gary W Moore

Antithrombotic prevention in vascular disease: bases for a new strategy in antithrombotic therapy

A tendency toward bleeding often undercuts the beneficial preventive effect of higher doses of a single antithrombotic drug or combined antithrombotic therapy. Although high doses of antithrombotic drugs may b...

Authors: Raul Altman

Hyperhomocysteinemia in women with unexplained sterility or recurrent early pregnancy loss from Southern Italy: a preliminary report

Hyperhomocysteinemia has been described as a risk factor for unexplained recurrent pregnancy loss. Increased levels of homocysteine may be due to inadequate dietary intake of folate and vitamin B12 and inherit...

Authors: Maristella D'Uva, Pierpaolo Di Micco, Ida Strina, Carlo Alviggi, Mariateresa Iannuzzo, Antonio Ranieri, Antonio Mollo and Giuseppe De Placido

Deep venous thrombosis in the antenatal period in a large cohort of pregnancies from western India

Deep venous thrombosis (DVT) is an important complication in the peripartal and postpartal period.

Authors: Sonal Vora, Kanjaksha Ghosh, Shrimati Shetty, Vinita Salvi and Purnima Satoskar

Why differentiate low molecular weight heparins for venous thromboembolism?

Authors: Jawed Fareed and Jeanine M Walenga

Increased platelet expression of FcGammaRIIa and its potential impact on platelet reactivity in patients with end stage renal disease

Increased platelet reactivity has been implicated in cardiovascular disease – the major cause of death in patients with end stage renal disease (ESRD). FcGammaRIIA is a component of glycoprotein VI and Ib-IX-V...

Authors: Feliciano A Serrano, Mohamed El-Shahawy, Richard J Solomon, Burton E Sobel and David J Schneider

Clopidogrel in Orthopaedic patients: a review of current practice in Scotland

Clopidogrel bisulfate is an antiplatelet agent used to prevent ischaemic events in patients with vascular disease. Current guidelines recommend withholding clopidogrel for 7 days pre-operatively. However these...

Authors: Jibu J Joseph, Anand Pillai and Diane Bramley

Platelet adhesion onto immobilized fibrinogen under arterial and venous in-vitro flow conditions does not significantly differ between men and women

Gender-related differences in incidence of arterial thrombosis have been a focus of interest for years. The platelet integrin αIIbβ3 is primarily responsible for the interaction between platelets and fibrinoge...

Authors: Robert Loncar, Reiner B Zotz, Christoph Sucker, Aleksandar Vodovnik, Mario Mihalj and Rüdiger E Scharf

Histological composition and progression of carotid plaque

To analyse histological composition and progression of carotid plaque.

Authors: Liz AndréaVillela Baroncini, Antonio Pazin Filho, Simone Gusmão Ramos, Antonio Roberto Martins and Luiz Otavio Murta Jr

Evaluation of the TEG^® platelet mapping™ assay in blood donors

Monitoring of antiplatelet therapy in patients at cardiovascular risk is difficult because existing platelet function tests are too sophisticated for clinical routine. The whole blood TEG^® Platelet Mapping™ assay...

Authors: Louise Bochsen, Bo Wiinberg, Mads Kjelgaard-Hansen, Daniel A Steinbrüchel and Pär I Johansson

HPA-1 polymorphism of αIIbβ3 modulates platelet adhesion onto immobilized fibrinogen in an in-vitro flow system

Platelet adhesion and subsequent thrombus formation on a subendothelial matrix at the site of vascular damage play a crucial role in the arrest of posttraumatic bleeding but also in different pathological thro...

Authors: Robert Loncar, Volker Stoldt, Sabine Hellmig, Rainer B Zotz, Mario Mihalj and Rüdiger E Scharf

Emergency correction of coagulation before major surgery in two elderly patients on oral anticoagulation

Recommendations for urgent reversal of oral anticoagulation with vitamin K₁ antagonists are largely derived from case series employing empirical dosing regimens with vitamin K₁ and prothrombin complex concentrate...

Authors: Marzia Angelo, Bernhard Gutmann, Michele Adami, Bernd Zagler, Anton Zelger, Christoph Pechlaner and Christian J Wiedermann

Benign intracranial hypertension associated to blood coagulation derangements

Benign Intracranial Hypertension (BIH) may be caused, at least in part, by intracranial sinus thrombosis. Thrombosis is normally due to derangements in blood coagulation cascade which may predispose to abnorma...

