Articles

Blue toe syndrome caused by emboli from anomalous left atrial septal pouch thrombus: a case report

Left atrial septal pouches (LASPs) are a relatively newly described but common anatomical cardiac variant thought to be associated with atrial fibrillation (AF) and cardio-embolic stroke. Blue toe syndrome (BT...

Authors: Snehasis Pradhan, Kciku Gresa, Jan-Peter Röing genannt Nölke and Hans-Joachim Trappe

Superior vena cava thrombosis and dilated cardiomyopathy as initial presentations of Behcet’s disease

Bechet’s disease (BD) is a relatively rare disease that causes recurrent oral and genital ulcers in addition to a variety of systemic manifestations. Concomitant superior-vena-cava (SVC) thrombosis and cardiac...

Authors: Ahmed M. Elzanaty, Mohammed T. Awad, Ashu Acharaya, Ebrahim Sabbagh, Eman Elsheikh and Moshrik AbdAlamir

Factor V Leiden 1691G > A mutation and the risk of recurrent pregnancy loss (RPL): systematic review and meta-analysis

Although numerous replication case-control studies have attempted to determine the association between Factor V Leiden (FVL) 1691G > A mutation and susceptibility to Recurrent pregnancy loss (RPL), there have ...

Authors: Mohammad Masoud Eslami, Majid khalili, Mina Soufizomorrod, Saeid Abroun and Bahman Razi

Effects of concomitant use of prasugrel with edoxaban on bleeding time, pharmacodynamics, and pharmacokinetics of edoxaban in healthy elderly Japanese male subjects: a clinical pharmacology study

Dual therapy with a direct oral anticoagulant (DOAC) plus a P2Y₁₂ receptor inhibitor is recommended in patients with nonvalvular atrial fibrillation who undergo percutaneous coronary intervention. Thus, we evalua...

Authors: Ippei Ikushima, Takaaki Akasaka, Yoshiyuki Morishima, Atsushi Takita, Tomoko Motohashi and Tetsuya Kimura

Increased dose primary thromboprophylaxis in ambulatory patients with advanced pancreatic ductal adenocarcinoma, a single centre cohort study

Advanced pancreatic ductal adenocarcinoma (aPDAC) patients have a lifetime all type thromboembolic event (ATTE) rate of 25–35%. Efficacy and safety of increased dose primary thromboprophylaxis (IDPTP) with low...

Authors: Anthony Maraveyas, Farzana Haque, Iqtedar Ahmed Muazzam, Waqas Ilyas and George Bozas

Comparative analysis of enoxaparin versus rivaroxaban in the treatment of cancer associated venous thromboembolism: experience from a tertiary care cancer centre

Venous Thromboembolism (VTE) in cancer patients is associated with increased mortality and morbidity. While newer data on use of direct oral anticoagulants (DOACs) in treating cancer associated thrombosis (CAT...

Authors: Anadil Faqah, Hassan Sheikh, Muhammad Abu Bakar, Fatima Tayyaab and Sahrish Khawaja

Thrombosis management in times of COVID-19 epidemy; a Dutch perspective

Authors: Hugo ten Cate

Rivaroxaban versus warfarin for treatment and prevention of recurrence of venous thromboembolism in African American patients: a retrospective cohort analysis

African Americans are under-represented in trials evaluating oral anticoagulants for the treatment of acute venous thromboembolism (VTE). The aim of this study was to evaluate the effectiveness and safety of r...

Authors: Olivia S. Costa, Stanley Thompson, Veronica Ashton, Michael Palladino, Thomas J. Bunz and Craig I. Coleman

Changes in anticoagulant prescription in Dutch patients with recent-onset atrial fibrillation: observations from the GARFIELD-AF registry

For the improvement of AF care, it is important to gain insight into current anticoagulation prescription practices and guideline adherence. This report focuses on the largest Dutch subset of AF-patients, deri...

