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  1. Content type: Review

    Direct oral anticoagulants (DOACs) have been licensed worldwide for several years for various indications. Each year, 10–15% of patients on oral anticoagulants will undergo an invasive procedure and expert gro...

    Authors: Virginie Dubois, Anne-Sophie Dincq, Jonathan Douxfils, Brigitte Ickx, Charles-Marc Samama, Jean-Michel Dogné, Maximilien Gourdin, Bernard Chatelain, François Mullier and Sarah Lessire

    Citation: Thrombosis Journal 2017 15:14

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  2. Content type: Review

    Recently, the European Medicines Agency (EMA) authorized the introduction and marketing of Thorinane® and Inhixa®, biosimilars of the Low Molecular Weight Heparin (LMWH) enoxaparin. The authorization path is c...

    Authors: Davide Imberti, Marco Marietta, Hernan Polo Friz and Claudio Cimminiello

    Citation: Thrombosis Journal 2017 15:13

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  3. Content type: Research

    The transmembrane receptor molecule CD31 is known to have immunomodulatory functions, suggesting a possible neuroprotective effect in the context of acute ischemic stroke by restricting an over-activation of s...

    Authors: Tobias Boeckh-Behrens, Justus Kleine, Johannes Kaesmacher, Claus Zimmer, Lucas Schirmer, Sophie Simon and Holger Poppert

    Citation: Thrombosis Journal 2017 15:11

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  4. Content type: Research

    Blood coagulation plays a crucial role in the blastocyst implantation process and its alteration may be related to in vitro fertilization (IVF) failure. We conducted a prospective observational longitudinal st...

    Authors: Grigoris T. Gerotziafas, Patrick Van Dreden, Emmanuelle Mathieu d’Argent, Eleftheria Lefkou, Matthieu Grusse, Marjorie Comtet, Rabiatou Sangare, Hela Ketatni, Annette K. Larsen and Ismail Elalamy

    Citation: Thrombosis Journal 2017 15:9

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  5. Content type: Case report

    Because the venous thromboembolisms (VTEs) due to the coagulation factor V R506Q (FV Leiden) mutation is often seen in Caucasians, the VTE onset in Japan has not been reported.

    Authors: Daisuke Sueta, Miwa Ito, Mitsuhiro Uchiba, Kenji Sakamoto, Eiichiro Yamamoto, Yasuhiro Izumiya, Sunao Kojima, Koichi Kaikita, Satoru Shinriki, Seiji Hokimoto, Hirotaka Matsui and Kenichi Tsujita

    Citation: Thrombosis Journal 2017 15:8

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  6. Content type: Research

    An increasing number of patients are treated with direct-acting oral anticoagulants (DOACs), but the optimal way to reverse the anticoagulant effect is not known. Specific antidotes are not available and proth...

    Authors: Nina Haagenrud Schultz, Hoa Thi Tuyet Tran, Stine Bjørnsen, Carola Elisabeth Henriksson, Per Morten Sandset and Pål Andre Holme

    Citation: Thrombosis Journal 2017 15:6

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  7. Content type: Research

    Platelets from untreated periodontitis patients are hyper-reactive and form more platelet-leukocyte complexes compared to cells from individuals without periodontitis. It is not known whether the improvement o...

    Authors: Efthymios Arvanitidis, Sergio Bizzarro, Elena Alvarez Rodriguez, Bruno G. Loos and Elena A. Nicu

    Citation: Thrombosis Journal 2017 15:5

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  8. Content type: Case report

    Although vein stenting is popular for treatment for venous thromboembolism due to mechanical compression, some cases are forced to avoid inserting align agents because of immunodeficiency.

    Authors: Naoya Nakashima, Daisuke Sueta, Yusuke Kanemaru, Seiji Takashio, Eiichiro Yamamoto, Shinsuke Hanatani, Hisanori Kanazawa, Yasuhiro Izumiya, Sunao Kojima, Koichi Kaikita, Seiji Hokimoto and Kenichi Tsujita

    Citation: Thrombosis Journal 2017 15:4

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  9. Content type: Research

    Strenuous exercise may trigger myocardial infarction through increased pro-coagulant activity. We aimed to investigate whether patients referred for exercise testing, who were found to have angiographically ve...

    Authors: Joanna Cwikiel, Ingebjorg Seljeflot, Eivind Berge, Harald Arnesen, Kristian Wachtell, Hilde Ulsaker and Arnljot Flaa

    Citation: Thrombosis Journal 2017 15:3

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  10. Content type: Research

    Patients undergoing major abdominal surgery are at high risk for developing venous thromboembolism in the post-operative period. Current evidence-based guidelines recommend routine pharmacological venous throm...

