Open Access

A case report of asymptomatic aortic thrombosis incidentally detected by computed tomography in apparently healthy subject with a history of cancer surgery

Thrombosis Journal201614:16

https://doi.org/10.1186/s12959-016-0090-4

Received: 15 June 2016

Accepted: 29 July 2016

Published: 2 August 2016

Abstract

Background

Aortic thrombosis is a rare disease and only a few cases of the disease, especially associated with chemotherapy for malignant diseases and/or blood diseases, have been previously reported. Although Virchow’s triad for thrombogenesis, namely hypercoagulability, blood flow stasis, and vessel wall injury, is the major factor promoting the formation of thrombosis, the detailed mechanism of the disease has not been well established.

Case presentation

We report a case of aortic thrombosis incidentally detected by computed tomography and then regressed by pharmacotherapy using warfarin. This case is an apparently healthy man in a postoperative state after lung cancer surgery with decreased protein-C activity.

Conclusions

A case of aortic thrombosis without an obvious abnormality of the aorta was incidentally identified. A few cases of aortic thrombosis in healthy aortas have been reported to be associated with chemotherapy or blood diseases, however our present case did not had such a background. Although the detailed mechanism remains to be elucidated, this case suggests that aortic thrombosis can develop in apparently healthy subjects with a history of cancer surgery.

Keywords

Aortic thrombosis Incidental Computed tomography Pharmacotherapy

Background

Aortic thrombosis is a rare disease and only a few cases have been previously reported [13]. Malignant diseases and/or blood diseases, such as thrombocytosis and chemotherapy-related hematological disorders, have been identified as one of the causes of aortic thrombosis in these previous reports [15]. While Virchow’s triad for thrombogenesis, namely hypercoagulability, blood flow stasis, and vessel wall injury, is the major factor accelerating the formation of thrombus in the aortic wall, the detailed mechanism of aortic thrombosis has not been fully elucidated. Moreover, its therapeutic strategy is still controversial [6].

Previously, we reported a case of multiple aortic thrombosis in a patient with malignant lymphoma complicated by splenic infarction, and successfully treated by non-invasive pharmacotherapy [7]. Since then, we have identified another case of aortic thrombosis which was incidentally detected by computed tomography (CT), when performed for follow-up of primary diseases. Unlike our previous report, the contribution of malignant disease and chemotherapy was not suggested in this case. Here, we report a case of aortic thrombosis with background of surgery for lung cancer 1.5 years ago and no signature of recurrence.

Case presentation

A 75-year-old Japanese man who had no history of thrombosis or thromboembolism underwent resection of his right upper lung lobe for adenocarcinoma of localized adenocarcinoma without distant metastasis, 2 years previously. Chemotherapy and radiation therapy were not performed. After the operation, periodic follow-up CT was undertaken every 6 months and fluorodeoxyglucose-positron emission tomography (FDG-PET) was performed after 1 year of operation in order to check for recurrence of lung cancer, and the results showed no recurrence or distant metastasis and no abnormality of the thoracic aorta or unexpected mural thrombus (Fig. 1a). However, an aortic thrombus was incidentally detected in the descending aortic arch 1.5 years after the primary operation (Fig. 1b). At that time, the patient was apparently healthy, with a body temperature of 36.2 °C, blood pressure of 122/68 mmHg, heart rate of 76 bpm, and peripheral oxygen saturation of 96 % in room air. Laboratory data showed slightly elevated D-dimer, decreased plasma protein-C activity, and normal liver function and lipid profile (Table 1). Lupus anticoagulant or anticardiolipin antibody was not detected and the patient stopped smoking at 60-year-old (Brinkman index 800). Although the cause and significance of decreased protein-C activity was not fully understood, we started anticoagulant therapy for aortic thrombosis using warfarin. Follow-up CT showed the aortic thrombus was gradually regressing and was eliminated completely after 6 months of anticoagulant therapy without major complications (Fig. 1c). Then, anticoagulant therapy was terminated without recurrence of aortic thrombus and plasma protein-C activity was recovered within normal range (72 %).
Fig. 1

