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  1. Thrombolytic therapy is effective in selected patients with deep vein thrombosis (DVT). Therefore, identification of a marker that reflects the age of thrombus is of particular concern. This pilot study aimed ...

    Authors: Eiji Furukoji, Toshihiro Gi, Atsushi Yamashita, Sayaka Moriguchi-Goto, Mio Kojima, Chihiro Sugita, Tatefumi Sakae, Yuichiro Sato, Toshinori Hirai and Yujiro Asada
    Citation: Thrombosis Journal 2016 14:46
    Content type: Research Published on:

  2. Besides maintaining intracellular glutathione stores, gamma-glutamyltransferase(GGT) generates reactive oxygen species and activates NFkB, a redox-sensitive transcription factor key in the induction of Tissue ...

    Authors: Valentina Scalise, Cristina Balia, Silvana Cianchetti, Tommaso Neri, Vittoria Carnicelli, Riccardo Zucchi, Maria Franzini, Alessandro Corti, Aldo Paolicchi, Alessandro Celi and Roberto Pedrinelli
    Citation: Thrombosis Journal 2016 14:45
    Content type: Research Published on:

  3. Heritable thrombophilias are assumed important etiologies for recurrent pregnancy loss. Unlike in the Caucasian populations, protein S and protein C deficiencies, instead of Factor V Lieden and Prothrombin mut...

    Authors: Ming-Ching Shen, Wan-Ju Wu, Po-Jen Cheng, Gwo-Chin Ma, Wen-Chu Li, Jui-Der Liou, Cheng-Shyong Chang, Wen-Hsiang Lin and Ming Chen
    Citation: Thrombosis Journal 2016 14:44
    Content type: Research Published on:

  4. Current treatment of hemophilia A (HemA) patients with repeated infusions of factor VIII (FVIII; abbreviated as F8 in constructs) is costly, inconvenient, and incompletely effective. In addition, approximately 25...

    Authors: Carol H. Miao
    Citation: Thrombosis Journal 2016 14(Suppl 1):41
    Content type: Review Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  6. Paroxysmal nocturnal hemoglobinuria (PNH) is a rare and acquired hematopoietic stem cell disease, with florid clinical presentations. Although this disease has been characterized in the western countries, its ...

    Authors: Wen-Chien Chou, Wei-Han Huang, Ming-Chung Wang, Chao-Sung Chang, Shih-Peng Yeh, Tzeon-Jye Chiou, Yeu-Chin Chen, Tseng-Hsi Lin and Ming-Ching Shen
    Citation: Thrombosis Journal 2016 14(Suppl 1):39
    Content type: Research Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  7. Thrombosis and coagulopathy are the commonest hematological manifestations of envenomation of Russell’s viper venom (RVV). Factor X is activated by a factor X-activating enzyme from Russell’s viper venom (RVV-...

    Authors: Ren-Chieh Wu, Ping-Tse Chou and Li-Kuang Chen
    Citation: Thrombosis Journal 2016 14(Suppl 1):38
    Content type: Research Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  9. Von Willebrand disease (VWD) is not uncommon in Taiwan. In type 2 or type 3 VWD hemorrhagic symptoms are severer and laboratory data relatively more distinctive. De novo mutation and somatic mosaicism of type 2 V...

    Authors: Ming-Ching Shen, Ming Chen, Gwo-Chin Ma, Shun-Ping Chang, Ching-Yeh Lin, Bo-Do Lin and Han-Ni Hsieh
    Citation: Thrombosis Journal 2016 14(Suppl 1):36
    Content type: Research Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  10. This review summarizes the evidence that collagen IV binding is physiologically important, and that the extravascular compartment of FIX is composed of type IV collagen. As we have previously demonstrated, 7 d...

    Authors: Darrel W. Stafford
    Citation: Thrombosis Journal 2016 14(Suppl 1):35
    Content type: Review Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  12. Preimplantation genetic diagnosis (PGD) is a powerful tool to tackle the transmission of monogenic inherited disorders in families carrying the diseases from generation to generation. It currently remains a ch...

    Authors: Ming Chen, Shun-Ping Chang, Gwo-Chin Ma, Wen-Hsian Lin, Hsin-Fu Chen, Shee-Uan Chen, Horng-Der Tsai, Feng-Po Tsai and Ming-Ching Shen
    Citation: Thrombosis Journal 2016 14(Suppl 1):33
    Content type: Review Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  13. Prophylaxis is considered optimal care for hemophilia patients to prevent bleeding and to preserve joint function thereby improving quality of life (QoL). The evidence for prophylaxis is irrefutable and is the...