    Authors: Bader Al Rawahi, Grégoire Le Gal, Rebecca Auer and Marc Carrier

    Citation: Thrombosis Journal 2017 15:2

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  11. Content type: Research

    Genome-wide association study (GWAS) has reported that rs6903956 within the first intron of androgen-dependent tissue factor pathway inhibitor (TFPI) regulating protein (ADTRP) gene is associated with coronary ar...

    Authors: Xuling Chang, Hui-Lin Chin, Swee-Chye Quek, Daniel Y. T. Goh, Rajkumar Dorajoo, Yechiel Friedlander and Chew-Kiat Heng

    Citation: Thrombosis Journal 2017 15:1

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  12. Content type: Research

    The objective of this analysis was to assess the effects of edoxaban compared with enoxaparin on key coagulation biomarkers and present pooled primary efficacy and safety results from phase 3 STARS E-3 and STA...

    Authors: Yohko Kawai, Takeshi Fuji, Satoru Fujita, Tetsuya Kimura, Kei Ibusuki, Kenji Abe and Shintaro Tachibana

    Citation: Thrombosis Journal 2016 14:48

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  13. Content type: Research

    Thrombolytic therapy is effective in selected patients with deep vein thrombosis (DVT). Therefore, identification of a marker that reflects the age of thrombus is of particular concern. This pilot study aimed ...

    Authors: Eiji Furukoji, Toshihiro Gi, Atsushi Yamashita, Sayaka Moriguchi-Goto, Mio Kojima, Chihiro Sugita, Tatefumi Sakae, Yuichiro Sato, Toshinori Hirai and Yujiro Asada

    Citation: Thrombosis Journal 2016 14:46

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  14. Content type: Research

    Besides maintaining intracellular glutathione stores, gamma-glutamyltransferase(GGT) generates reactive oxygen species and activates NFkB, a redox-sensitive transcription factor key in the induction of Tissue ...

    Authors: Valentina Scalise, Cristina Balia, Silvana Cianchetti, Tommaso Neri, Vittoria Carnicelli, Riccardo Zucchi, Maria Franzini, Alessandro Corti, Aldo Paolicchi, Alessandro Celi and Roberto Pedrinelli

    Citation: Thrombosis Journal 2016 14:45

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  15. Content type: Research

    Heritable thrombophilias are assumed important etiologies for recurrent pregnancy loss. Unlike in the Caucasian populations, protein S and protein C deficiencies, instead of Factor V Lieden and Prothrombin mut...

    Authors: Ming-Ching Shen, Wan-Ju Wu, Po-Jen Cheng, Gwo-Chin Ma, Wen-Chu Li, Jui-Der Liou, Cheng-Shyong Chang, Wen-Hsiang Lin and Ming Chen

    Citation: Thrombosis Journal 2016 14:44

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  16. Content type: Review

    Platelets are central mediators of thrombosis and hemostasis. At the site of vascular injury, platelet accumulation (i.e. adhesion and aggregation) constitutes the first wave of hemostasis. Blood coagulation, ...

    Authors: Xiaohong Ruby Xu, Naadiya Carrim, Miguel Antonio Dias Neves, Thomas McKeown, Tyler W. Stratton, Rodrigo Matos Pinto Coelho, Xi Lei, Pingguo Chen, Jianhua Xu, Xiangrong Dai, Benjamin Xiaoyi Li and Heyu Ni

    Citation: Thrombosis Journal 2016 14(Suppl 1):29

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    This article is part of a Supplement: Volume 14 Supplement 1

  17. Content type: Review

    Venous thromboembolism (VTE), which constitutes pulmonary embolism and deep vein thrombosis, is a common disorder associated with significant morbidity and mortality. Landmark trials have shown that direct ora...

    Authors: Siavash Piran and Sam Schulman

    Citation: Thrombosis Journal 2016 14(Suppl 1):23

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    This article is part of a Supplement: Volume 14 Supplement 1

  18. Content type: Review

    Platelets play a key role in the pathophysiological processes of hemostasis and thrombus formation. However, platelet functions beyond thrombosis and hemostasis have been increasingly identified in recent year...

    Authors: Yukio Ozaki, Shogo Tamura and Katsue Suzuki-Inoue

    Citation: Thrombosis Journal 2016 14(Suppl 1):27

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    This article is part of a Supplement: Volume 14 Supplement 1

  19. Content type: Review

    Snake venoms affect blood coagulation and platelet function in a complex manner. However, two classes of venom proteins, snaclecs and disintegrins have been shown to specifically target receptors including GPI...

