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  1. Blood flow-induced shear stress affects platelet participation in coagulation and thrombin generation. We aimed to develop an in vivo model to characterize thrombin generation rates under flow.

    Authors: Wei Yin, Andrew Dimatteo, Andrew Kumpfbeck, Stephen Leung, Marina Fandaros, Bryan Musmacker, David A. Rubenstein and Mary D. Frame
    Citation: Thrombosis Journal 2022 20:30
  2. Supplementation with antithrombin (AT) concentrates is now common in the treatment of congenital and acquired AT deficiency. However, there is no established consensus on the target and timing of supplementati...

    Authors: Takumi Tsuchida, Mineji Hayakawa, Shota Kawahara and Osamu Kumano
    Citation: Thrombosis Journal 2022 20:29
  3. Acquired hemophilia A (AHA) is a rare autoimmune disease characterized by bleeding events. Recombinant activated factor VII (rFVIIa) is a first-line bypassing agent, which is effective against clinically signi...

    Authors: Hiroki Hosoi, Yuina Akagi, Toshiki Mushino, Masahiro Takeyama, Naoto Minoura, Takayuki Hiroi, Yoshiaki Furuya, Masaya Morimoto, Shogo Murata, Shinobu Tamura and Takashi Sonoki
    Citation: Thrombosis Journal 2022 20:28
  4. High incidence of deep vein thrombosis (DVT) has been observed in patients with acute respiratory distress syndrome (ARDS) caused by COVID-19 and those by bacterial pneumonia. However, the differences of incid...

    Authors: Na Cui, Chunguo Jiang, Chenlu Yang, Liming Zhang and Xiaokai Feng
    Citation: Thrombosis Journal 2022 20:27
  5. Renal function is associated with prognoses for acute pulmonary embolism (PE).

    Authors: Dingyi Wang, Guohui Fan, Jieping Lei, Yuanhua Yang, Xiaomao Xu, Yingqun Ji, Qun Yi, Hong Chen, Xiaoyun Hu, Zhihong Liu, Yimin Mao, Jie Zhang, Juhong Shi, Zhu Zhang, Sinan Wu, Xincao Tao…
    Citation: Thrombosis Journal 2022 20:26
  6. The benefit of apixaban to reduce stroke risk in morbidly obese patients with nonvalvular atrial fibrillation (AF) is still undetermined. The International Society of Thrombosis and Hemostasis recommends avoid...

    Authors: Khalid Al Sulaiman, Hisham A. Badreldin, Ghazwa B. Korayem, Abeer A. Alenazi, Faisal Alsuwayyid, Abdulrahman Alrashidi, Mohammed Alhijris, Faisal Almutairi, Fahad Alharthi, Ramesh Vishwakarma, Omar Al Shaya, Abdulrahman Al Amri, Saqiba Tayyab, Abdulkareem M. Al Bekairy and Ohoud Aljuhani
    Citation: Thrombosis Journal 2022 20:25
  7. Thrombotic events cannot be completely prevented by antithrombotics, implicating a therapeutic gap due to inflammation, a not yet sufficiently addressed mechanism. Neutrophil extracellular traps (NETs) are an ...

    Authors: Yejia Chen, Xiaobo Li, Xinxin Lin, Hongbin Liang, Xuewei Liu, Xinlu Zhang, Qiuxia Zhang, Fengyun Zhou, Chen Yu, Li Lei and Jiancheng Xiu
    Citation: Thrombosis Journal 2022 20:24
  8. The fibrinolytic system plays an important role in coronary artery atherothrombosis, and especially circulating plasminogen-activator inhibitor (PAI) type 1 (PAI-1) associates with increased mortality, infarct...

    Authors: Jostein Nordeng, Svein Solheim, Sissel Åkra, Hossein Schandiz, Pavel Hoffmann, Borghild Roald, Bjørn Bendz, Harald Arnesen, Ragnhild Helseth and Ingebjørg Seljeflot
    Citation: Thrombosis Journal 2022 20:23
  9. Venous thromboembolism (VTE) is a major complication in patients with malignant tumors and orthopedic disorders. Although it is known that patients undergoing surgery for malignant musculoskeletal tumor are at...

