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  1. Content type: Review

    Our objective was to study the phenotype of and molecular genetic mechanisms underlying congenital protein C (PC) deficiency in Chinese neonates. We report the case of a neonate who presented 4 h after birth w...

    Authors: Xiaoying Li, Xiaoyan Li, Xiao Li, Yuanhua Zhuang, Lili Kang and Xiuli Ju

    Citation: Thrombosis Journal 2019 17:19

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  2. Content type: Case report

    Atypical hemolytic uremic syndrome is a rare group of disorders that have in common underlying complement amplifying conditions. These conditions can accelerate complement activation that results in a positive...

    Authors: Ramy M. Hanna, Noah Merin, Richard M. Burwick, Lama Abdelnour, Umut Selamet, Beshoy Yanny, Patrick Bui, Mary Fouad and Ira Kurtz

    Citation: Thrombosis Journal 2019 17:18

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  3. Content type: Research

    Thrombus formation is an important factor affecting cardiovascular events and venous thromboembolism in type 2 diabetes. However, it is unclear whether glycemic control reduces thrombogenicity. We investigated...

    Authors: Kiyoaki Yamamoto, Takashi Ito, Tomoka Nagasato, Atsushi Shinnakasu, Mihoko Kurano, Aiko Arimura, Hiroshi Arimura, Hiroshi Hashiguchi, Takahisa Deguchi, Ikuro Maruyama and Yoshihiko Nishio

    Citation: Thrombosis Journal 2019 17:17

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  5. Content type: Research

    Bridging anticoagulation is used in vitamin-K antagonist (VKA) patients undergoing invasive procedures and involves complex risk assessment in order to prevent thromboembolic and bleeding outcomes.

    Authors: M. J. Moesker, J. F. de Groot, N. L. Damen, N. R. Bijsterveld, J. W. R. Twisk, M. V. Huisman, M. C. de Bruijne and C. Wagner

    Citation: Thrombosis Journal 2019 17:15

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  6. Content type: Review

    Ambulatory management of isolated acute deep venous thrombosis (DVT) is the recommended standard of care in selected populations. However, in practice a significant number of patients continue to be managed as...

    Authors: Sarah Kelliher, Patricia Hall, Barry Kevane, Daniela Dinu, Karl Ewins, Peter MacMahon, Fionnuala Ní Áinle and Tomás Breslin

    Citation: Thrombosis Journal 2019 17:14

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  7. Content type: Research

    Although patients with acute myeloid leukemia (AML) were shown to have an increased risk of thrombosis, no thrombosis risk assessment scoring system has been developed for AML patients. The Khorana Risk Score ...

    Authors: Abu-Sayeef Mirza, Seongseok Yun, Najla Al Ali, Hannah Shin, Joseph Luke O’Neil, Maher Elharake, Daniel Schwartz, Katherine Robinson, Ethan Nowell, Grace Engle, Ibraahim Badat, Thomas Brimer, Amra Kuc, Ashton Sequeira, Sabbir Mirza, Dhiraj Sikaria…

    Citation: Thrombosis Journal 2019 17:13

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  8. Content type: Research

    The usefulness of the activated partial thromboplastin time (APTT) waveform has been reported in hemophilia, acquired hemophilia and monitoring for anticoagulants.

    Authors: Kei Suzuki, Hideo Wada, Takeshi Matsumoto, Makoto Ikejiri, Kohshi Ohishi, Yoshiki Yamashita, Hiroshi Imai, Toshiaki Iba and Naoyuki Katayama

    Citation: Thrombosis Journal 2019 17:12

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  9. Content type: Research

    Venous thromboembolism (VTE) of the lower limbs is an important complication post total knee arthroplasty (TKA). Current guidelines recommend routine chemical prophylaxis to all patients undergoing this proced...

    Authors: Jing Loong Moses Loh, Stephrene Chan, Keng Lin Wong, Sanjay de Mel and Eng Soo Yap

    Citation: Thrombosis Journal 2019 17:9

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  10. Content type: Case report

    Endocardial Fibroelastosis is diffuse, accentuated proliferation of ventricular endocardium causing a rare form of restrictive cardiomyopathy in both children and adults. It is an incompletely understood cause...