    Authors: Tur-Fu Huang, Chun-Chieh Hsu and Yu-Ju Kuo

    Citation: Thrombosis Journal 2016 14(Suppl 1):18

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    This article is part of a Supplement: Volume 14 Supplement 1

  20. Content type: Research

    Thrombosis and coagulopathy are the commonest hematological manifestations of envenomation of Russell’s viper venom (RVV). Factor X is activated by a factor X-activating enzyme from Russell’s viper venom (RVV-...

    Authors: Ren-Chieh Wu, Ping-Tse Chou and Li-Kuang Chen

    Citation: Thrombosis Journal 2016 14(Suppl 1):38

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    This article is part of a Supplement: Volume 14 Supplement 1

  21. Content type: Review

    Hemophilia is the most well-known hereditary bleeding disorder, with an incidence of one in every 5000 to 30,000 males worldwide. The disease is treated by infusion of protein products on demand and as prophyl...

    Authors: Ching-Tzu Yen, Meng-Ni Fan, Yung-Li Yang, Sheng-Chieh Chou, I-Shing Yu and Shu-Wha Lin

    Citation: Thrombosis Journal 2016 14(Suppl 1):22

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    This article is part of a Supplement: Volume 14 Supplement 1

  22. Content type: Review

    The antiphospholipid syndrome (APS) is an autoimmune disease characterised by a procoagulant state that predisposes to recurrent thrombosis and miscarriages. Two major discoveries have advanced our understandi...

    Authors: Fatima El-Assaad, Steven A. Krilis and Bill Giannakopoulos

    Citation: Thrombosis Journal 2016 14(Suppl 1):20

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    This article is part of a Supplement: Volume 14 Supplement 1

  23. Content type: Review

    Thrombosis is a common complication in cancer patients. Although the major inherited risk factors for thrombophilia are different between Asians and Caucasians, the main acquired risk factors that are associat...

    Authors: Pantep Angchaisuksiri

    Citation: Thrombosis Journal 2016 14(Suppl 1):26

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    This article is part of a Supplement: Volume 14 Supplement 1

  24. Content type: Review

    Venous thrombosis which mainly manifests as deep vein thrombosis of the leg or pulmonary embolism occurs in 1 per 1000 per year. It occurs due to interacting genetic, environmental and behavioral risk factors....

    Authors: F. R. Rosendaal

    Citation: Thrombosis Journal 2016 14(Suppl 1):24

    Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  25. Content type: Review

    Preimplantation genetic diagnosis (PGD) is a powerful tool to tackle the transmission of monogenic inherited disorders in families carrying the diseases from generation to generation. It currently remains a ch...

    Authors: Ming Chen, Shun-Ping Chang, Gwo-Chin Ma, Wen-Hsian Lin, Hsin-Fu Chen, Shee-Uan Chen, Horng-Der Tsai, Feng-Po Tsai and Ming-Ching Shen

    Citation: Thrombosis Journal 2016 14(Suppl 1):33

    Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  26. Content type: Review

    Atherosclerosis is one of the major causes of death. Data from animal experiments suggest that atherosclerosis involves an inflammatory process of the vascular wall under hyperlipidemia. Atherothrombosis can b...

    Authors: Satoshi Fujii, Tomonori Sugiura, Yasuaki Dohi and Nobuyuki Ohte

    Citation: Thrombosis Journal 2016 14(Suppl 1):21

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    This article is part of a Supplement: Volume 14 Supplement 1

  27. Content type: Research

    Von Willebrand disease (VWD) is not uncommon in Taiwan. In type 2 or type 3 VWD hemorrhagic symptoms are severer and laboratory data relatively more distinctive. De novo mutation and somatic mosaicism of type 2 V...

    Authors: Ming-Ching Shen, Ming Chen, Gwo-Chin Ma, Shun-Ping Chang, Ching-Yeh Lin, Bo-Do Lin and Han-Ni Hsieh

    Citation: Thrombosis Journal 2016 14(Suppl 1):36

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    This article is part of a Supplement: Volume 14 Supplement 1

  28. Content type: Review

    Current treatment of hemophilia A (HemA) patients with repeated infusions of factor VIII (FVIII; abbreviated as F8 in constructs) is costly, inconvenient, and incompletely effective. In addition, approximately 25...

    Authors: Carol H. Miao

    Citation: Thrombosis Journal 2016 14(Suppl 1):41

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    This article is part of a Supplement: Volume 14 Supplement 1

  29. Content type: Review

    Inhibitors are the most serious side effect of haemophilia treatment; they occur in 25–30 % of all patients with severe haemophilia A. Over the last 2 decades, conflicting data on the impact of clotting produc...

