Articles

Four-factor prothrombin complex concentrate improves thrombin generation and prothrombin time in patients with bleeding complications related to rivaroxaban: a single-center pilot trial

Direct oral anticoagulants (DOACs) pose a great challenge for physicians in life-threatening bleeding events. The aim of this study was to test the efficacy of reversing the DOAC rivaroxaban using four-factor ...

Authors: Bettina Schenk, Stephanie Goerke, Ronny Beer, Raimund Helbok, Dietmar Fries and Mirjam Bachler

Reference ranges for rotational thromboelastometry in male Sprague Dawley rats

A functional coagulation assay was used to investigate the extrinsic pathway of coagulation on citrated whole blood samples from healthy adult male Sprague Dawley rats using the mini cup and pin system.

Authors: Mariana Vigiola Cruz, Jenna N. Luker, Bonnie C. Carney, Kathleen E. Brummel-Ziedins, Maria-Cristina Bravo, Thomas Orfeo, Jason H. Chen, Lauren T. Moffatt and Jeffrey W. Shupp

Effect of sinus rhythm restoration on markers of thrombin generation in atrial fibrillation

Atrial fibrillation (AF) confers a hypercoagulable state; however, it is not clear whether restoration of sinus rhythm is associated with normalisation of markers of thrombogenesis. We studied the impact of su...

Authors: Anja Wiedswang Horjen, Ingebjørg Seljeflot, Trygve Berge, Pål Smith, Harald Arnesen and Arnljot Tveit

Video-assisted Thoracoscopic surgery (VATS) lobectomy for lung cancer does not induce a procoagulant state

Changes in the coagulation system in patients undergoing surgery for lung cancer have been sparsely investigated and the impact of the surgical trauma on the coagulation system is largely unknown in these pati...

Authors: Thomas Decker Christensen, Henrik Vad, Søren Pedersen, Peter B. Licht, Mads Nybo, Kåre Hornbech, Nora Elisabeth Zois and Anne-Mette Hvas

vWF/ADAMTS13 is associated with on-aspirin residual platelet reactivity and clinical outcome in patients with stable coronary artery disease

The mechanisms behind residual platelet reactivity (RPR) despite aspirin treatment are not established. It has been shown that coronary artery disease (CAD) patients with high on-aspirin RPR have elevated leve...

Authors: Ellen M. K. Warlo, Alf-Åge R. Pettersen, Harald Arnesen and Ingebjørg Seljeflot

Comparison of three different anti-Xa assays in major orthopedic surgery patients treated with direct oral anticoagulant

Measurement of edoxaban plasma concentration has been gathering attention in major orthopedic surgery patients receiving edoxaban for the prevention of venous thromboembolism (VTE).

Authors: Makoto Ikejiri, Hideo Wada, Shine Tone, Hiroki Wakabayashi, Masahiro Hasegawa, Takeshi Matsumoto, Naoki Fujimoto, Norikazu Yamada, Masaaki Ito, Kaname Nakatani and Akihiro Sudo

Treatment with direct oral anticoagulants in patients with upper extremity deep vein thrombosis

Upper extremity deep vein thrombosis (UEDVT) constitutes around 10% of all DVT, and can cause both pulmonary embolism (PE) and postthrombotic syndrome (PTS) in the arm. The incidence of secondary UEDVT is incr...

Authors: Francisco Sánchez Montiel, Raein Ghazvinian, Anders Gottsäter and Johan Elf

The risk of venous thromboembolism associated with peripherally inserted central catheters in ambulant cancer patients

Deep vein thrombosis (DVT) is a common complication of peripherally inserted central catheters (PICCs). PICCs are increasingly utilised in the management of cancer patients, a group which carries both addition...

Authors: Daniel Jones, Kurt Wismayer, George Bozas, June Palmer, Mandi Elliott and Anthony Maraveyas

Identification of novel mutations in congenital afibrinogenemia patients and molecular modeling of missense mutations in Pakistani population

Congenital afibrinogenemia (OMIM #202400) is a rare coagulation disorder that was first described in 1920. It is transmitted as an autosomal recessive trait that is characterized by absent levels of fibrinogen...

Authors: Arshi Naz, Arijit Biswas, Tehmina Nafees Khan, Anne Goodeve, Nisar Ahmed, Nazish Saqlain, Shariq Ahmed, Ikram Din Ujjan, Tahir S Shamsi and Johannes Oldenburg

Dabigatran reversal with idarucizumab in a patient undergoing heart transplantation: first European report

Dabigatran is a direct thrombin inhibitor with a favorable effectiveness and safety profile when compared to vitamin K antagonists, both in randomized trials and real world registries of atrial fibrillation pa...

