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  1. Venous thromboembolism (VTE) is a relatively rare condition in childhood with treatment mainly based on extrapolation from studies in adults. Therefore, clinical trials of anticoagulation in children require n...

    Authors: Anthonie W. A. Lensing, Christoph Male, Guy Young, Dagmar Kubitza, Gili Kenet, M. Patricia Massicotte, Anthony Chan, Angelo C. Molinari, Ulrike Nowak-Goettl, Ákos F. Pap, Ivet Adalbo, William T. Smith, Amy Mason, Kirstin Thelen, Scott D. Berkowitz, Mark Crowther…

    Citation: Thrombosis Journal 2018 16:34

    Content type: Research

    Published on:

  4. The EINSTEIN-Jr program will evaluate rivaroxaban for the treatment of venous thromboembolism (VTE) in children, targeting exposures similar to the 20 mg once-daily dose for adults. A physiologically based pha...

    Authors: Stefan Willmann, Kirstin Thelen, Dagmar Kubitza, Anthonie W. A. Lensing, Matthias Frede, Katrin Coboeken, Jan Stampfuss, Rolf Burghaus, Wolfgang Mück and Jörg Lippert

    Citation: Thrombosis Journal 2018 16:32

    Content type: Research

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  5. The EINSTEIN-Jr program will evaluate rivaroxaban for the treatment of venous thromboembolism (VTE) in children, targeting exposures similar to the 20 mg once-daily dose for adults.

    Authors: Dagmar Kubitza, Stefan Willmann, Michael Becka, Kirstin Thelen, Guy Young, Leonardo R. Brandão, Paul Monagle, Christoph Male, Anthony Chan, Gili Kennet, Ida Martinelli, Paola Saracco and Anthonie W. A. Lensing

    Citation: Thrombosis Journal 2018 16:31

    Content type: Research

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  6. Autoimmune paraphenomena, are associated with B-cell lymphoproliferative disorders, including monoclonal gammopathy of uncertain significance. These paraphenomena can rarely include acquired bleeding disorders.

    Authors: Elizabeth Sarah Mayne, Malcolm Tait, Barry Frank Jacobson, Evashin Pillay and Susan J. Louw

    Citation: Thrombosis Journal 2018 16:30

    Content type: Case report

    Published on:

  7. Serious bleeding events have been frequently described in patients taking direct oral anticoagulants (DOAC). In secondary analyses of phase 3 trials, DOAC plasma concentrations were shown to correlate with ble...

    Authors: Anne-Laure Sennesael, Anne-Sophie Larock, Jonathan Douxfils, Laure Elens, Gabriel Stillemans, Martin Wiesen, Max Taubert, Jean-Michel Dogné, Anne Spinewine and François Mullier

    Citation: Thrombosis Journal 2018 16:28

    Content type: Research

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  8. Venous thromboembolism (VTE) in young children is not well documented.

    Authors: Anthony Chan, Anthonie W. A. Lensing, Dagmar Kubitza, Grahaem Brown, Dolores Elorza, Marta Ybarra, Jacqueline Halton, Sebastian Grunt, Gili Kenet, Damien Bonnet, Amparo Santamaria, Paola Saracco, Tina Biss, Francesco Climent, Philip Connor, Joseph Palumbo…

    Citation: Thrombosis Journal 2018 16:29

    Content type: Research

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  9. Five patients with paroxysmal nocturnal haemoglobinuria and thrombotic complications under oral antithrombotic treatment with vitamin K antagonist were switched to receive the direct oral anticoagulant rivarox...

    Authors: Francesco Dragoni, Flavia Chiarotti, Anna Paola Iori, Ursula La Rocca and Arturo Cafolla

    Citation: Thrombosis Journal 2018 16:26

    Content type: Letter to the Editor

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  11. Globally, sickle cell disease (SCD) is one of the most common haemoglobinopathy. Considered a public health problem, it leads to vessel occlusion, blood stasis and chronic activation of the coagulation system ...

    Authors: Jean Jacques Noubiap, Mazou N. Temgoua, Ronni Tankeu, Joel Noutakdie Tochie, Ambroise Wonkam and Jean Joël Bigna

    Citation: Thrombosis Journal 2018 16:27

    Content type: Research

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  12. Recombinant human soluble thrombomodulin (rTM) has been used for the treatment of disseminated intravascular coagulation in Japan, and an international phase III clinical trial for rTM is currently in progress...

