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  1. Content type: Research

    Atrial fibrillation (AF) is a major risk factor for stroke as it increases the incidence of stroke nearly fivefold. Antithrombotic treatment is recommended for the prevention of stroke in AF patients. However,...

    Authors: Eyob Alemayehu Gebreyohannes, Akshaya Srikanth Bhagavathula and Henok Getachew Tegegn

    Citation: Thrombosis Journal 2018 16:22

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  2. Content type: Research

    Around 20% of venous thromboembolism (VTE) cases occur in patients with cancer. Current guidelines recommend low molecular weight heparin (LMWH) as the preferred anticoagulant for VTE treatment. However, some ...

    Authors: Alexander T. Cohen, Anthony Maraveyas, Jan Beyer-Westendorf, Agnes Y. Y. Lee, Lorenzo G. Mantovani and Miriam Bach

    Citation: Thrombosis Journal 2018 16:21

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  3. Content type: Case report

    Anticoagulation therapy for mechanical prosthetic valves is limited to vitamin K antagonists, unfractionated heparin and low-molecular-weight-heparin. Other forms of anticoagulation are either contraindicated ...

    Authors: Abeer Berry, George Degheim and Souheil Saba

    Citation: Thrombosis Journal 2018 16:23

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  4. Content type: Research

    Disseminated intravascular coagulation (DIC) is associated with high mortality in patients with sepsis. Several studies reporting that recombinant human soluble thrombomodulin (rhTM) reduced mortality in sepsi...

    Authors: Takahiro Kato and Katsuhiko Matsuura

    Citation: Thrombosis Journal 2018 16:19

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  6. Content type: Research

    We conducted a prospective observational study for investigating coagulofibrinolytic changes and mechanisms of antithrombin (AT) alternations in trauma.

    Authors: Hironori Matsumoto, Jun Takeba, Kensuke Umakoshi, Satoshi Kikuchi, Muneaki Ohshita, Suguru Annen, Naoki Moriyama, Yuki Nakabayashi, Norio Sato and Mayuki Aibiki

    Citation: Thrombosis Journal 2018 16:17

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  8. Content type: Review

    Both disseminated intravascular coagulation (DIC) and thrombotic microangiopathy (TMA) cause microvascular thrombosis associated with thrombocytopenia, bleeding tendency and organ failure.

    Authors: Hideo Wada, Takeshi Matsumoto, Kei Suzuki, Hiroshi Imai, Naoyuki Katayama, Toshiaki Iba and Masanori Matsumoto

    Citation: Thrombosis Journal 2018 16:14

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  9. Content type: Research

    Hyponatremia is common among patients with pulmonary embolism, while hypernatremia increases the risk of venous thromboembolism (VTE). Our objective was to evaluate the association between sodium imbalances an...

    Authors: Sally Temraz, Hani Tamim, Aurelie Mailhac and Ali Taher

    Citation: Thrombosis Journal 2018 16:11

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  10. Content type: Review

    The pathophysiological mechanisms of acute coagulopathy of trauma-shock (ACOTS) are reported to include activated protein C-mediated suppression of thrombin generation via the proteolytic inactivation of activ...

    Authors: Satoshi Gando, Toshihiko Mayumi and Tomohiko Ukai

    Citation: Thrombosis Journal 2018 16:13

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  11. Content type: Research

    Small studies have implicated plasminogen activator inhibitor-1 (PAI-1) as a predictor of cardiovascular events; however, these findings have been inconsistent.

    Authors: Richard G. Jung, Pouya Motazedian, F. Daniel Ramirez, Trevor Simard, Pietro Di Santo, Sarah Visintini, Mohammad Ali Faraz, Alisha Labinaz, Young Jung and Benjamin Hibbert

    Citation: Thrombosis Journal 2018 16:12

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  12. Content type: Correction

    Correction to: Thrombosis Journal (2018) 16:9 DOI 10.1186/s12959-018-0163-7

    Authors: Alexander T. Cohen, Cihan Ay, Philippe Hainaut, Hervé Décousus, Ulrich Hoffmann, Sean Gaine, Michiel Coppens, Pedro Marques da Silva, David Jimenez, Beatrice Amann-Vesti, Bernd Brüggenjürgen, Pierre Levy, Julio Lopez Bastida, Eric Vicaut, Petra Laeis, Eva-Maria Fronk…

    Citation: Thrombosis Journal 2018 16:18

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    The original article was published in Thrombosis Journal 2018 16:9

  13. Content type: Letter to the Editor

    Accurate thrombin generation determination by calibrated automated thrombinography can be sustained when reducing the plasma and reagent volumes up to half, but not for higher reductions or plasma dilutions.

