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  1. Anticoagulation with warfarin should be stopped 4–6 days before invasive procedures to avoid bleeding complications. Despite this routine, some patients still have high International Normalized Ratio (INR) val...

    Authors: Sam Schulman, Rajae Elbazi, Michelle Zondag and Martin O'Donnell
    Citation: Thrombosis Journal 2008 6:15
    Content type: Original clinical investigation Published on:

  2. Increase in tissue factor (TF) and loss in thrombomodulin (TM) antigen levels has been described in various inflammatory disorders. The functional consequences of such changes in antigen concentrations in the ...

    Authors: Kim Frederix, Ingeborg M Kooter, René van Oerle, Diane Fens, Karly Hamulyak, Miriam E Gerlofs-Nijland, Hugo ten Cate and Henri MH Spronk
    Citation: Thrombosis Journal 2008 6:14
    Content type: Original basic research Published on:

  4. To analyse the effects of rosiglitazone administered at different times on neointimal formation in hypercholesterolemic rabbits following vascular injury.

    Authors: Alexandre Alessi, Olímpio Ribeiro França Neto, Paulo Roberto Slud Brofman, Camila Prim, Lucia Noronha, Ruy Fernando Kuenzer Caetano Silva, Liz Andréa Villela Baroncini and Dalton Bertolim Précoma
    Citation: Thrombosis Journal 2008 6:12
    Content type: Original basic research Published on:

  5. Although cigarette smoking is a well-established risk factor for vascular disease, the genetic mechanisms that link cigarette smoking to an increased incidence of stroke are not well understood. Genetic variat...

    Authors: John W Cole, David W Brown, Wayne H Giles, Oscar C Stine, Jeffrey R O'Connell, Braxton D Mitchell, John D Sorkin, Marcella A Wozniak, Barney J Stern, Mary J Sparks, Mark T Dobbins, Latasha T Shoffner, Nancy K Zappala, Laurie J Reinhart and Steven J Kittner
    Citation: Thrombosis Journal 2008 6:11
    Content type: Original clinical investigation Published on:

  6. Venous thromboembolism (VTE) and thromboembolic arterial diseases are usually considered to be distinct entities, but there is evidence to suggest that these disorders may be linked. The aim of this study was ...

    Authors: Consuelo Huerta, Saga Johansson, Mari-Ann Wallander and Luis AGarcía Rodríguez
    Citation: Thrombosis Journal 2008 6:10
    Content type: Original clinical investigation Published on:

  7. Heparin-induced thrombocytopenia type II (HIT II) is a rare immune-mediated complication of heparin. The diagnosis of HIT is considered in patients exposed to heparin, presenting with thrombocytopenia and thro...

    Authors: Eva Serasli, Maria Antoniadou, Venetia Tsara, Vassilis Kalpakidis, Angelos Megalopoulos, George Trellopoulos, Georgia Papaioannou and Pandora Christaki
    Citation: Thrombosis Journal 2008 6:9
    Content type: Case report Published on:

  8. Neck of femur fractures predispose patients to venous thromboembolism (VTE). NICE has issued guideline 46 to reduce this risk through the use of antithrombic agents. We audited our department's VTE practise by...

    Authors: Radwane Faroug, Shireesha Konnuru, San S Min, Fazleenah Hussain and George Ampat
    Citation: Thrombosis Journal 2008 6:8
    Content type: Original clinical investigation Published on:

  9. Warfarin treatment has a narrow therapeutic range, requiring meticulous monitoring and dosage titration. Individual dosage requirement has recently partly been explained by genetic variation of the warfarin me...

    Authors: Kari BenteFoss Haug, Mohammad N Sharikabad, Marianne K Kringen, Sigrid Narum, Stine T Sjaatil, Per Wiik Johansen, Peter Kierulf, Ingebjørg Seljeflot, Harald Arnesen and Odd Brørs
    Citation: Thrombosis Journal 2008 6:7
    Content type: Original clinical investigation Published on:

  10. Atrial fibrillation affects an estimated 2.5 million Americans and incurs an average annual stroke risk of 4.5% per year. Despite warfarin reducing stroke risk by approximately 66%, prior studies show warfarin...