    Authors: Denizhan Ozdemir, Isabel Oliva Cortopassi and Robert Lawrence McNamara

    Citation: Thrombosis Journal 2019 17:8

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  13. Content type: Research

    Real-world data on non-vitamin K oral anticoagulants (NOACs) are essential in determining whether evidence from randomised controlled clinical trials translate into meaningful clinical benefits for patients in...

    Authors: Jan Beyer-Westendorf, A. John Camm, Keith A. A. Fox, Jean-Yves Le Heuzey, Sylvia Haas, Alexander G. G. Turpie, Saverio Virdone and Ajay K. Kakkar

    Citation: Thrombosis Journal 2019 17:7

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  14. Content type: Review

    Clinical practice shows that venous thromboembolism (VTE) presents a substantial burden in medical patients, and awareness and advocacy for its primary and secondary prevention remains inadequate. Specific pat...

    Authors: Benjamin Brenner, Russell Hull, Roopen Arya, Jan Beyer-Westendorf, James Douketis, Ismail Elalamy, Davide Imberti and Zhenguo Zhai

    Citation: Thrombosis Journal 2019 17:6

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  15. Content type: Correction

    Following the publication of this article [1], the authors noted the following typographical errors.

    Authors: Arshi Naz, Arijit Biswas, Tehmina Nafees Khan, Anne Goodeve, Nisar Ahmed, Nazish Saqlain, Shariq Ahmed, Ikram Din Ujjan, Tahir S. Shamsi and Johannes Oldenburg

    Citation: Thrombosis Journal 2019 17:5

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    The original article was published in Thrombosis Journal 2017 15:24

  16. Content type: Review

    Inflammatory diseases have become increasingly prevalent with industrialization. To address this, numerous anti-inflammatory agents and molecular targets have been considered in clinical trials. Among molecula...

    Authors: Dorothea M. Heuberger and Reto A. Schuepbach

    Citation: Thrombosis Journal 2019 17:4

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  17. Content type: Research

    This study involved a sensory evaluation of edoxaban orally disintegrating (OD) tablets in patients with nonvalvular atrial fibrillation who had been receiving the existing edoxaban film-coated tablets before ...

    Authors: Takeshi Yamashita, Joji Hagii, Yoshiyuki Morishima, Takaaki Akasaka, Takuyuki Matsumoto and Tetsuya Kimura

    Citation: Thrombosis Journal 2019 17:3

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  18. Content type: Review

    Peripherally inserted central catheters(PICC) lines are becoming increasingly popular in solid cancer patients for the administration of chemotherapy. This study aims looking at the incidence of PICC line rela...

    Authors: Osamah Al-Asadi, Manar Almusarhed and Hany Eldeeb

    Citation: Thrombosis Journal 2019 17:2

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  19. Content type: Research

    Nuclear histone proteins are released into the extracellular space, and act as major mediators of coagulopathy and remote organ failure in septic animals. However, the circulating histone levels in septic pati...

    Authors: Yayoi Yokoyama, Takashi Ito, Tomotsugu Yasuda, Hiroaki Furubeppu, Chinatsu Kamikokuryo, Shingo Yamada, Ikuro Maruyama and Yasuyuki Kakihana

    Citation: Thrombosis Journal 2019 17:1

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  20. Content type: Research

    Venous thromboembolism (VTE) is a relatively rare condition in childhood with treatment mainly based on extrapolation from studies in adults. Therefore, clinical trials of anticoagulation in children require n...