    Authors: Saartje Bloemen, Hilde Kelchtermans and H. Coenraad Hemker

    Citation: Thrombosis Journal 2018 16:10

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  14. Content type: Research

    Venous thromboembolism (VTE, including deep vein thrombosis [DVT] and pulmonary embolism [PE]) has an annual incidence rate of 104–183 per 100,000 person-years. After a VTE episode, the two-year recurrence rat...

    Authors: Alexander T. Cohen, Cihan Ay, Philippe Hainaut, Hervé Décousus, Ulrich Hoffmann, Sean Gaine, Michiel Coppens, Pedro Marques da Silva, David Jiménez, Beatrice Amann-Vesti, Bernd Brüggenjürgen, Pierre Levy, Julio Lopez Bastida, Eric Vicaut, Petra Laeis, Eva-Maria Fronk…

    Citation: Thrombosis Journal 2018 16:9

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    The Correction to this article has been published in Thrombosis Journal 2018 16:18

  15. Content type: Research

    In 2012, around 400.000 patients in the Netherlands were treated with Vitamin K Antagonists (VKA) for thromboembolic diseases. Since 2011, non-VKA oral anticoagulants (NOACs) are available. NOACs do not requir...

    Authors: J. M. van den Heuvel, A. M. Hövels, H. R. Büller, A. K. Mantel-Teeuwisse, A. de Boer and A. H. Maitland-van der Zee

    Citation: Thrombosis Journal 2018 16:7

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  16. Content type: Correction

    Following the publication of this study [1] the authors identified the following errors inadvertently introduced during the production process:

    Authors: George Bozas, Natalie Jeffery, Deiva Ramanujam-Venkatachala, Ged Avery, Andrew Stephens, Hilary Moss, June Palmer, Mandi Elliott and Anthony Maraveyas

    Citation: Thrombosis Journal 2018 16:15

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    The original article was published in Thrombosis Journal 2018 16:8

  17. Content type: Case report

    Patients with congenital afibrinogenemia suffer from spontaneous recurrent severe bleeding. While fibrinogen concentrates are known to effectively treat bleeding episodes, thrombotic complications often occur ...

    Authors: S. Le Quellec, A. Desjonqueres, L. Rugeri, H. Desmurs Clavel, F. Farhat, L. Mechtouff and Y. Dargaud

    Citation: Thrombosis Journal 2018 16:6

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  19. Content type: Research

    The risk of thromboembolic events is higher among cancer patients, especially in patients undergoing chemotherapy. Cisplatin-based regimens claim to be associated with a very high thromboembolic rate. In this ...

    Authors: Hikmat Abdel-Razeq, Asem Mansour, Hazem Abdulelah, Anas Al-Shwayat, Mohammad Makoseh, Mohammad Ibrahim, Mahmoud Abunasser, Dalia Rimawi, Abeer Al-Rabaiah, Rozan Alfar, Alaa’ Abufara, Alaa Ibrahim, Anas Bawaliz and Yousef Ismael

    Citation: Thrombosis Journal 2018 16:2

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  20. Content type: Research

    An incidental/unsuspected diagnosis of pulmonary embolism (IPE) in cancer patients is a frequent occurrence. This single-institution analysis of uniformly managed patients investigates short and long-term outc...

    Authors: George Bozas, Natalie Jeffery, Deiva Ramanujam-Venkatachala, Ged Avery, Andrew Stephens, Hilary Moss, June Palmer, Mandi Elliott and Anthony Maraveyas

    Citation: Thrombosis Journal 2018 16:8

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    The Correction to this article has been published in Thrombosis Journal 2018 16:15

  21. Content type: Research

    Traditional coagulation tests are included in emergency guidelines for management of patients on direct oral anticoagulants (DOACs) who experience acute bleeding or require surgery. We determined the ability o...

