Baptiste G, Bern MM, Bothe Jr A, Bistrian BR, Blackburn G. Low Antithrombin III in morbid obesity: improved levels following weight loss. J Parenter Enteral Nutr. 1983;7:447–9.
Bern MM, Bothe Jr A, Bistrian B, Batiste G, Haywood E, Blackburn G. Effects of low-dose warfarin on antithrombin III levels in morbidly obese patients. Surgery. 1983;94:78–83.
Francis CW, Marder VJ, Evarts CM, Yaukoolbodi S. Two-step warfarin therapy. Prevention of postoperative venous thrombosis without excessive bleeding. JAMA. 1983;249:374–8.
Bern MM, Bothe A, Bistrian B, Champagne CD, Keane MS, Blackburn G. Prophylaxis against central vein thrombosis with low-dose warfarin. Surgery. 1986;99:216–21.
Poller L, McKernan A, Thomson JM, Elstein M, Hirsh PJ, Jones JB. Fixed minidose warfarin: a new approach to prophylaxis against venous thrombosis after major surgery. Br Med J (Clin Res Ed). 1987;295:1309–12.
Bern MM, Lokich JJ, Wallach SR, Bothe Jr A, Benotti PN, Arkin CF, Greco FA, Huberman M, Moore C. Very low doses of warfarin can prevent thrombosis in central venous catheters. Ann Int Med. 1990;112:423–8.
MacCallum PK, Thomson JM, Poller L. Effects of fixed minidose warfarin on coagulation and fibrinolysis following major gynaecological surgery. Thromb Haemost. 1990;64:511–5.
Bern MM, Bierbaum B, Wetzner S, Brennan W, McAlister S. Very low dose warfarin as prophylaxis against ultrasound detected deep vein thrombosis following primary hip replacement. Am J Hemat. 2002;7:69–74.
Mismetti P, Mille D, Laporte S, for the CIP Study Group. Low-molecular weight heparin (nadroparin) and very low doses of warfarin in the prevention of upper extremity thrombosis in cancer patients with indwelling long-term central venous catheters: A pilot randomized trial. Haematologica. 2003;88:67–74.
Vives MJ, Hozack WJ, Sharkey PF, Moriarty L, Sokoloff B, Rothman RH. Fixed minidose versus adjusted low-dose warfarin after total joint arthroplasty: a randomized prospective study. J Arthroplasty. 2001;16:1030–7.
Bern MM, Deshmukh RV, Nelson R, Bierbaum BE, Sevier N, Howie N, Losina E, Katz JN. Low-dose warfarin coupled with lower leg compression is effective prophylaxis against thromboembolic disease after hip arthroplasty. J Arthroplasty. 2007;22:644–50.
Lavau-Denes S, Lacroix P, Maubon A, Preux PM, Genet D, Vénat-Bouvet L, Labourey JL, Martin J, Slaouti P, Tubiana-Mathieu N. Prophylaxis of catheter-related deep vein thrombosis in cancer patients with low-dose warfarin, low molecular weight heparin, or control: a randomized, controlled, phase III study. Cancer Chemother Pharmacol. 2013;72:65–73.
Holm J, Berntorp E, Carlsson R, Erhardt L. Low-dose warfarin decreases coagulability without affecting prothrombin complex activity. J Intern Med. 1993;234:303–8.
Boraks P, Seale J, Price J, Bass G, Ethell M, Keeling D, Mahendra P, Baglin T, Marcus R. Prevention of central venous catheter associated thrombosis using minidose warfarin in patients with haematological malignancies. Br J Haematol. 1998;101:483–6.
Bach AU, Anderson SA, Foley AL, Williams EC, Suttie JW. Assessment of vitamin K status in human subjects administered “minidose” warfarin. Am J Clin Nutr. 1996;64:894–902.
Uehara S, Gotoh K, Handa H, Honjo K, Hirayama A. Process of carboxylation of glutamic acid residues in th Gla domain of human des-gamma-carboxyprothrombin. Clin Chim Acta. 1999;289:33–44.
Stenflo J, Fernlurd P, Egon W, Roepstorff P. Vitamin K-dependent modification of glutamic acid residues in prothrombin. Proc Natl Acad Sci U S A. 1974;71:2730–3.
Tuhy PM, Bloom JW, Mann KG. Decarboxylation of bovine prothrombin fragment 1 and prothrombin. Biochemistry. 1979;18:5842–8.
Furie B, Furie BC. The molecular basis of blood coagulation. Cell. 1988;53:505–18.
Colpitts TL, Prorok M, Castellino FJ. Binding of calcium to individual gamma-carboxyglutamic acid residues of human protein C. Biochemistry. 1995;34:2424–30.
Ratcliffe JV, Furie B, Furie BC. The importance of specific gamma-carboxyglutamic acid residues in prothrombin. J Biol Chem. 1993;268:24339–45.
Rachidi S, Aldin ES, Greenberg C, Sachs B, Streiff M, Zeidan AM. The use of novel oral anticoagulants for thromboprophylaxis after elective major orthopedic surgery. Expert Rev Hematol. 2013;6:677–95. doi:10.1586/1747408.
