Articles

Lead thrombus under standard-dose edoxaban in a patient with normal to high creatinine clearance and protein S deficiency

Non-vitamin K antagonist oral anticoagulants (NOACs) are as effective and safe as warfarin for thromboembolic prevention and treatment. The efficacy of NOACs lacks evidence from large and randomized studies in...

Authors: Wei-Chieh Lee and Min-Ping Huang

Correction to: Thrombosis and bleeding outcomes in the treatment of cerebral venous thrombosis in cancer

Authors: Nadia I. Abelhad, Wei Qiao, Naveen Garg and Cristhiam M. Rojas-Hernandez

Incidence of peripheral intravenous catheter phlebitis and its associated factors among patients admitted to University of Gondar hospital, Northwest Ethiopia: a prospective, observational study

Phlebitis, inflammation of tunica intima of venous wall, occurred in 13–56% of hospitalized patients. It is characterized by pain, erythema, swelling, palpable venous cord, and pussy discharge at catheter site...

Authors: Mulugeta Lulie, Abilo Tadesse, Tewodros Tsegaye, Tesfaye Yesuf and Mezgebu Silamsaw

A review of thromboembolic events in hospitalized COVID-19 patients

A higher incidence of thromboembolic disorders in COVID-19 has been reported by many clinicians worldwide.

Authors: Paul Fontelo, Mrigendra M. Bastola, Zhaonian Zheng and Seo Hyon Baik

Comparison of anticoagulated versus non-anticoagulated patients with intra-aortic balloon pumps

There is limited guidance regarding the use of anticoagulation in patients on intra-aortic balloon pumps (IABP). The purpose of this study is to compare the safety outcomes in anticoagulated versus non-anticoa...

Authors: Julie Kelly, Rhynn Malloy and Danielle Knowles

Differential effect of statin use on coagulation markers: an active comparative analysis in the NEO study

Statins are a potential treatment for venous thromboembolism (VTE) prophylaxis complementary to conventional anticoagulants without associated bleeding complications. This study aimed to compare pro-thrombotic...

Authors: Mohammadreza Bordbar, Renée de Mutsert, Melike Cevval, Frits R. Rosendaal, J. Wouter Jukema and Willem M. Lijfering

Coagulation abnormalities in childhood acute lymphoblastic leukemia: assessing the impact of L-asparaginase therapy in Ghana

Although the rate of childhood acute lymphoblastic leukemia (ALL) is increasing in Africa, there is a dearth of information on the disease and the dynamics of hemostatic parameters with therapy.

Authors: William Osei-OWusu, David Ofosu Ntiamoah, Gordon Asare Akuffo, Selina Mintaah, Michael Owusu, Benedict Sackey, Lilian Antwi-Boateng, Ganiwu Abdul, Max Annani-Akollor, Eddie-Williams Owiredu, Alexander Yaw Debrah and Otchere Addai-Mensah

Review article inferior vena cava thrombosis: a case series of patients observed in Taiwan and literature review

Inferior vena cava thrombosis (IVCT) is rare and can be under-recognized. However, the associated complications and mortality may be severe. We report the first case series of IVCT observed in Taiwan with a br...

Authors: Hsuan-Yu Lin, Ching-Yeh Lin and Ming-Ching Shen

Risk factors of thrombosis in Chinese subjects with acute promyelocytic leukemia

Acute promyelocytic leukemia (APL) is a special type of acute myeloid leukemia Thrombosis is at increased risk complication in patients with this disease. However, the risk factors of thrombosis related to Chi...

Authors: Xueya Zhang and Xizhe Guo

Pregnancy complications in G20210A mutation carriers associated with high prothrombin activity

To study the association between high activity of Factor II (prothrombin) in blood plasma with G20210A mutation and the development of great obstetrical syndromes.