    Authors: Man-Chiu Poon and Adrienne Lee
    Citation: Thrombosis Journal 2016 14(Suppl 1):32
    Content type: Review Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  14. Inhibitors are the most serious side effect of haemophilia treatment; they occur in 25–30 % of all patients with severe haemophilia A. Over the last 2 decades, conflicting data on the impact of clotting produc...

    Authors: H. Marijke van den Berg
    Citation: Thrombosis Journal 2016 14(Suppl 1):31
    Content type: Review Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  16. Platelets are central mediators of thrombosis and hemostasis. At the site of vascular injury, platelet accumulation (i.e. adhesion and aggregation) constitutes the first wave of hemostasis. Blood coagulation, ...

    Authors: Xiaohong Ruby Xu, Naadiya Carrim, Miguel Antonio Dias Neves, Thomas McKeown, Tyler W. Stratton, Rodrigo Matos Pinto Coelho, Xi Lei, Pingguo Chen, Jianhua Xu, Xiangrong Dai, Benjamin Xiaoyi Li and Heyu Ni
    Citation: Thrombosis Journal 2016 14(Suppl 1):29
    Content type: Review Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  17. Multiple functions of platelets in various physiological and pathological conditions have prompted considerable attention on understanding how platelets are generated and activated. Of the adaptor proteins tha...

    Authors: Hui-Ju Tsai and Ching-Ping Tseng
    Citation: Thrombosis Journal 2016 14(Suppl 1):28
    Content type: Review Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  18. Platelets play a key role in the pathophysiological processes of hemostasis and thrombus formation. However, platelet functions beyond thrombosis and hemostasis have been increasingly identified in recent year...

    Authors: Yukio Ozaki, Shogo Tamura and Katsue Suzuki-Inoue
    Citation: Thrombosis Journal 2016 14(Suppl 1):27
    Content type: Review Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  19. Thrombosis is a common complication in cancer patients. Although the major inherited risk factors for thrombophilia are different between Asians and Caucasians, the main acquired risk factors that are associat...

    Authors: Pantep Angchaisuksiri
    Citation: Thrombosis Journal 2016 14(Suppl 1):26
    Content type: Review Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  20. In recent years, genetic analyses of congenital deficiencies of three anticoagulant proteins, antithrombin, protein C (PC) and protein S (PS), in East Asian patients with venous thromboembolism (VTE) have grea...

    Authors: Toshiyuki Miyata, Keiko Maruyama, Fumiaki Banno and Reiko Neki
    Citation: Thrombosis Journal 2016 14(Suppl 1):25
    Content type: Review Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  21. Venous thrombosis which mainly manifests as deep vein thrombosis of the leg or pulmonary embolism occurs in 1 per 1000 per year. It occurs due to interacting genetic, environmental and behavioral risk factors....

    Authors: F. R. Rosendaal
    Citation: Thrombosis Journal 2016 14(Suppl 1):24
    Content type: Review Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  22. Venous thromboembolism (VTE), which constitutes pulmonary embolism and deep vein thrombosis, is a common disorder associated with significant morbidity and mortality. Landmark trials have shown that direct ora...

    Authors: Siavash Piran and Sam Schulman
    Citation: Thrombosis Journal 2016 14(Suppl 1):23
    Content type: Review Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  23. Hemophilia is the most well-known hereditary bleeding disorder, with an incidence of one in every 5000 to 30,000 males worldwide. The disease is treated by infusion of protein products on demand and as prophyl...

    Authors: Ching-Tzu Yen, Meng-Ni Fan, Yung-Li Yang, Sheng-Chieh Chou, I-Shing Yu and Shu-Wha Lin
    Citation: Thrombosis Journal 2016 14(Suppl 1):22
    Content type: Review Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  24. Atherosclerosis is one of the major causes of death. Data from animal experiments suggest that atherosclerosis involves an inflammatory process of the vascular wall under hyperlipidemia. Atherothrombosis can b...

    Authors: Satoshi Fujii, Tomonori Sugiura, Yasuaki Dohi and Nobuyuki Ohte
    Citation: Thrombosis Journal 2016 14(Suppl 1):21
    Content type: Review Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  25. The antiphospholipid syndrome (APS) is an autoimmune disease characterised by a procoagulant state that predisposes to recurrent thrombosis and miscarriages. Two major discoveries have advanced our understandi...

    Authors: Fatima El-Assaad, Steven A. Krilis and Bill Giannakopoulos
    Citation: Thrombosis Journal 2016 14(Suppl 1):20
    Content type: Review Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  26. Atypical hemolytic uremic syndrome (aHUS) is a rare genetic disorder caused by defective complement regulation resulting in thrombotic microangiopathy (TMA). Patients can present as children or adults. The syn...