    Authors: Takuro Arishima, Takashi Ito, Tomotsugu Yasuda, Nozomi Yashima, Hiroaki Furubeppu, Chinatsu Kamikokuryo, Takahiro Futatsuki, Yutaro Madokoro, Shotaro Miyamoto, Tomohiro Eguchi, Hiroyuki Haraura, Ikuro Maruyama and Yasuyuki Kakihana

    Citation: Thrombosis Journal 2018 16:24

    Content type: Research

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  13. Atrial fibrillation (AF) is a major risk factor for stroke as it increases the incidence of stroke nearly fivefold. Antithrombotic treatment is recommended for the prevention of stroke in AF patients. However,...

    Authors: Eyob Alemayehu Gebreyohannes, Akshaya Srikanth Bhagavathula and Henok Getachew Tegegn

    Citation: Thrombosis Journal 2018 16:22

    Content type: Research

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  14. Around 20% of venous thromboembolism (VTE) cases occur in patients with cancer. Current guidelines recommend low molecular weight heparin (LMWH) as the preferred anticoagulant for VTE treatment. However, some ...

    Authors: Alexander T. Cohen, Anthony Maraveyas, Jan Beyer-Westendorf, Agnes Y. Y. Lee, Lorenzo G. Mantovani and Miriam Bach

    Citation: Thrombosis Journal 2018 16:21

    Content type: Research

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  15. Anticoagulation therapy for mechanical prosthetic valves is limited to vitamin K antagonists, unfractionated heparin and low-molecular-weight-heparin. Other forms of anticoagulation are either contraindicated ...

    Authors: Abeer Berry, George Degheim and Souheil Saba

    Citation: Thrombosis Journal 2018 16:23

    Content type: Case report

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  16. Disseminated intravascular coagulation (DIC) is associated with high mortality in patients with sepsis. Several studies reporting that recombinant human soluble thrombomodulin (rhTM) reduced mortality in sepsi...

    Authors: Takahiro Kato and Katsuhiko Matsuura

    Citation: Thrombosis Journal 2018 16:19

    Content type: Research

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  18. We conducted a prospective observational study for investigating coagulofibrinolytic changes and mechanisms of antithrombin (AT) alternations in trauma.

    Authors: Hironori Matsumoto, Jun Takeba, Kensuke Umakoshi, Satoshi Kikuchi, Muneaki Ohshita, Suguru Annen, Naoki Moriyama, Yuki Nakabayashi, Norio Sato and Mayuki Aibiki

    Citation: Thrombosis Journal 2018 16:17

    Content type: Research

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  20. Both disseminated intravascular coagulation (DIC) and thrombotic microangiopathy (TMA) cause microvascular thrombosis associated with thrombocytopenia, bleeding tendency and organ failure.

    Authors: Hideo Wada, Takeshi Matsumoto, Kei Suzuki, Hiroshi Imai, Naoyuki Katayama, Toshiaki Iba and Masanori Matsumoto

    Citation: Thrombosis Journal 2018 16:14

    Content type: Review

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  21. Hyponatremia is common among patients with pulmonary embolism, while hypernatremia increases the risk of venous thromboembolism (VTE). Our objective was to evaluate the association between sodium imbalances an...

    Authors: Sally Temraz, Hani Tamim, Aurelie Mailhac and Ali Taher

    Citation: Thrombosis Journal 2018 16:11

    Content type: Research

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  22. The pathophysiological mechanisms of acute coagulopathy of trauma-shock (ACOTS) are reported to include activated protein C-mediated suppression of thrombin generation via the proteolytic inactivation of activ...

    Authors: Satoshi Gando, Toshihiko Mayumi and Tomohiko Ukai

    Citation: Thrombosis Journal 2018 16:13

    Content type: Review

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  23. Small studies have implicated plasminogen activator inhibitor-1 (PAI-1) as a predictor of cardiovascular events; however, these findings have been inconsistent.