    Authors: Anthonie W. A. Lensing, Christoph Male, Guy Young, Dagmar Kubitza, Gili Kenet, M. Patricia Massicotte, Anthony Chan, Angelo C. Molinari, Ulrike Nowak-Goettl, Ákos F. Pap, Ivet Adalbo, William T. Smith, Amy Mason, Kirstin Thelen, Scott D. Berkowitz, Mark Crowther…

    Citation: Thrombosis Journal 2018 16:34

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  23. Content type: Research

    The EINSTEIN-Jr program will evaluate rivaroxaban for the treatment of venous thromboembolism (VTE) in children, targeting exposures similar to the 20 mg once-daily dose for adults. A physiologically based pha...

    Authors: Stefan Willmann, Kirstin Thelen, Dagmar Kubitza, Anthonie W. A. Lensing, Matthias Frede, Katrin Coboeken, Jan Stampfuss, Rolf Burghaus, Wolfgang Mück and Jörg Lippert

    Citation: Thrombosis Journal 2018 16:32

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  24. Content type: Research

    The EINSTEIN-Jr program will evaluate rivaroxaban for the treatment of venous thromboembolism (VTE) in children, targeting exposures similar to the 20 mg once-daily dose for adults.

    Authors: Dagmar Kubitza, Stefan Willmann, Michael Becka, Kirstin Thelen, Guy Young, Leonardo R. Brandão, Paul Monagle, Christoph Male, Anthony Chan, Gili Kennet, Ida Martinelli, Paola Saracco and Anthonie W. A. Lensing

    Citation: Thrombosis Journal 2018 16:31

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  25. Content type: Case report

    Autoimmune paraphenomena, are associated with B-cell lymphoproliferative disorders, including monoclonal gammopathy of uncertain significance. These paraphenomena can rarely include acquired bleeding disorders.

    Authors: Elizabeth Sarah Mayne, Malcolm Tait, Barry Frank Jacobson, Evashin Pillay and Susan J. Louw

    Citation: Thrombosis Journal 2018 16:30

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  26. Content type: Research

    Serious bleeding events have been frequently described in patients taking direct oral anticoagulants (DOAC). In secondary analyses of phase 3 trials, DOAC plasma concentrations were shown to correlate with ble...

    Authors: Anne-Laure Sennesael, Anne-Sophie Larock, Jonathan Douxfils, Laure Elens, Gabriel Stillemans, Martin Wiesen, Max Taubert, Jean-Michel Dogné, Anne Spinewine and François Mullier

    Citation: Thrombosis Journal 2018 16:28

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  27. Content type: Research

    Venous thromboembolism (VTE) in young children is not well documented.

    Authors: Anthony Chan, Anthonie W. A. Lensing, Dagmar Kubitza, Grahaem Brown, Dolores Elorza, Marta Ybarra, Jacqueline Halton, Sebastian Grunt, Gili Kenet, Damien Bonnet, Amparo Santamaria, Paola Saracco, Tina Biss, Francesco Climent, Philip Connor, Joseph Palumbo…

    Citation: Thrombosis Journal 2018 16:29

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  28. Content type: Letter to the Editor

    Five patients with paroxysmal nocturnal haemoglobinuria and thrombotic complications under oral antithrombotic treatment with vitamin K antagonist were switched to receive the direct oral anticoagulant rivarox...

    Authors: Francesco Dragoni, Flavia Chiarotti, Anna Paola Iori, Ursula La Rocca and Arturo Cafolla

    Citation: Thrombosis Journal 2018 16:26

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  30. Content type: Research

    Globally, sickle cell disease (SCD) is one of the most common haemoglobinopathy. Considered a public health problem, it leads to vessel occlusion, blood stasis and chronic activation of the coagulation system ...

    Authors: Jean Jacques Noubiap, Mazou N. Temgoua, Ronni Tankeu, Joel Noutakdie Tochie, Ambroise Wonkam and Jean Joël Bigna

    Citation: Thrombosis Journal 2018 16:27

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  31. Content type: Research

    Recombinant human soluble thrombomodulin (rTM) has been used for the treatment of disseminated intravascular coagulation in Japan, and an international phase III clinical trial for rTM is currently in progress...