    Authors: Yvonne M. C. Henskens, Anouk J. W. Gulpen, René van Oerle, Rick Wetzels, Paul Verhezen, Henri Spronk, Simon Schalla, Harry J. Crijns, Hugo ten Cate and Arina ten Cate-Hoek

    Citation: Thrombosis Journal 2018 16:3

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  22. Content type: Review

    Although the incidence of venous thromboembolism (VTE) in Asian populations is lower than in Western countries, the overall burden of VTE in Asia has been considerably underestimated. Factors that may explain ...

    Authors: Kang-Ling Wang, Eng Soo Yap, Shinya Goto, Shu Zhang, Chung-Wah Siu and Chern-En Chiang

    Citation: Thrombosis Journal 2018 16:4

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  23. Content type: Research

    Direct oral anticoagulants (DOACs) pose a great challenge for physicians in life-threatening bleeding events. The aim of this study was to test the efficacy of reversing the DOAC rivaroxaban using four-factor ...

    Authors: Bettina Schenk, Stephanie Goerke, Ronny Beer, Raimund Helbok, Dietmar Fries and Mirjam Bachler

    Citation: Thrombosis Journal 2018 16:1

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  24. Content type: Research

    A functional coagulation assay was used to investigate the extrinsic pathway of coagulation on citrated whole blood samples from healthy adult male Sprague Dawley rats using the mini cup and pin system.

    Authors: Mariana Vigiola Cruz, Jenna N. Luker, Bonnie C. Carney, Kathleen E. Brummel-Ziedins, Maria-Cristina Bravo, Thomas Orfeo, Jason H. Chen, Lauren T. Moffatt and Jeffrey W. Shupp

    Citation: Thrombosis Journal 2017 15:31

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  25. Content type: Research

    Atrial fibrillation (AF) confers a hypercoagulable state; however, it is not clear whether restoration of sinus rhythm is associated with normalisation of markers of thrombogenesis. We studied the impact of su...

    Authors: Anja Wiedswang Horjen, Ingebjørg Seljeflot, Trygve Berge, Pål Smith, Harald Arnesen and Arnljot Tveit

    Citation: Thrombosis Journal 2017 15:30

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  26. Content type: Research

    Changes in the coagulation system in patients undergoing surgery for lung cancer have been sparsely investigated and the impact of the surgical trauma on the coagulation system is largely unknown in these pati...

    Authors: Thomas Decker Christensen, Henrik Vad, Søren Pedersen, Peter B. Licht, Mads Nybo, Kåre Hornbech, Nora Elisabeth Zois and Anne-Mette Hvas

    Citation: Thrombosis Journal 2017 15:29

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  27. Content type: Research

    The mechanisms behind residual platelet reactivity (RPR) despite aspirin treatment are not established. It has been shown that coronary artery disease (CAD) patients with high on-aspirin RPR have elevated leve...

    Authors: Ellen M. K. Warlo, Alf-Åge R. Pettersen, Harald Arnesen and Ingebjørg Seljeflot

    Citation: Thrombosis Journal 2017 15:28

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  28. Content type: Research

    Measurement of edoxaban plasma concentration has been gathering attention in major orthopedic surgery patients receiving edoxaban for the prevention of venous thromboembolism (VTE).

    Authors: Makoto Ikejiri, Hideo Wada, Shine Tone, Hiroki Wakabayashi, Masahiro Hasegawa, Takeshi Matsumoto, Naoki Fujimoto, Norikazu Yamada, Masaaki Ito, Kaname Nakatani and Akihiro Sudo

    Citation: Thrombosis Journal 2017 15:27

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  29. Content type: Research

    Upper extremity deep vein thrombosis (UEDVT) constitutes around 10% of all DVT, and can cause both pulmonary embolism (PE) and postthrombotic syndrome (PTS) in the arm. The incidence of secondary UEDVT is incr...