Authors: M. G. Nikolaeva, A. P. Momot, M. S. Zainulina, N. N. Yasafova and I. A. Taranenko

Platelet adhesion in type 2 diabetes: impact of plasma albumin and mean platelet volume

Altered mean platelet volume (MPV) and plasma albumin has been reported in type 2 diabetes (T2D). MPV is suggested to predict cardiovascular risk but there is a lack of evidence for associations between MPV an...

Authors: Mona Johansson, Andreas C. Eriksson, Carl Johan Östgren and Per A. Whiss

Point of care diagnostic of hypercoagulability and platelet function in COVID-19 induced acute respiratory distress syndrome: a retrospective observational study

Coronavirus disease 2019 (COVID-19) associated coagulopathy (CAC) leads to thromboembolic events in a high number of critically ill COVID-19 patients. However, specific diagnostic or therapeutic algorithms for...

Authors: Johannes Herrmann, Quirin Notz, Tobias Schlesinger, Jan Stumpner, Markus Kredel, Magdalena Sitter, Benedikt Schmid, Peter Kranke, Harald Schulze, Patrick Meybohm and Christopher Lotz

Point of care ultrasound screening for deep vein thrombosis in critically ill COVID-19 patients, an observational study

Deep vein thrombosis (DVT) is common in critically ill patients with Coronavirus disease 2019 (COVID-19) and may cause fatal pulmonary embolism (PE) prior to diagnosis due to subtle clinical symptoms. The aim ...

Authors: Sarah Galien, Michael Hultström, Miklós Lipcsey, Karl Stattin, Robert Frithiof and Jacob Rosén

Thrombosis and bleeding outcomes in the treatment of cerebral venous thrombosis in cancer

There is a need for clinical outcome data of cerebral venous thrombosis (CVT) in cancer patients. We examined the recanalization, thrombosis recurrence and major bleeding during CVT treatment in a cancer exclu...

Authors: Nadia I Abelhad, Wei Qiao, Naveen Garg and Cristhiam M. Rojas-Hernandez

Coagulopathy and its associated factors among patients with a bleeding diathesis at the University of Gondar Specialized Referral Hospital, Northwest Ethiopia

Coagulopathy is the major cause of mortality and morbidity throughout the world. Globally, about 26–45% of healthy people have a history of bleeding symptoms, which may be a result of thrombocytopenia, factor ...

Authors: Melak Aynalem, Elias Shiferaw, Yemataw Gelaw and Bamlaku Enawgaw

Serial markers of coagulation and inflammation and the occurrence of clinical pulmonary thromboembolism in mechanically ventilated patients with SARS-CoV-2 infection; the prospective Maastricht intensive care COVID cohort

The incidence of pulmonary thromboembolism is high in SARS-CoV-2 patients admitted to the Intensive Care. Elevated biomarkers of coagulation (fibrinogen and D-dimer) and inflammation (c-reactive protein (CRP) ...

Authors: Mark M. G. Mulder, LIoyd Brandts, Renée A. G. Brüggemann, Marcel Koelmann, Alexander S. Streng, Renske H. Olie, Hester A. Gietema, Henri M. H. Spronk, Iwan C. C. van der Horst, Jan-Willem E. M. Sels, Joachim E. Wildberger, Sander M. J. van Kuijk, Ronny M. Schnabel, Hugo ten Cate, Yvonne M. C. Henskens and Bas C. T. van Bussel

Enoxaparin-induced reactive thrombocytosis: a case report

Enoxaparin is an anticoagulant that falls in the class of medications called low molecular weight heparins (LMWHs), and is used to prevent or treat patients with deep vein thrombosis (DVT) and pulmonary emboli...

Authors: Tao Xiang and Ming Cheng

Prevalence and impact of fibrinolytic dysregulation in patients with acute coronary syndromes

Dual antiplatelet therapy can reduce coronary thrombosis and improve the prognosis in patients with acute coronary syndrome (ACS). However, there was limited prognostic information about fibrinolytic dysregula...

