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  1. Pulmonary embolism (PE) is a disease with a significant impact on public health. However, international epidemiological data are unclear and show considerable heterogeneity. The present study aims to investiga...

    Authors: Dimitrios G. Raptis, Konstantinos I. Gourgoulianis, Zoe Daniil and Foteini Malli

    Citation: Thrombosis Journal 2020 18:1

    Content type: Research

    Published on:

  2. Venous thromboembolism (VTE) accounts for an estimated 900,000 cases per year in the US alone and constitutes a considerable burden on healthcare systems across the globe.

    Authors: Benjamin Brenner, Roopen Arya, Jan Beyer-Westendorf, James Douketis, Russell Hull, Ismail Elalamy, Davide Imberti and Zhenguo Zhai

    Citation: Thrombosis Journal 2019 17:24

    Content type: Review

    Published on:

  3. Use of LMWH in pregnancy is not only limited to VTE management, but it extends, to the management of vascular gestational complications and the optimization of IVF pregnancies despite the lack of concrete scie...

    Authors: E. Papadakis, A. Pouliakis, Α. Aktypi, A. Christoforidou, P. Kotsi, G. Αnagnostou, A. Foifa and E. Grouzi

    Citation: Thrombosis Journal 2019 17:23

    Content type: Research

    Published on:

  4. We aimed to compare effectiveness and safety of non-vitamin K antagonist oral anticoagulants (NOACs) versus vitamin-K antagonists (VKA) in atrial fibrillation (AF) patients with chronic kidney disease (CKD) no...

    Authors: Emma Kirstine Laugesen, Laila Staerk, Nicholas Carlson, Anne-Lise Kamper, Jonas Bjerring Olesen, Christian Torp-Pedersen, Gunnar Gislason and Anders Nissen Bonde

    Citation: Thrombosis Journal 2019 17:21

    Content type: Research

    Published on:

  5. Following the publication of this article [1], the authors reported an incorrect citation in the following sentence in the “Metalloproteases” sub-section:

    Authors: Dorothea M. Heuberger and Reto A. Schuepbach

    Citation: Thrombosis Journal 2019 17:22

    Content type: Correction

    Published on:

    The original article was published in Thrombosis Journal 2019 17:4

  6. Physiologically, upon platelet activation, uncontrolled propagation of thrombosis is prevented by regulating mechanisms which affect the expression and function of either platelet adhesion receptors or integri...

    Authors: Ehteramolsadat Hosseini, Maryam Mohtashami and Mehran Ghasemzadeh

    Citation: Thrombosis Journal 2019 17:20

    Content type: Review

    Published on:

  7. Our objective was to study the phenotype of and molecular genetic mechanisms underlying congenital protein C (PC) deficiency in Chinese neonates. We report the case of a neonate who presented 4 h after birth w...

    Authors: Xiaoying Li, Xiaoyan Li, Xiao Li, Yuanhua Zhuang, Lili Kang and Xiuli Ju

    Citation: Thrombosis Journal 2019 17:19

    Content type: Review

    Published on:

  8. Atypical hemolytic uremic syndrome is a rare group of disorders that have in common underlying complement amplifying conditions. These conditions can accelerate complement activation that results in a positive...

    Authors: Ramy M. Hanna, Noah Merin, Richard M. Burwick, Lama Abdelnour, Umut Selamet, Beshoy Yanny, Patrick Bui, Mary Fouad and Ira Kurtz

    Citation: Thrombosis Journal 2019 17:18

    Content type: Case report

    Published on:

  9. Thrombus formation is an important factor affecting cardiovascular events and venous thromboembolism in type 2 diabetes. However, it is unclear whether glycemic control reduces thrombogenicity. We investigated...

    Authors: Kiyoaki Yamamoto, Takashi Ito, Tomoka Nagasato, Atsushi Shinnakasu, Mihoko Kurano, Aiko Arimura, Hiroshi Arimura, Hiroshi Hashiguchi, Takahisa Deguchi, Ikuro Maruyama and Yoshihiko Nishio

    Citation: Thrombosis Journal 2019 17:17

    Content type: Research

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  11. Bridging anticoagulation is used in vitamin-K antagonist (VKA) patients undergoing invasive procedures and involves complex risk assessment in order to prevent thromboembolic and bleeding outcomes.