    Authors: Takuro Arishima, Takashi Ito, Tomotsugu Yasuda, Nozomi Yashima, Hiroaki Furubeppu, Chinatsu Kamikokuryo, Takahiro Futatsuki, Yutaro Madokoro, Shotaro Miyamoto, Tomohiro Eguchi, Hiroyuki Haraura, Ikuro Maruyama and Yasuyuki Kakihana

    Citation: Thrombosis Journal 2018 16:24

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  32. Content type: Research

    Atrial fibrillation (AF) is a major risk factor for stroke as it increases the incidence of stroke nearly fivefold. Antithrombotic treatment is recommended for the prevention of stroke in AF patients. However,...

    Authors: Eyob Alemayehu Gebreyohannes, Akshaya Srikanth Bhagavathula and Henok Getachew Tegegn

    Citation: Thrombosis Journal 2018 16:22

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  33. Content type: Research

    Around 20% of venous thromboembolism (VTE) cases occur in patients with cancer. Current guidelines recommend low molecular weight heparin (LMWH) as the preferred anticoagulant for VTE treatment. However, some ...

    Authors: Alexander T. Cohen, Anthony Maraveyas, Jan Beyer-Westendorf, Agnes Y. Y. Lee, Lorenzo G. Mantovani and Miriam Bach

    Citation: Thrombosis Journal 2018 16:21

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  34. Content type: Case report

    Anticoagulation therapy for mechanical prosthetic valves is limited to vitamin K antagonists, unfractionated heparin and low-molecular-weight-heparin. Other forms of anticoagulation are either contraindicated ...

    Authors: Abeer Berry, George Degheim and Souheil Saba

    Citation: Thrombosis Journal 2018 16:23

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  35. Content type: Research

    Disseminated intravascular coagulation (DIC) is associated with high mortality in patients with sepsis. Several studies reporting that recombinant human soluble thrombomodulin (rhTM) reduced mortality in sepsi...

    Authors: Takahiro Kato and Katsuhiko Matsuura

    Citation: Thrombosis Journal 2018 16:19

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  37. Content type: Research

    We conducted a prospective observational study for investigating coagulofibrinolytic changes and mechanisms of antithrombin (AT) alternations in trauma.

    Authors: Hironori Matsumoto, Jun Takeba, Kensuke Umakoshi, Satoshi Kikuchi, Muneaki Ohshita, Suguru Annen, Naoki Moriyama, Yuki Nakabayashi, Norio Sato and Mayuki Aibiki

    Citation: Thrombosis Journal 2018 16:17

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  39. Content type: Review

    Both disseminated intravascular coagulation (DIC) and thrombotic microangiopathy (TMA) cause microvascular thrombosis associated with thrombocytopenia, bleeding tendency and organ failure.

    Authors: Hideo Wada, Takeshi Matsumoto, Kei Suzuki, Hiroshi Imai, Naoyuki Katayama, Toshiaki Iba and Masanori Matsumoto

    Citation: Thrombosis Journal 2018 16:14

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  40. Content type: Research

    Hyponatremia is common among patients with pulmonary embolism, while hypernatremia increases the risk of venous thromboembolism (VTE). Our objective was to evaluate the association between sodium imbalances an...

    Authors: Sally Temraz, Hani Tamim, Aurelie Mailhac and Ali Taher

    Citation: Thrombosis Journal 2018 16:11

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  41. Content type: Review

    The pathophysiological mechanisms of acute coagulopathy of trauma-shock (ACOTS) are reported to include activated protein C-mediated suppression of thrombin generation via the proteolytic inactivation of activ...

    Authors: Satoshi Gando, Toshihiko Mayumi and Tomohiko Ukai

    Citation: Thrombosis Journal 2018 16:13

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  42. Content type: Research

    Small studies have implicated plasminogen activator inhibitor-1 (PAI-1) as a predictor of cardiovascular events; however, these findings have been inconsistent.