    Authors: Ajay Srivastava, Michael Hudson, Ihab Hamoud, Joao Cavalcante, Chetan Pai and Scott Kaatz
    Citation: Thrombosis Journal 2008 6:6
    Content type: Original clinical investigation Published on:

  11. The relationship of D-dimer and deep-vein thrombosis (DVT) after total knee arthroplasty (TKA) remains controversial. The purpose of this study was to assess the value of D-dimer in the detection of early DVT ...

    Authors: Chung-Jen Chen, Ching-Jen Wang and Chung-Cheng Huang
    Citation: Thrombosis Journal 2008 6:5
    Content type: Original clinical investigation Published on:

  12. The objective was to evaluate the effects of rosiglitazone on iliac arteries of hypercholesterolemic rabbits undergoing balloon catheter injury in the contralateral iliac arteries.

    Authors: Olímpio Ribeiro França Neto, Dalton Bertolim Precoma, Alexandre Alessi, Camila Prim, Ruy FernandoKuenzerCaetano da Silva, Lucia de Noronha and Liz AndréaVillela Baroncini
    Citation: Thrombosis Journal 2008 6:4
    Content type: Original basic research Published on:

  15. To test the hypothesis that point-of-care assays of platelet reactivity would demonstrate reduced response to antiplatelet therapy in patients who experienced Drug Eluting Stent (DES) ST whilst on dual antipla...

    Authors: Alex R Hobson, Graham Petley, Geraint Morton, Keith D Dawkins and Nick P Curzen
    Citation: Thrombosis Journal 2008 6:1
    Content type: Original clinical investigation Published on:

  17. To prospectively determine the role of platelet glycoprotein IIIa (GP IIIa) gene PlA1/PlA2 polymorphism on the long-term clinical outcome in patients with coronary artery disease undergoing coronary stenting.

    Authors: Claire Le Hello, Rémy Morello, Agnès Lequerrec, Christine Duarte, John Riddell and Martial Hamon
    Citation: Thrombosis Journal 2007 5:19
    Content type: Original clinical investigation Published on:

  19. The true relationship between methylenetetrahydrofolate reductase C677T homozygosity and risk of recurrent spontaneous abortion is unknown, and it is unclear if women with these mutations should be anticoagula...

    Authors: Ivy Altomare, Alan Adler and Louis M Aledort
    Citation: Thrombosis Journal 2007 5:17
    Content type: Original clinical investigation Published on:

  20. Influenza infections have been associated with procoagulant changes. Whether influenza infections lead to an increased risk of pulmonary embolism remains to be established.

    Authors: Matthijs van Wissen, Tymen T Keller, Brechje Ronkes, Victor EA Gerdes, Hans L Zaaijer, Eric CM van Gorp, Dees PM Brandjes, Marcel Levi and Harry R Büller
    Citation: Thrombosis Journal 2007 5:16
    Content type: Original clinical investigation Published on:

  22. Although a number of studies have demonstrated the influence of ABO blood group on plasma levels of von Willebrand factor (VWF), the nature of this association and its clinical importance is still largely unkn...

    Authors: Massimo Franchini, Franco Capra, Giovanni Targher, Martina Montagnana and Giuseppe Lippi
    Citation: Thrombosis Journal 2007 5:14
    Content type: Review Published on:

  23. During gram-negative sepsis, lipopolysaccharide (LPS) induces tissue factor expression on monocytes. The resulting disseminated intravascular coagulation leads to tissue ischemia and worsens the prognosis of s...

    Authors: Christoph Sucker, Kai Zacharowski, Matthias Thielmann and Matthias Hartmann
    Citation: Thrombosis Journal 2007 5:13
    Content type: Original clinical investigation Published on:

  24. Oral anticoagulation compromises conventional lupus anticoagulant (LA) screening assays. Mixing studies can counteract the oral anticoagulant effect but the dilution reduces sensitivity and can generate false ...

    Authors: Gary W Moore
    Citation: Thrombosis Journal 2007 5:12
    Content type: Original basic research Published on:

  26. Hyperhomocysteinemia has been described as a risk factor for unexplained recurrent pregnancy loss. Increased levels of homocysteine may be due to inadequate dietary intake of folate and vitamin B12 and inherit...