Authors: J. Seelig, F. W. A. Verheugt, M. E. W. Hemels, L. Illingworth, A. Lucassen, H. Adriaansen, M. C. M. Bongaerts, M. Pieterse, J. P. R. Herrman, P. Hoogslag, W. Hermans, B. E. Groenemeijer, L. V. A. Boersma, K. Pieper and H. ten Cate

Multiple trauma including pelvic fracture with multiple arterial embolization: an autopsy case report

Pelvic fracture with high energy trauma has a high mortality rate, especially in men. In addition, severe multiple trauma, major hemorrhage, and administration of red blood cells predict mortality in elderly p...

Authors: Takahito Miyake, Hideshi Okada, Norihide Kanda, Fuminori Yamaji, Haruka Okamoto, Hiroaki Ushikoshi, Kei Noguchi, Hiroyuki Tomita, Shozo Yoshida and Shinji Ogura

Analysis of the association between resolution of disseminated intravascular coagulation (DIC) and treatment outcomes in post-marketing surveillance of thrombomodulin alpha for DIC with infectious disease and with hematological malignancy by organ failure

Although disseminated intravascular coagulation (DIC) is life-threatening, any organ failure associated with DIC resolution and outcomes have been unclear.

Authors: Noriaki Kawano, Hideo Wada, Toshimasa Uchiyama, Kazuo Kawasugi, Seiji Madoiwa, Naoki Takezako, Kei Suzuki, Yoshinobu Seki, Takayuki Ikezoe, Tsuyoshi Hattori and Kohji Okamoto

Time trends for pulmonary embolism incidence in Greece

Pulmonary embolism (PE) is a disease with a significant impact on public health. However, international epidemiological data are unclear and show considerable heterogeneity. The present study aims to investiga...

Authors: Dimitrios G. Raptis, Konstantinos I. Gourgoulianis, Zoe Daniil and Foteini Malli

Evaluation of unmet clinical needs in prophylaxis and treatment of venous thromboembolism in at-risk patient groups: pregnancy, elderly and obese patients

Venous thromboembolism (VTE) accounts for an estimated 900,000 cases per year in the US alone and constitutes a considerable burden on healthcare systems across the globe.

Authors: Benjamin Brenner, Roopen Arya, Jan Beyer-Westendorf, James Douketis, Russell Hull, Ismail Elalamy, Davide Imberti and Zhenguo Zhai

Low molecular weight heparins use in pregnancy: a practice survey from Greece and a review of the literature

Use of LMWH in pregnancy is not only limited to VTE management, but it extends, to the management of vascular gestational complications and the optimization of IVF pregnancies despite the lack of concrete scie...

Authors: E. Papadakis, A. Pouliakis, Α. Aktypi, A. Christoforidou, P. Kotsi, G. Αnagnostou, A. Foifa and E. Grouzi

Non-vitamin K antagonist oral anticoagulants vs. vitamin-K antagonists in patients with atrial fibrillation and chronic kidney disease: a nationwide cohort study

We aimed to compare effectiveness and safety of non-vitamin K antagonist oral anticoagulants (NOACs) versus vitamin-K antagonists (VKA) in atrial fibrillation (AF) patients with chronic kidney disease (CKD) no...

Authors: Emma Kirstine Laugesen, Laila Staerk, Nicholas Carlson, Anne-Lise Kamper, Jonas Bjerring Olesen, Christian Torp-Pedersen, Gunnar Gislason and Anders Nissen Bonde

Correction to: protease-activated receptors (PARs): mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases

Following the publication of this article [1], the authors reported an incorrect citation in the following sentence in the “Metalloproteases” sub-section:

Authors: Dorothea M. Heuberger and Reto A. Schuepbach

Down-regulation of platelet adhesion receptors is a controlling mechanism of thrombosis, while also affecting post-transfusion efficacy of stored platelets

Physiologically, upon platelet activation, uncontrolled propagation of thrombosis is prevented by regulating mechanisms which affect the expression and function of either platelet adhesion receptors or integri...