Authors: António Tralhão, Carlos Aguiar, Jorge Ferreira, Maria José Rebocho, Emília Santos, Dinis Martins and José Pedro Neves

β₃ phosphorylation of platelet α_IIbβ₃ is crucial for stability of arterial thrombus and microparticle formation in vivo

It is well accepted that functional activity of platelet integrin α_IIbβ₃ is crucial for hemostasis and thrombosis. The β₃ subunit of the complex undergoes tyrosine phosphorylation shown to be critical for outside...

Authors: Weiyi Feng, Manojkumar Valiyaveettil, Tejasvi Dudiki, Ganapati H. Mahabeleshwar, Patrick Andre, Eugene A. Podrez and Tatiana V. Byzova

Comparison of different laboratory tests in the evaluation of hemorrhagic risk of patients using rivaroxaban in the critical care setting: diagnostic accuracy study

Rivaroxaban is a direct oral anticoagulant designed to dispense with the necessity of laboratory monitoring. However, monitoring rivaroxaban levels is necessary in certain clinical conditions, especially in th...

Authors: Marjorie Paris Colombini, Priscilla Bento Matos Cruz Derogis, Valdir Fernandes de Aranda, João Carlos de Campos Guerra, Nelson Hamerschlak and Cristóvão Luis Pitangueiras Mangueira

Paget-Schroetter syndrome in the absence of common predisposing factors: a case report

Paget-Schrotter Syndrome (PSS) also known as “effort thrombosis” is a form of primary thrombosis in the subclavian vein at the costoclavicular junction is usually seen in younger patients after repeated strenu...

Authors: Ramy Ibrahim, Irina Dashkova, Myia Williams, Andrzej Kozikowski, Neeraj Abrol, Anjula Gandhi and Renee Pekmezaris

Awareness of venous thromboembolism and thromboprophylaxis among hospitalized patients: a cross-sectional study

Patient awareness of venous thromboembolism (VTE) and thromboprophylaxis is essential for their safety. In this study, we evaluated patients’ awareness of VTE and their perceptions of thromboprophylaxis.

Authors: Hind Almodaimegh, Lama Alfehaid, Nada Alsuhebany, Rami Bustami, Shmylan Alharbi, Abdulmalik Alkatheri and Abdulkareem Albekairy

Fatal pulmonary embolism following splenectomy in a patient with Evan’s syndrome: case report and review of the literature

Evans syndrome (ES) is a rare disease characterized by simultaneous or sequential development of autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP) with or without immune neutropenia. Splenec...

Authors: Varun Monga, Seth M. Maliske and Usha Perepu

The approval of revised diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis

As proposed diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis has been approved and revised, the contents and changes are informed.

Authors: Hideo Wada, Hoyu Takahashi, Toshimasa Uchiyama, Yutaka Eguchi, Kohji Okamoto, Kazuo Kawasugi, Seiji Madoiwa and Hidesaku Asakura

Procoagulatory changes induced by head-up tilt test in patients with syncope: observational study

Orthostatic hypercoagulability is proposed as a mechanism promoting cardiovascular and thromboembolic events after awakening and during prolonged orthostasis.

Authors: Viktor Hamrefors, Artur Fedorowski, Karin Strandberg, Richard Sutton and Nazim Isma

Effects of Ramadan fasting on platelet reactivity in diabetic patients treated with clopidogrel

The effects of Ramadan fasting (RF) on clopidogrel antiplatelet inhibition were not previously investigated. The present study evaluated the influence of RF on platelet reactivity in patients with high cardiov...

Authors: W. Bouida, H. Baccouche, M. Sassi, Z. Dridi, T. Chakroun, I. Hellara, R. Boukef, M. Hassine, F. Added, R. Razgallah, I. Khochtali and S. Nouira

Perioperative management of patients on direct oral anticoagulants

Direct oral anticoagulants (DOACs) have been licensed worldwide for several years for various indications. Each year, 10–15% of patients on oral anticoagulants will undergo an invasive procedure and expert gro...