    Authors: Kenta Hayashida, Yusuke Kawabata, Keiju Saito, Shintaro Fujita, Hyonmin Choe, Ikuma Kato, Masanobu Takeyama and Yutaka Inaba
    Citation: Thrombosis Journal 2022 20:22
  10. Despite strong antiplatelet therapy with ticagrelor, serious ischemic events still occur in patients with acute coronary syndrome (ACS). The predictability of platelet reactivity to the residual risk of ischem...

    Authors: Yuting Zou, Yuyan Wang, Yangxun Wu, Shizhao Zhang, Haiping Liu and Tong Yin
    Citation: Thrombosis Journal 2022 20:21
  11. Lymphomas are characterized by elevated synthesis of inflammatory soluble mediators that could trigger the development of venous thromboembolism (VTE). However, data on the relationship between specific immune...

    Authors: Vladimir Otasevic, Biljana Mihaljevic, Natasa Milic, Dejana Stanisavljevic, Vojin Vukovic, Kristina Tomic, Jawed Fareed and Darko Antic
    Citation: Thrombosis Journal 2022 20:20
  12. High on-treatment platelet reactivity (HTPR) remains a major problem in the acute management of ST-elevation myocardial infarction (STEMI), leading to higher rates of stent thrombosis and mortality. We aimed t...

    Authors: Georg Gelbenegger, Juergen Grafeneder, Gloria M. Gager, Jolanta M. Siller-Matula, Michael Schwameis, Bernd Jilma and Christian Schoergenhofer
    Citation: Thrombosis Journal 2022 20:19
  13. An increase in the incidence of central venous catheter (CVC)-related thrombosis (CRT) has been reported in pediatric intensive care patients over the past decade. Risk factors for the development of CRT are n...

    Authors: Haomin Li, Yang Lu, Xian Zeng, Yuqing Feng, Cangcang Fu, Huilong Duan, Qiang Shu and Jihua Zhu
    Citation: Thrombosis Journal 2022 20:18
  14. Tranexamic acid (TXA) is an antifibrinolytic agent frequently used in elective surgery to reduce blood loss. We recently found it also acts as a potent immune-modulator in patients undergoing cardiac surgery.

    Authors: Dominik F. Draxler, Gryselda Hanafi, Saffanah Zahra, Fiona McCutcheon, Heidi Ho, Charithani B. Keragala, Zikou Liu, David Daly, Thomas Painter, Sophia Wallace, Magdalena Plebanski, Paul S. Myles and Robert L. Medcalf
    Citation: Thrombosis Journal 2022 20:17
  15. Thromboembolic events are a common complicated health problem. Although anticoagulants have several positive effects on these conditions, they also have several characteristics that strongly affect compliance ...

    Authors: Samah W. Al-Jabi, Amal Abu Dalu, Amer A. Koni, Maher R. Khdour, Adham Abu Taha, Riad Amer and Sa’ed H. Zyoud
    Citation: Thrombosis Journal 2022 20:15
  16. The study of prevalence and risk factors of postoperative lower limb deep vein thrombosis (DVT) in Thai gynecologic patients was limited. The present study was conducted to evaluate this issue.

    Authors: Supakorn Lorchaivej, Prapaporn Suprasert, Tanop Srisuwan and Jintana Rujiwetpongstorn
    Citation: Thrombosis Journal 2022 20:14
  17. Tigecycline has broad-spectrum anti-bacterial activity and often used for critically ill patients with complicated infections. Only a few clinical studies have reported the coagulation disorder induced by tige...

    Authors: Mingxing Guo, Jinwei Liang, Dandan Li, Ying Zhao, Wanyi Xu, Lei Wang and Xiangli Cui
    Citation: Thrombosis Journal 2022 20:12
  18. Vaccine-induced thrombotic thrombocytopenia (VITT) is a rare but devastating adverse event following adenoviral vector-based vaccinations for COVID-19, resulting in thrombosis, especially of the cerebral and s...