    Authors: H. Marijke van den Berg

    Citation: Thrombosis Journal 2016 14(Suppl 1):31

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    This article is part of a Supplement: Volume 14 Supplement 1

  30. Content type: Review

    Atypical hemolytic uremic syndrome (aHUS) is a rare genetic disorder caused by defective complement regulation resulting in thrombotic microangiopathy (TMA). Patients can present as children or adults. The syn...

    Authors: Yu-Min Shen

    Citation: Thrombosis Journal 2016 14(Suppl 1):19

    Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  31. Content type: Research

    Paroxysmal nocturnal hemoglobinuria (PNH) is a rare and acquired hematopoietic stem cell disease, with florid clinical presentations. Although this disease has been characterized in the western countries, its ...

    Authors: Wen-Chien Chou, Wei-Han Huang, Ming-Chung Wang, Chao-Sung Chang, Shih-Peng Yeh, Tzeon-Jye Chiou, Yeu-Chin Chen, Tseng-Hsi Lin and Ming-Ching Shen

    Citation: Thrombosis Journal 2016 14(Suppl 1):39

    Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  32. Content type: Review

    Prophylaxis is considered optimal care for hemophilia patients to prevent bleeding and to preserve joint function thereby improving quality of life (QoL). The evidence for prophylaxis is irrefutable and is the...

    Authors: Man-Chiu Poon and Adrienne Lee

    Citation: Thrombosis Journal 2016 14(Suppl 1):32

    Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  33. Content type: Review

    In recent years, genetic analyses of congenital deficiencies of three anticoagulant proteins, antithrombin, protein C (PC) and protein S (PS), in East Asian patients with venous thromboembolism (VTE) have grea...

    Authors: Toshiyuki Miyata, Keiko Maruyama, Fumiaki Banno and Reiko Neki

    Citation: Thrombosis Journal 2016 14(Suppl 1):25

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    This article is part of a Supplement: Volume 14 Supplement 1

  34. Content type: Review

    This review summarizes the evidence that collagen IV binding is physiologically important, and that the extravascular compartment of FIX is composed of type IV collagen. As we have previously demonstrated, 7 d...

    Authors: Darrel W. Stafford

    Citation: Thrombosis Journal 2016 14(Suppl 1):35

    Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  35. Content type: Review

    Multiple functions of platelets in various physiological and pathological conditions have prompted considerable attention on understanding how platelets are generated and activated. Of the adaptor proteins tha...

    Authors: Hui-Ju Tsai and Ching-Ping Tseng

    Citation: Thrombosis Journal 2016 14(Suppl 1):28

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    This article is part of a Supplement: Volume 14 Supplement 1

  36. Content type: Review

    Disseminated intravascular coagulation (DIC) is a serious disease that, in the presence of underlying disease, causes persistent, generalized, marked coagulation activation. Early treatment based on an appropr...

    Authors: Hidesaku Asakura, Hoyu Takahashi, Toshimasa Uchiyama, Yutaka Eguchi, Kohji Okamoto, Kazuo Kawasugi, Seiji Madoiwa and Hideo Wada

    Citation: Thrombosis Journal 2016 14:42

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  37. Content type: Research

    We tested the hypothesis that disseminated intravascular coagulation (DIC) during the early phase of post-cardiopulmonary resuscitation (CPR) is associated with systemic inflammatory response syndrome (SIRS), ...

    Authors: Takeshi Wada, Satoshi Gando, Yuichi Ono, Kunihiko Maekawa, Kenichi Katabami, Mineji Hayakawa and Atsushi Sawamura

    Citation: Thrombosis Journal 2016 14:43

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  38. Content type: Case report

    Aortic thrombosis is a rare disease and only a few cases of the disease, especially associated with chemotherapy for malignant diseases and/or blood diseases, have been previously reported. Although Virchow’s ...

    Authors: Tomonori Sugiura, Yasuaki Dohi, Sumiyo Yamashita, Shunsuke Murai and Nobuyuki Ohte

    Citation: Thrombosis Journal 2016 14:16

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  39. Content type: Review

    Vitamin K antagonists (VKAs) are effective oral anticoagulants that are titrated to a narrow therapeutic international normalized ratio (INR) range. We reviewed published literature assessing the impact of INR...

    Authors: Jeff R. Schein, C. Michael White, Winnie W. Nelson, Jeffrey Kluger, Elizabeth S. Mearns and Craig I. Coleman

    Citation: Thrombosis Journal 2016 14:14

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