Articles

Antithrombin III (AT) and recombinant tissue plasminogen activator (R-TPA) used singly and in combination versus supportive care for treatment of endotoxin-induced disseminated intravascular coagulation (DIC) in the neonatal pig

Disseminated intravascular coagulation (DIC) is a pathological disturbance of the complex balance between coagulation and anticoagulation that is precipitated by vascular injury, acidosis, endotoxin release an...

Authors: Rachel Davis-Jackson, Hernan Correa, Ronald Horswell, Halina Sadowska-Krowicka, Kathleen McDonough, Chittaranjan Debata, Renee' Gardner and Duna Penn

Oral heparin: status review

Unfractionated heparin and low molecular weight heparin are the most commonly used antithrombotic and thromboprophylactic agents in hospital practice. Extended out-of-hospital treatment is inconvenient in that...

Authors: Ehud Arbit, Michael Goldberg, Isabel Gomez-Orellana and Shingai Majuru

Thrombin generation by activated factor VII on platelet activated by different agonists. Extending the cell-based model of hemostasis

Platelet activation is crucial in normal hemostasis. Using a clotting system free of external tissue factor, we investigated whether activated Factor VII in combination with platelet agonists increased thrombi...

Authors: Raul Altman, Alejandra Silvia Scazziota, Maria de Lourdes Herrera and Claudio Gonzalez

Recent acquisitions in the pathophysiology, diagnosis and treatment of disseminated intravascular coagulation

Disseminated intravascular coagulation (DIC) is a disorder characterized by both acute generalized, widespread activation of coagulation, which results in thrombotic complications due to the intravascular form...

Authors: Massimo Franchini, Giuseppe Lippi and Franco Manzato

Detection and quantification of lupus anticoagulants in plasma from heparin treated patients, using addition of polybrene

Lupus anticoagulants prolong clotting times in phospholipid-dependent coagulation tests. Lupus Ratio assays are integrated tests for lupus anticoagulants that may be based on APTT, RVVT or dPT clotting times. ...

Authors: Eva M Jacobsen, Elin J Trettenes, Finn Wisløff and Ulrich Abildgaard

Plasma D-dimer concentration in patients with systemic sclerosis

Systemic sclerosis (SSc) is an autoimmune disorder of the connective tissue characterized by widespread vascular lesions and fibrosis. Little is known so far on the activation of the hemostatic and fibrinolyti...

Authors: Giuseppe Lippi, Alessandro Volpe, Paola Caramaschi, Gian Luca Salvagno, Martina Montagnana and Gian Cesare Guidi

Ineffective off-label use of recombinant activated factor VII in a case of bone-marrow transplantation-related gastrointestinal bleeding

For patients with a normal coagulation system, who experience serious bleeding, sound evidence for recombinant activated factor VII (rFVIIa) as an effective haemostatic agent is only scarcely available so far ...

Authors: P Eller, C Pechlaner and CJ Wiedermann

Socio economic crisis and mortality. Epidemiological testimony of the financial collapse of Argentina

Natural disasters, war, and terrorist attacks, have been linked to cardiac mortality. We sought to investigate whether a major financial crisis may impact on the medical management and outcomes of acute corona...

Authors: Enrique P Gurfinkel, Gerardo E Bozovich, Omar Dabbous, Branco Mautner and Frederick Anderson

Systemic coagulation parameters in mice after treatment with vascular targeting agents

Vascular targeting of malignant tumors has become a clinically validated new treatment approach with clear patient benefit. However clinical studies have also revealed that some types of vascular targeting age...

Authors: Maike Unruh, Andrea Grunow and Claudia Gottstein

Anticoagulant treatment at a specialized outpatient anticoagulant therapy unit, a descriptive study

The indications for continuous oral anticoagulant treatment, the target interval and the procedures for withdrawing treatment have changed in the last 10 years.

Authors: Kim Ekblom, Johan Hultdin, Bo Carlberg and Tage Strand

Large mobile thrombus in non-atherosclerotic thoracic aorta as the source of peripheral arterial embolism

The presence of thrombi in the atherosclerotic and/or aneurysmatic aorta with peripheral arterial embolism is a common scenario. Thrombus formation in a morphologically normal aorta, however, is a rare event. ...

Authors: Nasser M Malyar, Rolf A Janosi, Zoran Brkovic and Raimund Erbel

Intermittent pneumatic compression for prevention of pulmonary thromboembolism after gynecologic surgery

To investigate the incidence of pulmonary embolism and risk factors for this condition after obstetric and gynecologic surgery, as well as the efficacy of intermittent pneumatic compression.

