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  1. Research

    Non enzymatic upregulation of tissue factor expression by gamma-glutamyl transferase in human peripheral blood mononuclear cells

    Besides maintaining intracellular glutathione stores, gamma-glutamyltransferase(GGT) generates reactive oxygen species and activates NFkB, a redox-sensitive transcription factor key in the induction of Tissue ...

    Valentina Scalise, Cristina Balia, Silvana Cianchetti, Tommaso Neri, Vittoria Carnicelli, Riccardo Zucchi, Maria Franzini, Alessandro Corti, Aldo Paolicchi, Alessandro Celi and Roberto Pedrinelli

    Thrombosis Journal 2016 14:45

    Published on: 4 November 2016

  2. Research

    Low-molecular-weight-heparin can benefit women with recurrent pregnancy loss and sole protein S deficiency: a historical control cohort study from Taiwan

    Heritable thrombophilias are assumed important etiologies for recurrent pregnancy loss. Unlike in the Caucasian populations, protein S and protein C deficiencies, instead of Factor V Lieden and Prothrombin mut...

    Ming-Ching Shen, Wan-Ju Wu, Po-Jen Cheng, Gwo-Chin Ma, Wen-Chu Li, Jui-Der Liou, Cheng-Shyong Chang, Wen-Hsiang Lin and Ming Chen

    Thrombosis Journal 2016 14:44

    Published on: 28 October 2016

  3. Review

    DOACs – advances and limitations in real world

    The group of new oral anticoagulants or NOACs, now termed direct oral anticoagulants or DOACs, with their favourable results from large scale phase III clinical trials, represent a major advancement and expand...

    Lai Heng Lee

    Thrombosis Journal 2016 14(Suppl 1):17

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  4. Review

    New horizon in platelet function: with special reference to a recently-found molecule, CLEC-2

    Platelets play a key role in the pathophysiological processes of hemostasis and thrombus formation. However, platelet functions beyond thrombosis and hemostasis have been increasingly identified in recent year...

    Yukio Ozaki, Shogo Tamura and Katsue Suzuki-Inoue

    Thrombosis Journal 2016 14(Suppl 1):27

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  5. Review

    Anti-thrombotic agents derived from snake venom proteins

    Snake venoms affect blood coagulation and platelet function in a complex manner. However, two classes of venom proteins, snaclecs and disintegrins have been shown to specifically target receptors including GPI...

    Tur-Fu Huang, Chun-Chieh Hsu and Yu-Ju Kuo

    Thrombosis Journal 2016 14(Suppl 1):18

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  6. Review

    Current animal models of hemophilia: the state of the art

    Hemophilia is the most well-known hereditary bleeding disorder, with an incidence of one in every 5000 to 30,000 males worldwide. The disease is treated by infusion of protein products on demand and as prophyl...

    Ching-Tzu Yen, Meng-Ni Fan, Yung-Li Yang, Sheng-Chieh Chou, I-Shing Yu and Shu-Wha Lin

    Thrombosis Journal 2016 14(Suppl 1):22

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  7. Review

    Posttranslational forms of beta 2-glycoprotein I in the pathogenesis of the antiphospholipid syndrome

    The antiphospholipid syndrome (APS) is an autoimmune disease characterised by a procoagulant state that predisposes to recurrent thrombosis and miscarriages. Two major discoveries have advanced our understandi...

    Fatima El-Assaad, Steven A. Krilis and Bill Giannakopoulos

    Thrombosis Journal 2016 14(Suppl 1):20

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  8. Review

    Cancer-associated thrombosis in Asia

    Thrombosis is a common complication in cancer patients. Although the major inherited risk factors for thrombophilia are different between Asians and Caucasians, the main acquired risk factors that are associat...

    Pantep Angchaisuksiri

    Thrombosis Journal 2016 14(Suppl 1):26

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  9. Review

    Causes of venous thrombosis

    Venous thrombosis which mainly manifests as deep vein thrombosis of the leg or pulmonary embolism occurs in 1 per 1000 per year. It occurs due to interacting genetic, environmental and behavioral risk factors....