    Authors: Richard G. Jung, Pouya Motazedian, F. Daniel Ramirez, Trevor Simard, Pietro Di Santo, Sarah Visintini, Mohammad Ali Faraz, Alisha Labinaz, Young Jung and Benjamin Hibbert

    Citation: Thrombosis Journal 2018 16:12

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  43. Content type: Correction

    Correction to: Thrombosis Journal (2018) 16:9 DOI 10.1186/s12959-018-0163-7

    Authors: Alexander T. Cohen, Cihan Ay, Philippe Hainaut, Hervé Décousus, Ulrich Hoffmann, Sean Gaine, Michiel Coppens, Pedro Marques da Silva, David Jimenez, Beatrice Amann-Vesti, Bernd Brüggenjürgen, Pierre Levy, Julio Lopez Bastida, Eric Vicaut, Petra Laeis, Eva-Maria Fronk…

    Citation: Thrombosis Journal 2018 16:18

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    The original article was published in Thrombosis Journal 2018 16:9

  44. Content type: Letter to the Editor

    Accurate thrombin generation determination by calibrated automated thrombinography can be sustained when reducing the plasma and reagent volumes up to half, but not for higher reductions or plasma dilutions.

    Authors: Saartje Bloemen, Hilde Kelchtermans and H. Coenraad Hemker

    Citation: Thrombosis Journal 2018 16:10

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  45. Content type: Research

    Venous thromboembolism (VTE, including deep vein thrombosis [DVT] and pulmonary embolism [PE]) has an annual incidence rate of 104–183 per 100,000 person-years. After a VTE episode, the two-year recurrence rat...

    Authors: Alexander T. Cohen, Cihan Ay, Philippe Hainaut, Hervé Décousus, Ulrich Hoffmann, Sean Gaine, Michiel Coppens, Pedro Marques da Silva, David Jiménez, Beatrice Amann-Vesti, Bernd Brüggenjürgen, Pierre Levy, Julio Lopez Bastida, Eric Vicaut, Petra Laeis, Eva-Maria Fronk…

    Citation: Thrombosis Journal 2018 16:9

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    The Correction to this article has been published in Thrombosis Journal 2018 16:18

  46. Content type: Correction

    Following the publication of this study [1] the authors identified the following errors inadvertently introduced during the production process:

    Authors: George Bozas, Natalie Jeffery, Deiva Ramanujam-Venkatachala, Ged Avery, Andrew Stephens, Hilary Moss, June Palmer, Mandi Elliott and Anthony Maraveyas

    Citation: Thrombosis Journal 2018 16:15

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    The original article was published in Thrombosis Journal 2018 16:8

  47. Content type: Research

    In 2012, around 400.000 patients in the Netherlands were treated with Vitamin K Antagonists (VKA) for thromboembolic diseases. Since 2011, non-VKA oral anticoagulants (NOACs) are available. NOACs do not requir...

    Authors: J. M. van den Heuvel, A. M. Hövels, H. R. Büller, A. K. Mantel-Teeuwisse, A. de Boer and A. H. Maitland-van der Zee

    Citation: Thrombosis Journal 2018 16:7

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  48. Content type: Case report

    Patients with congenital afibrinogenemia suffer from spontaneous recurrent severe bleeding. While fibrinogen concentrates are known to effectively treat bleeding episodes, thrombotic complications often occur ...

    Authors: S. Le Quellec, A. Desjonqueres, L. Rugeri, H. Desmurs Clavel, F. Farhat, L. Mechtouff and Y. Dargaud

    Citation: Thrombosis Journal 2018 16:6

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  50. Content type: Research

    The risk of thromboembolic events is higher among cancer patients, especially in patients undergoing chemotherapy. Cisplatin-based regimens claim to be associated with a very high thromboembolic rate. In this ...

    Authors: Hikmat Abdel-Razeq, Asem Mansour, Hazem Abdulelah, Anas Al-Shwayat, Mohammad Makoseh, Mohammad Ibrahim, Mahmoud Abunasser, Dalia Rimawi, Abeer Al-Rabaiah, Rozan Alfar, Alaa’ Abufara, Alaa Ibrahim, Anas Bawaliz and Yousef Ismael

    Citation: Thrombosis Journal 2018 16:2

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