Authors: Nao Suzuki, Fumio Kataoka, Atsushi Higashiguchi, Takeshi Hirao, Sachiko Ezawa, Hiroyuki Nomura, Akiyo Tomita, Nobuyuki Susumu and Daisuke Aoki

Increased PAI-1 plasma levels and risk of death from dengue: no association with the 4G/5G promoter polymorphism

Dengue virus infected patients have high plasminogen activator inhibitor type I (PAI-1) plasma concentrations. Whether the insertion/deletion (4G/5G) polymorphism in the promotor region of the PAI-1 gene is as...

Authors: ATA Mairuhu, TE Setiati, P Koraka, CE Hack, A Leyte, SMH Faradz, H ten Cate, DPM Brandjes, ADME Osterhaus, PH Reitsma and ECM van Gorp

Towards a standardization of thrombin generation assessment: The influence of tissue factor, platelets and phospholipids concentration on the normal values of Thrombogram-Thrombinoscope assay

Thrombin generation assay was developed several years ago to mimic physiological coagulation mechanisms but it had important limitations. Thrombogram-Thrombinoscope assay using a fluorogenic substrate, allows ...

Authors: Grigoris T Gerotziafas, François Depasse, Joël Busson, Lena Leflem, Ismail Elalamy and Meyer M Samama

Elevated levels of procoagulant microparticles in a patient with myocardial infarction, antiphospholipid antibodies and multifocal cardiac thrombosis

Circulating procoagulant microparticles (MP) are pathogenic markers of enhanced coagulability associated to a variety of disorders and released from stimulated vascular cells. When derived from endothelial cel...

Authors: O Morel, L Jesel, JM Freyssinet and F Toti

Heparin-induced thrombocytopenia: an update

Heparin-induced thrombocytopenia (HIT) is the most important and most frequent drug-induced, immune-mediated type of thrombocytopenia. It is associated with significant morbidity and mortality if unrecognized....

Authors: Massimo Franchini

Homocysteine, MTHFR C677T gene polymorphism, folic acid and vitamin B 12 in patients with retinal vein occlusion

Many available data have suggested that hyperhomocysteinaemia, an established independent risk factor for thrombosis (arterial and venous), may be associated with an increased risk of retinal vein occlusion (R...

Authors: Paola Ferrazzi, Pierpaolo Di Micco, Ilaria Quaglia, Lisa Simona Rossi, Alessandro Giacco Bellatorre, Giorgio Gaspari, Lidia Luciana Rota and Corrado Lodigiani

Analysis of blood coagulation in mice: pre-analytical conditions and evaluation of a home-made assay for thrombin-antithrombin complexes

The use of mouse models for the study of thrombotic disorders has gained increasing importance. Methods for measurement of coagulation activation in mice are, however, scarce. The primary aim of this study was...

Authors: Dirkje W Sommeijer, René van Oerle, Pieter H Reitsma, Janneke J Timmerman, Joost CM Meijers, Henri MH Spronk and Hugo ten Cate

Catheter-related septic thrombophlebitis of the great central veins successfully treated with low-dose streptokinase thrombolysis and antimicrobials

Septic thrombophlebitis is an iatrogenic life-threatening disease associated with use of central venous devices and intravenous (IV) therapy. In cancer patients receiving chemotherapy, vein resection or surgic...

Authors: Patricia Volkow, Patricia Cornejo-Juárez, Ana Berta Arizpe-Bravo, Jorge García-Méndez, Enrique Baltazares-Lipp and Rogelio Pérez-Padilla

Resistance to aspirin is increased by ST-elevation myocardial infarction and correlates with adenosine diphosphate levels

To be fully activated platelets are dependent on two positive feedback loops; the formation of thromboxane A₂ by cyclooxygenase in the platelets and the release of ADP. We wanted to evaluate the effect of aspirin...

Authors: Catharina Borna, Eduardo Lazarowski, Catharina van Heusden, Hans Öhlin and David Erlinge

Intracardiac thrombus in Behçet's disease: Two case reports

Intracardiac thrombus in Behçet's disease is an extremely rare manifestation. We report two such cases. A 20-year-old man presented with dyspnoea, cough and haemoptysis. Right heart thrombus associated with pu...

Authors: Sonia Hammami, Silvia Mahjoub, Khaldoun Ben-Hamda, Radhia Brahem, Habib Gamra and Mohamed Ben Farhat

Comparison of incidence/risk of venous thromboembolism (VTE) among selected clinical and hereditary risk markers: A community-based cohort study

Little information is available from community-based long-term VTE cohort studies to compare the absolute thrombosis risk of established clinical and genetic risk factors.

Authors: Michael Spannagl, Lothar AJ Heinemann, Thai DoMinh, Anita Assmann, Wolfgang Schramm and Rolf Schürmann

Thrombosis in Clinical Practice. Edited by: Andrew D Blann, Gregory YH Lip, Alexander GG Turpie.

