Heit JA, Spencer FA, White RH. The epidemiology of venous thromboembolism. J Thromb Thrombolysis. 2016;41(1):3–14.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pastori D, Farcomeni A, Milanese A, Del Sole F, Menichelli D, Hiatt WR, et al. Statins and major adverse limb events in patients with peripheral artery disease: a systematic review and meta-analysis. Thromb Haemost. 2020;120(5):866–75.
Article
PubMed
Google Scholar
Braekkan SK, Caram-Deelder C, Siegerink B, van Hylckama VA, le Cessie S, Rosendaal FR, et al. Statin use and risk of recurrent venous thrombosis: results from the MEGA follow-up study. Res Pract Thromb Haemostasis. 2017;1(1):112–9.
Article
CAS
Google Scholar
Kunutsor SK, Seidu S, Khunti K. Statins and secondary prevention of venous thromboembolism: pooled analysis of published observational cohort studies. Eur Heart J. 2017;38(20):1608–12.
Article
PubMed
PubMed Central
Google Scholar
Li L, Zhang P, Tian JH, Yang K. Statins for primary prevention of venous thromboembolism. Cochrane Database Syst Rev. 2014;12:Cd008203.
Google Scholar
Schmidt M, Cannegieter SC, Johannesdottir SA, Dekkers OM, Horvath-Puho E, Sorensen HT. Statin use and venous thromboembolism recurrence: a combined nationwide cohort and nested case-control study. J Thromb Haemostasis. 2014;12(8):1207–15.
Article
CAS
Google Scholar
Smith NL, Harrington LB, Blondon M, Wiggins KL, Floyd JS, Sitlani CM, et al. The association of statin therapy with the risk of recurrent venous thrombosis. J Thromb Haemostasis. 2016;14(7):1384–92.
Article
CAS
Google Scholar
Tagalakis V, Eberg M, Kahn S, Azoulay L. Use of statins and reduced risk of recurrence of VTE in an older population. A population-based cohort study. Thromb Haemost. 2016;115(6):1220–8.
Article
PubMed
Google Scholar
Lassila R, Jula A, Pitkaniemi J, Haukka J. The association of statin use with reduced incidence of venous thromboembolism: a population-based cohort study. BMJ Open. 2014;4(11):e005862.
Article
PubMed
PubMed Central
Google Scholar
Gaertner S, Cordeanu EM, Nouri S, Mirea C, Stephan D. Statins and prevention of venous thromboembolism: myth or reality? Arch Cardiovasc Dis. 2016;109(3):216–22.
Article
PubMed
Google Scholar
Takemoto M, Liao JK. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors. Arterioscler Thromb Vasc Biol. 2001;21(11):1712–9.
Article
CAS
PubMed
Google Scholar
Pignatelli P, Carnevale R, Pastori D, Cangemi R, Napoleone L, Bartimoccia S, et al. Immediate antioxidant and antiplatelet effect of atorvastatin via inhibition of Nox2. Circulation. 2012;126(1):92–103.
Article
CAS
PubMed
Google Scholar
Chaffey P, Thompson M, Pai AD, Tafreshi AR, Tafreshi J, Pai RG. Usefulness of statins for prevention of venous thromboembolism. Am J Cardiol. 2018;121(11):1436–40.
Article
CAS
PubMed
Google Scholar
Adams NB, Lutsey PL, Folsom AR, Herrington DH, Sibley CT, Zakai NA, et al. Statin therapy and levels of hemostatic factors in a healthy population: the multi-ethnic study of atherosclerosis. J Thromb Haemostasis. 2013;11(6):1078–84.
Article
CAS
Google Scholar
Bianconi V, Sahebkar A, Banach M, Pirro M. Statins, haemostatic factors and thrombotic risk. Curr Opin Cardiol. 2017;32(4):460–6.
Article
PubMed
Google Scholar
Oikonomou E, Leopoulou M, Theofilis P, Antonopoulos AS, Siasos G, Latsios G, et al. A link between inflammation and thrombosis in atherosclerotic cardiovascular diseases: clinical and therapeutic implications. Atherosclerosis. 2020;309:16–26.
Article
CAS
PubMed
Google Scholar
Biedermann JS, Kruip M, van der Meer FJ, Rosendaal FR, Leebeek FWG, Cannegieter SC, et al. Rosuvastatin use improves measures of coagulation in patients with venous thrombosis. Eur Heart J. 2018;39(19):1740–7.
Article
CAS
PubMed
Google Scholar
Law MR, Wald NJ, Rudnicka AR. Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. BMJ (Clinical research ed). 2003;326(7404):1423.