Authors: Huaibin Wan, Xin Fan, Zhihao Wu, Zhenbang Lie, Daqiang Li and Shaohui Su

Prevalence and risk factors of thrombotic events on patients with COVID-19: a systematic review and meta‐analysis

Coagulation abnormalities in COVID-19 patients accompanied with poor prognosis. This study aimed to determine the prevalence and risk factors of thrombotic events on COVID-19 patients.

Authors: Xiaoming Xiong, Jianhua Chi and Qinglei Gao

Giant intracardiac thrombosis in an infant with leukaemia and prolonged COVID-19 viral RNA shedding: a case report

COVID-19 can induce thrombotic disease both in the venous and arterial circulations, as a result of inflammation, platelet activation, endothelial dysfunction, and stasis. Although several studies have describ...

Authors: Ehsan Aghaei Moghadam, Shima Mahmoudi, Alieh Safari Sharari, Mehrnoush Afsharipour, Mojtaba Gorji, Amene Navaeian, Azin Ghamari and Setareh Mamishi

Prognostic Value of D-dimer in patients with acute coronary syndrome treated by percutaneous coronary intervention: a retrospective cohort study

Associations between D-dimer and outcomes of patients with acute coronary syndromes (ACS) remain controversial. This study aimed to investigate the prognostic value of D-dimer in ACS patients treated by percut...

Authors: Runzhen Chen, Chen Liu, Peng Zhou, Yu Tan, Zhaoxue Sheng, Jiannan Li, Jinying Zhou, Yi Chen, Li Song, Hanjun Zhao and Hongbing Yan

Evaluation of the analytical performance of the PC100 platelet counter

Platelet count can be altered in various diseases and treatments and measuring it may provide better insight into the expected outcome. So far, quantification of platelet count is done within laboratory condit...

Authors: Magdolna Nagy, Sepanta Fazaeli, René van Oerle, Hugo ten Cate, Marcel Schemmann, John Sherry, Gillian Kelleher and Henri M. H. Spronk

Cardiac implantable electronic device surgery with interruption of warfarin forgoing post-operative bridging therapy in patients with moderate or high thromboembolic risks

For patients taking warfarin and undergoing pacemaker or implantable cardioverter-defibrillator surgery, clinical evidence and guidelines support continuation of warfarin therapy, as opposed to interruption of...

Authors: Andrew Kei-Yan Ng, Pauline Yeung Ng, Eva Wai-Ying Tam, Chung-Wah Siu and Katherine Fan

The role of Sphingomyelin synthase 2 (SMS2) in platelet activation and its clinical significance

Sphingomyelin (SM) is an essential component of biological lipid rafts, and it plays an indispensable role in maintaining plasma membrane stability and in mediating signal transduction. The ultimate biosynthes...

Authors: Yifan Guo, Lin Chang, Ge Zhang, Zhanyan Gao, Hao Lin, Yuting Zhang, Liang Hu, She Chen, Bing Fan, Si Zhang and Ruyi Xue

An evaluation of venous thromboembolism by whole-body enhanced CT scan for critical COVID-19 pneumonia with markedly rises of coagulopathy related factors: a case series study

Coronavirus disease (COVID-19) pneumonitis associated with severe respiratory failure has a high mortality rate. Based on recent reports, the most severely ill patients present with coagulopathy, and dissemina...

Authors: Fumihiro Ogawa, Yasufumi Oi, Kento Nakajima, Reo Matsumura, Tomoki Nakagawa, Takao Miyagawa, Takeru Abe and Ichiro Takeuchi

Nonnegligible causes of symptoms of acute lower extremities——3 cases of May-Thurner syndrome with deep vein thrombosis

May-Thurner syndrome is a kind of disease caused by the compression of the left common iliac vein. It is one of the causes of incomplete venous valves and superficial varicose veins in lower limbs, and is also...

Authors: Yi Sun and Shenghan Song

Peripherally inserted central venous catheter in upper extremities leads to an increase in D-dimer and deep vein thrombosis in lower extremities

The purpose of this study is to elucidate the association between peripherally inserted central venous catheter (PICC) in upper extremities and lower extremity deep venous thrombosis (LEDVT) by observing the c...