    Authors: M. J. Moesker, J. F. de Groot, N. L. Damen, N. R. Bijsterveld, J. W. R. Twisk, M. V. Huisman, M. C. de Bruijne and C. Wagner

    Citation: Thrombosis Journal 2019 17:15

    Content type: Research

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  12. Ambulatory management of isolated acute deep venous thrombosis (DVT) is the recommended standard of care in selected populations. However, in practice a significant number of patients continue to be managed as...

    Authors: Sarah Kelliher, Patricia Hall, Barry Kevane, Daniela Dinu, Karl Ewins, Peter MacMahon, Fionnuala Ní Áinle and Tomás Breslin

    Citation: Thrombosis Journal 2019 17:14

    Content type: Review

    Published on:

  13. Although patients with acute myeloid leukemia (AML) were shown to have an increased risk of thrombosis, no thrombosis risk assessment scoring system has been developed for AML patients. The Khorana Risk Score ...

    Authors: Abu-Sayeef Mirza, Seongseok Yun, Najla Al Ali, Hannah Shin, Joseph Luke O’Neil, Maher Elharake, Daniel Schwartz, Katherine Robinson, Ethan Nowell, Grace Engle, Ibraahim Badat, Thomas Brimer, Amra Kuc, Ashton Sequeira, Sabbir Mirza, Dhiraj Sikaria…

    Citation: Thrombosis Journal 2019 17:13

    Content type: Research

    Published on:

  14. The usefulness of the activated partial thromboplastin time (APTT) waveform has been reported in hemophilia, acquired hemophilia and monitoring for anticoagulants.

    Authors: Kei Suzuki, Hideo Wada, Takeshi Matsumoto, Makoto Ikejiri, Kohshi Ohishi, Yoshiki Yamashita, Hiroshi Imai, Toshiaki Iba and Naoyuki Katayama

    Citation: Thrombosis Journal 2019 17:12

    Content type: Research

    Published on:

  15. Venous thromboembolism (VTE) of the lower limbs is an important complication post total knee arthroplasty (TKA). Current guidelines recommend routine chemical prophylaxis to all patients undergoing this proced...

    Authors: Jing Loong Moses Loh, Stephrene Chan, Keng Lin Wong, Sanjay de Mel and Eng Soo Yap

    Citation: Thrombosis Journal 2019 17:9

    Content type: Research

    Published on:

  16. Endocardial Fibroelastosis is diffuse, accentuated proliferation of ventricular endocardium causing a rare form of restrictive cardiomyopathy in both children and adults. It is an incompletely understood cause...

    Authors: Denizhan Ozdemir, Isabel Oliva Cortopassi and Robert Lawrence McNamara

    Citation: Thrombosis Journal 2019 17:8

    Content type: Case report

    Published on:

  19. Real-world data on non-vitamin K oral anticoagulants (NOACs) are essential in determining whether evidence from randomised controlled clinical trials translate into meaningful clinical benefits for patients in...

    Authors: Jan Beyer-Westendorf, A. John Camm, Keith A. A. Fox, Jean-Yves Le Heuzey, Sylvia Haas, Alexander G. G. Turpie, Saverio Virdone and Ajay K. Kakkar

    Citation: Thrombosis Journal 2019 17:7

    Content type: Research

    Published on:

  20. Clinical practice shows that venous thromboembolism (VTE) presents a substantial burden in medical patients, and awareness and advocacy for its primary and secondary prevention remains inadequate. Specific pat...