Authors: Domenico De Lucia, Marisanta Napolitano, Pierpaolo Di Micco, Alferio Niglio, Andrea Fontanella and Giuseppe Di lorio

An unusual case of Behçet's disease presenting with postpartum ovarian iliac vein thrombosis and pulmonary embolism

Thrombosis of the ovarian vein is a rare complication which arises classically in the postpartum. We report a case of 24-year-old woman with a history of Behçet's disease, who presented with pelvic and thoraci...

Authors: Sonia Hammami, Mondher Golli, Faouzi Addad, Chiraz Hafsa, Amira Hamzaoui, Silvia Mahjoub and Amor Gannouni

Antithrombin significantly influences platelet adhesion onto immobilized fibrinogen in an in-vitro system simulating low flow

Adhesion of platelets onto immobilized fibrinogen is of importance in initiation and development of thrombosis. According to a recent increase in evidence of a multiple biological property of antithrombin, we ...

Authors: Robert Loncar, Uwe Kalina, Volker Stoldt, Volker Thomas, Rüdiger E Scharf and Aleksandar Vodovnik

Preparation of platelet-rich plasma as a tissue adhesive for experimental transplantation in rabbits

Platelet-rich plasma (PRP) is an autologous substance with adhesive properties. We aimed at developing and testing the efficacy of a method for PRP preparation in rabbits.

Authors: Federico Luengo Gimeno, Silvia Gatto, José Ferro, Juan Oscar Croxatto and Juan Eduardo Gallo

Outcomes of thromboprophylaxis with enoxaparin vs. unfractionated heparin in medical inpatients

Clinical trials have shown low-molecular weight heparin (LMWH) to be at least as safe and efficacious as unfractionated heparin (UFH) for preventing venous thromboembolism (VTE) in acutely-ill medical inpatients.

Authors: Lisa J McGarry, Michael E Stokes and David Thompson

The screening power of methylenetetrahydrofolate reductase C677T polymorphism versus plasma homocysteine concentration in patients with stenosis of the internal carotid artery

Hyperhomocysteinemia is an important and independent risk factor for vascular disease. About 35% of patients with stroke and 47% of patients with peripheral arterial disease have elevated plasma homocysteine (...

Authors: Robert Loncar, Barbara T Müller, Reiner B Zotz, Christof Sucker, Wilhelm Sandmann and Rüdiger E Scharf

Hereditary thrombophilia

Thrombophilia can be defined as a predisposition to form clots inappropriately. Thrombotic events during infancy and childhood are increasingly recognized as a significant source of mortality and morbidity. Th...

Authors: Salwa Khan and Joseph D Dickerman

Development of an in vitro model to study clot lysis activity of thrombolytic drugs

Thrombolytic drugs are widely used for the management of cerebral venous sinus thrombosis patients. Several in vitro models have been developed to study clot lytic activity of thrombolytic drugs, but all of th...

Authors: Sweta Prasad, Rajpal S Kashyap, Jayant Y Deopujari, Hemant J Purohit, Girdhar M Taori and Hatim F Daginawala

Low dose endotoxin priming is accountable for coagulation abnormalities and organ damage observed in the Shwartzman reaction. A comparison between a single-dose endotoxemia model and a double-hit endotoxin-induced Shwartzman reaction

The clinical response of sepsis to a systemic inflammatory infection may be complicated by disseminated intravascular coagulation or DIC. In order to experimentally study the syndrome of DIC, we aimed for a se...

Authors: Sjoukje H Slofstra, Hugo ten Cate and C Arnold Spek

Soluble fibrin inhibits monocyte adherence and cytotoxicity against tumor cells: implications for cancer metastasis

Soluble fibrin (sFn) is a marker for disseminated intravascular coagulation and may have prognostic significance, especially in metastasis. However, a role for sFn in the etiology of metastatic cancer growth h...

Authors: John P Biggerstaff, Brandy Weidow, Jacqueline Vidosh, Judith Dexheimer, Shonak Patel and Pretesh Patel

Acquired activated protein C resistance and thrombosis in multiple myeloma patients

An increased incidence of deep venous thrombosis (DVT) has been described in multiple myeloma (MM). A recently described mechanism of hypercoagulability in cancer patients including MM patients is acquired act...

Authors: Jiménez-Zepeda Víctor Hugo and Domínguez-Martínez Virginia Jeanet

Comparison of platelet function between sedentary individuals and competitive athletes at rest

There are controversial evidences on the effect of different types and workloads of physical exercise on primary hemostasis. In particular, little is known on the chronic influence of a strenuous and regular a...