    Authors: Francisco Sánchez Montiel, Raein Ghazvinian, Anders Gottsäter and Johan Elf

    Citation: Thrombosis Journal 2017 15:26

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  30. Content type: Research

    Deep vein thrombosis (DVT) is a common complication of peripherally inserted central catheters (PICCs). PICCs are increasingly utilised in the management of cancer patients, a group which carries both addition...

    Authors: Daniel Jones, Kurt Wismayer, George Bozas, June Palmer, Mandi Elliott and Anthony Maraveyas

    Citation: Thrombosis Journal 2017 15:25

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  31. Content type: Research

    Congenital afibrinogenemia (OMIM #202400) is a rare coagulation disorder that was first described in 1920. It is transmitted as an autosomal recessive trait that is characterized by absent levels of fibrinogen...

    Authors: Arshi Naz, Arijit Biswas, Tehmina Nafees Khan, Anne Goodeve, Nisar Ahmed, Nazish Saqlain, Shariq Ahmed, Ikram Din Ujjan, Tahir S Shamsi and Johannes Oldenburg

    Citation: Thrombosis Journal 2017 15:24

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  32. Content type: Case report

    Dabigatran is a direct thrombin inhibitor with a favorable effectiveness and safety profile when compared to vitamin K antagonists, both in randomized trials and real world registries of atrial fibrillation pa...

    Authors: António Tralhão, Carlos Aguiar, Jorge Ferreira, Maria José Rebocho, Emília Santos, Dinis Martins and José Pedro Neves

    Citation: Thrombosis Journal 2017 15:23

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  33. Content type: Research

    It is well accepted that functional activity of platelet integrin αIIbβ3 is crucial for hemostasis and thrombosis. The β3 subunit of the complex undergoes tyrosine phosphorylation shown to be critical for outside...

    Authors: Weiyi Feng, Manojkumar Valiyaveettil, Tejasvi Dudiki, Ganapati H. Mahabeleshwar, Patrick Andre, Eugene A. Podrez and Tatiana V. Byzova

    Citation: Thrombosis Journal 2017 15:22

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  34. Content type: Research

    Rivaroxaban is a direct oral anticoagulant designed to dispense with the necessity of laboratory monitoring. However, monitoring rivaroxaban levels is necessary in certain clinical conditions, especially in th...

    Authors: Marjorie Paris Colombini, Priscilla Bento Matos Cruz Derogis, Valdir Fernandes de Aranda, João Carlos de Campos Guerra, Nelson Hamerschlak and Cristóvão Luis Pitangueiras Mangueira

    Citation: Thrombosis Journal 2017 15:21

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  35. Content type: Case report

    Paget-Schrotter Syndrome (PSS) also known as “effort thrombosis” is a form of primary thrombosis in the subclavian vein at the costoclavicular junction is usually seen in younger patients after repeated strenu...

    Authors: Ramy Ibrahim, Irina Dashkova, Myia Williams, Andrzej Kozikowski, Neeraj Abrol, Anjula Gandhi and Renee Pekmezaris

    Citation: Thrombosis Journal 2017 15:20

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  36. Content type: Research

    Patient awareness of venous thromboembolism (VTE) and thromboprophylaxis is essential for their safety. In this study, we evaluated patients’ awareness of VTE and their perceptions of thromboprophylaxis.

    Authors: Hind Almodaimegh, Lama Alfehaid, Nada Alsuhebany, Rami Bustami, Shmylan Alharbi, Abdulmalik Alkatheri and Abdulkareem Albekairy

    Citation: Thrombosis Journal 2017 15:19

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  37. Content type: Case report

    Evans syndrome (ES) is a rare disease characterized by simultaneous or sequential development of autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP) with or without immune neutropenia. Splenec...

    Authors: Varun Monga, Seth M. Maliske and Usha Perepu

    Citation: Thrombosis Journal 2017 15:18

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  38. Content type: Letter to the Editor

    As proposed diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis has been approved and revised, the contents and changes are informed.