Anderson Jr FA, Wheeler HB, Goldberg RJ, Hosmer DW, Patwardhan NA, Jovanovic B, Forcier ADalen JE. A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study. Arch Intern Med. 1991;151:933–8.
Piovella F, Wang CJ, Lu H, Lee K, Lee LH, Turpie AGG, Gallus AS, Planes A, Passera R Rouillon A for the AIDA Investigators. Deep-vein thrombosis rates after major orthopedic surgery in Asia. An epidemiological study based on postoperative screening with centrally adjudicated bilateral venography. J Thromb Haemost. 2005;3:2664–70.
Turpie AG, Levin MN, Hirsh J, Carter CJ, Jay RM, Powers PJ, Andrew M, Hull RD, Gent M. A randomized controlled trial of low molecular–weight heparin (enoxaparin) to prevent deep vein thrombosis in patients undergoing elective hip surgery. N Eng J Med. 1986;315:925–9.
Hoek JA, Nurmohamed MT, Hamelyck KJ, Marti RK, Knipscheer HC, ten Cate H, Büller HR, Magnani HN, ten Cate JW. Prevention of deep vein thrombosis following total hip replacement by low molecular weight heparinoid. Thrombo Haemost. 1992;67:28–32.
McKenna K, Bachmann F, Kaushal SP, Galante JO. Thromboembolic disease in patients undergoing knee replacement. J Bone Joint Surg Am. 1976;58:928–32.
Stulberg BN, Insal JN, Willaims GW, Ghelman B. Deep-vein thrombosis following total knee replacement. An analysis of six hundred and thirty-eight arthroplasties. J Bone Joint Surg Am. 1984;66:194–201.
Januel JM, Chen G, Ruffieux C, Quan H, Douketis JD, Crowther MA, Colin C, Ghali WA, Burnand B; IMECCHI Group. Symptomatic in-hospital deep vein thrombosis and pulmonary embolism following hip and knee arthroplasty among patients receiving recommended prophylaxis: a systematic review. JAMA. 2012;307:294–303.
Enyart JJ, Jones RJ. Low-dose warfarin for prevention of symptomatic thromboembolism after orthopedic surgery. Ann Pharmacother. 2005;39:1002–7.
Kwong LM. Comparative safety and efficacy of antithrombotics in the management of venous thromboembolism after knee and hip replacement surgery: focus on rivaroxaban. Clin Pharmacol. 2013;5:143–8.
Turpie AG, Bauer KA, Eriksson BI, Lassen MR. Fondaparinux vs enoxaparin for prevention of venous thromboembolism in major orthopaedic surgery: a meta-analysis of 4 randomized double-blind studies. Arch Intern Med. 2002;162:1833–40.
Eriksson BI, Bauer KA, Lassen MR, Turpie AG, Steering Committee for of the Pentasaccaride in Hip-Fracture Study Group. Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip fracture surgery. N Engl J Med. 2001;345:1298–304.
Bauer KA, Eriksson BI, Lassen MR, Turpie AG, Steering Committee for of the Pentasaccaride in Hip-Fracture Study Group. Fondaparinux compared to enoxaparin for the prevention of venous thromboembolism after elective knee surgery. N Engl J Med. 2001;345:1305–10.
Tran AH, Lee G. Fondaparinux for prevention of venous thromboembolism in major orthopedic surgery. Ann Pharmacother. 2003;37:1632–43.
Poller L, Thomson JM, MacCallum PK, Nicholson DA, Weighill FJ, Lemon JG. Minidose warfarin and failure to prevent deep vein thrombosis after joint replacement surgery despite inhibiting the postoperative rise in plasminogen activator inhibitor activity. Clin Appl Throm Hemost. 1995;1:267–73.
Fordyce MJ, Baker AS, Staddon GE. Efficacy of fixed minidose warfarin prophylaxis in total hip replacement. BMJ. 1991;303:219–20.
Heaton DC, Han DY, Inder A. Minidose (1mg) warfarin as prophylaxis for central vein catheter thrombosis. Int Med J. 2002;3:84–8.
Couban D, Goodyear M, Burnell M, Dolan D, Wasi P, Barnes D, Macleod D, Burton E, Andreou P, Anderson DR. Randomized placebo-controlled study of low-dose warfarin for the prevention of central venous catheter-associated thrombosis in patients with cancer. J Clin Oncol. 2005;23:4063–9.
Young AM, Billingham LJ, Begum G, Kerr DJ, Hughes AI, Rea DW, Shepherd S, Stanley A, Sweeney A, Wilde J, Wheatley K, WARP Collaborative Group, UK. Warfarin thromboprophylaxis in caner patient with central venous catheters (WARP): an open-label randomized trial. Lancet. 2009;373:567–74. doi:10.1016/S0140-6736(09)60205-1.
Ruud E, Holmstrøm H, De Lange C, Hogstad EM, Wesenberg F. Low-dose warfarin for the prevention of central line-associated thrombosis in children with malignancies—a randomized, controlled study. Acta Paediatr. 2006;95:1053–9.