    Authors: Benjamin Brenner, Russell Hull, Roopen Arya, Jan Beyer-Westendorf, James Douketis, Ismail Elalamy, Davide Imberti and Zhenguo Zhai

    Citation: Thrombosis Journal 2019 17:6

    Content type: Review

    Published on:

  21. Following the publication of this article [1], the authors noted the following typographical errors.

    Authors: Arshi Naz, Arijit Biswas, Tehmina Nafees Khan, Anne Goodeve, Nisar Ahmed, Nazish Saqlain, Shariq Ahmed, Ikram Din Ujjan, Tahir S. Shamsi and Johannes Oldenburg

    Citation: Thrombosis Journal 2019 17:5

    Content type: Correction

    Published on:

    The original article was published in Thrombosis Journal 2017 15:24

  22. Inflammatory diseases have become increasingly prevalent with industrialization. To address this, numerous anti-inflammatory agents and molecular targets have been considered in clinical trials. Among molecula...

    Authors: Dorothea M. Heuberger and Reto A. Schuepbach

    Citation: Thrombosis Journal 2019 17:4

    Content type: Review

    Published on:

    The Correction to this article has been published in Thrombosis Journal 2019 17:22

  23. This study involved a sensory evaluation of edoxaban orally disintegrating (OD) tablets in patients with nonvalvular atrial fibrillation who had been receiving the existing edoxaban film-coated tablets before ...

    Authors: Takeshi Yamashita, Joji Hagii, Yoshiyuki Morishima, Takaaki Akasaka, Takuyuki Matsumoto and Tetsuya Kimura

    Citation: Thrombosis Journal 2019 17:3

    Content type: Research

    Published on:

  24. Peripherally inserted central catheters(PICC) lines are becoming increasingly popular in solid cancer patients for the administration of chemotherapy. This study aims looking at the incidence of PICC line rela...

    Authors: Osamah Al-Asadi, Manar Almusarhed and Hany Eldeeb

    Citation: Thrombosis Journal 2019 17:2

    Content type: Review

    Published on:

  25. Nuclear histone proteins are released into the extracellular space, and act as major mediators of coagulopathy and remote organ failure in septic animals. However, the circulating histone levels in septic pati...

    Authors: Yayoi Yokoyama, Takashi Ito, Tomotsugu Yasuda, Hiroaki Furubeppu, Chinatsu Kamikokuryo, Shingo Yamada, Ikuro Maruyama and Yasuyuki Kakihana

    Citation: Thrombosis Journal 2019 17:1

    Content type: Research

    Published on:

  26. Venous thromboembolism (VTE) is a relatively rare condition in childhood with treatment mainly based on extrapolation from studies in adults. Therefore, clinical trials of anticoagulation in children require n...

    Authors: Anthonie W. A. Lensing, Christoph Male, Guy Young, Dagmar Kubitza, Gili Kenet, M. Patricia Massicotte, Anthony Chan, Angelo C. Molinari, Ulrike Nowak-Goettl, Ákos F. Pap, Ivet Adalbo, William T. Smith, Amy Mason, Kirstin Thelen, Scott D. Berkowitz, Mark Crowther…

    Citation: Thrombosis Journal 2018 16:34

    Content type: Research

    Published on:

  29. The EINSTEIN-Jr program will evaluate rivaroxaban for the treatment of venous thromboembolism (VTE) in children, targeting exposures similar to the 20 mg once-daily dose for adults. A physiologically based pha...

    Authors: Stefan Willmann, Kirstin Thelen, Dagmar Kubitza, Anthonie W. A. Lensing, Matthias Frede, Katrin Coboeken, Jan Stampfuss, Rolf Burghaus, Wolfgang Mück and Jörg Lippert

    Citation: Thrombosis Journal 2018 16:32

    Content type: Research

    Published on:

  30. The EINSTEIN-Jr program will evaluate rivaroxaban for the treatment of venous thromboembolism (VTE) in children, targeting exposures similar to the 20 mg once-daily dose for adults.

    Authors: Dagmar Kubitza, Stefan Willmann, Michael Becka, Kirstin Thelen, Guy Young, Leonardo R. Brandão, Paul Monagle, Christoph Male, Anthony Chan, Gili Kennet, Ida Martinelli, Paola Saracco and Anthonie W. A. Lensing

    Citation: Thrombosis Journal 2018 16:31

    Content type: Research

    Published on:

  31. Autoimmune paraphenomena, are associated with B-cell lymphoproliferative disorders, including monoclonal gammopathy of uncertain significance. These paraphenomena can rarely include acquired bleeding disorders.

