Articles

Heparin-induced thrombocytopenia presenting as splenic hemorrhage following cardiac surgery: a case report

Heparin-induced thrombocytopenia with thrombosis (HITT) is a paradoxical prothrombotic complication of anticoagulant therapy. As many as 3% of patients undergoing cardiac surgery develop clinical HIT presentin...

Authors: Joseph Ferry, Samuel Youssef, Pierce Wu and Livia Hegerova

Predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis: a cross-sectional study

Post-thrombotic syndrome (PTS) is a frequent chronic complication of proximal deep vein thrombosis (DVT) of the lower limb, but predictors of PTS are not well established. We aimed to examine predictors of PTS...

Authors: Marit Engeseth, Tone Enden, Per Morten Sandset and Hilde Skuterud Wik

Unprovoked internal jugular vein thrombosis: a case report and literature review

Managing thrombosis in rare sites is challenging. Existing studies and guidelines provide detailed explanations on how to overcome lower-limb thromboses and pulmonary embolisms, but few studies have examined t...

Authors: Loïc Payrard, Léa Iten, Jacques Donzé and Gregor John

Fatal pulmonary arterial thrombosis in a COVID-19 patient, with asymptomatic history, occurred after swab negativization

A considerable number of SARS-CoV-2 infected individuals could be asymptomatic and don’t need medical treatment. The clinical spectrum of SARS-CoV-2 infection ranges from asymptomatic cases, medium-intensity f...

Authors: Franca Del Nonno, Daniele Colombo, Roberta Nardacci and Laura Falasca

Correction to: Incidence of thromboembolism in patients with COVID-19: a systematic review and meta-analysis

An amendment to this paper has been published and can be accessed via the original article.

Authors: Kochawan Boonyawat, Pichika Chantrathammachart, Pawin Numthavaj, Nithita Nanthatanti, Sithakom Phusanti, Angsana Phuphuakrat, Pimjai Niparuck and Pantep Angchaisuksiri

Coagulation abnormalities in SARS-CoV-2 infection: overexpression tissue factor

Among the pathways and mediators that may be dysregulated in COVID-19 infection, there are proinflammatory cytokines, lymphocyte apoptosis, and the coagulation cascade. Venous and arterial thromboembolisms als...

Authors: Zahra Eslamifar, Mahin Behzadifard, Masoud Soleimani and Saba Behzadifard

Suspected heparin-induced thrombocytopenia in a COVID-19 patient on extracorporeal membrane oxygenation support: a case report

Extracorporeal membrane oxygenation (ECMO) support can be life-saving in critically ill COVID-19 patients. However, there are many complications associated with this procedure, including Heparin-induced thromb...

Authors: Xuan T. Phan, Tuan H. Nguyen, Tung T. Tran, Thu-Hien T. Huynh, Thuy-Ha T. Hoang, Vinh-Chau V. Nguyen and Thao N. T. Pham

Maternal mortality following thromboembolism; incidences and prophylaxis strategies

Thromboembolism is one of the main causes of maternal mortality, which can be prevented in many cases. The present study was designed to investigate the incidence and prophylaxis strategies for maternal mortal...

Authors: Mahboobeh Shirazi, Behrokh Sahebdel, Mahnoosh Torkzaban, Elham Feizabad and Marjan Ghaemi

The association of alcohol with circulating total fibrinogen and plasma clot density is mediated by fibrinogen and FXIII genotypes

Alcohol consumption is associated with haemostasis and so may influence cardiovascular conditions. It is unknown whether the association of alcohol with total and γ’ fibrinogen concentrations, as well as clot ...

Authors: Petro Hannie Rautenbach, Cornelie Nienaber-Rousseau and Marlien Pieters

Incidence of thromboembolism in patients with COVID-19: a systematic review and meta-analysis

Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, the incidence of thromboembolism has been increasingly reported. The aim of this systematic review was to explore the incidence of venou...

Authors: Kochawan Boonyawat, Pichika Chantrathammachart, Pawin Numthavaj, Nithita Nanthatanti, Sithakom Phusanti, Angsana Phuphuakrat, Pimjai Niparuck and Pantep Angchaisuksiri

Von Willebrand factor:antigen and ADAMTS-13 level, but not soluble P-selectin, are risk factors for the first asymptomatic deep vein thrombosis in cancer patients undergoing chemotherapy

There is a high incidence of deep vein thrombosis (DVT) among cancer patients undergoing chemotherapy. Chemotherapy-induced vascular endothelial cell activation (VECA) is characterized by increased plasma leve...