    Authors: Christy V. John, Rajesh Kumar, Anil Kumar Sivan, Sangeetha Jithin, Rojin Abraham and Chepsy C. Philip
    Citation: Thrombosis Journal 2022 20:11
  19. For patients with suspected pulmonary embolism (PE), age- or clinically-adjusted D-dimer threshold level can be used to define a negative test that safely excludes PE and reduces the use of imaging. However, t...

    Authors: Carmen Rodríguez, Luis Jara-Palomares, Eva Tabernero, Andrés Tenes, Sara González, Winnifer Briceño, José Luis Lobo, Raquel Morillo, Behnood Bikdeli and David Jiménez
    Citation: Thrombosis Journal 2022 20:10
  20. The summary of product characteristics of vaccines administered intramuscularly, including the vaccine for coronavirus SARS-CoV-2 (COVID-19) and Influenza, warned for risks of bleeding in patients treated with...

    Authors: Daniel Caldeira, Bárbara Sucena Rodrigues, Mariana Alves, Fausto J. Pinto and Joaquim J. Ferreira
    Citation: Thrombosis Journal 2022 20:9
  21. The authors have done commendable work in exploring the utility of a comprehensive viscoelastic test for assessment of the coagulation cascade in Coronavirus disease 2019 (COVID-19) patients. This article publ...

    Authors: Syed Nabeel Muzaffar, Suhail Sarwar Siddiqui, Nilanchal Chakraborty and Afzal Azim
    Citation: Thrombosis Journal 2022 20:8
  22. Administration of recombinant human soluble thrombomodulin (rTM) is often used in Japan to treat septic disseminated intravascular coagulation (DIC). Thrombin-activatable fibrinolysis inhibitor (TAFI) is a fib...

    Authors: Takaaki Totoki, Takashi Ito, Midori Kakuuchi, Nozomi Yashima, Ikuro Maruyama and Yasuyuki Kakihana
    Citation: Thrombosis Journal 2022 20:6
  23. Vaccine-induced immune thrombocytopenia and thrombosis (VITT) is triggered by nCOV-19 adenovirus-vectored vaccines against SARS-CoV2. Pathogenesis has been mainly related to platelet activation via PF4-reactiv...

    Authors: Lasse Myllylahti, Hanna Pitkänen, Harry Magnani and Riitta Lassila
    Citation: Thrombosis Journal 2022 20:4
  24. Continuous agitation during storage slows down the platelet storage lesions. However, in special circumstances, manual-mixing can be alternatively used to store products for short time periods without compromi...

    Authors: Ehteramolsadat Hosseini, Amin Solouki, Masood Haghshenas, Mehran Ghasemzadeh and Simone M. Schoenwaelder
    Citation: Thrombosis Journal 2022 20:3

    The Correction to this article has been published in Thrombosis Journal 2022 20:16

  25. Growing evidence suggests the relationship between obstructive sleep apnea (OSA) and venous thromboembolism (VTE). Few studies focused on VTE recurrence risk associated with OSA after anticoagulation cessation.

    Authors: Olivier Nepveu, Charles Orione, Cécile Tromeur, Alexandre Fauché, Cecile L’heveder, Marie Guegan, Catherine Lemarié, David Jimenez, Christophe Leroyer, Karine Lacut, Francis Couturaud and Raphael Le Mao
    Citation: Thrombosis Journal 2022 20:1
  26. Antithrombin deficiency (ATD) is an autosomal dominant thrombophilia presenting with varying phenotypes. In pediatric patients with ATD, thrombosis typically develops during the neonatal period or adolescence....