    Authors: Yu-Min Shen
    Citation: Thrombosis Journal 2016 14(Suppl 1):19
    Content type: Review Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  27. Snake venoms affect blood coagulation and platelet function in a complex manner. However, two classes of venom proteins, snaclecs and disintegrins have been shown to specifically target receptors including GPI...

    Authors: Tur-Fu Huang, Chun-Chieh Hsu and Yu-Ju Kuo
    Citation: Thrombosis Journal 2016 14(Suppl 1):18
    Content type: Review Published on:

    This article is part of a Supplement: Volume 14 Supplement 1

  29. Disseminated intravascular coagulation (DIC) is a serious disease that, in the presence of underlying disease, causes persistent, generalized, marked coagulation activation. Early treatment based on an appropr...

    Authors: Hidesaku Asakura, Hoyu Takahashi, Toshimasa Uchiyama, Yutaka Eguchi, Kohji Okamoto, Kazuo Kawasugi, Seiji Madoiwa and Hideo Wada
    Citation: Thrombosis Journal 2016 14:42
    Content type: Review Published on:

  30. We tested the hypothesis that disseminated intravascular coagulation (DIC) during the early phase of post-cardiopulmonary resuscitation (CPR) is associated with systemic inflammatory response syndrome (SIRS), ...

    Authors: Takeshi Wada, Satoshi Gando, Yuichi Ono, Kunihiko Maekawa, Kenichi Katabami, Mineji Hayakawa and Atsushi Sawamura
    Citation: Thrombosis Journal 2016 14:43
    Content type: Research Published on:

  31. Aortic thrombosis is a rare disease and only a few cases of the disease, especially associated with chemotherapy for malignant diseases and/or blood diseases, have been previously reported. Although Virchow’s ...

    Authors: Tomonori Sugiura, Yasuaki Dohi, Sumiyo Yamashita, Shunsuke Murai and Nobuyuki Ohte
    Citation: Thrombosis Journal 2016 14:16
    Content type: Case report Published on:

  33. Vitamin K antagonists (VKAs) are effective oral anticoagulants that are titrated to a narrow therapeutic international normalized ratio (INR) range. We reviewed published literature assessing the impact of INR...

    Authors: Jeff R. Schein, C. Michael White, Winnie W. Nelson, Jeffrey Kluger, Elizabeth S. Mearns and Craig I. Coleman
    Citation: Thrombosis Journal 2016 14:14
    Content type: Review Published on:

  34. Guidelines from the Japanese Circulation Society recommend prophylaxis with anticoagulation plus intermittent pneumatic compression or graduated compression stockings (GCS) among patients at the highest risk f...

    Authors: Takeshi Fuji, Satoru Fujita, Tetsuya Kimura, Kei Ibusuki, Kenji Abe, Shintaro Tachibana and Mashio Nakamura
    Citation: Thrombosis Journal 2016 14:13
    Content type: Research Published on:

  35. The need for anticoagulation therapy (AC) in patients with subsegmental pulmonary embolism (SSPE) diagnosed by computed tomography of the pulmonary arteries (CTPA) has been questioned, as these patients run lo...

    Authors: R. Ghazvinian, A. Gottsäter and J. Elf
    Citation: Thrombosis Journal 2016 14:12
    Content type: Research Published on:

  36. Authors: Norikazu Yamada, Atsushi Hirayama, Hideaki Maeda, Satoru Sakagami, Hiroo Shikata, Martin H. Prins, Anthonie W. A. Lensing, Masaharu Kato, Junichi Onuma, Yuki Miyamoto, Kazuma Iekushi and Mariko Kajikawa
    Citation: Thrombosis Journal 2016 14:11
    Content type: Erratum Published on:

    The original article was published in Thrombosis Journal 2015 13:2

  37. Dabigatran etexilate may be underutilized in geriatric patients because of inadequate clinical experience in individuals with severe renal impairment and post-marketing reports of bleeding events. Assessing th...

    Authors: Luigi Brunetti, Betty Sanchez-Catanese, Leonid Kagan, Xia Wen, Min Liu, Brian Buckley, James P. Luyendyk and Lauren M. Aleksunes
    Citation: Thrombosis Journal 2016 14:10
    Content type: Research Published on:

  38. In hereditary spherocytosis with severe anemia, splenectomy is a recommended treatment. However, the spleen carries an important role both in immune function and coagulation. The increased risk of bacterial in...