Authors: Ehteramolsadat Hosseini, Maryam Mohtashami and Mehran Ghasemzadeh

Genotypic and phenotypic character of Chinese neonates with congenital protein C deficiency: a case report and literature review

Our objective was to study the phenotype of and molecular genetic mechanisms underlying congenital protein C (PC) deficiency in Chinese neonates. We report the case of a neonate who presented 4 h after birth w...

Authors: Xiaoying Li, Xiaoyan Li, Xiao Li, Yuanhua Zhuang, Lili Kang and Xiuli Ju

Successful use of eculizumab to treat atypical hemolytic uremic syndrome in patients with inflammatory bowel disease

Atypical hemolytic uremic syndrome is a rare group of disorders that have in common underlying complement amplifying conditions. These conditions can accelerate complement activation that results in a positive...

Authors: Ramy M. Hanna, Noah Merin, Richard M. Burwick, Lama Abdelnour, Umut Selamet, Beshoy Yanny, Patrick Bui, Mary Fouad and Ira Kurtz

Effects of glycemic control and hypoglycemia on Thrombus formation assessed using automated microchip flow chamber system: an exploratory observational study

Thrombus formation is an important factor affecting cardiovascular events and venous thromboembolism in type 2 diabetes. However, it is unclear whether glycemic control reduces thrombogenicity. We investigated...

Authors: Kiyoaki Yamamoto, Takashi Ito, Tomoka Nagasato, Atsushi Shinnakasu, Mihoko Kurano, Aiko Arimura, Hiroshi Arimura, Hiroshi Hashiguchi, Takahisa Deguchi, Ikuro Maruyama and Yoshihiko Nishio

Hypoxia and HIF activation as a possible link between sepsis and thrombosis

Risk factors for thrombosis include hypoxia and sepsis, but the mechanisms that control sepsis-induced thrombus formation are incompletely understood. A recent article published in Thrombosis Journal: (i) revi...

Authors: Colin E. Evans

Guideline compliance for bridging anticoagulation use in vitamin-K antagonist patients; practice variation and factors associated with non-compliance

Bridging anticoagulation is used in vitamin-K antagonist (VKA) patients undergoing invasive procedures and involves complex risk assessment in order to prevent thromboembolic and bleeding outcomes.

Authors: M. J. Moesker, J. F. de Groot, N. L. Damen, N. R. Bijsterveld, J. W. R. Twisk, M. V. Huisman, M. C. de Bruijne and C. Wagner

Implementation of an acute DVT ambulatory care pathway in a large urban centre: current challenges and future opportunities

Ambulatory management of isolated acute deep venous thrombosis (DVT) is the recommended standard of care in selected populations. However, in practice a significant number of patients continue to be managed as...

Authors: Sarah Kelliher, Patricia Hall, Barry Kevane, Daniela Dinu, Karl Ewins, Peter MacMahon, Fionnuala Ní Áinle and Tomás Breslin

Validation of the Khorana score in acute myeloid leukemia patients: a single-institution experience

Although patients with acute myeloid leukemia (AML) were shown to have an increased risk of thrombosis, no thrombosis risk assessment scoring system has been developed for AML patients. The Khorana Risk Score ...

Authors: Abu-Sayeef Mirza, Seongseok Yun, Najla Al Ali, Hannah Shin, Joseph Luke O’Neil, Maher Elharake, Daniel Schwartz, Katherine Robinson, Ethan Nowell, Grace Engle, Ibraahim Badat, Thomas Brimer, Amra Kuc, Ashton Sequeira, Sabbir Mirza, Dhiraj Sikaria…

Usefulness of the APTT waveform for the diagnosis of DIC and prediction of the outcome or bleeding risk

The usefulness of the activated partial thromboplastin time (APTT) waveform has been reported in hemophilia, acquired hemophilia and monitoring for anticoagulants.