Contrast-enhanced computed tomography (CT) of the chest undertaken 1 years after surgery for lung cancer (a) Contrast-enhanced CT of the chest 1.5 years after surgery for lung cancer. An aortic thrombus was incidentally detected in the distal aortic arch (b) Contrast-enhanced CT of the chest 2 years after surgery for lung cancer. The thrombus in the distal aortic arch has disappeared after 6 months of anticoagulant therapy without an event of symptomatic distal embolism (c) Arrows indicate thrombosis

Table 1

Characteristics of the case

Variable

Patient value

Reference range

White Blood Cell (/μL)

5400

3600–9600

Hemoglobin (g/dl)

14.9

13.2–17.2

Platelet (/10−4 μL)

12.3

14.8–33.9

CK (U/L)

150

62–287

AST (U/L)

18

13–33

ALT (U/L)

17

6–30

LDH (U/L)

171

119–223

Creatinine (mg/dl)

0.89

0.60–1.10

Causal blood glucose (mg/dl)

107

70–139

Total-cholesterol (mg/dl)

165

128–219

HDL-cholesterol (mg/dl)

43

40–96

CRP (mg/dl)

0.06

<0.3

BNP (pg/ml)

31.1

< 18.4

APTT (%)

116.1

76.0–130.0

PT (%)

91.6

70.0–130.0

HbA1c (%)

6.1

4.6–6.2

D-dimer (μg/ml)

1.5

<0.5

Protein C activity (%)

45

64–146

Protein C level (%)

39

70–150

Total protein S antigen (%)

84

60–150

Free Protein S antigen (%)

91

65–135

Antithrombin III (mg/dl)

25.4

22.6–33.5

Lupus anticoagulant (second)

Undetected

-

Anticardiolipin antibody

Undetected

-

Anticardiolipin β2GPI antibodies

Undetected

-

CK creatine kinase, AST aspartate aminotransferase, ALT alanine aminotransferase, LDH lactate dehydrogenase, HDL high-density lipoprotein, CRP C reactive protein, BNP brain natriuretic peptide, APTT activated partial thromboplastin time, PT prothrombin time, β2GPI β2 antiglycoprotein I

Aortic thrombosis is a rare disease which can cause distal embolism, but can also be detected incidentally in asymptomatic cases [1, 2]. Although aortic mural thrombus associated with abnormal aortic disease, such as aortic aneurysm and aortic dissection, is often seen, a thrombus in an apparently healthy aorta is very rare, since the aortic blood flow is too fast for clotting and the formation of a growing thrombus [1, 2]. Virchow’s triad for thrombogenesis, featuring hypercoagulability, blood flow stasis, and vessel wall injury, is known to be important in thrombus formation, however the concept is generally adopted for thrombosis in veins and/or small arteries [6]. On the other hand, thromboembolism complicated with atrial fibrillation is well-known, but arrhythmia cannot be the etiology of local thrombus of the aorta. Thus, the detailed mechanism of the etiology of aortic thrombosis is not well understood [1, 2].

In the present report, we describe a case of aortic thrombosis which was seen in an apparently healthy man in a postoperative state after lung cancer surgery with decreased protein-C activity. Although hereditary protein-C deficiency is well known to be associated with recurrent thrombosis [8, 9], this patient and his family did not have episodes of thrombosis. Moreover, the protein-C activity was recovered within normal range after termination of anticoagulant therapy. Protein-C deficiency is often seen in the acute phase of thrombosis and in patients undergoing anticoagulation therapy, since protein-C and protein-S are vitamin K-dependent glycoproteins that are massively lost in such conditions [8, 9]. Thus, the contribution of protein-C deficiency to the development of aortic thrombosis, while possible, is not clear. Present case is in contrast to several recent reports of aortic thrombosis which were associated with malignant disease, hematological disorders, and chemotherapy-related thrombosis, especially in relation to cisplatin-based chemotherapy [4, 5]. Actually, the background of our previously reported case of aortic thrombosis included malignant lymphoma and related chemotherapy [6].