Authors: Budi Setiawan, Cecilia Oktaria Permatadewi, Baringin de Samakto, Ashar Bugis, Ridho M. Naibaho, Eko Adhi Pangarsa, Damai Santosa and Catharina Suharti

Combined thrombogenic effects of vessel injury, pregnancy and procoagulant immune globulin administration in mice

Pregnant women are at increased risk of thrombotic adverse events. Plasma derived immune globulin (IG) products, which are used in pregnancy for various indications, may contain procoagulant impurity activated...

Authors: Yanqun Xu, Yideng Liang, Leonid Parunov, Daryl Despres, Michael Eckhaus, Dorothy Scott, Mikhail Ovanesov and Evi B. Struble

A modified microchip-based flow chamber system for evaluating thrombogenicity in patients with thrombocytopenia

In the intensive care unit (ICU), patients with thrombocytopenia are at high risk for bleeding and should be assessed for their thrombogenic potential. However, the analytical conditions of conventional hemost...

Authors: Bengo Atari, Takashi Ito, Tomoka Nagasato, Tomoko Ohnishi, Kazuya Hosokawa, Tomotsugu Yasuda, Ikuro Maruyama and Yasuyuki Kakihana

Postpartum vertebral artery dissection: case report and review of the literature

Hypertensive disorders of pregnancy are associated with vascular complications, including ischemic stroke and cervical artery dissection. Vertebral artery dissection (VAD), however, is rare. We describe a 31-y...

Authors: Nicholas T. Manasewitsch, Ahmed A. Hanfy, Bryce D. Beutler, Daniel Antwi-Amoabeng, Moutaz Taha, Mohamed Elnaggar and Gurpreet S. Chahal

Direct oral anticoagulant use in left ventricular thrombus

Left ventricular thrombus (LVT) is associated with a significant risk of ischemic stroke (IS) and peripheral embolization. Societal guidelines recommend the use of warfarin, with direct oral anticoagulants (DO...

Authors: Zafar Ali, Nicholas Isom, Tarun Dalia, Farhad Sami, Uzair Mahmood, Zubair Shah and Kamal Gupta

Switching of vascular cells towards atherogenesis, and other factors contributing to atherosclerosis: a systematic review

Onset, development and progression of atherosclerosis are complex multistep processes. Many aspects of atherogenesis are not yet properly known. This study investigates the changes in vasculature that contribu...

Authors: Ovais Shafi

Coagulopathy associated with COVID-19 – Perspectives & Preventive strategies using a biological response modifier Glucan

Direct endothelial injury by viruses and dysregulation of clotting mechanisms due to cytokine storm are the major precipitating factors of mortality in COVID-19; both are attributed to a fundamental dysregulat...

Authors: Nobunao Ikewaki, Kosagi-Sharaf Rao, Armando Durant Archibold, Masaru Iwasaki, Rajappa Senthilkumar, Senthilkumar Preethy, Shojiro Katoh and Samuel J. K. Abraham

The predictive value of D-dimer test for venous thromboembolism during puerperium in women age 35 or older: a prospective cohort study

This study aimed to investigate the predictive value of the D-dimer level for venous thromboembolism (VTE) events during puerperium of women age at 35 years or older, as well as to identify other risk factors ...

Authors: Wen Hu, Dong Xu, Juan Li, Cheng Chen, Yuan Chen, Fangfang Xi, Feifei Zhou, Xiaohan Guo, Baihui Zhao and Qiong Luo

Disseminated intravascular coagulation: new identity as endotheliopathy-associated vascular microthrombotic disease based on in vivo hemostasis and endothelial molecular pathogenesis

Disseminated intravascular coagulation (DIC) can be correctly redefined as disseminated intravascular microthrombosis based on “two-path unifying theory” of in vivo hemostasis. “DIC” is a form of vascular micr...

Authors: Jae C. Chang

The effect of civil and military flights on coagulation, fibrinolysis and blood flow: insight from a rat model

Air travel thrombosis continues to be a controversial topic. Exposure to hypoxia and hypobaric conditions during air travel is assumed a risk factor. The aim of this study is to explore changes in parameters o...

Authors: Anna Levkovsky, Rima Dardik, Daniel Barazany, David M. Steinberg, Mark Dan Kirichenko, Sara Apter, Edna Peleg, Daniel Silverberg, Ehud Grossman and Ophira Salomon

Prevalence of venous obstructions in (recurrent) venous thromboembolism: a case-control study

The role of venous obstructions as a risk factor for recurrent venous thromboembolism has never been evaluated. This study aimed to determine whether there is a difference in prevalence of venous obstructions ...