Authors: Wanli Liu, Lianxiang He, Wenjing Zeng, Liqing Yue, Jie Wei, Shuangshuang Zeng, Xiang Wang and Zhicheng Gong

Apixaban anti-Xa level monitoring in treatment of acute upper extremity deep vein thrombosis for patient on chronic hemodialysis: a case report

Patients on dialysis are at higher risk of major bleeding and recurrent thrombosis creating acute venous thromboembolism (VTE) treatment challenges. DOACs represent an interesting option but there are concerns...

Authors: Guillaume Roberge and Philip Stephen Wells

Persistent or permanent atrial fibrillation is associated with severe cardioembolic stroke in patients with non-valvular atrial fibrillation

Little is known about the difference in the severity of cardioembolic (CE) stroke between patients with paroxysmal atrial fibrillation (PAF) and persistent/permanent AF (PerAF). We assessed stroke severity in ...

Authors: Joji Hagii, Norifumi Metoki, Shin Saito, Hiroshi Shiroto, Satoko Sasaki, Koki Takahashi, Hiroyasu Hitomi, Yoshiko Baba, Natsumi Yamada, Satoshi Seino, Takaatsu Kamada, Takamitsu Uchizawa, Taigen Nakamura, Minoru Yasujima and Hirofumi Tomita

Current status of treatment of cancer-associated venous thromboembolism

Patients with cancer are prone to develop venous thromboembolism (VTE) that is the second leading cause of mortality among them. Cancer patients with VTE may encounter higher rates of VTE recurrence and bleedi...

Authors: Wei Xiong

Thrombotic antiphospholipid syndrome in a child with human immunodeficiency virus: a rare case report

Antiphospholipid syndrome (APS) is a non-inflammatory autoimmune disorder induced by antiphospholipid antibodies, which occurs exceedingly rarely in pediatric population and even more rarely reported in HIV po...

Authors: Rong-Jing Dong, Su-Yun Lei, Jun Li, Xin-Ping Yang, Yu-Ye Li and Yun-Gui Zhang

Lupus anticoagulant hypoprothrombinemia syndrome associated with bilateral adrenal haemorrhage in a child: early diagnosis and intervention

Lupus anticoagulant-hypoprothrombinemia syndrome (LAHPS) is characterized by bleeding and thrombosis in patients with autoimmune diseases or infections. Paediatric LAHPS exhibits various degrees of bleeding, r...

Authors: Atsushi Sakamoto, Masao Ogura, Atsushi Hattori, Kinji Tada, Reiko Horikawa, Hisaya Nakadate, Kimikazu Matsumoto, Keiji Nogami, Masahiro Ieko and Akira Ishiguro

Viscoelastometry for detecting oral anticoagulants

Determination of anticoagulant therapy is of pronounced interest in emergency situations. However, routine tests do not provide sufficient insight. This study was performed to investigate the impact of anticoa...

Authors: Philipp Groene, Daniela Wagner, Tobias Kammerer, Lars Kellert, Andreas Giebl, Steffen Massberg and Simon Thomas Schäfer

ADAMTS13 activity decreases in the early phase of trauma associated with coagulopathy and systemic inflammation: a prospective observational study

We conducted a prospective observational study for investigating the changes in the 13th member of a disintegrin-like and metalloprotease with thrombospondin type 1 motif (ADAMTS13) and its association with th...

Authors: Hironori Matsumoto, Jun Takeba, Kensuke Umakoshi, Satoshi Kikuchi, Muneaki Ohshita, Suguru Annen, Naoki Moriyama, Yuki Nakabayashi, Norio Sato and Mayuki Aibiki

JAK2V617F positive polycythemia vera with paroxysmal nocturnal hemoglobinuria and visceral thromboses: a case report and review of the literature

Polycythemia vera (PV) is characterized by red cell mass expansion in the peripheral blood and can be complicated with thrombosis, bleeding, evolution to acute myeloid leukemia (AML) or a fibrotic phase. Parox...