Wells PS, Anderson DR, Bormanis J, Guy F, Mitchell M, Gray L, Clement C, Robinson KS, Lewandorski B. Value of assessment of pretest probability of deep-vein thrombosis in clinical management. Lancet. 1997;350:1795–8.
Fraser JD, Anderson DR. Deep vein thrombosis: recent advances and optimal investigation with US. Radiology. 1999;211:9–14.
Subramaniam RM, Heath R, Chou T, Cox K, Davis G, Swarbrick M. Deep venous thrombosis: withholding anticoagulation therapy after negative complete lower limb US findings. Radiology. 2005;237:348–52.
Bergqvist D, Benoni G, Björgell O, Fredin H, Hedlundh U, Nicolas S, Nisson P, Nylander G. Low-molecular-weight heparin (enoxaparin) as prophylaxis against venous thromboembolism after total hip replacement. N Engl J Med. 1996;335:696–700.
Planes A, Vochelle N, Fagola M, Bellaud M. Comparison of two low-molecular-weight heparins for the prevention of postoperative venous thromboembolism after elective hip surgery. Reviparin Study Group. Blood Coagul Fibrinolysis. 1998;9:499–505.
Eriksson BI, Ekman S, Kalebo P, Zachrisson B, Bach D, Close P. Prevention of deep-vein thrombosis after total hip replacement: direct thrombin inhibition with recombinant hirudin, CGP 39393. Lancet. 1996;347:635–9.
Hull RD, Pineo GF, Francis C, Bergqvist D, Fellenius C, Soderberg K, Holmqvist A, Mant M, Dear R, Baylis B, Mah A, Brant R. Low-molecular-weight heparin prophylaxis using dalteparin in close proximity to surgery vs. warfarin in hip arthroplasty patients: a double- blind, randomized comparison. The North American Fragmin Trial Investigators. Arch Int Med. 2000;160:2199–207.
Leclerc JR, Geerts WH, Desjardins L, Laflamme GH, L’Espérance B, Demers C, Kassis J, Cruickshank M, Whitman L, Delorme F. Prevention of venous thromboembolism after knee arthroplasty. A randomized, double-blind trial comparing enoxaparin with warfarin. Ann Int Med. 1996;124:619–26.
Aglietti P, Baldini A, Vena LM, Abbate R, Fedi S, Falciani M. Effect of tourniquet use on activation of coagulation in total knee replacement. Clin Orthop Relat Res. 2000;169–177.
Weiss G, Lison S, Spannagl M, Heindl B. Expressiveness of global coagulation parameters in dilutional coagulopathy. Br J Anaesth. 2010;105:429–36.
Schramko A, Suojaranta-Ylinen R, Kuitunen A, Raivio P, Kukkonen S, Niemi T. Hydroxyethylstarch and gelatin solutions impair blood coagulation after cardiac surgery: a prospective randomized trial. Br J Anaesth. 2010;104:691–7.
Haisch G, Boldt J, Krebs C, Suttner S, Lehmann A, Isgro F. Influence of a new hydroxyethylstarch preparation (HES 130/0.4) on coagulation in cardiac surgical patients. J Cardiothorac Vasc Anesth. 2011;25:755–7.
Konkle B. Acquired disorders of platelet function. American Society of Hematology: Hematology; 2011. p. 391–6.
Kuruvilla J, Wells PS, Morrow B, MacKinnon K, Keeney M, Kovacs MJ. Prospective assessment of the natural history of positive D-dimer results in persons with acute venous thromboembolism (DVT or PE). Thromb Haemost. 2003;89:284–7.
Prandoni P, Bruchi O, Sabbion P, Tanduro C, Scudeller A, Sardella C, Errigo G, Pietobelli F, Maso G, Girolami A. Prolonged thromboprophylaxis with oral anticoagulants after total hip arthroplasty: a prospective controlled randomized study. Arch Intern Med. 2002;162:1966–71.
Eriksson BI, Lassen MR, for the PENTasaccharide in Hip-Fracture Surgery Investigators. Duration of prophylaxis against venous thromboembolism with fondaparinux after hip fracture surgery. Arch Intern Med. 2003;163:1337–42.
Cohen AT, Bailey CS, Alikhan R, Cooper DJ. Extended thromboprophylaxis with low molecular weight heparin reduces symptomatic venous thromboembolism following lower limb arthroplasty-a meta-analysis. Thromb Haemost. 2001;85:940–1.
Sobieraj DM, Lee S, Coleman CI, Tongbram V, Chen W, Colby J, Makanji S, Ashaye AO. Prolonged versus standard-duration venous thromboprophylaxis in major orthopedic surgery. Ann Intern Med. 2012;156:720–7.
Eriksson BI. Improvements in the prevention of postoperative venous thromboembolism in hip fracture patients. Orthopedics. 2003;26 suppl 8:s851–8.
Turpie AG. Fondaparinux: a factor Xa inhibitor for antithrombotic therapy. Expert Opin Pharmacother. 2004;5:1373–84.
Cohen AT, Khushal A. Extended thromboprophylaxis following lower limb arthroplasty: what do the clinical trials mean? Haemostasis. 2000;30 suppl 2:88–94.