Authors: Pascale Notten, Rob H. W. Strijkers, Irwin Toonder, Hugo ten Cate and Arina J. ten Cate-Hoek

Thrombotic events following tocilizumab therapy in critically ill COVID-19 patients: a Façade for prognostic markers

Hospitals in the Middle East Gulf region have experienced an influx of COVID-19 patients to their medical wards and intensive care units. The hypercoagulability of these patients has been widely reported on a ...

Authors: Bassam Atallah, Wasim El Nekidy, Saad I. Mallah, Antoine Cherfan, Laila AbdelWareth, Jihad Mallat and Fadi Hamed

Management of the thrombotic risk associated with COVID-19: guidance for the hemostasis laboratory

Coronavirus disease 2019 (COVID-19) is associated with extreme inflammatory response, disordered hemostasis and high thrombotic risk. A high incidence of thromboembolic events has been reported despite thrombo...

Authors: M. Hardy, T. Lecompte, J. Douxfils, S. Lessire, J. M. Dogné, B. Chatelain, S. Testa, I. Gouin-Thibault, Y. Gruel, R. L. Medcalf, H. ten Cate, G. Lippi and F. Mullier

No differences in hemostatic and endothelial activations between haploidentical and matched-donor hematopoietic stem cell transplantation in thalassemia disease

Hemostatic changes and endothelial activations have been recognized in β-thalassemic patients after matched-donor hematopoietic stem cell transplantation (HSCT) but there are limited studies for haploidentical...

Authors: Surapong Lertthammakiat, Peerasit Sitthirat, Usanarat Anurathapan, Duantida Songdej, Samart Pakakasama, Ampaiwan Chuansumrit, Nattaphat Putawornsub, Sawitt Sirasittikarn, Sataporn Wantanawijarn, Praguywan Kadegasem, Suradej Hongeng and Nongnuch Sirachainan

SARS-CoV-2 and pulmonary embolism: who stole the platelets?

Patients infected with SARS-CoV-2 often develop venous and arterial thrombosis. The high patient mortality is partly attributed to thrombotic events. An emerging trend is the presence of immunological phenomen...

Authors: Michael Tran, Chirag Sheth, Rohan Bhandari, Scott J. Cameron and Deborah Hornacek

GST null polymorphisms may affect the risk of coronary artery disease: evidence from a meta-analysis

Whether glutathione S-transferase (GST) null polymorphisms, namely GSTM1 null, GSTP1 null and GSTT1 null polymorphisms, influence the risk of coronary artery disease (CAD) or not remains unclear. Thus, the author...

Authors: Hongling Su, Yunshan Cao, Jing Li, Yan Zhu and Xuming Ma

Collagen-dependent platelet dysfunction and its relevance to either mitochondrial ROS or cytosolic superoxide generation: a question about the quality and functional competence of long-stored platelets

Upon vascular damage, the exposed subendothelial matrix recruits circulating platelets to site of injury while inducing their firm adhesion mainly via GPVI-collagen interaction. GPVI also supports aggregatory ...

Authors: Ehteramolsadat Hosseini, Saba Hojjati, Safoora Afzalniaye gashti and Mehran Ghasemzadeh

A case-report of widespread pulmonary embolism in a middle-aged male seven weeks after asymptomatic suspected COVID 19 infection

Pulmonary embolism (PE) is seen in high frequency in hospital-treated patients with Covid-19. We present a case of suspected Covid-19 with long-term dyspnea and widespread PE.

Authors: Mats Beckman, Sven Nyrén and Anna Kistner

Reversal of rivaroxaban anticoagulant effect by prothrombin complex concentrates: which dose is sufficient to restore normal thrombin generation?

Rivaroxaban has the most available data to support the use of prothrombin complex concentrates (PCC) as a reversal agent. However, PCC might increase the incidence of thrombotic events by shifting the haemosta...

Authors: Lorine Giffard-Quillon, Helene Desmurs-Clavel, Claire Grange, Yohann Jourdy and Yesim Dargaud

Therapeutic duplication of anticoagulants: a retrospective study of frequency and consequences in a tertiary referral hospital

Anticoagulants are commonly prescribed in medical practices and could be of significant harm in the case of medication errors. We conducted a retrospective observational study to determine the frequency and co...

Authors: Ramin Rahmanzade, Francisco Cabrera Diaz, Claudia Zaugg, Philipp Schuetz and Ali Reza Salili

Blue toe syndrome caused by emboli from anomalous left atrial septal pouch thrombus: a case report

Left atrial septal pouches (LASPs) are a relatively newly described but common anatomical cardiac variant thought to be associated with atrial fibrillation (AF) and cardio-embolic stroke. Blue toe syndrome (BT...