Authors: Sevastianos Chatzidavid, Nefeli Giannakopoulou, Panagiotis Theodorou Diamantopoulos, Eleni Gavriilaki, Panagiota Katsiampoura, Eleftheria Lakiotaki, Stratigoula Sakellariou, Nora-Athina Viniou and Georgios Dryllis

Proximal deep vein thrombosis and pulmonary embolism in COVID-19 patients: a systematic review and meta-analysis

COVID-19 appears to be associated with a high risk of venous thromboembolism (VTE). We aimed to systematically review and meta-analyze the risk of clinically relevant VTE in patients hospitalized for COVID-19.

Authors: Gregoire Longchamp, Sara Manzocchi-Besson, Alban Longchamp, Marc Righini, Helia Robert-Ebadi and Marc Blondon

Low incidence of venous thrombosis but high incidence of arterial thrombotic complications among critically ill COVID-19 patients in Singapore

Arterial and venous thrombosis are reported to be common in critically ill COVID-19 patients.

Authors: Chuen Wen Tan, Bingwen Eugene Fan, Winnie Z. Y. Teo, Moon Ley Tung, Humaira Shafi, Dheepa Christopher, Shuwei Zheng, Wee Ming Peh, Stephrene Seok Wei Chan, Vanessa Cui Lian Chong, Christian Aledia Gallardo, Cheng Chieh Ray Chang, Li Min Ling, Jing Yuan Tan, Ken Cheah Hooi Lee, Ghee Chee Phua…

High rate of bleeding and arterial thrombosis in COVID-19: Saudi multicenter study

Several observational studies have reported the rate of venous and arterial thrombotic events in patients infected with COVID-19, with conflicting results. The aim of this study was to estimate the rate of thr...

Authors: Abdulrahman Al Raizah, Ahmed Al Askar, Naila Shaheen, Khalid Aldosari, Mohamed Alnahdi, Musumadi Luhanga, Turki Alshuaibi, Wail Bajhmoum, Khaled Alharbi, Ghaida Alsahari, Hadeel Algahtani, Eunice Alrayes, Abdulrahim Basendwah, Alia Abotaleb and Mosaad Almegren

Hypofibrinogenemia is associated with a high degree of risk in infectious diseases: a post-hoc analysis of post-marketing surveillance of patients with disseminated intravascular coagulation treated with thrombomodulin alfa

In patients with infectious diseases, disseminated intravascular coagulation (DIC) is often diagnosed without the fibrinogen value. The relationship between hypofibrinogenemia and outcomes of DIC in infectious...

Authors: Kazuo Kawasugi, Hideo Wada, Goichi Honda, Noriaki Kawano, Toshimasa Uchiyama, Seiji Madoiwa, Naoki Takezako, Kei Suzuki, Yoshinobu Seki, Takayuki Ikezoe, Toshiaki Iba and Kohji Okamoto

Detailed histological analysis of a thrombectomy-resistant ischemic stroke thrombus: a case report

Mechanical removal of a thrombus by thrombectomy can be quite challenging. For reasons that are not fully understood, some thrombi require multiple passes to achieve successful recanalization, whereas other th...

Authors: Senna Staessens, Olivier François, Linda Desender, Peter Vanacker, Tom Dewaele, Raf Sciot, Karen Vanhoorelbeke, Tommy Andersson and Simon F. De Meyer

Pathological findings in rotation thromboelastometry associated with thromboembolic events in COVID-19 patients

Severe thromboembolic events are one of the major complications associated with COVID-19 infection, especially among critically ill patients. We analysed ROTEM measurements in COVID-19 patients with a severe d...

Authors: Kristina Boss, Andreas Kribben and Bartosz Tyczynski

A cross-sectional, multicenter, observational study to assess the prophylaxis of venous thromboembolism in Lebanese and Jordanian hospitals

There is a growing body of evidence showing substantial underuse of appropriate venous thromboembolism (VTE) prophylaxis in patients at risk. In the present study, our goal was to assess the current practices ...