    Authors: Richard G. Jung, Pouya Motazedian, F. Daniel Ramirez, Trevor Simard, Pietro Di Santo, Sarah Visintini, Mohammad Ali Faraz, Alisha Labinaz, Young Jung and Benjamin Hibbert

    Citation: Thrombosis Journal 2018 16:12

    Content type: Research

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  24. Correction to: Thrombosis Journal (2018) 16:9 DOI 10.1186/s12959-018-0163-7

    Authors: Alexander T. Cohen, Cihan Ay, Philippe Hainaut, Hervé Décousus, Ulrich Hoffmann, Sean Gaine, Michiel Coppens, Pedro Marques da Silva, David Jimenez, Beatrice Amann-Vesti, Bernd Brüggenjürgen, Pierre Levy, Julio Lopez Bastida, Eric Vicaut, Petra Laeis, Eva-Maria Fronk…

    Citation: Thrombosis Journal 2018 16:18

    Content type: Correction

    Published on:

    The original article was published in Thrombosis Journal 2018 16:9

  25. Accurate thrombin generation determination by calibrated automated thrombinography can be sustained when reducing the plasma and reagent volumes up to half, but not for higher reductions or plasma dilutions.

    Authors: Saartje Bloemen, Hilde Kelchtermans and H. Coenraad Hemker

    Citation: Thrombosis Journal 2018 16:10

    Content type: Letter to the Editor

    Published on:

  26. Venous thromboembolism (VTE, including deep vein thrombosis [DVT] and pulmonary embolism [PE]) has an annual incidence rate of 104–183 per 100,000 person-years. After a VTE episode, the two-year recurrence rat...

    Authors: Alexander T. Cohen, Cihan Ay, Philippe Hainaut, Hervé Décousus, Ulrich Hoffmann, Sean Gaine, Michiel Coppens, Pedro Marques da Silva, David Jiménez, Beatrice Amann-Vesti, Bernd Brüggenjürgen, Pierre Levy, Julio Lopez Bastida, Eric Vicaut, Petra Laeis, Eva-Maria Fronk…

    Citation: Thrombosis Journal 2018 16:9

    Content type: Research

    Published on:

    The Correction to this article has been published in Thrombosis Journal 2018 16:18

  27. Following the publication of this study [1] the authors identified the following errors inadvertently introduced during the production process:

    Authors: George Bozas, Natalie Jeffery, Deiva Ramanujam-Venkatachala, Ged Avery, Andrew Stephens, Hilary Moss, June Palmer, Mandi Elliott and Anthony Maraveyas

    Citation: Thrombosis Journal 2018 16:15

    Content type: Correction

    Published on:

    The original article was published in Thrombosis Journal 2018 16:8

  28. In 2012, around 400.000 patients in the Netherlands were treated with Vitamin K Antagonists (VKA) for thromboembolic diseases. Since 2011, non-VKA oral anticoagulants (NOACs) are available. NOACs do not requir...

    Authors: J. M. van den Heuvel, A. M. Hövels, H. R. Büller, A. K. Mantel-Teeuwisse, A. de Boer and A. H. Maitland-van der Zee

    Citation: Thrombosis Journal 2018 16:7

    Content type: Research

    Published on:

  29. Patients with congenital afibrinogenemia suffer from spontaneous recurrent severe bleeding. While fibrinogen concentrates are known to effectively treat bleeding episodes, thrombotic complications often occur ...

    Authors: S. Le Quellec, A. Desjonqueres, L. Rugeri, H. Desmurs Clavel, F. Farhat, L. Mechtouff and Y. Dargaud

    Citation: Thrombosis Journal 2018 16:6

    Content type: Case report

    Published on:

  31. The risk of thromboembolic events is higher among cancer patients, especially in patients undergoing chemotherapy. Cisplatin-based regimens claim to be associated with a very high thromboembolic rate. In this ...

    Authors: Hikmat Abdel-Razeq, Asem Mansour, Hazem Abdulelah, Anas Al-Shwayat, Mohammad Makoseh, Mohammad Ibrahim, Mahmoud Abunasser, Dalia Rimawi, Abeer Al-Rabaiah, Rozan Alfar, Alaa’ Abufara, Alaa Ibrahim, Anas Bawaliz and Yousef Ismael

    Citation: Thrombosis Journal 2018 16:2

    Content type: Research

    Published on:

  32. An incidental/unsuspected diagnosis of pulmonary embolism (IPE) in cancer patients is a frequent occurrence. This single-institution analysis of uniformly managed patients investigates short and long-term outc...