Authors: Snehasis Pradhan, Kciku Gresa, Jan-Peter Röing genannt Nölke and Hans-Joachim Trappe

Superior vena cava thrombosis and dilated cardiomyopathy as initial presentations of Behcet’s disease

Bechet’s disease (BD) is a relatively rare disease that causes recurrent oral and genital ulcers in addition to a variety of systemic manifestations. Concomitant superior-vena-cava (SVC) thrombosis and cardiac...

Authors: Ahmed M. Elzanaty, Mohammed T. Awad, Ashu Acharaya, Ebrahim Sabbagh, Eman Elsheikh and Moshrik AbdAlamir

Factor V Leiden 1691G > A mutation and the risk of recurrent pregnancy loss (RPL): systematic review and meta-analysis

Although numerous replication case-control studies have attempted to determine the association between Factor V Leiden (FVL) 1691G > A mutation and susceptibility to Recurrent pregnancy loss (RPL), there have ...

Authors: Mohammad Masoud Eslami, Majid khalili, Mina Soufizomorrod, Saeid Abroun and Bahman Razi

Effects of concomitant use of prasugrel with edoxaban on bleeding time, pharmacodynamics, and pharmacokinetics of edoxaban in healthy elderly Japanese male subjects: a clinical pharmacology study

Dual therapy with a direct oral anticoagulant (DOAC) plus a P2Y₁₂ receptor inhibitor is recommended in patients with nonvalvular atrial fibrillation who undergo percutaneous coronary intervention. Thus, we evalua...

Authors: Ippei Ikushima, Takaaki Akasaka, Yoshiyuki Morishima, Atsushi Takita, Tomoko Motohashi and Tetsuya Kimura

Increased dose primary thromboprophylaxis in ambulatory patients with advanced pancreatic ductal adenocarcinoma, a single centre cohort study

Advanced pancreatic ductal adenocarcinoma (aPDAC) patients have a lifetime all type thromboembolic event (ATTE) rate of 25–35%. Efficacy and safety of increased dose primary thromboprophylaxis (IDPTP) with low...

Authors: Anthony Maraveyas, Farzana Haque, Iqtedar Ahmed Muazzam, Waqas Ilyas and George Bozas

Comparative analysis of enoxaparin versus rivaroxaban in the treatment of cancer associated venous thromboembolism: experience from a tertiary care cancer centre

Venous Thromboembolism (VTE) in cancer patients is associated with increased mortality and morbidity. While newer data on use of direct oral anticoagulants (DOACs) in treating cancer associated thrombosis (CAT...

Authors: Anadil Faqah, Hassan Sheikh, Muhammad Abu Bakar, Fatima Tayyaab and Sahrish Khawaja

Thrombosis management in times of COVID-19 epidemy; a Dutch perspective

Authors: Hugo ten Cate

Rivaroxaban versus warfarin for treatment and prevention of recurrence of venous thromboembolism in African American patients: a retrospective cohort analysis

African Americans are under-represented in trials evaluating oral anticoagulants for the treatment of acute venous thromboembolism (VTE). The aim of this study was to evaluate the effectiveness and safety of r...

Authors: Olivia S. Costa, Stanley Thompson, Veronica Ashton, Michael Palladino, Thomas J. Bunz and Craig I. Coleman

Changes in anticoagulant prescription in Dutch patients with recent-onset atrial fibrillation: observations from the GARFIELD-AF registry

For the improvement of AF care, it is important to gain insight into current anticoagulation prescription practices and guideline adherence. This report focuses on the largest Dutch subset of AF-patients, deri...

Authors: J. Seelig, F. W. A. Verheugt, M. E. W. Hemels, L. Illingworth, A. Lucassen, H. Adriaansen, M. C. M. Bongaerts, M. Pieterse, J. P. R. Herrman, P. Hoogslag, W. Hermans, B. E. Groenemeijer, L. V. A. Boersma, K. Pieper and H. ten Cate

Multiple trauma including pelvic fracture with multiple arterial embolization: an autopsy case report

Pelvic fracture with high energy trauma has a high mortality rate, especially in men. In addition, severe multiple trauma, major hemorrhage, and administration of red blood cells predict mortality in elderly p...

Authors: Takahito Miyake, Hideshi Okada, Norihide Kanda, Fuminori Yamaji, Haruka Okamoto, Hiroaki Ushikoshi, Kei Noguchi, Hiroyuki Tomita, Shozo Yoshida and Shinji Ogura

Analysis of the association between resolution of disseminated intravascular coagulation (DIC) and treatment outcomes in post-marketing surveillance of thrombomodulin alpha for DIC with infectious disease and with hematological malignancy by organ failure

Although disseminated intravascular coagulation (DIC) is life-threatening, any organ failure associated with DIC resolution and outcomes have been unclear.