    Authors: M. Müller-Knapp, C. F. Classen, R. Knöfler, C. Spang, C. Hauenstein, T. Heinrich, F. L. P. Gabriel, J. Däbritz, D. A. Reuter and J. Ehler
    Citation: Thrombosis Journal 2021 19:105
  27. Antiphospholipid Syndrome (APS) is a multisystemic autoimmune disease characterized by arterial and venous thrombosis and / or obstetric morbidity in the presence of at least one circulating anti-phospholipid ...

    Authors: Vanda Pinto, Augusto Ministro, Nuno Reis Carreira, Ana Cardoso, Catarina Sousa Gonçalves, Mickael Henriques, João Rato, Emanuel Silva and Luís Mendes Pedro
    Citation: Thrombosis Journal 2021 19:103
  28. Data on the prognostic role of D-dimer in patients with acute coronary syndrome (ACS) are controversial. Our aim was to summarize current evidence on the association between D-dimer levels and short/long-term ...

    Authors: Flavio Giuseppe Biccirè, Alessio Farcomeni, Carlo Gaudio, Pasquale Pignatelli, Gaetano Tanzilli and Daniele Pastori
    Citation: Thrombosis Journal 2021 19:102

    The Correction to this article has been published in Thrombosis Journal 2022 20:7

  29. To our knowledge, the treatment, outcome, clinical presentation, risk stratification of patients with venous thromboembolism and COVID-19 have not been well characterized.

    Authors: Mauricio Castillo-Perez, Carlos Jerjes-Sanchez, Alejandra Castro-Varela, Jose Gildardo Paredes-Vazquez, Eduardo Vazquez-Garza, Ray Erick Ramos-Cazares, Jose Alfredo Salinas-Casanova, Abigail Montserrat Molina-Rodriguez, Arturo Adrián Martinez-Ibarra, Mario Alejandro Fabiani, Yoezer Z Flores-Sayavedra, Jaime Alberto Guajardo-Lozano, Hector Lopez-de la Garza, Hector Betancourt-del Campo, Daniela Martinez-Magallanes and Jathniel Panneflek
    Citation: Thrombosis Journal 2021 19:101
  30. The choice of optimal antithrombotic therapy in atrial fibrillation (AF) patients with acute coronary syndrome (ACS) or percutaneous coronary intervention (PCI) remains controversial. The aim of this longitudi...

    Authors: Chiao-Chin Lee, Chiao-Hsiang Chang, Yuan Hung, Chin-Sheng Lin, Shih-Ping Yang, Shu-Meng Cheng, Fan-Han Yu, Wei-Shiang Lin and Wen-Yu Lin
    Citation: Thrombosis Journal 2021 19:100
  31. To evaluate the anticoagulant treatment response in venous thrombi with different morphologies (size, shape, and echogenicity) by measuring the change in thrombus thickness.

    Authors: Tanapong Panpikoon, Wisanu Phattharaprueksa, Tharintorn Treesit, Chinnarat Bua-ngam, Kaewpitcha Pichitpichatkul and Apichaya Sriprachyakul
    Citation: Thrombosis Journal 2021 19:99
  32. Long-term oral anticoagulant should be considered or recommended in patients with atrial fibrillation (AF) and CHA2DS2VASc score ≥ 1 for stroke prevention. Warfarin and different direct oral anticoagulants (DO...

    Authors: Wei-Chieh Lee, Pai-Wei Lee, Po-Jui Wu, Yen-Nan Fang, Huang-Chung Chen, Yu-Sheng Lin, Hsiu-Yu Fang, Shang-Hung Chang, Ping-Yen Liu and Mien-Cheng Chen
    Citation: Thrombosis Journal 2021 19:98

    The Correction to this article has been published in Thrombosis Journal 2021 19:106

  33. Knowledge on the pharmacodynamic effects of antiplatelet drugs including clopidogrel and ticagrelor on Asian patients is scarce. We aim to evaluate the effects of the two drugs on platelet reactivity in the tr...