Authors: Virginie Dubois, Anne-Sophie Dincq, Jonathan Douxfils, Brigitte Ickx, Charles-Marc Samama, Jean-Michel Dogné, Maximilien Gourdin, Bernard Chatelain, François Mullier and Sarah Lessire

The introduction of biosimilars of low molecular weight heparins in Europe: a critical review and reappraisal endorsed by the Italian Society for Haemostasis and Thrombosis (SISET) and the Italian Society for Angiology and Vascular Medicine (SIAPAV)

Recently, the European Medicines Agency (EMA) authorized the introduction and marketing of Thorinane® and Inhixa®, biosimilars of the Low Molecular Weight Heparin (LMWH) enoxaparin. The authorization path is c...

Authors: Davide Imberti, Marco Marietta, Hernan Polo Friz and Claudio Cimminiello

Reduced cardiac function and risk of venous thromboembolism in Asian countries

Patients with reduced cardiac function are thought to have a higher risk of venous thromboembolism (VTE). Additionally, they are vulnerable to complications of pulmonary embolism (PE) as well as right heart fa...

Authors: Ruiqi Zhu, Yu Hu and Liang Tang

The CD31 molecule: a possible neuroprotective agent in acute ischemic stroke?

The transmembrane receptor molecule CD31 is known to have immunomodulatory functions, suggesting a possible neuroprotective effect in the context of acute ischemic stroke by restricting an over-activation of s...

Authors: Tobias Boeckh-Behrens, Justus Kleine, Johannes Kaesmacher, Claus Zimmer, Lucas Schirmer, Sophie Simon and Holger Poppert

Apixaban for the treatment of saphenous vein graft thrombosis presenting as unstable angina: a case report

Saphenous vein graft thrombosis can present as unstable angina. However, percutaneous coronary intervention for saphenous vein graft lesions poses a high risk of slow flow related to the procedure. Here we pre...

Authors: Makoto Saigan, Tsuyoshi Isawa and Tatsushi Ootomo

Impact of blood hypercoagulability on in vitro fertilization outcomes: a prospective longitudinal observational study

Blood coagulation plays a crucial role in the blastocyst implantation process and its alteration may be related to in vitro fertilization (IVF) failure. We conducted a prospective observational longitudinal st...

Authors: Grigoris T. Gerotziafas, Patrick Van Dreden, Emmanuelle Mathieu d’Argent, Eleftheria Lefkou, Matthieu Grusse, Marjorie Comtet, Rabiatou Sangare, Hela Ketatni, Annette K. Larsen and Ismail Elalamy

A case of pulmonary thromboembolism due to coagulation factor V Leiden in Japan ~ usefulness of next generation sequencing~

Because the venous thromboembolisms (VTEs) due to the coagulation factor V R506Q (FV Leiden) mutation is often seen in Caucasians, the VTE onset in Japan has not been reported.

Authors: Daisuke Sueta, Miwa Ito, Mitsuhiro Uchiba, Kenji Sakamoto, Eiichiro Yamamoto, Yasuhiro Izumiya, Sunao Kojima, Koichi Kaikita, Satoru Shinriki, Seiji Hokimoto, Hirotaka Matsui and Kenichi Tsujita

Oligonucleotides targeting coagulation factor mRNAs: use in thrombosis and hemophilia research and therapy

Small interfering (si) RNAs and antisense oligonucleotides (ASOs; here for simplicity reasons, both referred to as oligonucleotides) are small synthetic RNA or DNA molecules with a sequence complementary to a ...

Authors: Marco Heestermans and Bart J.M. van Vlijmen

The reversal effect of prothrombin complex concentrate (PCC), activated PCC and recombinant activated factor VII against anticoagulation of Xa inhibitor

An increasing number of patients are treated with direct-acting oral anticoagulants (DOACs), but the optimal way to reverse the anticoagulant effect is not known. Specific antidotes are not available and proth...

Authors: Nina Haagenrud Schultz, Hoa Thi Tuyet Tran, Stine Bjørnsen, Carola Elisabeth Henriksson, Per Morten Sandset and Pål Andre Holme

Reduced platelet hyper-reactivity and platelet-leukocyte aggregation after periodontal therapy

Platelets from untreated periodontitis patients are hyper-reactive and form more platelet-leukocyte complexes compared to cells from individuals without periodontitis. It is not known whether the improvement o...

Authors: Efthymios Arvanitidis, Sergio Bizzarro, Elena Alvarez Rodriguez, Bruno G. Loos and Elena A. Nicu

Successful treatment of deep vein thrombosis caused by iliac vein compression syndrome with a single-dose direct oral anti-coagulant

Although vein stenting is popular for treatment for venous thromboembolism due to mechanical compression, some cases are forced to avoid inserting align agents because of immunodeficiency.