Authors: Giuseppe Lippi, Martina Montagnana, Gian Luca Salvagno, Massimo Franchini and Gian Cesare Guidi

Haemostasis, inflammation and renal function following exercise in patients with intermittent claudication on statin and aspirin therapy

Previous studies have suggested that exercise in patients with intermittent claudication (IC) may induce a systemic thrombo-inflammatory response. The effect of secondary prevention therapy on this response is...

Authors: Patrick Collins, Isobel Ford, Bernard Croal, Derek Ball, Michael Greaves, Ewan Macaulay and Julie Brittenden

An update on prevention of venous thromboembolism in hospitalized acutely ill medical patients

Both the recently updated consensus guidelines published by the American College of Chest Physicians, and the International Union of Angiology recommend thromboprophylaxis with either low-molecular-weight hepa...

Authors: Meyer Michel Samama and Franz-Xaver Kleber

Antithrombin III (AT) and recombinant tissue plasminogen activator (R-TPA) used singly and in combination versus supportive care for treatment of endotoxin-induced disseminated intravascular coagulation (DIC) in the neonatal pig

Disseminated intravascular coagulation (DIC) is a pathological disturbance of the complex balance between coagulation and anticoagulation that is precipitated by vascular injury, acidosis, endotoxin release an...

Authors: Rachel Davis-Jackson, Hernan Correa, Ronald Horswell, Halina Sadowska-Krowicka, Kathleen McDonough, Chittaranjan Debata, Renee' Gardner and Duna Penn

Oral heparin: status review

Unfractionated heparin and low molecular weight heparin are the most commonly used antithrombotic and thromboprophylactic agents in hospital practice. Extended out-of-hospital treatment is inconvenient in that...

Authors: Ehud Arbit, Michael Goldberg, Isabel Gomez-Orellana and Shingai Majuru

Thrombin generation by activated factor VII on platelet activated by different agonists. Extending the cell-based model of hemostasis

Platelet activation is crucial in normal hemostasis. Using a clotting system free of external tissue factor, we investigated whether activated Factor VII in combination with platelet agonists increased thrombi...

Authors: Raul Altman, Alejandra Silvia Scazziota, Maria de Lourdes Herrera and Claudio Gonzalez

Recent acquisitions in the pathophysiology, diagnosis and treatment of disseminated intravascular coagulation

Disseminated intravascular coagulation (DIC) is a disorder characterized by both acute generalized, widespread activation of coagulation, which results in thrombotic complications due to the intravascular form...

Authors: Massimo Franchini, Giuseppe Lippi and Franco Manzato

Detection and quantification of lupus anticoagulants in plasma from heparin treated patients, using addition of polybrene

Lupus anticoagulants prolong clotting times in phospholipid-dependent coagulation tests. Lupus Ratio assays are integrated tests for lupus anticoagulants that may be based on APTT, RVVT or dPT clotting times. ...

Authors: Eva M Jacobsen, Elin J Trettenes, Finn Wisløff and Ulrich Abildgaard

Plasma D-dimer concentration in patients with systemic sclerosis

Systemic sclerosis (SSc) is an autoimmune disorder of the connective tissue characterized by widespread vascular lesions and fibrosis. Little is known so far on the activation of the hemostatic and fibrinolyti...

Authors: Giuseppe Lippi, Alessandro Volpe, Paola Caramaschi, Gian Luca Salvagno, Martina Montagnana and Gian Cesare Guidi

Ineffective off-label use of recombinant activated factor VII in a case of bone-marrow transplantation-related gastrointestinal bleeding

For patients with a normal coagulation system, who experience serious bleeding, sound evidence for recombinant activated factor VII (rFVIIa) as an effective haemostatic agent is only scarcely available so far ...

Authors: P Eller, C Pechlaner and CJ Wiedermann

Socio economic crisis and mortality. Epidemiological testimony of the financial collapse of Argentina

Natural disasters, war, and terrorist attacks, have been linked to cardiac mortality. We sought to investigate whether a major financial crisis may impact on the medical management and outcomes of acute corona...

Authors: Enrique P Gurfinkel, Gerardo E Bozovich, Omar Dabbous, Branco Mautner and Frederick Anderson

Systemic coagulation parameters in mice after treatment with vascular targeting agents

Vascular targeting of malignant tumors has become a clinically validated new treatment approach with clear patient benefit. However clinical studies have also revealed that some types of vascular targeting age...