    Authors: Elizabeth Sarah Mayne, Malcolm Tait, Barry Frank Jacobson, Evashin Pillay and Susan J. Louw

    Citation: Thrombosis Journal 2018 16:30

    Content type: Case report

    Published on:

  32. Serious bleeding events have been frequently described in patients taking direct oral anticoagulants (DOAC). In secondary analyses of phase 3 trials, DOAC plasma concentrations were shown to correlate with ble...

    Authors: Anne-Laure Sennesael, Anne-Sophie Larock, Jonathan Douxfils, Laure Elens, Gabriel Stillemans, Martin Wiesen, Max Taubert, Jean-Michel Dogné, Anne Spinewine and François Mullier

    Citation: Thrombosis Journal 2018 16:28

    Content type: Research

    Published on:

  33. Venous thromboembolism (VTE) in young children is not well documented.

    Authors: Anthony Chan, Anthonie W. A. Lensing, Dagmar Kubitza, Grahaem Brown, Dolores Elorza, Marta Ybarra, Jacqueline Halton, Sebastian Grunt, Gili Kenet, Damien Bonnet, Amparo Santamaria, Paola Saracco, Tina Biss, Francesco Climent, Philip Connor, Joseph Palumbo…

    Citation: Thrombosis Journal 2018 16:29

    Content type: Research

    Published on:

  34. Five patients with paroxysmal nocturnal haemoglobinuria and thrombotic complications under oral antithrombotic treatment with vitamin K antagonist were switched to receive the direct oral anticoagulant rivarox...

    Authors: Francesco Dragoni, Flavia Chiarotti, Anna Paola Iori, Ursula La Rocca and Arturo Cafolla

    Citation: Thrombosis Journal 2018 16:26

    Content type: Letter to the Editor

    Published on:

  36. Globally, sickle cell disease (SCD) is one of the most common haemoglobinopathy. Considered a public health problem, it leads to vessel occlusion, blood stasis and chronic activation of the coagulation system ...

    Authors: Jean Jacques Noubiap, Mazou N. Temgoua, Ronni Tankeu, Joel Noutakdie Tochie, Ambroise Wonkam and Jean Joël Bigna

    Citation: Thrombosis Journal 2018 16:27

    Content type: Research

    Published on:

  37. Recombinant human soluble thrombomodulin (rTM) has been used for the treatment of disseminated intravascular coagulation in Japan, and an international phase III clinical trial for rTM is currently in progress...

    Authors: Takuro Arishima, Takashi Ito, Tomotsugu Yasuda, Nozomi Yashima, Hiroaki Furubeppu, Chinatsu Kamikokuryo, Takahiro Futatsuki, Yutaro Madokoro, Shotaro Miyamoto, Tomohiro Eguchi, Hiroyuki Haraura, Ikuro Maruyama and Yasuyuki Kakihana

    Citation: Thrombosis Journal 2018 16:24

    Content type: Research

    Published on:

  38. Atrial fibrillation (AF) is a major risk factor for stroke as it increases the incidence of stroke nearly fivefold. Antithrombotic treatment is recommended for the prevention of stroke in AF patients. However,...

    Authors: Eyob Alemayehu Gebreyohannes, Akshaya Srikanth Bhagavathula and Henok Getachew Tegegn

    Citation: Thrombosis Journal 2018 16:22

    Content type: Research

    Published on:

  39. Around 20% of venous thromboembolism (VTE) cases occur in patients with cancer. Current guidelines recommend low molecular weight heparin (LMWH) as the preferred anticoagulant for VTE treatment. However, some ...

    Authors: Alexander T. Cohen, Anthony Maraveyas, Jan Beyer-Westendorf, Agnes Y. Y. Lee, Lorenzo G. Mantovani and Miriam Bach

    Citation: Thrombosis Journal 2018 16:21

    Content type: Research

    Published on:

  40. Anticoagulation therapy for mechanical prosthetic valves is limited to vitamin K antagonists, unfractionated heparin and low-molecular-weight-heparin. Other forms of anticoagulation are either contraindicated ...