Article
CAS
Google Scholar
Sipahi I, Nicholls SJ, Tuzcu EM, Nissen SE. Coronary atherosclerosis can regress with very intensive statin therapy. Cleve Clin J Med. 2006;73(10):937–44.
Article
PubMed
Google Scholar
Rahimi K, Bhala N, Kamphuisen P, Emberson J, Biere-Rafi S, Krane V, et al. Effect of statins on venous thromboembolic events: a meta-analysis of published and unpublished evidence from randomised controlled trials. PLoS Med. 2012;9(9):e1001310.
Article
CAS
PubMed
PubMed Central
Google Scholar
de Mutsert R, den Heijer M, Rabelink TJ, Smit JW, Romijn JA, Jukema JW, et al. The Netherlands epidemiology of obesity (NEO) study: study design and data collection. Eur J Epidemiol. 2013;28(6):513–23.
Article
PubMed
Google Scholar
Reiner Z, Catapano AL, De Backer G, Graham I, Taskinen MR, Wiklund O, et al. ESC/EAS guidelines for the management of dyslipidaemias: the task force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European atherosclerosis society (EAS). Eur Heart J. 2011;32(14):1769–818.
Article
PubMed
Google Scholar
Ramcharan AS, Van Stralen KJ, Snoep JD, Mantel-Teeuwisse AK, Rosendaal FR, Doggen CJ. HMG-CoA reductase inhibitors, other lipid-lowering medication, antiplatelet therapy, and the risk of venous thrombosis. J Thromb Haemostasis. 2009;7(4):514–20.
Article
CAS
Google Scholar
Krysiak R, Okopien B. Haemostatic effects of simvastatin in subjects with impaired glucose tolerance. Intern Med J. 2011;41(6):473–81.
Article
CAS
PubMed
Google Scholar
Krysiak R, Zmuda W, Okopien B. The effect of ezetimibe and simvastatin on hemostasis in patients with isolated hypercholesterolemia. Fundam Clin Pharmacol. 2012;26(3):424–31.
Article
CAS
PubMed
Google Scholar
Hashikata T, Yamaoka-Tojo M, Kakizaki R, Nemoto T, Fujiyoshi K, Namba S, et al. Ezetimibe enhances and stabilizes anticoagulant effect of warfarin. Heart Vessel. 2017;32(1):47–54.
Article
Google Scholar
Yu CY, Campbell SE, Zhu B, Knadler MP, Small DS, Sponseller CA, et al. Effect of pitavastatin vs. rosuvastatin on international normalized ratio in healthy volunteers on steady-state warfarin. Curr Med Res Opin. 2012;28(2):187–94.
Article
CAS
PubMed
Google Scholar
van Rein N, Biedermann JS, Bonafacio SM, Kruip MJ, van der Meer FJ, Lijfering WM. Statin use decreases coagulation in users of vitamin K antagonists. Eur J Clin Pharmacol. 2016;72(12):1441–7.
Article
PubMed
PubMed Central
CAS
Google Scholar
Zimmer JE, Spillert CR, Puppala S, Zamecki K, Bhatt BA, Arora RR. Pravastatin potentiates the anticoagulant effects of low molecular weight heparin. Thromb Res. 2004;113(6):407–10.
Article
CAS
PubMed
Google Scholar
Jindal D, Tandon M, Sharma S, Pillai KK. Pharmacodynamic evaluation of warfarin and rosuvastatin co-administration in healthy subjects. Eur J Clin Pharmacol. 2005;61(9):621–5.
Article
CAS
PubMed
Google Scholar
Biedermann JS, Cannegieter SC, Roest M, van der Meer FJ, Reitsma PH, Kruip MJ, et al. Platelet reactivity in patients with venous thrombosis who use rosuvastatin: a randomized controlled clinical trial. J Thromb Haemostasis. 2016;14(7):1404–9.
Article
CAS
Google Scholar
Seljeflot I, Tonstad S, Hjermann I, Arnesen H. Improved fibrinolysis after 1-year treatment with HMG CoA reductase inhibitors in patients with coronary heart disease. Thromb Res. 2002;105(4):285–90.
Article
CAS
PubMed
Google Scholar
Joukhadar C, Klein N, Prinz M, Schrolnberger C, Vukovich T, Wolzt M, et al. Similar effects of atorvastatin, simvastatin and pravastatin on thrombogenic and inflammatory parameters in patients with hypercholesterolemia. Thromb Haemost. 2001;85(1):47–51.