Authors: Raul Altman

Adrenal failure followed by status epilepticus and hemolytic anemia in primary antiphospholipid syndrome

We report on a 14 year old boy who presented with the symptoms abdominal pain, fever and proteinuria. A hematoma in the region of the right pararenal space was diagnosed. Prothrombin time and activated partial...

Authors: Patrick Gerner, Michael Heldmann, Peter Borusiak, Vladimir Bures and Stefan Wirth

VTE Risk assessment – a prognostic Model: BATER Cohort Study of young women

Community-based cohort studies are not available that evaluated the predictive power of both clinical and genetic risk factors for venous thromboembolism (VTE). There is, however, clinical need to forecast the li...

Authors: Lothar AJ Heinemann, Thai DoMinh, Anita Assmann, Wolfgang Schramm, Rolf Schürmann, Jan Hilpert and Michael Spannagl

Rates of clinically apparent heparin-induced thrombocytopenia for unfractionated heparin vs. low molecular weight heparin in non-surgical patients are low and similar

With the growing use of low-molecular-weight heparins (LMWH) for the treatment and prevention of venous thromboembolism (VTE), it is important to provide an evidence-based comparison with unfractionated hepari...

Authors: Charles FS Locke, John Dooley and Jonathan Gerber

A hypothesis-generating study to evaluate platelet activity in diabetics with chronic kidney disease

It is well described that diabetes mellitus is a hypercoagulable state. It is also known that patients with renal dysfunction have impaired platelet aggregation and function. It is not well described how renal...

Authors: Donald F Brophy, rika J Martin, Todd WB Gehr and Marcus E Carr Jr

Clotting state after cardioversion of atrial fibrillation: a haemostasis index could detect the relationship with the arrhythmia duration

Fibrin D-dimer levels have been advocated as an useful clinical marker of thrombogenesis.

Authors: Eleni Hatzinikolaou-Kotsakou, Zafirios Kartasis, Dimitrios Tziakas, Dimitrios Stakos, Athanasios Hotidis, Georgios Chalikias, Georgios Bourikas and Dimitrios I Hatseras

The risk of hemorrhagic complications in hospital in-patients who fall while receiving antithrombotic therapy

The use of antithrombotic agents and falls are independently associated with an increased risk of hemorrhagic injury. However, few studies have delineated the risk of fall-related hemorrhagic complications in ...

Authors: Andrew J Bond, Frank J Molnar, Marilyn Li, Marlene Mackey and Malcolm Man-Son-Hing

Blood coagulation and the risk of atherothrombosis: a complex relationship

The principles of Virchov's triad appear to be operational in atherothrombosis or arterial thrombosis: local flow changes and particularly vacular wall damage are the main pathophysiological elements. Furtherm...

Authors: Henri MH Spronk, Danielle van der Voort and Hugo ten Cate

Platelet-derived NO slows thrombus growth on a collagen type III surface

Nitric oxide (NO) is a free radical that plays an important role in modulating platelet adhesion and aggregation. Platelets are a source of vascular NO, but since erythrocytes avidly scavenge NO, the functiona...

Authors: Robert H Williams and Matthias U Nollert

Thromboembolic events and haematological diseases: a case of stroke as clinical onset of a paroxysmal nocturnal haemoglobinuria

Some haematological diseases are associated to an increased risk of thromboembolic events. We report a case of paroxysmal nocturnal haemoglobinuria (PNH) in which a cerebrovascular event represented the first ...

Authors: Gianluca Granata, Tiziana Izzo, Pierpaolo Di Micco, Barbara Bonamassa, Giampiero Castaldo, Vito Giuseppe Viggiano, Ugo Picillo, Giuseppe Castaldo and Alferio Niglio

Recombinant activated factor VII (rFVIIa) as salvage treatment for intractable hemorrhage

Recently, there has been an increased use of recombinant activated factor VII (rFVIIa) to promote hemostasis in various hemorrhagic conditions. The objective of this study was to determine the outcome of patie...

Authors: Anita Aggarwal, Vera Malkovska, Joseph P Catlett and Kirsten Alcorn

Traumatic deep vein thrombosis in a soccer player: A case study

A 42 year-old male former semi-professional soccer player sustained a right lower extremity popliteal contusion during a soccer game. He was clinically diagnosed with a possible traumatic deep vein thrombosis ...

Authors: Paul S Echlin, Ross EG Upshur, Douglas B McKeag and Harsha P Jayatilake

Relationship between CRP and hypofibrinolysis: Is this a possible mechanism to explain the association between CRP and outcome in critically ill patients?

Endothelial cell dysfunction may be implicated in the development of multiple organ failure (MOF) by a number of mechanisms. Among these, altered fibrinolysis promotes fibrin deposition, which may create micro...