    Authors: George Bozas, Natalie Jeffery, Deiva Ramanujam-Venkatachala, Ged Avery, Andrew Stephens, Hilary Moss, June Palmer, Mandi Elliott and Anthony Maraveyas

    Citation: Thrombosis Journal 2018 16:8

    Content type: Research

    Published on:

    The Correction to this article has been published in Thrombosis Journal 2018 16:15

  33. Traditional coagulation tests are included in emergency guidelines for management of patients on direct oral anticoagulants (DOACs) who experience acute bleeding or require surgery. We determined the ability o...

    Authors: Yvonne M. C. Henskens, Anouk J. W. Gulpen, René van Oerle, Rick Wetzels, Paul Verhezen, Henri Spronk, Simon Schalla, Harry J. Crijns, Hugo ten Cate and Arina ten Cate-Hoek

    Citation: Thrombosis Journal 2018 16:3

    Content type: Research

    Published on:

  34. Although the incidence of venous thromboembolism (VTE) in Asian populations is lower than in Western countries, the overall burden of VTE in Asia has been considerably underestimated. Factors that may explain ...

    Authors: Kang-Ling Wang, Eng Soo Yap, Shinya Goto, Shu Zhang, Chung-Wah Siu and Chern-En Chiang

    Citation: Thrombosis Journal 2018 16:4

    Content type: Review

    Published on:

  35. Direct oral anticoagulants (DOACs) pose a great challenge for physicians in life-threatening bleeding events. The aim of this study was to test the efficacy of reversing the DOAC rivaroxaban using four-factor ...

    Authors: Bettina Schenk, Stephanie Goerke, Ronny Beer, Raimund Helbok, Dietmar Fries and Mirjam Bachler

    Citation: Thrombosis Journal 2018 16:1

    Content type: Research

    Published on:

  36. A functional coagulation assay was used to investigate the extrinsic pathway of coagulation on citrated whole blood samples from healthy adult male Sprague Dawley rats using the mini cup and pin system.

    Authors: Mariana Vigiola Cruz, Jenna N. Luker, Bonnie C. Carney, Kathleen E. Brummel-Ziedins, Maria-Cristina Bravo, Thomas Orfeo, Jason H. Chen, Lauren T. Moffatt and Jeffrey W. Shupp

    Citation: Thrombosis Journal 2017 15:31

    Content type: Research

    Published on:

  37. Atrial fibrillation (AF) confers a hypercoagulable state; however, it is not clear whether restoration of sinus rhythm is associated with normalisation of markers of thrombogenesis. We studied the impact of su...

    Authors: Anja Wiedswang Horjen, Ingebjørg Seljeflot, Trygve Berge, Pål Smith, Harald Arnesen and Arnljot Tveit

    Citation: Thrombosis Journal 2017 15:30

    Content type: Research

    Published on:

  38. Changes in the coagulation system in patients undergoing surgery for lung cancer have been sparsely investigated and the impact of the surgical trauma on the coagulation system is largely unknown in these pati...

    Authors: Thomas Decker Christensen, Henrik Vad, Søren Pedersen, Peter B. Licht, Mads Nybo, Kåre Hornbech, Nora Elisabeth Zois and Anne-Mette Hvas

    Citation: Thrombosis Journal 2017 15:29

    Content type: Research

    Published on:

  39. The mechanisms behind residual platelet reactivity (RPR) despite aspirin treatment are not established. It has been shown that coronary artery disease (CAD) patients with high on-aspirin RPR have elevated leve...

    Authors: Ellen M. K. Warlo, Alf-Åge R. Pettersen, Harald Arnesen and Ingebjørg Seljeflot

    Citation: Thrombosis Journal 2017 15:28

    Content type: Research

    Published on:

  40. Measurement of edoxaban plasma concentration has been gathering attention in major orthopedic surgery patients receiving edoxaban for the prevention of venous thromboembolism (VTE).

    Authors: Makoto Ikejiri, Hideo Wada, Shine Tone, Hiroki Wakabayashi, Masahiro Hasegawa, Takeshi Matsumoto, Naoki Fujimoto, Norikazu Yamada, Masaaki Ito, Kaname Nakatani and Akihiro Sudo

    Citation: Thrombosis Journal 2017 15:27

    Content type: Research

    Published on:

  41. Upper extremity deep vein thrombosis (UEDVT) constitutes around 10% of all DVT, and can cause both pulmonary embolism (PE) and postthrombotic syndrome (PTS) in the arm. The incidence of secondary UEDVT is incr...