Authors: Kei Suzuki, Hideo Wada, Takeshi Matsumoto, Makoto Ikejiri, Kohshi Ohishi, Yoshiki Yamashita, Hiroshi Imai, Toshiaki Iba and Naoyuki Katayama

Chemoprophylaxis in addition to mechanical prophylaxis after total knee arthroplasty surgery does not reduce the incidence of venous thromboembolism

Venous thromboembolism (VTE) of the lower limbs is an important complication post total knee arthroplasty (TKA). Current guidelines recommend routine chemical prophylaxis to all patients undergoing this proced...

Authors: Jing Loong Moses Loh, Stephrene Chan, Keng Lin Wong, Sanjay de Mel and Eng Soo Yap

An illustrative case of endocardial fibroelastosis and recalcitrant intracardiac thrombosis: a case report

Endocardial Fibroelastosis is diffuse, accentuated proliferation of ventricular endocardium causing a rare form of restrictive cardiomyopathy in both children and adults. It is an incompletely understood cause...

Authors: Denizhan Ozdemir, Isabel Oliva Cortopassi and Robert Lawrence McNamara

Sepsis and septic shock: endothelial molecular pathogenesis associated with vascular microthrombotic disease

In addition to protective “immune response”, sepsis is characterized by destructive “endothelial response” of the host, leading to endotheliopathy and its molecular dysfunction. Complement activation generates...

Authors: Jae C. Chang

A brief review on resistance to P2Y₁₂ receptor antagonism in coronary artery disease

Platelet inhibition is important for patients with coronary artery disease. When dual antiplatelet therapy (DAPT) is required, a P2Y₁₂-antagonist is usually recommended in addition to standard aspirin therapy. Th...

Authors: Ellen M. K. Warlo, Harald Arnesen and Ingebjørg Seljeflot

International longitudinal registry of patients with atrial fibrillation and treated with rivaroxaban: RIVaroxaban Evaluation in Real life setting (RIVER)

Real-world data on non-vitamin K oral anticoagulants (NOACs) are essential in determining whether evidence from randomised controlled clinical trials translate into meaningful clinical benefits for patients in...

Authors: Jan Beyer-Westendorf, A. John Camm, Keith A. A. Fox, Jean-Yves Le Heuzey, Sylvia Haas, Alexander G. G. Turpie, Saverio Virdone and Ajay K. Kakkar

Evaluation of unmet clinical needs in prophylaxis and treatment of venous thromboembolism in high-risk patient groups: cancer and critically ill

Clinical practice shows that venous thromboembolism (VTE) presents a substantial burden in medical patients, and awareness and advocacy for its primary and secondary prevention remains inadequate. Specific pat...

Authors: Benjamin Brenner, Russell Hull, Roopen Arya, Jan Beyer-Westendorf, James Douketis, Ismail Elalamy, Davide Imberti and Zhenguo Zhai

Correction to: Identification of novel mutations in congenital afibrinogenemia patients and molecular modeling of missense mutations in Pakistani population

Following the publication of this article [1], the authors noted the following typographical errors.

Authors: Arshi Naz, Arijit Biswas, Tehmina Nafees Khan, Anne Goodeve, Nisar Ahmed, Nazish Saqlain, Shariq Ahmed, Ikram Din Ujjan, Tahir S. Shamsi and Johannes Oldenburg

Protease-activated receptors (PARs): mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases

Inflammatory diseases have become increasingly prevalent with industrialization. To address this, numerous anti-inflammatory agents and molecular targets have been considered in clinical trials. Among molecula...

Authors: Dorothea M. Heuberger and Reto A. Schuepbach

Sensory evaluation of edoxaban orally disintegrating tablets: an open-label interventional study (secondary publication)

This study involved a sensory evaluation of edoxaban orally disintegrating (OD) tablets in patients with nonvalvular atrial fibrillation who had been receiving the existing edoxaban film-coated tablets before ...

Authors: Takeshi Yamashita, Joji Hagii, Yoshiyuki Morishima, Takaaki Akasaka, Takuyuki Matsumoto and Tetsuya Kimura

Predictive risk factors of venous thromboembolism (VTE) associated with peripherally inserted central catheters (PICC) in ambulant solid cancer patients: retrospective single Centre cohort study

Peripherally inserted central catheters(PICC) lines are becoming increasingly popular in solid cancer patients for the administration of chemotherapy. This study aims looking at the incidence of PICC line rela...