The therapeutic strategy for aortic thrombosis is controversial, however, the main strategy is conservative pharmacotherapy [13]. There is no definitive evidence as to the antithrombotic therapy to be selected or the appropriate duration of such treatment in the case of aortic thrombosis. Therefore, we chose warfarin therapy for 6 months in accordance with the standard therapy in the case of venous thrombosis. After termination of the warfarin therapy, the recurrence of aortic thrombosis has not been confirmed more than 6 months. Another strategy is surgical therapy, which is particularly useful for symptomatic cases with distal thromboembolism, and combined therapy may also be selected occasionally [13]. We selected conservative pharmacotherapy since signs of distal thromboembolism were not evident. However, recently the technique of aortic stent graft treatment has been dramatically improved, allowing an alternative treatment choice for aortic thrombosis, especially in emergency cases or in unfavorable conditions [10].

Conclusions

We identified a case of aortic thrombosis without an abnormality of the aorta. A few cases of aortic thrombosis in healthy aortas have been reported to be associated with chemotherapy or blood diseases, however our present case did not have such a background. Although the detailed mechanism remains to be elucidated, this case suggest that aortic thrombosis can develop in apparently healthy subjects with a history of cancer surgery.

Abbreviations

APTE, acute pulmonary thromboembolism; CT, computed tomography; FDG-PET, fluorodeoxyglucose-positron emission tomography

Declarations

Acknowledgements

None.

Funding

Not applicable.

Availability of data and materials

Not applicable.

Authors’ contribution

TS, did bedside work and prepared the manuscript. YD, discussed the case, modified manuscript. SY, did bedside work. SM, did bedside work. NO, discussed the case, modified the manuscript. All authors read and approved the final manuscript.

Competing interest

The authors declare that they have no competing interests.

Consent for publication

Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.

Ethics approval and consent to participate

Not applicable.

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences
(2)
Department of Internal Medicine, Faculty of Rehabilitation Science, Nagoya Gakuin University

References

  1. Sohn V, Arthurs Z, Andersen C, Starnes B. Aortic thrombus due to essential thrombocytosis: strategies for medical and surgical management. Ann Vasc Surg. 2008;22:676–80.View ArticlePubMedGoogle Scholar
  2. Fayad ZY, Semaan E, Fahoum B, Briggs M, Tortolani A, D’Ayala M. Aortic mural thrombus in the normal or minimally atherosclerotic aorta. Ann Vasc Surg. 2013;27:282–90.View ArticlePubMedGoogle Scholar
  3. Geha AS, El-Zein C, Massad MG, Bagai J, Khoury F, Evans A, Kpodonu J. Surgery for aortic arch thrombosis. Thorac Cardiovasc Surg. 2004;52:187–90.View ArticlePubMedGoogle Scholar
  4. Hahn SJ, Oh JY, Kim JS, Kim DY. A case of acute aortic thrombosis after cisplatin-based chemotherapy. Int J Clin Oncol. 2011;16:732–6.View ArticlePubMedGoogle Scholar
  5. Ito S, Nakamura Y, Noumi T, Sasaki Y. Acute aortic thrombosis during cisplatin based chemotherapy for gastric cancer. Intern Med. 2013;52:973–5.View ArticlePubMedGoogle Scholar
  6. Wolberg AS, Aleman MM, Leiderman K, Machlus KR. Procoagulant activity in hemostasis and thrombosis: Virchow’s triad revisited. Anesth Analg. 2012;114:275–85.View ArticlePubMedGoogle Scholar
  7. Hachiya K, Sugiura T, Dohi Y, Ohte N. Multiple aortic thrombosis successfully treated using pharmacotherapy. Intern Med. 2013;52:2155–6.View ArticlePubMedGoogle Scholar
  8. Onwuanyi A, Sachdeva R, Hamirani K, Islam M, Parris R. Multiple aortic thrombi associated with protein C and S deficiency. Mayo Clin Proc. 2001;76:319–22.View ArticlePubMedGoogle Scholar
  9. Wypasek E, Undas A. Protein C and protein S deficiency - practical diagnostic issues. Adv Clin Exp Med. 2013;22:459–67.PubMedGoogle Scholar
  10. Verma H, Meda N, Vora S, George RK, Tripathi RK. Contemporary management of symptomatic primary aortic mural thrombus. J Vasc Surg. 2014;60:1524–34.View ArticlePubMedGoogle Scholar

Copyright

© The Author(s). 2016

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