    Authors: Maristella D'Uva, Pierpaolo Di Micco, Ida Strina, Carlo Alviggi, Mariateresa Iannuzzo, Antonio Ranieri, Antonio Mollo and Giuseppe De Placido
    Citation: Thrombosis Journal 2007 5:10
    Content type: Original clinical investigation Published on:

  29. Increased platelet reactivity has been implicated in cardiovascular disease – the major cause of death in patients with end stage renal disease (ESRD). FcGammaRIIA is a component of glycoprotein VI and Ib-IX-V...

    Authors: Feliciano A Serrano, Mohamed El-Shahawy, Richard J Solomon, Burton E Sobel and David J Schneider
    Citation: Thrombosis Journal 2007 5:7
    Content type: Original clinical investigation Published on:

  31. Gender-related differences in incidence of arterial thrombosis have been a focus of interest for years. The platelet integrin αIIbβ3 is primarily responsible for the interaction between platelets and fibrinoge...

    Authors: Robert Loncar, Reiner B Zotz, Christoph Sucker, Aleksandar Vodovnik, Mario Mihalj and Rüdiger E Scharf
    Citation: Thrombosis Journal 2007 5:5
    Content type: Original basic research Published on:

  33. Monitoring of antiplatelet therapy in patients at cardiovascular risk is difficult because existing platelet function tests are too sophisticated for clinical routine. The whole blood TEG® Platelet Mapping™ assay...

    Authors: Louise Bochsen, Bo Wiinberg, Mads Kjelgaard-Hansen, Daniel A Steinbrüchel and Pär I Johansson
    Citation: Thrombosis Journal 2007 5:3
    Content type: Original clinical investigation Published on:

  34. Platelet adhesion and subsequent thrombus formation on a subendothelial matrix at the site of vascular damage play a crucial role in the arrest of posttraumatic bleeding but also in different pathological thro...

    Authors: Robert Loncar, Volker Stoldt, Sabine Hellmig, Rainer B Zotz, Mario Mihalj and Rüdiger E Scharf
    Citation: Thrombosis Journal 2007 5:2
    Content type: Original basic research Published on:

  35. Recommendations for urgent reversal of oral anticoagulation with vitamin K1 antagonists are largely derived from case series employing empirical dosing regimens with vitamin K1 and prothrombin complex concentrate...

    Authors: Marzia Angelo, Bernhard Gutmann, Michele Adami, Bernd Zagler, Anton Zelger, Christoph Pechlaner and Christian J Wiedermann
    Citation: Thrombosis Journal 2007 5:1
    Content type: Case report Published on:

  36. Benign Intracranial Hypertension (BIH) may be caused, at least in part, by intracranial sinus thrombosis. Thrombosis is normally due to derangements in blood coagulation cascade which may predispose to abnorma...

    Authors: Domenico De Lucia, Marisanta Napolitano, Pierpaolo Di Micco, Alferio Niglio, Andrea Fontanella and Giuseppe Di lorio
    Citation: Thrombosis Journal 2006 4:21
    Content type: Original clinical investigation Published on:

  37. Thrombosis of the ovarian vein is a rare complication which arises classically in the postpartum. We report a case of 24-year-old woman with a history of Behçet's disease, who presented with pelvic and thoraci...

    Authors: Sonia Hammami, Mondher Golli, Faouzi Addad, Chiraz Hafsa, Amira Hamzaoui, Silvia Mahjoub and Amor Gannouni
    Citation: Thrombosis Journal 2006 4:20
    Content type: Case report Published on:

  38. Adhesion of platelets onto immobilized fibrinogen is of importance in initiation and development of thrombosis. According to a recent increase in evidence of a multiple biological property of antithrombin, we ...

    Authors: Robert Loncar, Uwe Kalina, Volker Stoldt, Volker Thomas, Rüdiger E Scharf and Aleksandar Vodovnik
    Citation: Thrombosis Journal 2006 4:19
    Content type: Original basic research Published on:

  39. Platelet-rich plasma (PRP) is an autologous substance with adhesive properties. We aimed at developing and testing the efficacy of a method for PRP preparation in rabbits.

