Articles

Decreased soluble cell adhesion molecules after tirofiban infusion in patients with unstable angina pectoris

The inflammatory response, initiated by neutrophil and monocyte adhesion to endothelial cells, is important in the pathogenesis of acute coronary syndromes. Platelets play an important role in inflammatory pro...

Authors: Ertugrul Ercan, Huseyin Bozdemir, Istemihan Tengiz, Cevad Sekuri, Emil Aliyev, Azem Akilli and Mustafa Akin

Use of venous thromboprophylaxis and adherence to guideline recommendations: a cross-sectional study

Consensus Conferences and Guidelines for deep vein thrombosis prophylaxis have been published, which recommend the use of prophylactic heparins in patients with risk of venous thromboembolism (VTE). The aim of...

Authors: Antonio Vallano, Josep Maria Arnau, Gaietà Permanyer Miralda and Jaume Pérez-Bartolí

Cardiac thrombi in a patient with protein-C and S deficiencies: a case report

Authors: Ertugrul Ercan, Istemihan Tengiz, Cevad Sekuri, Fahri Sahin, Emil Aliyev, Mustafa Akin and Unal Acıkel

The antithrombotic profile of aspirin. Aspirin resistance, or simply failure?

Authors: Raul Altman, Héctor L Luciardi, Juan Muntaner and Ramón N Herrera

Multivariate relationships between international normalized ratio and vitamin K-dependent coagulation-derived parameters in normal healthy donors and oral anticoagulant therapy patients

International Normalized Ratio (INR) is a world-wide routinely used factor in the monitoring of oral anticoagulation treatment (OAT). However, it was reported that other factors, e. g. factor II, may even bett...

Authors: Cezary Watala, Jacek Golanski and Przemyslaw Kardas

Induction of Tissue Factor Expression in Endothelial Cells by Basic Fibroblast Growth Factor and its Modulation by Fenofibric acid

Tissue factor (TF), expressed in endothelial cells (ECs) and enriched in human atherosclerotic lesions, acts as a critical initiator of blood coagulation in acute coronary syndrome. Basic fibroblast growth fac...

Authors: Takeaki Kaneko, Satoshi Fujii, Akio Matsumoto, Daisuke Goto, Naomasa Makita, Junichi Hamada, Tetsuya Moriuchi and Akira Kitabatake

Angiotensin Converting Enzyme and Angiotensin II Type 1 Receptor Polymorphisms in Patients with Coronary Aneurysms

Conflicting results have been reported regarding the association of gene polymorphisms in the renin-angiotensin system (RAS) with different aspects of coronary artery disease (CAD), such as myocardial infarcti...

Authors: Nicolas Lamblin, Xavier Hermant, Jean-Marc Lablanche, Nicole Helbecque, Philippe Amouyel and Christophe Bauters

Risk factors in coronary atherosclerosis athero-inflammation: the meeting point

Authors: Raul Altman

Thrombin generation during cardiopulmonary bypass: the possible role of retransfusion of blood aspirated from the surgical field

In spite of using heparin-coated extracorporeal circuits, cardiopulmonary bypass (CPB) is still associated with an extensive thrombin generation, which is only partially suppressed by the use of high dosages o...

Authors: Patrick W Weerwind, Theo Lindhout, Nicole EH Caberg and Dick S de Jong

Acute coronary disease Athero-Inflammation: Therapeutic approach

Antithrombotic therapy is the cornerstone of the treatment of acute coronary syndromes, but there is now evidence which indicates that by blocking inflammation, thrombosis and thus, acute coronary events, coul...

Authors: Raul Altman

Point-of-Care Testing of Hemostasis in Cardiac Surgery

An excessive perioperative blood loss, that requires transfusion of blood products, sometimes occurs in patients undergoing cardiopulmonary bypass for cardiac surgery. Blood loss and transfusion requirements i...

Authors: Domenico Prisco and Rita Paniccia