Authors: Osamah Al-Asadi, Manar Almusarhed and Hany Eldeeb

Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study

Nuclear histone proteins are released into the extracellular space, and act as major mediators of coagulopathy and remote organ failure in septic animals. However, the circulating histone levels in septic pati...

Authors: Yayoi Yokoyama, Takashi Ito, Tomotsugu Yasuda, Hiroaki Furubeppu, Chinatsu Kamikokuryo, Shingo Yamada, Ikuro Maruyama and Yasuyuki Kakihana

Rivaroxaban versus standard anticoagulation for acute venous thromboembolism in childhood. Design of the EINSTEIN-Jr phase III study

Venous thromboembolism (VTE) is a relatively rare condition in childhood with treatment mainly based on extrapolation from studies in adults. Therefore, clinical trials of anticoagulation in children require n...

Authors: Anthonie W. A. Lensing, Christoph Male, Guy Young, Dagmar Kubitza, Gili Kenet, M. Patricia Massicotte, Anthony Chan, Angelo C. Molinari, Ulrike Nowak-Goettl, Ákos F. Pap, Ivet Adalbo, William T. Smith, Amy Mason, Kirstin Thelen, Scott D. Berkowitz, Mark Crowther…

Splanchnic venous thrombosis in JAK2 V617F mutation positive myeloproliferative neoplasms – long term follow-up of a regional case series

Splanchnic Vein Thrombosis (SVT) is strongly associated with underlying JAK2 V617F positive myeloproliferative neoplasms (MPN).

Authors: Graeme Greenfield and Mary Frances McMullin

Thrombotic thrombocytopenic purpura (TTP)-like syndrome in the HIV era

The thrombotic microangiopathies (TMAs) is a heterogeneous group of relatively uncommon but serious disorders presenting with thrombocytopenia and microangiopathic haemolysis. Thrombotic thrombocytopenic purpu...

Authors: Susan Louw, Reenelle Gounden and Elizabeth Sarah Mayne

Pharmacokinetics of rivaroxaban in children using physiologically based and population pharmacokinetic modelling: an EINSTEIN-Jr phase I study

The EINSTEIN-Jr program will evaluate rivaroxaban for the treatment of venous thromboembolism (VTE) in children, targeting exposures similar to the 20 mg once-daily dose for adults. A physiologically based pha...

Authors: Stefan Willmann, Kirstin Thelen, Dagmar Kubitza, Anthonie W. A. Lensing, Matthias Frede, Katrin Coboeken, Jan Stampfuss, Rolf Burghaus, Wolfgang Mück and Jörg Lippert

Exploratory evaluation of pharmacodynamics, pharmacokinetics and safety of rivaroxaban in children and adolescents: an EINSTEIN-Jr phase I study

The EINSTEIN-Jr program will evaluate rivaroxaban for the treatment of venous thromboembolism (VTE) in children, targeting exposures similar to the 20 mg once-daily dose for adults.

Authors: Dagmar Kubitza, Stefan Willmann, Michael Becka, Kirstin Thelen, Guy Young, Leonardo R. Brandão, Paul Monagle, Christoph Male, Anthony Chan, Gili Kennet, Ida Martinelli, Paola Saracco and Anthonie W. A. Lensing

Combination of acquired von Willebrand syndrome (AVWS) and Glanzmann thrombasthenia in monoclonal gammopathy of uncertain significance (MGUS), a case report

Autoimmune paraphenomena, are associated with B-cell lymphoproliferative disorders, including monoclonal gammopathy of uncertain significance. These paraphenomena can rarely include acquired bleeding disorders.