    Authors: Hideo Wada, Hoyu Takahashi, Toshimasa Uchiyama, Yutaka Eguchi, Kohji Okamoto, Kazuo Kawasugi, Seiji Madoiwa and Hidesaku Asakura

    Citation: Thrombosis Journal 2017 15:17

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  40. Content type: Research

    The effects of Ramadan fasting (RF) on clopidogrel antiplatelet inhibition were not previously investigated. The present study evaluated the influence of RF on platelet reactivity in patients with high cardiov...

    Authors: W. Bouida, H. Baccouche, M. Sassi, Z. Dridi, T. Chakroun, I. Hellara, R. Boukef, M. Hassine, F. Added, R. Razgallah, I. Khochtali and S. Nouira

    Citation: Thrombosis Journal 2017 15:15

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  41. Content type: Review

    Direct oral anticoagulants (DOACs) have been licensed worldwide for several years for various indications. Each year, 10–15% of patients on oral anticoagulants will undergo an invasive procedure and expert gro...

    Authors: Virginie Dubois, Anne-Sophie Dincq, Jonathan Douxfils, Brigitte Ickx, Charles-Marc Samama, Jean-Michel Dogné, Maximilien Gourdin, Bernard Chatelain, François Mullier and Sarah Lessire

    Citation: Thrombosis Journal 2017 15:14

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  42. Content type: Review

    Recently, the European Medicines Agency (EMA) authorized the introduction and marketing of Thorinane® and Inhixa®, biosimilars of the Low Molecular Weight Heparin (LMWH) enoxaparin. The authorization path is c...

    Authors: Davide Imberti, Marco Marietta, Hernan Polo Friz and Claudio Cimminiello

    Citation: Thrombosis Journal 2017 15:13

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  44. Content type: Research

    The transmembrane receptor molecule CD31 is known to have immunomodulatory functions, suggesting a possible neuroprotective effect in the context of acute ischemic stroke by restricting an over-activation of s...

    Authors: Tobias Boeckh-Behrens, Justus Kleine, Johannes Kaesmacher, Claus Zimmer, Lucas Schirmer, Sophie Simon and Holger Poppert

    Citation: Thrombosis Journal 2017 15:11

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  46. Content type: Research

    Blood coagulation plays a crucial role in the blastocyst implantation process and its alteration may be related to in vitro fertilization (IVF) failure. We conducted a prospective observational longitudinal st...

    Authors: Grigoris T. Gerotziafas, Patrick Van Dreden, Emmanuelle Mathieu d’Argent, Eleftheria Lefkou, Matthieu Grusse, Marjorie Comtet, Rabiatou Sangare, Hela Ketatni, Annette K. Larsen and Ismail Elalamy

    Citation: Thrombosis Journal 2017 15:9

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  47. Content type: Case report

    Because the venous thromboembolisms (VTEs) due to the coagulation factor V R506Q (FV Leiden) mutation is often seen in Caucasians, the VTE onset in Japan has not been reported.

    Authors: Daisuke Sueta, Miwa Ito, Mitsuhiro Uchiba, Kenji Sakamoto, Eiichiro Yamamoto, Yasuhiro Izumiya, Sunao Kojima, Koichi Kaikita, Satoru Shinriki, Seiji Hokimoto, Hirotaka Matsui and Kenichi Tsujita

    Citation: Thrombosis Journal 2017 15:8

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  49. Content type: Research

    An increasing number of patients are treated with direct-acting oral anticoagulants (DOACs), but the optimal way to reverse the anticoagulant effect is not known. Specific antidotes are not available and proth...

    Authors: Nina Haagenrud Schultz, Hoa Thi Tuyet Tran, Stine Bjørnsen, Carola Elisabeth Henriksson, Per Morten Sandset and Pål Andre Holme

    Citation: Thrombosis Journal 2017 15:6

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  50. Content type: Research

    Platelets from untreated periodontitis patients are hyper-reactive and form more platelet-leukocyte complexes compared to cells from individuals without periodontitis. It is not known whether the improvement o...

    Authors: Efthymios Arvanitidis, Sergio Bizzarro, Elena Alvarez Rodriguez, Bruno G. Loos and Elena A. Nicu

    Citation: Thrombosis Journal 2017 15:5

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