Authors: Naoya Nakashima, Daisuke Sueta, Yusuke Kanemaru, Seiji Takashio, Eiichiro Yamamoto, Shinsuke Hanatani, Hisanori Kanazawa, Yasuhiro Izumiya, Sunao Kojima, Koichi Kaikita, Seiji Hokimoto and Kenichi Tsujita

Pro-coagulant activity during exercise testing in patients with coronary artery disease

Strenuous exercise may trigger myocardial infarction through increased pro-coagulant activity. We aimed to investigate whether patients referred for exercise testing, who were found to have angiographically ve...

Authors: Joanna Cwikiel, Ingebjorg Seljeflot, Eivind Berge, Harald Arnesen, Kristian Wachtell, Hilde Ulsaker and Arnljot Flaa

A survey of thrombosis experts evaluating practices and opinions regarding venous thromboprophylaxis in patients post major abdominal surgery

Patients undergoing major abdominal surgery are at high risk for developing venous thromboembolism in the post-operative period. Current evidence-based guidelines recommend routine pharmacological venous throm...

Authors: Bader Al Rawahi, Grégoire Le Gal, Rebecca Auer and Marc Carrier

The genetic variation rs6903956 in the novel androgen-dependent tissue factor pathway inhibitor regulating protein (ADTRP) gene is not associated with levels of plasma coagulation factors in the Singaporean Chinese

Genome-wide association study (GWAS) has reported that rs6903956 within the first intron of androgen-dependent tissue factor pathway inhibitor (TFPI) regulating protein (ADTRP) gene is associated with coronary ar...

Authors: Xuling Chang, Hui-Lin Chin, Swee-Chye Quek, Daniel Y. T. Goh, Rajkumar Dorajoo, Yechiel Friedlander and Chew-Kiat Heng

Pre-analytical issues in the haemostasis laboratory: guidance for the clinical laboratories

Ensuring quality has become a daily requirement in laboratories. In haemostasis, even more than in other disciplines of biology, quality is determined by a pre-analytical step that encompasses all procedures, ...

Authors: A. Magnette, M. Chatelain, B. Chatelain, H. Ten Cate and F. Mullier

Pathways for outpatient management of venous thromboembolism in a UK centre

It has become widely recognised that outpatient treatment may be suitable for many patients with venous thromboembolism. In addition, non-vitamin K antagonist oral anticoagulants that have been approved over t...

Authors: Robin Condliffe

Edoxaban versus enoxaparin for the prevention of venous thromboembolism after total knee or hip arthroplasty: pooled analysis of coagulation biomarkers and primary efficacy and safety endpoints from two phase 3 trials

The objective of this analysis was to assess the effects of edoxaban compared with enoxaparin on key coagulation biomarkers and present pooled primary efficacy and safety results from phase 3 STARS E-3 and STA...

Authors: Yohko Kawai, Takeshi Fuji, Satoru Fujita, Tetsuya Kimura, Kei Ibusuki, Kenji Abe and Shintaro Tachibana

CD163 macrophage and erythrocyte contents in aspirated deep vein thrombus are associated with the time after onset: a pilot study

Thrombolytic therapy is effective in selected patients with deep vein thrombosis (DVT). Therefore, identification of a marker that reflects the age of thrombus is of particular concern. This pilot study aimed ...

Authors: Eiji Furukoji, Toshihiro Gi, Atsushi Yamashita, Sayaka Moriguchi-Goto, Mio Kojima, Chihiro Sugita, Tatefumi Sakae, Yuichiro Sato, Toshinori Hirai and Yujiro Asada

Non enzymatic upregulation of tissue factor expression by gamma-glutamyl transferase in human peripheral blood mononuclear cells

Besides maintaining intracellular glutathione stores, gamma-glutamyltransferase(GGT) generates reactive oxygen species and activates NFkB, a redox-sensitive transcription factor key in the induction of Tissue ...

Authors: Valentina Scalise, Cristina Balia, Silvana Cianchetti, Tommaso Neri, Vittoria Carnicelli, Riccardo Zucchi, Maria Franzini, Alessandro Corti, Aldo Paolicchi, Alessandro Celi and Roberto Pedrinelli

Low-molecular-weight-heparin can benefit women with recurrent pregnancy loss and sole protein S deficiency: a historical control cohort study from Taiwan

Heritable thrombophilias are assumed important etiologies for recurrent pregnancy loss. Unlike in the Caucasian populations, protein S and protein C deficiencies, instead of Factor V Lieden and Prothrombin mut...