Article
CAS
PubMed
Google Scholar
Dangas G, Badimon JJ, Smith DA, Unger AH, Levine D, Shao JH, et al. Pravastatin therapy in hyperlipidemia: effects on thrombus formation and the systemic hemostatic profile. J Am Coll Cardiol. 1999;33(5):1294–304.
Article
CAS
PubMed
Google Scholar
Gottsater A, Anwaar I, Lind P, Mattiasson I, Lindgarde F. Increasing plasma fibrinogen, but unchanged levels of intraplatelet cyclic nucleotides, plasma endothelin-1, factor VII, and neopterin during cholesterol lowering with fluvastatin. Blood Coagul Fibrinolysis. 1999;10(3):133–40.
Article
CAS
PubMed
Google Scholar
Sbarouni E, Melissari E, Kyriakides ZS, Kremastinos DT. Effects of simvastatin or hormone replacement therapy, or both, on fibrinogen, factor VII, and plasminogen activator inhibitor levels in postmenopausal women with proven coronary artery disease. Am J Cardiol. 2000;86(1):80–3.
Article
CAS
PubMed
Google Scholar
Ambrosi P, Aillaud MF, Habib G, Kreitmann B, Metras D, Luccioni R, et al. Fluvastatin decreases soluble thrombomodulin in cardiac transplant recipients. Thromb Haemost. 2000;83(1):46–8.
Article
CAS
PubMed
Google Scholar
Lijfering WM, Biedermann JS, Kruip MJ, Leebeek FW, Rosendaal FR, Cannegieter SC. Can we prevent venous thrombosis with statins: an epidemiologic review into mechanism and clinical utility. Expert Rev Hematol. 2016;9(11):1023–30.
Article
CAS
PubMed
Google Scholar
Kunutsor SK, Seidu S, Khunti K. Statins and primary prevention of venous thromboembolism: a systematic review and meta-analysis. Lancet Haematol. 2017;4(2):e83–93.
Article
PubMed
Google Scholar
Glynn RJ, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, et al. A randomized trial of rosuvastatin in the prevention of venous thromboembolism. N Engl J Med. 2009;360(18):1851–61.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hippisley-Cox J, Coupland C. Unintended effects of statins in men and women in England and Wales: population based cohort study using the QResearch database. BMJ (Clinical research ed). 2010;340:c2197.
Article
Google Scholar
Rosendaal FR. Statins and venous thrombosis: a story too good to be true? PLoS Med. 2012;9(9):e1001311.
Article
PubMed
PubMed Central
Google Scholar
Biere-Rafi S, Hutten BA, Squizzato A, Ageno W, Souverein PC, de Boer A, et al. Statin treatment and the risk of recurrent pulmonary embolism. Eur Heart J. 2013;34(24):1800–6.
Article
CAS
PubMed
Google Scholar
Agarwal V, Phung OJ, Tongbram V, Bhardwaj A, Coleman CI. Statin use and the prevention of venous thromboembolism: a meta-analysis. Int J Clin Pract. 2010;64(10):1375–83.
Article
CAS
PubMed
Google Scholar
El-Refai SM, Black EP, Adams VR, Talbert JC, Brown JD. Statin use and venous thromboembolism in cancer: a large, active comparator, propensity score matched cohort study. Thromb Res. 2017;158:49–58.
Article
CAS
PubMed
PubMed Central
Google Scholar
Davalos D, Akassoglou K. Fibrinogen as a key regulator of inflammation in disease. Seminars in immunopathology; 2012.
Google Scholar
Balk EM, Lau J, Goudas LC, Jordan HS, Kupelnick B, Kim LU, et al. Effects of statins on nonlipid serum markers associated with cardiovascular disease: a systematic review. Ann Intern Med. 2003;139(8):670–82.
Article
CAS
PubMed
Google Scholar
Schol-Gelok S, de Maat MPM, Biedermann JS, van Gelder T, Leebeek FWG, Lijfering WM, et al. Rosuvastatin use increases plasma fibrinolytic potential: a randomised clinical trial. Br J Haematol. 2020;190:916.
Article
CAS
PubMed
PubMed Central
Google Scholar
Takeuchi S, Takahashi Y, Asai S. Comparison of pleiotropic effects of statins vs fibrates on laboratory parameters in patients with dyslipidemia: a retrospective cohort study. Medicine. 2020;99(50):e23427.
Article
CAS
PubMed
PubMed Central
Google Scholar
Squizzato A, Galli M, Romualdi E, Dentali F, Kamphuisen PW, Guasti L, et al. Statins, fibrates, and venous thromboembolism: a meta-analysis. Eur Heart J. 2010;31(10):1248–56.
Article
CAS
PubMed
Google Scholar