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Research
Besides maintaining intracellular glutathione stores, gamma-glutamyltransferase(GGT) generates reactive oxygen species and activates NFkB, a redox-sensitive transcription factor key in the induction of Tissue ...
Thrombosis Journal 2016 14:45
Published on: 4 November 2016
Research
Heritable thrombophilias are assumed important etiologies for recurrent pregnancy loss. Unlike in the Caucasian populations, protein S and protein C deficiencies, instead of Factor V Lieden and Prothrombin mut...
Thrombosis Journal 2016 14:44
Published on: 28 October 2016
Review
The group of new oral anticoagulants or NOACs, now termed direct oral anticoagulants or DOACs, with their favourable results from large scale phase III clinical trials, represent a major advancement and expand...
Thrombosis Journal 2016 14(Suppl 1):17
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
Review
Platelets play a key role in the pathophysiological processes of hemostasis and thrombus formation. However, platelet functions beyond thrombosis and hemostasis have been increasingly identified in recent year...
Thrombosis Journal 2016 14(Suppl 1):27
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
Review
Snake venoms affect blood coagulation and platelet function in a complex manner. However, two classes of venom proteins, snaclecs and disintegrins have been shown to specifically target receptors including GPI...
Thrombosis Journal 2016 14(Suppl 1):18
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
Research
Thrombosis and coagulopathy are the commonest hematological manifestations of envenomation of Russell’s viper venom (RVV). Factor X is activated by a factor X-activating enzyme from Russell’s viper venom (RVV-...
Thrombosis Journal 2016 14(Suppl 1):38
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
Review
Hemophilia is the most well-known hereditary bleeding disorder, with an incidence of one in every 5000 to 30,000 males worldwide. The disease is treated by infusion of protein products on demand and as prophyl...
Thrombosis Journal 2016 14(Suppl 1):22
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
Review
The antiphospholipid syndrome (APS) is an autoimmune disease characterised by a procoagulant state that predisposes to recurrent thrombosis and miscarriages. Two major discoveries have advanced our understandi...
Thrombosis Journal 2016 14(Suppl 1):20
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
Review
Thrombopoietin was posited to exist in 1958 and cloned in 1994, and in the ensuing two decades we have learned a great deal about the physiology and pathology of the primary regulator of thrombopoiesis. This p...
Thrombosis Journal 2016 14(Suppl 1):40
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
Review
Thrombosis is a common complication in cancer patients. Although the major inherited risk factors for thrombophilia are different between Asians and Caucasians, the main acquired risk factors that are associat...
Thrombosis Journal 2016 14(Suppl 1):26
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
Review
Venous thrombosis which mainly manifests as deep vein thrombosis of the leg or pulmonary embolism occurs in 1 per 1000 per year. It occurs due to interacting genetic, environmental and behavioral risk factors....
Thrombosis Journal 2016 14(Suppl 1):24
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
Review
Retrospective and prospective studies unambiguously show that prophylactic treatment of severe hemophilia A or B should be started as primary prophylaxis at 1–2 years’ of age and ideally before the first joint...
Thrombosis Journal 2016 14(Suppl 1):30
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
Review
As life expectancy greatly increases in persons with hemophilia (PWH), more age-related diseases such as cancer and cardiovascular disease (CVD) emerge among this patient group. The aim of this study was to re...
Thrombosis Journal 2016 14(Suppl 1):34
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
Review
Preimplantation genetic diagnosis (PGD) is a powerful tool to tackle the transmission of monogenic inherited disorders in families carrying the diseases from generation to generation. It currently remains a ch...
Thrombosis Journal 2016 14(Suppl 1):33
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
Review
Atherosclerosis is one of the major causes of death. Data from animal experiments suggest that atherosclerosis involves an inflammatory process of the vascular wall under hyperlipidemia. Atherothrombosis can b...
Thrombosis Journal 2016 14(Suppl 1):21
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
Research
Von Willebrand disease (VWD) is not uncommon in Taiwan. In type 2 or type 3 VWD hemorrhagic symptoms are severer and laboratory data relatively more distinctive. De novo mutation and somatic mosaicism of type 2 V...
Thrombosis Journal 2016 14(Suppl 1):36
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
Review
Current treatment of hemophilia A (HemA) patients with repeated infusions of factor VIII (FVIII; abbreviated as F8 in constructs) is costly, inconvenient, and incompletely effective. In addition, approximately 25...
Thrombosis Journal 2016 14(Suppl 1):41
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
Review
Inhibitors are the most serious side effect of haemophilia treatment; they occur in 25–30 % of all patients with severe haemophilia A. Over the last 2 decades, conflicting data on the impact of clotting produc...
Thrombosis Journal 2016 14(Suppl 1):31
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
Review
Atypical hemolytic uremic syndrome (aHUS) is a rare genetic disorder caused by defective complement regulation resulting in thrombotic microangiopathy (TMA). Patients can present as children or adults. The syn...
Thrombosis Journal 2016 14(Suppl 1):19
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
Research
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare and acquired hematopoietic stem cell disease, with florid clinical presentations. Although this disease has been characterized in the western countries, its ...
Thrombosis Journal 2016 14(Suppl 1):39
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
Review
Prophylaxis is considered optimal care for hemophilia patients to prevent bleeding and to preserve joint function thereby improving quality of life (QoL). The evidence for prophylaxis is irrefutable and is the...
Thrombosis Journal 2016 14(Suppl 1):32
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
Review
In recent years, genetic analyses of congenital deficiencies of three anticoagulant proteins, antithrombin, protein C (PC) and protein S (PS), in East Asian patients with venous thromboembolism (VTE) have grea...
Thrombosis Journal 2016 14(Suppl 1):25
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
Review
This review summarizes the evidence that collagen IV binding is physiologically important, and that the extravascular compartment of FIX is composed of type IV collagen. As we have previously demonstrated, 7 d...
Thrombosis Journal 2016 14(Suppl 1):35
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
Review
Multiple functions of platelets in various physiological and pathological conditions have prompted considerable attention on understanding how platelets are generated and activated. Of the adaptor proteins tha...
Thrombosis Journal 2016 14(Suppl 1):28
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
Introduction
Thrombosis Journal 2016 14(Suppl 1):37
Published on: 4 October 2016
This article is part of a Supplement: Volume 14 Supplement 1
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