Authors: Imad Hajj, Mahmoud AL-Masri, Kaldoun Bashaireh, Mohammed Bani Hani, Shadi Hamouri, Joe Khouzami, Nisrine Sabra and Chahine Fadel

Autopsy and statistical evidence of disturbed hemostasis progress in COVID-19: medical records from 407 patients

The progression of coagulation in COVID-19 patients with confirmed discharge status and the combination of autopsy with complete hemostasis parameters have not been well studied.

Authors: Tiebin Jiang, Bo Lv, Hongxia Liu, Shiwen He, Guogang Zhang, Chanyi Li, Wanqiong Li, Weilin Li, Yaqi He, Tong Zhang, Yunyun Wang, Wu Mo, Ning Yi, Luying Peng, Ying Li, Chunhong Ruan…

Warfarin versus direct oral anticoagulants for treating left ventricular thrombus: a systematic review and meta-analysis

Left ventricular thrombus (LVT) is not uncommon and pose a risk of systemic embolism, which can be mitigated by adequate anticoagulation. Direct oral anticoagulants (DOACs) are increasingly being used as alter...

Authors: Tarun Dalia, Shubham Lahan, Sagar Ranka, Amandeep Goyal, Sara Zoubek, Kamal Gupta and Zubair Shah

Feasibility of anticoagulation using low molecular-weight heparin during catheter-directed thrombolysis for lower extremity deep venous thrombosis

The optimal anticoagulant scheme during catheter-directed thrombolysis (CDT) for deep venous thrombosis (DVT) remains unknown. This study was performed to evaluate the feasibility of anticoagulation therapy us...

Authors: Yonghui Li, Junwei Wang, Rongzhou He, Junmeng Zheng, Zhibo Chen, Chen Yao and Kai Huang

Possible involvement of Syndecan-1 in the state of COVID-19 related to endothelial injury

The coronavirus infection 2019 (COVID-19) is associated with microvascular endothelial injury. Here, we report that syndecan-1, a component of endothelial glycocalyx, may reflect the disease state of COVID-19 ...

Authors: Keiko Suzuki, Hideshi Okada, Hiroyuki Tomita, Kazuyuki Sumi, Yoshinori Kakino, Ryu Yasuda, Yuichiro Kitagawa, Tetsuya Fukuta, Takahito Miyake, Shozo Yoshida, Akio Suzuki and Shinji Ogura

Heparin-induced thrombocytopenia presenting as splenic hemorrhage following cardiac surgery: a case report

Heparin-induced thrombocytopenia with thrombosis (HITT) is a paradoxical prothrombotic complication of anticoagulant therapy. As many as 3% of patients undergoing cardiac surgery develop clinical HIT presentin...

Authors: Joseph Ferry, Samuel Youssef, Pierce Wu and Livia Hegerova

Predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis: a cross-sectional study

Post-thrombotic syndrome (PTS) is a frequent chronic complication of proximal deep vein thrombosis (DVT) of the lower limb, but predictors of PTS are not well established. We aimed to examine predictors of PTS...

Authors: Marit Engeseth, Tone Enden, Per Morten Sandset and Hilde Skuterud Wik

Unprovoked internal jugular vein thrombosis: a case report and literature review

Managing thrombosis in rare sites is challenging. Existing studies and guidelines provide detailed explanations on how to overcome lower-limb thromboses and pulmonary embolisms, but few studies have examined t...

Authors: Loïc Payrard, Léa Iten, Jacques Donzé and Gregor John

Fatal pulmonary arterial thrombosis in a COVID-19 patient, with asymptomatic history, occurred after swab negativization

A considerable number of SARS-CoV-2 infected individuals could be asymptomatic and don’t need medical treatment. The clinical spectrum of SARS-CoV-2 infection ranges from asymptomatic cases, medium-intensity f...

Authors: Franca Del Nonno, Daniele Colombo, Roberta Nardacci and Laura Falasca