    Authors: Francisco Sánchez Montiel, Raein Ghazvinian, Anders Gottsäter and Johan Elf

    Citation: Thrombosis Journal 2017 15:26

    Content type: Research

    Published on:

  42. Deep vein thrombosis (DVT) is a common complication of peripherally inserted central catheters (PICCs). PICCs are increasingly utilised in the management of cancer patients, a group which carries both addition...

    Authors: Daniel Jones, Kurt Wismayer, George Bozas, June Palmer, Mandi Elliott and Anthony Maraveyas

    Citation: Thrombosis Journal 2017 15:25

    Content type: Research

    Published on:

  43. Congenital afibrinogenemia (OMIM #202400) is a rare coagulation disorder that was first described in 1920. It is transmitted as an autosomal recessive trait that is characterized by absent levels of fibrinogen...

    Authors: Arshi Naz, Arijit Biswas, Tehmina Nafees Khan, Anne Goodeve, Nisar Ahmed, Nazish Saqlain, Shariq Ahmed, Ikram Din Ujjan, Tahir S Shamsi and Johannes Oldenburg

    Citation: Thrombosis Journal 2017 15:24

    Content type: Research

    Published on:

    The Correction to this article has been published in Thrombosis Journal 2019 17:5

  44. Dabigatran is a direct thrombin inhibitor with a favorable effectiveness and safety profile when compared to vitamin K antagonists, both in randomized trials and real world registries of atrial fibrillation pa...

    Authors: António Tralhão, Carlos Aguiar, Jorge Ferreira, Maria José Rebocho, Emília Santos, Dinis Martins and José Pedro Neves

    Citation: Thrombosis Journal 2017 15:23

    Content type: Case report

    Published on:

  45. It is well accepted that functional activity of platelet integrin αIIbβ3 is crucial for hemostasis and thrombosis. The β3 subunit of the complex undergoes tyrosine phosphorylation shown to be critical for outside...

    Authors: Weiyi Feng, Manojkumar Valiyaveettil, Tejasvi Dudiki, Ganapati H. Mahabeleshwar, Patrick Andre, Eugene A. Podrez and Tatiana V. Byzova

    Citation: Thrombosis Journal 2017 15:22

    Content type: Research

    Published on:

  46. Rivaroxaban is a direct oral anticoagulant designed to dispense with the necessity of laboratory monitoring. However, monitoring rivaroxaban levels is necessary in certain clinical conditions, especially in th...

    Authors: Marjorie Paris Colombini, Priscilla Bento Matos Cruz Derogis, Valdir Fernandes de Aranda, João Carlos de Campos Guerra, Nelson Hamerschlak and Cristóvão Luis Pitangueiras Mangueira

    Citation: Thrombosis Journal 2017 15:21

    Content type: Research

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  47. Paget-Schrotter Syndrome (PSS) also known as “effort thrombosis” is a form of primary thrombosis in the subclavian vein at the costoclavicular junction is usually seen in younger patients after repeated strenu...

    Authors: Ramy Ibrahim, Irina Dashkova, Myia Williams, Andrzej Kozikowski, Neeraj Abrol, Anjula Gandhi and Renee Pekmezaris

    Citation: Thrombosis Journal 2017 15:20

    Content type: Case report

    Published on:

  48. Patient awareness of venous thromboembolism (VTE) and thromboprophylaxis is essential for their safety. In this study, we evaluated patients’ awareness of VTE and their perceptions of thromboprophylaxis.

    Authors: Hind Almodaimegh, Lama Alfehaid, Nada Alsuhebany, Rami Bustami, Shmylan Alharbi, Abdulmalik Alkatheri and Abdulkareem Albekairy

    Citation: Thrombosis Journal 2017 15:19

    Content type: Research

    Published on:

  49. Evans syndrome (ES) is a rare disease characterized by simultaneous or sequential development of autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP) with or without immune neutropenia. Splenec...

    Authors: Varun Monga, Seth M. Maliske and Usha Perepu

    Citation: Thrombosis Journal 2017 15:18

    Content type: Case report

    Published on:

  50. As proposed diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis has been approved and revised, the contents and changes are informed.

    Authors: Hideo Wada, Hoyu Takahashi, Toshimasa Uchiyama, Yutaka Eguchi, Kohji Okamoto, Kazuo Kawasugi, Seiji Madoiwa and Hidesaku Asakura

    Citation: Thrombosis Journal 2017 15:17

    Content type: Letter to the Editor

    Published on:

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