    Authors: Abeer Berry, George Degheim and Souheil Saba

    Citation: Thrombosis Journal 2018 16:23

    Content type: Case report

    Published on:

  41. Disseminated intravascular coagulation (DIC) is associated with high mortality in patients with sepsis. Several studies reporting that recombinant human soluble thrombomodulin (rhTM) reduced mortality in sepsi...

    Authors: Takahiro Kato and Katsuhiko Matsuura

    Citation: Thrombosis Journal 2018 16:19

    Content type: Research

    Published on:

  43. We conducted a prospective observational study for investigating coagulofibrinolytic changes and mechanisms of antithrombin (AT) alternations in trauma.

    Authors: Hironori Matsumoto, Jun Takeba, Kensuke Umakoshi, Satoshi Kikuchi, Muneaki Ohshita, Suguru Annen, Naoki Moriyama, Yuki Nakabayashi, Norio Sato and Mayuki Aibiki

    Citation: Thrombosis Journal 2018 16:17

    Content type: Research

    Published on:

  45. Both disseminated intravascular coagulation (DIC) and thrombotic microangiopathy (TMA) cause microvascular thrombosis associated with thrombocytopenia, bleeding tendency and organ failure.

    Authors: Hideo Wada, Takeshi Matsumoto, Kei Suzuki, Hiroshi Imai, Naoyuki Katayama, Toshiaki Iba and Masanori Matsumoto

    Citation: Thrombosis Journal 2018 16:14

    Content type: Review

    Published on:

  46. Hyponatremia is common among patients with pulmonary embolism, while hypernatremia increases the risk of venous thromboembolism (VTE). Our objective was to evaluate the association between sodium imbalances an...

    Authors: Sally Temraz, Hani Tamim, Aurelie Mailhac and Ali Taher

    Citation: Thrombosis Journal 2018 16:11

    Content type: Research

    Published on:

  47. The pathophysiological mechanisms of acute coagulopathy of trauma-shock (ACOTS) are reported to include activated protein C-mediated suppression of thrombin generation via the proteolytic inactivation of activ...

    Authors: Satoshi Gando, Toshihiko Mayumi and Tomohiko Ukai

    Citation: Thrombosis Journal 2018 16:13

    Content type: Review

    Published on:

  48. Small studies have implicated plasminogen activator inhibitor-1 (PAI-1) as a predictor of cardiovascular events; however, these findings have been inconsistent.

    Authors: Richard G. Jung, Pouya Motazedian, F. Daniel Ramirez, Trevor Simard, Pietro Di Santo, Sarah Visintini, Mohammad Ali Faraz, Alisha Labinaz, Young Jung and Benjamin Hibbert

    Citation: Thrombosis Journal 2018 16:12

    Content type: Research

    Published on:

  49. Correction to: Thrombosis Journal (2018) 16:9 DOI 10.1186/s12959-018-0163-7

    Authors: Alexander T. Cohen, Cihan Ay, Philippe Hainaut, Hervé Décousus, Ulrich Hoffmann, Sean Gaine, Michiel Coppens, Pedro Marques da Silva, David Jimenez, Beatrice Amann-Vesti, Bernd Brüggenjürgen, Pierre Levy, Julio Lopez Bastida, Eric Vicaut, Petra Laeis, Eva-Maria Fronk…

    Citation: Thrombosis Journal 2018 16:18

    Content type: Correction

    Published on:

    The original article was published in Thrombosis Journal 2018 16:9

  50. Accurate thrombin generation determination by calibrated automated thrombinography can be sustained when reducing the plasma and reagent volumes up to half, but not for higher reductions or plasma dilutions.

    Authors: Saartje Bloemen, Hilde Kelchtermans and H. Coenraad Hemker

    Citation: Thrombosis Journal 2018 16:10

    Content type: Letter to the Editor

    Published on:

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