Authors: Karim Zouaoui Boudjeltia, Michael Piagnerelli, Dany Brohée, Michel Guillaume, Philippe Cauchie, Jean-Louis Vincent, Claude Remacle, Yves Bouckaert and Michel Vanhaeverbeek

Nadroparine calcium or enoxaparine in acute coronary syndrome patients suffering renal insufficiency: The nadroparin versus enoxaparin (NaVe) study design

In the general population, mild renal impairment is associated with increases risk for coronary artery disease and stroke, suggesting that cardiovascular disease begins to develop early in the natural history ...

Authors: Enrique P Gurfinkel, Cecilia Perel and Gonzalo Pombo

MRI of coronary artery atherosclerosis in rabbits: Histopathology-MRI correlation and atheroma characterization

We report in vivo magnetic resonance imaging (MRI) characteristics and histopathology correlation of the thrombus formation in atherosclerosis the rabbit animal model.

Authors: Rakesh Sharma and Ram B Singh

Decreased soluble cell adhesion molecules after tirofiban infusion in patients with unstable angina pectoris

The inflammatory response, initiated by neutrophil and monocyte adhesion to endothelial cells, is important in the pathogenesis of acute coronary syndromes. Platelets play an important role in inflammatory pro...

Authors: Ertugrul Ercan, Huseyin Bozdemir, Istemihan Tengiz, Cevad Sekuri, Emil Aliyev, Azem Akilli and Mustafa Akin

Use of venous thromboprophylaxis and adherence to guideline recommendations: a cross-sectional study

Consensus Conferences and Guidelines for deep vein thrombosis prophylaxis have been published, which recommend the use of prophylactic heparins in patients with risk of venous thromboembolism (VTE). The aim of...

Authors: Antonio Vallano, Josep Maria Arnau, Gaietà Permanyer Miralda and Jaume Pérez-Bartolí

Cardiac thrombi in a patient with protein-C and S deficiencies: a case report

Authors: Ertugrul Ercan, Istemihan Tengiz, Cevad Sekuri, Fahri Sahin, Emil Aliyev, Mustafa Akin and Unal Acıkel

The antithrombotic profile of aspirin. Aspirin resistance, or simply failure?

Authors: Raul Altman, Héctor L Luciardi, Juan Muntaner and Ramón N Herrera

Multivariate relationships between international normalized ratio and vitamin K-dependent coagulation-derived parameters in normal healthy donors and oral anticoagulant therapy patients

International Normalized Ratio (INR) is a world-wide routinely used factor in the monitoring of oral anticoagulation treatment (OAT). However, it was reported that other factors, e. g. factor II, may even bett...

Authors: Cezary Watala, Jacek Golanski and Przemyslaw Kardas

Induction of Tissue Factor Expression in Endothelial Cells by Basic Fibroblast Growth Factor and its Modulation by Fenofibric acid

Tissue factor (TF), expressed in endothelial cells (ECs) and enriched in human atherosclerotic lesions, acts as a critical initiator of blood coagulation in acute coronary syndrome. Basic fibroblast growth fac...

Authors: Takeaki Kaneko, Satoshi Fujii, Akio Matsumoto, Daisuke Goto, Naomasa Makita, Junichi Hamada, Tetsuya Moriuchi and Akira Kitabatake

Angiotensin Converting Enzyme and Angiotensin II Type 1 Receptor Polymorphisms in Patients with Coronary Aneurysms

Conflicting results have been reported regarding the association of gene polymorphisms in the renin-angiotensin system (RAS) with different aspects of coronary artery disease (CAD), such as myocardial infarcti...

Authors: Nicolas Lamblin, Xavier Hermant, Jean-Marc Lablanche, Nicole Helbecque, Philippe Amouyel and Christophe Bauters

Risk factors in coronary atherosclerosis athero-inflammation: the meeting point

Authors: Raul Altman

Thrombin generation during cardiopulmonary bypass: the possible role of retransfusion of blood aspirated from the surgical field

In spite of using heparin-coated extracorporeal circuits, cardiopulmonary bypass (CPB) is still associated with an extensive thrombin generation, which is only partially suppressed by the use of high dosages o...

Authors: Patrick W Weerwind, Theo Lindhout, Nicole EH Caberg and Dick S de Jong

Acute coronary disease Athero-Inflammation: Therapeutic approach

Antithrombotic therapy is the cornerstone of the treatment of acute coronary syndromes, but there is now evidence which indicates that by blocking inflammation, thrombosis and thus, acute coronary events, coul...

Authors: Raul Altman

Point-of-Care Testing of Hemostasis in Cardiac Surgery

An excessive perioperative blood loss, that requires transfusion of blood products, sometimes occurs in patients undergoing cardiopulmonary bypass for cardiac surgery. Blood loss and transfusion requirements i...

Authors: Domenico Prisco and Rita Paniccia