    Authors: Yang Zhang, Rui Peng, Xiaojuan Li, Gaowa Cheng, Ximing Wang, Jinxing Yu, Muxing Hua, Xi Chen and Zhou Zhou
    Citation: Thrombosis Journal 2021 19:97
  34. Acute limb ischemia (ALI) is an important clinical event threatening both life and the affected limbs, but the optimal treatment for ALI remains undefined. The aim of this study was to compare the safety and e...

    Authors: Maofeng Gong, Xu He, Boxiang Zhao, Jie Kong, Jianping Gu and Guoping Chen
    Citation: Thrombosis Journal 2021 19:96
  35. Cancer-associated venous thromboembolism (VTE) is common in patients with primary lung cancer. It has been understudied which authoritative risk assessment score of cancer-associated VTE is optimal for the ass...

    Authors: Wei Xiong, Yunfeng Zhao, He Du, Yanmin Wang, Mei Xu and Xuejun Guo
    Citation: Thrombosis Journal 2021 19:95
  36. Type 3 von Willebrand disease (VWD) exhibits severe hemorrhagic tendency with complicated pathogenesis. The C-terminal cystine knot (CTCK) domain plays an important role in the dimerization and secretion of vo...

    Authors: Yuxin Zhang, Fengwu Chen, Aizhen Yang, Xiaoying Wang, Yue Han, Depei Wu, Yi Wu and Jingyu Zhang
    Citation: Thrombosis Journal 2021 19:94
  37. Immune-mediated necrotizing myopathy (IMNM) is characterized by proximal muscle weakness, elvated serum muscle enzyme levels, myopathic electromyography findings, and necrotic muscle fiber with few inflammator...

    Authors: Jiali Li, Mingming Yan, Jiao Qin, Lingyan He, Cao Dai and Rui Wen
    Citation: Thrombosis Journal 2021 19:92
  38. Anticoagulation in hospitalized COVID-19 patients has been associated with survival benefit; however, the optimal anticoagulant strategy has not yet been defined. The objective of this meta-analysis was to inv...

    Authors: Sirui Zhang, Yupei Li, Guina Liu and Baihai Su
    Citation: Thrombosis Journal 2021 19:91
  39. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is considered to have multiple roles in the development of atherosclerosis, which is recently reported to participate in the thrombotic process. We aimed t...

    Authors: Jia Peng, Ming-Ming Liu, Hui-Hui Liu, Yuan-Lin Guo, Na-Qiong Wu, Qian Dong, Jie Qian, Ke-Fei Dou, Cheng-Gang Zhu and Jian-Jun Li
    Citation: Thrombosis Journal 2021 19:90
  40. Post-operative atrial fibrillation (POAF) is the most common complication after cardiac surgery. Recent studies had shown this phenomenon is no longer considered transitory and is associated with higher risk o...

    Authors: Mariana Fragão-Marques, Francisco Teixeira, Jennifer Mancio, Nair Seixas, João Rocha-Neves, Inês Falcão-Pires and Adelino Leite-Moreira
    Citation: Thrombosis Journal 2021 19:89
  41. Rupture of an atherosclerotic plaque and subsequent exposure of the subendothelial prothrombotic matrix to blood cause arterial thrombosis. Circulating platelets play an indispensable role in the growth of art...

    Authors: Yuu Oda, Takashi Ito, Yoichiro Yamada, Tadashi Koga, Tomoka Nagasato, Tomoko Ohnishi-Wada, Kazuya Hosokawa, Hiroyuki Fukase, Teruto Hashiguchi and Ikuro Maruyama
    Citation: Thrombosis Journal 2021 19:88
  42. The prevalence of venous thromboembolism (VTE) is high in critically ill patients with COVID-19. Dosing of Low Molecular Weight Heparin (LMWH) for thromboprophylaxis in patients with severe COVID-19 is subject...

    Authors: David Oliver Hamilton, Alexander Main-Ian, Jessie Tebbutt, Maya Thrasher, Alicia Waite and Ingeborg Welters
    Citation: Thrombosis Journal 2021 19:87

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  • Thrombosis Journal is the official journal of the Asian-Pacific Society on Thrombosis and Hemostasis.

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