Authors: Elizabeth Sarah Mayne, Malcolm Tait, Barry Frank Jacobson, Evashin Pillay and Susan J. Louw

Rivaroxaban plasma levels in patients admitted for bleeding events: insights from a prospective study

Serious bleeding events have been frequently described in patients taking direct oral anticoagulants (DOAC). In secondary analyses of phase 3 trials, DOAC plasma concentrations were shown to correlate with ble...

Authors: Anne-Laure Sennesael, Anne-Sophie Larock, Jonathan Douxfils, Laure Elens, Gabriel Stillemans, Martin Wiesen, Max Taubert, Jean-Michel Dogné, Anne Spinewine and François Mullier

Clinical presentation and therapeutic management of venous thrombosis in young children: a retrospective analysis

Venous thromboembolism (VTE) in young children is not well documented.

Authors: Anthony Chan, Anthonie W. A. Lensing, Dagmar Kubitza, Grahaem Brown, Dolores Elorza, Marta Ybarra, Jacqueline Halton, Sebastian Grunt, Gili Kenet, Damien Bonnet, Amparo Santamaria, Paola Saracco, Tina Biss, Francesco Climent, Philip Connor, Joseph Palumbo…

Antithrombotic therapy with rivaroxaban in five patients with paroxysmal nocturnal haemoglobinuria and thrombotic events

Five patients with paroxysmal nocturnal haemoglobinuria and thrombotic complications under oral antithrombotic treatment with vitamin K antagonist were switched to receive the direct oral anticoagulant rivarox...

Authors: Francesco Dragoni, Flavia Chiarotti, Anna Paola Iori, Ursula La Rocca and Arturo Cafolla

Venous thromboembolism prophylaxis may cause more harm than benefit: an evidence-based analysis of Canadian and international guidelines

A majority of deep vein thromboses identified in screening studies of hospitalized patients remain clinically insignificant. Guidelines based on these studies markedly overestimate the risk of clinical venous ...

Authors: Andrew Kotaska

Sickle cell disease, sickle trait and the risk for venous thromboembolism: a systematic review and meta-analysis

Globally, sickle cell disease (SCD) is one of the most common haemoglobinopathy. Considered a public health problem, it leads to vessel occlusion, blood stasis and chronic activation of the coagulation system ...

Authors: Jean Jacques Noubiap, Mazou N. Temgoua, Ronni Tankeu, Joel Noutakdie Tochie, Ambroise Wonkam and Jean Joël Bigna

Circulating activated protein C levels are not increased in septic patients treated with recombinant human soluble thrombomodulin

Recombinant human soluble thrombomodulin (rTM) has been used for the treatment of disseminated intravascular coagulation in Japan, and an international phase III clinical trial for rTM is currently in progress...

Authors: Takuro Arishima, Takashi Ito, Tomotsugu Yasuda, Nozomi Yashima, Hiroaki Furubeppu, Chinatsu Kamikokuryo, Takahiro Futatsuki, Yutaro Madokoro, Shotaro Miyamoto, Tomohiro Eguchi, Hiroyuki Haraura, Ikuro Maruyama and Yasuyuki Kakihana

Poor outcomes associated with antithrombotic undertreatment in patients with atrial fibrillation attending Gondar University Hospital: a retrospective cohort study

Atrial fibrillation (AF) is a major risk factor for stroke as it increases the incidence of stroke nearly fivefold. Antithrombotic treatment is recommended for the prevention of stroke in AF patients. However,...

Authors: Eyob Alemayehu Gebreyohannes, Akshaya Srikanth Bhagavathula and Henok Getachew Tegegn

COSIMO – patients with active cancer changing to rivaroxaban for the treatment and prevention of recurrent venous thromboembolism: a non-interventional study

Around 20% of venous thromboembolism (VTE) cases occur in patients with cancer. Current guidelines recommend low molecular weight heparin (LMWH) as the preferred anticoagulant for VTE treatment. However, some ...

Authors: Alexander T. Cohen, Anthony Maraveyas, Jan Beyer-Westendorf, Agnes Y. Y. Lee, Lorenzo G. Mantovani and Miriam Bach