    Authors: Federico Luengo Gimeno, Silvia Gatto, José Ferro, Juan Oscar Croxatto and Juan Eduardo Gallo
    Citation: Thrombosis Journal 2006 4:18
    Content type: Original basic research Published on:

  40. Clinical trials have shown low-molecular weight heparin (LMWH) to be at least as safe and efficacious as unfractionated heparin (UFH) for preventing venous thromboembolism (VTE) in acutely-ill medical inpatients.

    Authors: Lisa J McGarry, Michael E Stokes and David Thompson
    Citation: Thrombosis Journal 2006 4:17
    Content type: Original clinical investigation Published on:

  41. Hyperhomocysteinemia is an important and independent risk factor for vascular disease. About 35% of patients with stroke and 47% of patients with peripheral arterial disease have elevated plasma homocysteine (...

    Authors: Robert Loncar, Barbara T Müller, Reiner B Zotz, Christof Sucker, Wilhelm Sandmann and Rüdiger E Scharf
    Citation: Thrombosis Journal 2006 4:16
    Content type: Original clinical investigation Published on:

  42. Thrombophilia can be defined as a predisposition to form clots inappropriately. Thrombotic events during infancy and childhood are increasingly recognized as a significant source of mortality and morbidity. Th...

    Authors: Salwa Khan and Joseph D Dickerman
    Citation: Thrombosis Journal 2006 4:15
    Content type: Review Published on:

  43. Thrombolytic drugs are widely used for the management of cerebral venous sinus thrombosis patients. Several in vitro models have been developed to study clot lytic activity of thrombolytic drugs, but all of th...

    Authors: Sweta Prasad, Rajpal S Kashyap, Jayant Y Deopujari, Hemant J Purohit, Girdhar M Taori and Hatim F Daginawala
    Citation: Thrombosis Journal 2006 4:14
    Content type: Original basic research Published on:

  44. The clinical response of sepsis to a systemic inflammatory infection may be complicated by disseminated intravascular coagulation or DIC. In order to experimentally study the syndrome of DIC, we aimed for a se...

    Authors: Sjoukje H Slofstra, Hugo ten Cate and C Arnold Spek
    Citation: Thrombosis Journal 2006 4:13
    Content type: Original basic research Published on:

  45. Soluble fibrin (sFn) is a marker for disseminated intravascular coagulation and may have prognostic significance, especially in metastasis. However, a role for sFn in the etiology of metastatic cancer growth h...

    Authors: John P Biggerstaff, Brandy Weidow, Jacqueline Vidosh, Judith Dexheimer, Shonak Patel and Pretesh Patel
    Citation: Thrombosis Journal 2006 4:12
    Content type: Original basic research Published on:

  46. An increased incidence of deep venous thrombosis (DVT) has been described in multiple myeloma (MM). A recently described mechanism of hypercoagulability in cancer patients including MM patients is acquired act...

    Authors: Jiménez-Zepeda Víctor Hugo and Domínguez-Martínez Virginia Jeanet
    Citation: Thrombosis Journal 2006 4:11
    Content type: Original clinical investigation Published on:

  47. There are controversial evidences on the effect of different types and workloads of physical exercise on primary hemostasis. In particular, little is known on the chronic influence of a strenuous and regular a...

    Authors: Giuseppe Lippi, Martina Montagnana, Gian Luca Salvagno, Massimo Franchini and Gian Cesare Guidi
    Citation: Thrombosis Journal 2006 4:10
    Content type: Original clinical investigation Published on:

  48. Previous studies have suggested that exercise in patients with intermittent claudication (IC) may induce a systemic thrombo-inflammatory response. The effect of secondary prevention therapy on this response is...

    Authors: Patrick Collins, Isobel Ford, Bernard Croal, Derek Ball, Michael Greaves, Ewan Macaulay and Julie Brittenden
    Citation: Thrombosis Journal 2006 4:9
    Content type: Original clinical investigation Published on:

  50. Disseminated intravascular coagulation (DIC) is a pathological disturbance of the complex balance between coagulation and anticoagulation that is precipitated by vascular injury, acidosis, endotoxin release an...

    Authors: Rachel Davis-Jackson, Hernan Correa, Ronald Horswell, Halina Sadowska-Krowicka, Kathleen McDonough, Chittaranjan Debata, Renee' Gardner and Duna Penn
    Citation: Thrombosis Journal 2006 4:7
    Content type: Original basic research Published on:
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