    F. R. Rosendaal

    Thrombosis Journal 2016 14(Suppl 1):24

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  10. Review

    Aspects of prophylactic treatment of hemophilia

    Retrospective and prospective studies unambiguously show that prophylactic treatment of severe hemophilia A or B should be started as primary prophylaxis at 1–2 years’ of age and ideally before the first joint...

    Rolf Ljung

    Thrombosis Journal 2016 14(Suppl 1):30

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  11. Review

    Preimplantation genetic diagnosis of hemophilia A

    Preimplantation genetic diagnosis (PGD) is a powerful tool to tackle the transmission of monogenic inherited disorders in families carrying the diseases from generation to generation. It currently remains a ch...

    Ming Chen, Shun-Ping Chang, Gwo-Chin Ma, Wen-Hsian Lin, Hsin-Fu Chen, Shee-Uan Chen, Horng-Der Tsai, Feng-Po Tsai and Ming-Ching Shen

    Thrombosis Journal 2016 14(Suppl 1):33

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  12. Review

    MicroRNA in atherothromobosis: is it useful as a disease marker?

    Atherosclerosis is one of the major causes of death. Data from animal experiments suggest that atherosclerosis involves an inflammatory process of the vascular wall under hyperlipidemia. Atherothrombosis can b...

    Satoshi Fujii, Tomonori Sugiura, Yasuaki Dohi and Nobuyuki Ohte

    Thrombosis Journal 2016 14(Suppl 1):21

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  13. Research

    De novo mutation and somatic mosaicism of gene mutation in type 2A, 2B and 2M VWD

    Von Willebrand disease (VWD) is not uncommon in Taiwan. In type 2 or type 3 VWD hemorrhagic symptoms are severer and laboratory data relatively more distinctive. De novo mutation and somatic mosaicism of type 2 V...

    Ming-Ching Shen, Ming Chen, Gwo-Chin Ma, Shun-Ping Chang, Ching-Yeh Lin, Bo-Do Lin and Han-Ni Hsieh

    Thrombosis Journal 2016 14(Suppl 1):36

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  14. Review

    Clinical evaluation of thrombotic microangiopathy: identification of patients with suspected atypical hemolytic uremic syndrome

    Atypical hemolytic uremic syndrome (aHUS) is a rare genetic disorder caused by defective complement regulation resulting in thrombotic microangiopathy (TMA). Patients can present as children or adults. The syn...

    Yu-Min Shen

    Thrombosis Journal 2016 14(Suppl 1):19

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  15. Research

    Characteristics of Taiwanese patients of PNH in the international PNH registry

    Paroxysmal nocturnal hemoglobinuria (PNH) is a rare and acquired hematopoietic stem cell disease, with florid clinical presentations. Although this disease has been characterized in the western countries, its ...

    Wen-Chien Chou, Wei-Han Huang, Ming-Chung Wang, Chao-Sung Chang, Shih-Peng Yeh, Tzeon-Jye Chiou, Yeu-Chin Chen, Tseng-Hsi Lin and Ming-Ching Shen

    Thrombosis Journal 2016 14(Suppl 1):39

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  16. Review

    Individualized prophylaxis for optimizing hemophilia care: can we apply this to both developed and developing nations?

    Prophylaxis is considered optimal care for hemophilia patients to prevent bleeding and to preserve joint function thereby improving quality of life (QoL). The evidence for prophylaxis is irrefutable and is the...

    Man-Chiu Poon and Adrienne Lee

    Thrombosis Journal 2016 14(Suppl 1):32

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  17. Review

    Thrombophilia in East Asian countries: are there any genetic differences in these countries?

    In recent years, genetic analyses of congenital deficiencies of three anticoagulant proteins, antithrombin, protein C (PC) and protein S (PS), in East Asian patients with venous thromboembolism (VTE) have grea...

    Toshiyuki Miyata, Keiko Maruyama, Fumiaki Banno and Reiko Neki

    Thrombosis Journal 2016 14(Suppl 1):25

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  18. Review

    Extravascular FIX and coagulation

    This review summarizes the evidence that collagen IV binding is physiologically important, and that the extravascular compartment of FIX is composed of type IV collagen. As we have previously demonstrated, 7 d...

    Darrel W. Stafford

    Thrombosis Journal 2016 14(Suppl 1):35

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

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