    Authors: Cedric Davidsen, Terje Hjalmar Larsen, Eva Gerdts and Mai Tone Lønnebakken
    Citation: Thrombosis Journal 2016 14:9
    Content type: Case report Published on:

  39. Thromboprophylaxis is recommended for patients undergoing total hip or total knee replacement (THR, TKR). An international, open-label, prospective, observational, single-arm study in a routine clinical settin...

    Authors: Nadia Rosencher, Charles M. Samama, Martin Feuring, Martina Brueckmann, Eva Kleine, Andreas Clemens and Simon Frostick
    Citation: Thrombosis Journal 2016 14:8
    Content type: Original clinical investigation Published on:

  40. Studies show the In-hospital Mortality for Pulmonary embolism using Claims daTa (IMPACT) rule can accurately identify pulmonary embolism (PE) patients at low-risk of early mortality in a retrospective setting ...

    Authors: Erin R. Weeda, Christine G. Kohn, Gregory J. Fermann, W. Frank Peacock, Christopher Tanner, Daniel McGrath, Concetta Crivera, Jeff R. Schein and Craig I. Coleman
    Citation: Thrombosis Journal 2016 14:7
    Content type: Research Published on:

  42. The Editors of Thrombosis Journal would like to thank all of our reviewers who have contributed to the journal in Volume 13 (2015) and whose valuable support is fundamental to its success.

    Authors: Hugo ten Cate and Yukio Ozaki
    Citation: Thrombosis Journal 2016 14:5
    Content type: Reviewer acknowledgement Published on:

  43. Data estimating the annual incidence of venous thromboembolism (VTE) in France, taking into account both hospital and community settings, are very lacking.

    Authors: Stéphane Bouée, Corinne Emery, Adeline Samson, Julie Gourmelen, Cécile Bailly and François-Emery Cotté
    Citation: Thrombosis Journal 2016 14:4
    Content type: Original basic research Published on:

  45. Despite the association of cancer-derived circulating tissue factor (TF)-containing microvesicles and hypercoagulable state, correlations with the incidence of thrombosis remain unclear.

    Authors: Camille Ettelaie, Mary EW Collier, Sophie Featherby, Naima E. Benelhaj, John Greenman and Anthony Maraveyas
    Citation: Thrombosis Journal 2016 14:2
    Content type: Original basic research Published on:

  46. Thus far, validated whole blood assays used in in vitro fibrinolysis experiments using thromboelastometry (ROTEM) are lacking or have yet to be tested in humans.

    Authors: Gerhardus J. A. J. M. Kuiper, Marie-Claire F. Kleinegris, René van Oerle, Henri M. H. Spronk, Marcus D. Lancé, Hugo ten Cate and Yvonne M. C. Henskens
    Citation: Thrombosis Journal 2016 14:1
    Content type: Original basic research Published on:

  47. The aim of the study was to discuss the results of catheter-directed thrombolysis and complementary procedures to treat acute iliofemoral deep vein thrombosis (DVT) evaluating the safety and effectivness of an...

    Authors: Leslie Fiengo, Federico Bucci, Elias Khalil and Bruno Salvati
    Citation: Thrombosis Journal 2015 13:40
    Content type: Original basic research Published on:

  48. Dabigatran is an alternative to warfarin (WF) for the thromboprophylaxis of stroke in patients with non-valvular atrial fibrillation (NVAF). The advantage of dabigatran over WF is that monitoring is not requir...

    Authors: Kazunori Otsui, Diana A. Gorog, Junichiro Yamamoto, Takayuki Yoshioka, Sachiyo Iwata, Atsushi Suzuki, Toru Ozawa, Asumi Takei and Nobutaka Inoue
    Citation: Thrombosis Journal 2015 13:39
    Content type: Original clinical investigation Published on:

  49. Although aspirin has a well-established role in preventing adverse events in patients with known cardiovascular disease (CVD), its benefit in patients without a history of CVD remains under scrutiny. Current d...

    Authors: Jobert Richie N. Nansseu and Jean Jacques N. Noubiap
    Citation: Thrombosis Journal 2015 13:38
    Content type: Review Published on:

  50. The aim of this study was to assess the safety and efficacy of switching therapy from low molecular weight heparin (LMWH; enoxaparin) to dabigatran for prevention of venous thromboembolic events (VTE) in patie...

    Authors: Christian Wurnig, Andreas Clemens, Helmuth Rauscher, Eva Kleine, Martin Feuring, Reinhard Windhager and Josef Grohs
    Citation: Thrombosis Journal 2015 13:37
    Content type: Original clinical investigation Published on:
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Thrombosis Journal

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