Authors: Noriaki Kawano, Hideo Wada, Toshimasa Uchiyama, Kazuo Kawasugi, Seiji Madoiwa, Naoki Takezako, Kei Suzuki, Yoshinobu Seki, Takayuki Ikezoe, Tsuyoshi Hattori and Kohji Okamoto

Time trends for pulmonary embolism incidence in Greece

Pulmonary embolism (PE) is a disease with a significant impact on public health. However, international epidemiological data are unclear and show considerable heterogeneity. The present study aims to investiga...

Authors: Dimitrios G. Raptis, Konstantinos I. Gourgoulianis, Zoe Daniil and Foteini Malli

Evaluation of unmet clinical needs in prophylaxis and treatment of venous thromboembolism in at-risk patient groups: pregnancy, elderly and obese patients

Venous thromboembolism (VTE) accounts for an estimated 900,000 cases per year in the US alone and constitutes a considerable burden on healthcare systems across the globe.

Authors: Benjamin Brenner, Roopen Arya, Jan Beyer-Westendorf, James Douketis, Russell Hull, Ismail Elalamy, Davide Imberti and Zhenguo Zhai

Low molecular weight heparins use in pregnancy: a practice survey from Greece and a review of the literature

Use of LMWH in pregnancy is not only limited to VTE management, but it extends, to the management of vascular gestational complications and the optimization of IVF pregnancies despite the lack of concrete scie...

Authors: E. Papadakis, A. Pouliakis, Α. Aktypi, A. Christoforidou, P. Kotsi, G. Αnagnostou, A. Foifa and E. Grouzi

Non-vitamin K antagonist oral anticoagulants vs. vitamin-K antagonists in patients with atrial fibrillation and chronic kidney disease: a nationwide cohort study

We aimed to compare effectiveness and safety of non-vitamin K antagonist oral anticoagulants (NOACs) versus vitamin-K antagonists (VKA) in atrial fibrillation (AF) patients with chronic kidney disease (CKD) no...

Authors: Emma Kirstine Laugesen, Laila Staerk, Nicholas Carlson, Anne-Lise Kamper, Jonas Bjerring Olesen, Christian Torp-Pedersen, Gunnar Gislason and Anders Nissen Bonde

Correction to: protease-activated receptors (PARs): mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases

Following the publication of this article [1], the authors reported an incorrect citation in the following sentence in the “Metalloproteases” sub-section:

Authors: Dorothea M. Heuberger and Reto A. Schuepbach

Down-regulation of platelet adhesion receptors is a controlling mechanism of thrombosis, while also affecting post-transfusion efficacy of stored platelets

Physiologically, upon platelet activation, uncontrolled propagation of thrombosis is prevented by regulating mechanisms which affect the expression and function of either platelet adhesion receptors or integri...

Authors: Ehteramolsadat Hosseini, Maryam Mohtashami and Mehran Ghasemzadeh

Genotypic and phenotypic character of Chinese neonates with congenital protein C deficiency: a case report and literature review

Our objective was to study the phenotype of and molecular genetic mechanisms underlying congenital protein C (PC) deficiency in Chinese neonates. We report the case of a neonate who presented 4 h after birth w...

Authors: Xiaoying Li, Xiaoyan Li, Xiao Li, Yuanhua Zhuang, Lili Kang and Xiuli Ju

Successful use of eculizumab to treat atypical hemolytic uremic syndrome in patients with inflammatory bowel disease

Atypical hemolytic uremic syndrome is a rare group of disorders that have in common underlying complement amplifying conditions. These conditions can accelerate complement activation that results in a positive...

Authors: Ramy M. Hanna, Noah Merin, Richard M. Burwick, Lama Abdelnour, Umut Selamet, Beshoy Yanny, Patrick Bui, Mary Fouad and Ira Kurtz

Effects of glycemic control and hypoglycemia on Thrombus formation assessed using automated microchip flow chamber system: an exploratory observational study

Thrombus formation is an important factor affecting cardiovascular events and venous thromboembolism in type 2 diabetes. However, it is unclear whether glycemic control reduces thrombogenicity. We investigated...

Authors: Kiyoaki Yamamoto, Takashi Ito, Tomoka Nagasato, Atsushi Shinnakasu, Mihoko Kurano, Aiko Arimura, Hiroshi Arimura, Hiroshi Hashiguchi, Takahisa Deguchi, Ikuro Maruyama and Yoshihiko Nishio