Authors: Ming-Ching Shen, Wan-Ju Wu, Po-Jen Cheng, Gwo-Chin Ma, Wen-Chu Li, Jui-Der Liou, Cheng-Shyong Chang, Wen-Hsiang Lin and Ming Chen

Hemophilia A gene therapy via intraosseous delivery of factor VIII-lentiviral vectors

Current treatment of hemophilia A (HemA) patients with repeated infusions of factor VIII (FVIII; abbreviated as F8 in constructs) is costly, inconvenient, and incompletely effective. In addition, approximately 25...

Authors: Carol H. Miao

Characteristics of Taiwanese patients of PNH in the international PNH registry

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare and acquired hematopoietic stem cell disease, with florid clinical presentations. Although this disease has been characterized in the western countries, its ...

Authors: Wen-Chien Chou, Wei-Han Huang, Ming-Chung Wang, Chao-Sung Chang, Shih-Peng Yeh, Tzeon-Jye Chiou, Yeu-Chin Chen, Tseng-Hsi Lin and Ming-Ching Shen

No best, only better: another APSTH milestone

Authors: Ming-Ching Shen

De novo mutation and somatic mosaicism of gene mutation in type 2A, 2B and 2M VWD

Von Willebrand disease (VWD) is not uncommon in Taiwan. In type 2 or type 3 VWD hemorrhagic symptoms are severer and laboratory data relatively more distinctive. De novo mutation and somatic mosaicism of type 2 V...

Authors: Ming-Ching Shen, Ming Chen, Gwo-Chin Ma, Shun-Ping Chang, Ching-Yeh Lin, Bo-Do Lin and Han-Ni Hsieh

Extravascular FIX and coagulation

This review summarizes the evidence that collagen IV binding is physiologically important, and that the extravascular compartment of FIX is composed of type IV collagen. As we have previously demonstrated, 7 d...

Authors: Darrel W. Stafford

Preimplantation genetic diagnosis of hemophilia A

Preimplantation genetic diagnosis (PGD) is a powerful tool to tackle the transmission of monogenic inherited disorders in families carrying the diseases from generation to generation. It currently remains a ch...

Authors: Ming Chen, Shun-Ping Chang, Gwo-Chin Ma, Wen-Hsian Lin, Hsin-Fu Chen, Shee-Uan Chen, Horng-Der Tsai, Feng-Po Tsai and Ming-Ching Shen

Individualized prophylaxis for optimizing hemophilia care: can we apply this to both developed and developing nations?

Prophylaxis is considered optimal care for hemophilia patients to prevent bleeding and to preserve joint function thereby improving quality of life (QoL). The evidence for prophylaxis is irrefutable and is the...

Authors: Man-Chiu Poon and Adrienne Lee

Different impact of factor VIII products on inhibitor development?

Inhibitors are the most serious side effect of haemophilia treatment; they occur in 25–30 % of all patients with severe haemophilia A. Over the last 2 decades, conflicting data on the impact of clotting produc...

Authors: H. Marijke van den Berg

The adaptor protein Disabled-2: new insights into platelet biology and integrin signaling

Multiple functions of platelets in various physiological and pathological conditions have prompted considerable attention on understanding how platelets are generated and activated. Of the adaptor proteins tha...

Authors: Hui-Ju Tsai and Ching-Ping Tseng

Thrombophilia in East Asian countries: are there any genetic differences in these countries?

In recent years, genetic analyses of congenital deficiencies of three anticoagulant proteins, antithrombin, protein C (PC) and protein S (PS), in East Asian patients with venous thromboembolism (VTE) have grea...

Authors: Toshiyuki Miyata, Keiko Maruyama, Fumiaki Banno and Reiko Neki

MicroRNA in atherothromobosis: is it useful as a disease marker?

Atherosclerosis is one of the major causes of death. Data from animal experiments suggest that atherosclerosis involves an inflammatory process of the vascular wall under hyperlipidemia. Atherothrombosis can b...

Authors: Satoshi Fujii, Tomonori Sugiura, Yasuaki Dohi and Nobuyuki Ohte

Clinical evaluation of thrombotic microangiopathy: identification of patients with suspected atypical hemolytic uremic syndrome

Atypical hemolytic uremic syndrome (aHUS) is a rare genetic disorder caused by defective complement regulation resulting in thrombotic microangiopathy (TMA). Patients can present as children or adults. The syn...

Authors: Yu-Min Shen