Authors: Maike Unruh, Andrea Grunow and Claudia Gottstein

Anticoagulant treatment at a specialized outpatient anticoagulant therapy unit, a descriptive study

The indications for continuous oral anticoagulant treatment, the target interval and the procedures for withdrawing treatment have changed in the last 10 years.

Authors: Kim Ekblom, Johan Hultdin, Bo Carlberg and Tage Strand

Large mobile thrombus in non-atherosclerotic thoracic aorta as the source of peripheral arterial embolism

The presence of thrombi in the atherosclerotic and/or aneurysmatic aorta with peripheral arterial embolism is a common scenario. Thrombus formation in a morphologically normal aorta, however, is a rare event. ...

Authors: Nasser M Malyar, Rolf A Janosi, Zoran Brkovic and Raimund Erbel

Intermittent pneumatic compression for prevention of pulmonary thromboembolism after gynecologic surgery

To investigate the incidence of pulmonary embolism and risk factors for this condition after obstetric and gynecologic surgery, as well as the efficacy of intermittent pneumatic compression.

Authors: Nao Suzuki, Fumio Kataoka, Atsushi Higashiguchi, Takeshi Hirao, Sachiko Ezawa, Hiroyuki Nomura, Akiyo Tomita, Nobuyuki Susumu and Daisuke Aoki

Increased PAI-1 plasma levels and risk of death from dengue: no association with the 4G/5G promoter polymorphism

Dengue virus infected patients have high plasminogen activator inhibitor type I (PAI-1) plasma concentrations. Whether the insertion/deletion (4G/5G) polymorphism in the promotor region of the PAI-1 gene is as...

Authors: ATA Mairuhu, TE Setiati, P Koraka, CE Hack, A Leyte, SMH Faradz, H ten Cate, DPM Brandjes, ADME Osterhaus, PH Reitsma and ECM van Gorp

Towards a standardization of thrombin generation assessment: The influence of tissue factor, platelets and phospholipids concentration on the normal values of Thrombogram-Thrombinoscope assay

Thrombin generation assay was developed several years ago to mimic physiological coagulation mechanisms but it had important limitations. Thrombogram-Thrombinoscope assay using a fluorogenic substrate, allows ...

Authors: Grigoris T Gerotziafas, François Depasse, Joël Busson, Lena Leflem, Ismail Elalamy and Meyer M Samama

Elevated levels of procoagulant microparticles in a patient with myocardial infarction, antiphospholipid antibodies and multifocal cardiac thrombosis

Circulating procoagulant microparticles (MP) are pathogenic markers of enhanced coagulability associated to a variety of disorders and released from stimulated vascular cells. When derived from endothelial cel...

Authors: O Morel, L Jesel, JM Freyssinet and F Toti

Heparin-induced thrombocytopenia: an update

Heparin-induced thrombocytopenia (HIT) is the most important and most frequent drug-induced, immune-mediated type of thrombocytopenia. It is associated with significant morbidity and mortality if unrecognized....

Authors: Massimo Franchini

Homocysteine, MTHFR C677T gene polymorphism, folic acid and vitamin B 12 in patients with retinal vein occlusion

Many available data have suggested that hyperhomocysteinaemia, an established independent risk factor for thrombosis (arterial and venous), may be associated with an increased risk of retinal vein occlusion (R...

Authors: Paola Ferrazzi, Pierpaolo Di Micco, Ilaria Quaglia, Lisa Simona Rossi, Alessandro Giacco Bellatorre, Giorgio Gaspari, Lidia Luciana Rota and Corrado Lodigiani

Analysis of blood coagulation in mice: pre-analytical conditions and evaluation of a home-made assay for thrombin-antithrombin complexes

The use of mouse models for the study of thrombotic disorders has gained increasing importance. Methods for measurement of coagulation activation in mice are, however, scarce. The primary aim of this study was...

Authors: Dirkje W Sommeijer, René van Oerle, Pieter H Reitsma, Janneke J Timmerman, Joost CM Meijers, Henri MH Spronk and Hugo ten Cate

Catheter-related septic thrombophlebitis of the great central veins successfully treated with low-dose streptokinase thrombolysis and antimicrobials

Septic thrombophlebitis is an iatrogenic life-threatening disease associated with use of central venous devices and intravenous (IV) therapy. In cancer patients receiving chemotherapy, vein resection or surgic...

Authors: Patricia Volkow, Patricia Cornejo-Juárez, Ana Berta Arizpe-Bravo, Jorge García-Méndez, Enrique Baltazares-Lipp and Rogelio Pérez-Padilla